[Lung function testing under COVID-19: A position paper].
Authors: Plantier L, Costes F, groupes de travail 'Fonction' et 'Alvéole' de la Société de pneumologie de langue française PMID: 32600900 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - July 2, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Pragmatic proposals of respiratory follow-up for patients with SARS-CoV-2 infection established in record time for all healthcare practioners].
Authors: Raherison C PMID: 32564800 [PubMed - in process] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - June 23, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Pulmonologist perceptions and practices of palliative care for people with chronic obstructive pulmonary disease].
CONCLUSION: Uncertainty as to when to begin a palliative approach for COPD patients and perceptions around communication in chronic diseases appear to be the main obstacles to a palliative approach. PMID: 32505369 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - June 10, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Extracellular molecules controlling the contraction of airway smooth muscle and their potential contribution to bronchial hyperresponsiveness].
Authors: Gazzola M, Flamand N, Bossé Y Abstract INTRODUCTION: A significant portion of symptoms in some lung diseases results from an excessive constriction of airways due to the contraction of smooth muscle and bronchial hyperresponsiveness. A better understanding of the extracellular molecules that control smooth muscle contractility is necessary to identify the underlying causes of the problem. STATE OF KNOWLEDGE: Almost a hundred molecules, some of which newly identified, influence the contractility of airway smooth muscle. While some molecules activate the contraction, others activate the relaxation...
Source: Revue des Maladies Respiratoires - June 5, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Ileum and brain, unusual metastatic sites for a thymoma].
CONCLUSIONS: Extra-thoracic metastases of thymoma are exceptional but their existence should not be overlooked. Their management is not standardised because of lack of data in the literature. Though surgical excision in oligo-metastatic subjects is a frequently reported therapeutic option, a radiotherapeutic approach, particularly in cerebral situations, could be a credible alternative. PMID: 32482379 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - June 3, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Acute respiratory distress syndrome secondary to SARS-CoV-2 infection in an infant].
Authors: Lahfaoui M, Azizi M, Elbakkaoui M, El Amrani R, Kamaoui I, Benhaddou H PMID: 32471720 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - May 31, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Antibiotic strategy in pleural empyema in children: Consensus by the DELPHI method].
CONCLUSIONS: The result of this work highlights the needed for new French recommendations based on the evolution of microbial epidemiology in the post PCV13 era. PMID: 32439250 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - May 24, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Hamartochondroma: An unusual cause of endobronchial obstruction in smoking patients].
Authors: Hustache-Castaing R, Ghrenassia G, Raherison C, Peloni JM, Thumerel M, Jougon J Abstract Endobronchial hamartochondroma is a rare benign tumor which differs from the parenchymal form in its symptomatology and also by its treatment which should be as conservative as possible. The endobronchial location is exceptional. Here we present the cases of two patients with endobronchial hamartochondroma associated with clinical manifestation, chest pain and repeated pulmonary infections, respectively. The diagnosis was made after performing a CT-scan, a PET-SCAN and histological analysis. After discussion in a multi...
Source: Revue des Maladies Respiratoires - May 21, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Management of a patient with a double EGFR and MET anomaly by combined treatment].
CONCLUSIONS: This case highlights the efficacy of concomitant treatment in a patient with two oncogenic drivers. PMID: 32430158 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - May 21, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Asthma and COVID-19: a risk population?]
Authors: Underner M, Peiffer G, Perriot J, Jaafari N PMID: 32419737 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - May 20, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Acupuncture and smoking cessation, a review of the literature].
CONCLUSION: Acupuncture can be offered to patients wishing to stop smoking within the framework of a global management programme. The association of acupuncture with classical aids increases the chances of the patient stopping. The conditions of intervention should be defined precisely within the framework of a randomised controlled trial. PMID: 32416946 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - May 18, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Pulmonary histoplasmosis in an immunocompetent patient].
CONCLUSION: This case presents an immunocompetent patient with pulmonary histoplasmosis and multiple, radiologically atypical, nodules. The diagnosis was established by BAL culture. PMID: 32409000 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - May 17, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Guide for follow-up of patients with SARS-CoV-2 pneumonia. Management proposals developed by the French-language Respiratory Medicine Society. Version of 10 May 2020].
Authors: Andrejak C, Blanc FX, Costes F, Crestani B, Perez T, Philippe B, Plantier L, Schlemmer F, Sese L, Stach B, Uzunhan Y, Zanetti C, Zysman M, Raherison C, Maitre B Abstract The French-language Respiratory Medicine Society proposes a guide for the follow-up of patients who have presented with SARS-CoV-2 pneumonia. The proposals are based on known data from previous epidemics, on acute lesions observed in SARS-CoV-2 patients and on expert opinion. This guide proposes a follow-up based on three categories of patients: 1) patients managed outside hospital for possible or proven SARS-CoV-2 infection, referred by t...
Source: Revue des Maladies Respiratoires - May 17, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Telemonitoring in continuous positive airway pressure-treated patients with obstructive sleep apnoea syndrome: An algorithm proposal].
Authors: Prigent A, Gentina T, Launois S, Meurice JC, Pia d'Ortho M, Philippe C, Tamisier R, Gagnadoux F, Jaffuel D, groupe de travail de la Société française de recherche et médecine du sommeil et la Société de pneumologie de langue française Abstract Most of the continuous positive airway pressure (CPAP) devices currently in use allow telemonitoring of observance, leaks and the apnoea-hypopnoea index (AHI). La Société française de recherche et de médecine du sommeil (SFRMS) and La Société de pneumologie de langue fran&ccedi...
Source: Revue des Maladies Respiratoires - May 14, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Parardoxical reaction following tuberculosis treatment in non HIV-infected patients].
Authors: Kassegne L, Bourgarit A, Fraisse P Abstract A paradoxical reaction is the worsening of prior existing, or the appearance of, new tuberculous lesions, following the initiation of treatment with anti-tuberculous drugs, after the exclusion of poor compliance, malabsorption, drug interaction or multiresistant mycobacteria. Well known and well managed in the context of HIV coinfection, it is not well known outside this context. An increasing number of publications have described this syndrome. This review aims to describe the pathogenic, epidemiological, clinical, prognostic and therapeutic elements of non-HIV-...
Source: Revue des Maladies Respiratoires - May 11, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Cannabis: Similarities and differences with tobacco].
Authors: Mura P, Underner M, Brunet B Abstract Nicotine is the specific psychoactive substance of tobacco while tetrahydrocannabinol (THC) is the specific component of cannabis. The inhalation technique of cannabis is different from that of tobacco smoking: the volume of puffs is larger, inhalation is deeper, and pulmonary retention time is longer. Cannabis addiction is difficult to evaluate, both products often being smoked concomitantly. The principle physical side effects of cannabis affect organs and functions in a similar way to tobacco: pulmonary, cardiovascular, endocrine and stomatological. Gastrointestinal...
Source: Revue des Maladies Respiratoires - May 10, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[IgA vasculitis secondary to Klebsiella pneumoniae infection].
CONCLUSION: This observation reminds us of the need to search carefully for any pathogenic agent that may be driving IgA vasculitis as this may be important both for understanding aetiology and for treatment. PMID: 32360054 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - May 4, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Smoking and coronavirus disease 2019 (COVID-19)].
Authors: Underner M, Peiffer G, Perriot J, Jaafari N PMID: 32331829 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 27, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Management of mild asthma in 2019-2020: What about new international therapeutic proposals (GINA 2019)?]
Authors: Raherison C, Deschildre A, Garcia G, Girodet PO, Taillé C, Chenivesse C, Devouassoux G, Molimard M, Didier A PMID: 32331830 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 27, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Computed tomography in children with cystic fibrosis: The role of an expiratory protocol].
Authors: Simon S, Baunin C, Vial J, Mas E, Roditis L, Michelet M, Mittaine M Abstract INTRODUCTION: Chest computed tomography (CT) is essential to monitor lung disease in children with cystic fibrosis, but it involves recurrent exposure to ionizing radiation. The aim of this study was to compare the current complete CT protocol (volumetric end-inspiratory plus sequential expiratory acquisition) to a sequential expiratory acquisition protocol alone in terms of image analysis and ionizing radiation dose. METHODS: Seventy-eight CT scans from 57 children aged 5 to 18 years old were scored on the complete protocol i...
Source: Revue des Maladies Respiratoires - April 27, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Molecular diagnosis of tuberculosis].
Authors: Morel F, Jaffré J, Sougakoff W, Aubry A, Véziris N Abstract Tuberculosis is caused by the M. tuberculosis complex. Its slow growth delays the bacteriological diagnosis based on phenotypic tests. Molecular biology has significantly reduced this delay, notably thanks to the deployment of the Xpert® MTB/RIF test (Cepheid), which detects the M. tuberculosis complex and rifampicin resistance in 2hours. Other tests detecting isoniazid and second-line antituberculous drugs resistance have been developed. However, the performances of molecular tests are significantly reduced if the acid...
Source: Revue des Maladies Respiratoires - April 27, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Carbon monoxide poisoning in active or passive shisha smokers].
Authors: Underner M, Perriot J, Peiffer G, Dewitte JD, Jaafari N Abstract In France, shisha (narghile) smoking is increasingly popular among adolescents and young adults and is generally thought to be less harmful and addictive than cigarettes. This systematic review of data on carbon monoxide (CO) poisoning in active or passive shisha tobacco smokers selected 17 studies. Sixteen case reports, including 39 patients (mean age: 22.3 years; males: 51.3%), described acute carbon monoxide poisoning in active shisha smokers. The most common symptoms were dizziness, headache, and nausea. Loss of consciousness occurred in ...
Source: Revue des Maladies Respiratoires - April 27, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[A case of systemic sclerosis].
We report the case of a woman initially treated for drug-induced acute interstitial lung disease revealing chronic interstitial pneumonia with autoimmune features. The disease evolved in three stages with the occurrence of a rapidly progressive diffuse skin sclerosis with anti-ARNPol3 antibodies in the context of ovarian cancer remission. PMID: 32284205 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 16, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Aspergillus-related respiratory conditions and COPD: Diagnostic challenges].
CONCLUSION: The complexity of the diagnosis of pulmonary aspergillosis is related to its multiple types with sometimes unclear distinctions. Any type of pulmonary aspergillosis can be observed in patients with COPD, depending on associated risks factors. It would be helpful to establish specific classifications adapted to patients with COPD. This will require larger, prospective, multicentre studies. PMID: 32284206 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 16, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Diagnostic and therapeutic management of venous thromboembolic disease in obese patients].
Authors: Tromeur C, Le Mao R, Leven C, Couturaud F, Théreaux J, Lacut K Abstract Despite the high proportion of obese patients this population remains understudied in the field of venous thromboembolic disease (VTE). Obesity is a risk factor for pulmonary embolism and/or deep vein thrombosis, especially when it is associated with other risk factors for VTE. Currently there is no validated diagnostic algorithm for VTE in the population of obese patients. Moreover, imaging examinations can be of poor quality and inconclusive. In the prevention of VTE, data concerning obese patients are mainly based on low-leve...
Source: Revue des Maladies Respiratoires - April 16, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[The effect of air pollution in diffuse interstitial lung disease].
Authors: Sesé L, Jeny F, Uzunhan Y, Khamis W, Freynet O, Valeyre D, Bernaudin JF, Annesi-Maesano I, Nunes H Abstract Few studies have examined the effects of air pollution in diffuse interstitial lung disease and they have focused on small numbers of patients. Most data are available in idiopathic pulmonary fibrosis and studies suggest that the level of exposure to pollutants may influence the development of acute exacerbations (ozone and NO2), their incidence (NO2), decline in respiratory function (PM10) and death (PM10 and PM2.5). Several studies show an increase in the incidence of rheumatoid arthritis in...
Source: Revue des Maladies Respiratoires - April 14, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Kanamycin-induced ototoxicity during treatment of multidrug-resistant tuberculosis].
Authors: Poka-Mayap V, Balkissou Adamou D, Pefura-Yone EW, Kuaban C Abstract INTRODUCTION: Aminoglycosides are commonly used in the treatment of multidrug-resistant tuberculosis (MDR-TB). Their use can cause ototoxicity with irreversible hearing loss. The aim of this study was to determine the incidence and to identify factors associated to kanamycin-induced ototoxicity during MDR-TB treatment in Yaounde. METHODS: The records of patients hospitalized in the pulmonology department of the Jamot Hospital of Yaounde between May 2008 and July 2015 (7 years) for treatment of MDR-TB with regimens containing kanamycin ...
Source: Revue des Maladies Respiratoires - April 14, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[An unusual mass].
Authors: Betraoui F PMID: 32278509 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 14, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Enteral nutrition in malnourished patients with lung cancer].
Authors: Pierret T, Fontaine É, Pérol M, Avrillon V, Swalduz A, Pinsolle J, Giaj-Levra M, Moro-Sibilot D, Toffart A PMID: 32279889 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 14, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Diagnostic difficulties of chronic pulmonary berylliosis in France].
CONCLUSION: In this study, we report 33 cases of CBD followed in France between 2010 and 2014. The poor understanding of CBD and the exposure leading to it, the late development after the end of exposure, the complexity of the diagnosis and the similarities with sarcoidosis may explain the small number of cases reported. PMID: 32279890 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 14, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Physical activity in severe asthma: Results of the FASE-CPHG Study].
Authors: Coëtmeur D, Parrat É, Nocent-Ejnaini C, Mangiapan G, Prud'homme A, Oster JP, Vecchi CA, Maurer C, Raherison C, Debieuvre D, Portel L Abstract INTRODUCTION: Data on physical activity in severe asthma are scarce. From May 2016 to June 2017, 1502 adult patients with severe asthma visiting a pulmonologist practicing in one of the 104 non-academic hospitals participating in the study were included in this prospective, cross-sectional, multicenter study, provided they gave consent. Physical activity was classified according to 4 levels: 1 (no activity), 2 (occasional), 3 (regular), or 4 (frequent). C...
Source: Revue des Maladies Respiratoires - April 13, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[E-cigarette use among cannabis users and multi-users of psychoactive products: A cohort study].
CONCLUSION: Cannabis users and multi-users would tend to experiment with e-cigarettes more than other patients but this use would not be sustained. PMID: 32276746 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 13, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Pneumocystis jirovecii and quantitative PCR: Pneumonia or colonization?]
Authors: Gazaignes S, Bergeron A, Menotti J, Desseaux K, Molina JM, De Castro N Abstract BACKGROUND: Quantitative PCR to detect Pneumocystis jirovecii (Pj) is a new tool for the diagnosis of Pneumocystis jirovecii pneumonia (PJP). The yield of this technique, in cases of low fungal burden, when the standard technique using immunofluorescence (IF) is negative, needs to be evaluated. METHODS: We retrospectively reviewed the charts of all patients with a positive PCR but negative IF test (PCR+/IF-) in bronchoalveolar lavage (BAL) fluid performed over one year. We used an algorithm based on underlying immunosuppres...
Source: Revue des Maladies Respiratoires - April 11, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Short-term results of video-assisted lung cancer surgery in octogenarians].
CONCLUSIONS: Videoassisted lung cancer resection in a selected population of octogenarians is associated with satisfactory short-term results. It is reasonable to favour minimally invasive techniques in this population, even if the proof of their superiority has not yet been firmly established. PMID: 32273117 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 11, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[The impact of exposure to cigarette smoke on the haemodynamic response during exercise of patients under specific treatment for pulmonary arterial hypertension].
DISCUSSION: Our study did not show any significant difference in terms of haemodynamic changes during exercise between a group of patients under specific PH treatment exposed to cigarette smoke and a group unexposed. Endothelial dysfunction induced by smoke exposure does not appear to have a major impact on the response to the specific PH treatment. PMID: 32199735 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - March 24, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[How to reduce lung cancer mortality among people living with HIV?]
Authors: Ruppert AM, Lavolé A, Makinson A, Le Maître B, Cadranel J Abstract Lung cancer is the leading cause of cancer related death among people living with HIV (PLHIV). Tobacco exposure is higher among PLHIV (38.5%) and mainly explains the increased risk of lung cancer. To reduce lung cancer mortality, two approaches need to be implemented: lung cancer screening with low-dose thoracic CT scan and smoking cessation. Low dose CT scan is feasible in PLHIV. The false positive rate is not higher than in the general population, except for cases with CD4
Source: Revue des Maladies Respiratoires - March 22, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[A case of multifocal cavernous haemangiomas of the lung, spleen and bone].
CONCLUSIONS: Bronchopulmonary cavernous haemangiomas associated with extra-thoracic lesions are exceptionally rare and their presentation, suggesting, a malignant cause, often leads to surgical resection for diagnostic and, eventually, therapeutic management. We report an original case of cavernous haemangiomas involving lung, lymph nodes, spleen and bone. PMID: 32171443 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - March 18, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[The expression and role of nerve growth factor (NGF) in pulmonary hypertension].
Authors: Cardouat G, Guibert C, Freund-Michel V Abstract Pulmonary hypertension is a severe multifactorial disease of the pulmonary circulation characterized by a progressive elevation in mean pulmonary arterial pressure (PAPm), leading to right ventricular failure and the death of the patient. Current therapies slow the progression of the disease but do not offer a cure. Nerve growth factor NGF is a growth factor playing a significant role in the pathophysiology of pulmonary hypertension, particularly in pulmonary arterial hyperreactivity, and the remodelling and inflammation of the pulmonary vasculature. Thus, ta...
Source: Revue des Maladies Respiratoires - March 12, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[SLC6A14, a modifier gene in cystic fibrosis].
Authors: Ruffin M, Mercier J, Calmel C, Mésinèle J, Corvol H, Guillot L Abstract Although cystic fibrosis is a monogenic disease, a considerable clinical phenotypic variability is observed in patients with the same CFTR mutations. Thanks to the development of new and powerful tools for carrying out genetic studies, several genes called "modifier genes" have been identified as being associated with the severity of the lung function disorder in cystic fibrosis patients. Among these genes, SLC6A14 may modulate the anti-infective response and epithelial integrity of the airways, thus providing a...
Source: Revue des Maladies Respiratoires - March 10, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[HSP27: A new target for treating idiopathic pulmonary fibrosis?]
Authors: Pommerolle L, Burgy O, Bonniaud P, Goirand F Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease without therapeutic options. The development of new therapeutic strategies for the disease is needed. IPF is characterized by myofibroblast accumulation and collagen overproduction. Transforming growth factor-β1 (TGF-β1) is a key cytokine activating these pathological processes. Heat shock proteins (HSPs) are crucial regulators and promote TGF-β1 activity. Among them, HSP27 is overexpressed in animal models and in the lung of patients with IPF. HSP27 activates pro-fibr...
Source: Revue des Maladies Respiratoires - March 10, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Characterisation of the protective role of erythropoetin in a murine model of acute lung injury].
Authors: Yegen CH, Haine L, Marchant D, Boncoeur E, Voituron N Abstract In addition to its role in erythropoiesis, erythropoietin (Epo) plays a role in tissue protection, which includes cardioprotective, nephroprotective and neuroprotective effects. The presence of Epo and its receptor (Epo-R) in pulmonary tissue also suggests a cytoprotective effect of Epo in the lung. Our project aims to document this role in a murine model under-expressing Epo. The obtained results will lead to a better understanding of the cytoprotective effects of Epo and will also give an appreciation of its beneficial effects in cases of lun...
Source: Revue des Maladies Respiratoires - March 10, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Is hypoxia a factor in the progression of pulmonary sarcoidosis?]
Authors: Jeny F, Bernaudin JF, Valeyre D, Nunes H, Planès C, Besnard V Abstract Sarcoidosis is a systemic granulomatous disease that can reduce life expectancy mainly due to pulmonary fibrosis resulting from granulomatous inflammation The lack of vascularization within pulmonary granulomas suggests that macrophages localized in the center of these structures are hypoxic. Hypoxia signaling pathways are known to be pro-inflammatory and pro-fibrotic in various pathological conditions. Recent data suggest an involvement of the transcription factor hypoxia-inducible factor (HIF) in the pathogenesis of sarcoidosis...
Source: Revue des Maladies Respiratoires - March 10, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Modelling the bronchial epithelium in chronic obstructive pulmonary disease using human induced pluripotential stem cells].
Authors: Fieldès M, Ahmed E, Bourguignon C, Mianné J, Vernisse C, Fort A, Vachier I, Bourdin A, Assou S, De Vos J Abstract Chronic obstructive pulmonary disease (COPD) is a chronic lung disease leading to irreversible destruction of the terminal bronchioles. Although the precise patho-physiological mechanisms remain to be elucidated, the bronchial epithelium seems to play a pivotal role in the disease. Recent studies have highlighted a great heterogeneity among COPD patients, with various disease courses including, in about half the cases, an origin in childhood. Modelling of COPD is a major goal but ...
Source: Revue des Maladies Respiratoires - March 10, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Bronchial smooth muscle mitochondria: A new target for asthma therapy?]
Authors: Esteves P, Celle A, Berger P, Trian T Abstract The main purpose of this review is to highlight mitochondria as a new therapeutic target to prevent bronchial smooth muscle (BSM) remodeling in asthma. Severe asthmatic patients, representing 5-10% of all asthmatics, are characterized by an increased BSM mass which is highly correlated with the severity of the disease and the rate of exacerbations. None of the current asthma therapies are effective in reducing BSM remodelling. This review, based on the current literature, reports the role of mitochondria in BSM, particularly in calcium signaling. PMID: 321...
Source: Revue des Maladies Respiratoires - March 8, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Research in respiratory health in 2019: some breath to energize your research].
Authors: Vachier I, Bonniaud P, Maitre B, Roche N, Similowski T PMID: 32115293 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - March 4, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Cor pulmonale].
Authors: Aubry A, Paternot A, Vieillard-Baron A Abstract Cor pulmonale is a disease of the heart characterised by dilatation of the right ventricle and paradoxical movement of the interventricular septum. The diagnosis depends on echocardiography even if pulmonary artery catheterisation suggests it. It is secondary to pulmonary disease or a disorder of the pulmonary circulation. These two mechanisms, which are often connected, involve pulmonary hypertension as the origin of a systolic and diastolic overload of the right ventricle, which then leads to the alterations of its structure and performance. Acute cor pulmo...
Source: Revue des Maladies Respiratoires - February 24, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Management of right ventricular failure in pulmonary vascular diseases].
Authors: Boucly A, Savale L, Vuillard C, Turpin M, Jaïs X, Montani D, Humbert M, Sitbon O Abstract Right ventricular failure (RVF) is a common cause of admission to the intensive care unit and its presence is a major prognostic factor in acute pulmonary embolism (PE) and chronic pulmonary hypertension (PH). RVF results from an incapacity of the RV to adapt to an increase in afterload so it can become critical in acute PE and chronic PH. The presence of RVF in cases of acute PE with haemodynamic instability is an indication for thrombolytic therapy. RVF represents the most common cause of death in chronic PH. F...
Source: Revue des Maladies Respiratoires - February 19, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Woman's asthma throughout life: Towards a personalized management?]
Authors: Raherison C, Hamzaoui A, Nocent-Ejnaini C, Essari LA, Ouksel H, Zysman M, Prudhomme A, groupe de travail Femmes et poumons de la SPLF Abstract In a woman's life, asthma can affect her in a variety of ways, with the onset of premenstrual asthma currently under-diagnosed. It is estimated that about 20% of women with asthma have premenstrual asthma, which is more common in patients with severe asthma. Women with asthma are at high risk of exacerbations and of severe asthma. Asthma is the most common chronic disease during pregnancy with potential maternal and foetal complications. Asthma medications are safe ...
Source: Revue des Maladies Respiratoires - February 16, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Diagnosis of allergy in asthma].
Authors: Doyen V, Casset A, Divaret-Chauveau A, Khayath N, Peiffer G, Bonniaud P, Dalphin JC, De Blay F Abstract Allergy is a hypersensitivity reaction induced by immunological mechanisms. In asthma, allergy has a complex role and is usually IgE mediated. Allergy must be evaluated during the work up but evidence of IgE sensitivity does not mean that allergens play a role in the pathophysiology of the disease. The clinical relevance of the sensitivity has to be considered. This paper describes current available tools to screen for IgE sensitivity, allergen exposure and their role in asthma. PMID: 32057505 [PubMe...
Source: Revue des Maladies Respiratoires - February 16, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[A special micronodular lung disease].
Authors: Chatelain E, Traclet J, Freymond N, Duval C, Si-Mohamed S, Cottin V PMID: 32044194 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - February 13, 2020 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research