[Out of standard dyspnea].
Authors: D'Arco L, Seyer L, Fages T, Aouba A, Bergot E, Audemard-Verger A PMID: 31301923 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - July 17, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Allergic respiratory diseases related to mould in the home].
Authors: Schaller A, Delmas C, De Blay F Abstract Exposure to mould is a potential risk factor for asthma in both adults and children. In adult, the relation between exposure, sensitization and symptoms has been demonstrated in severe asthmatics sensitized to Alternaria. For children, exposure to mould in childhood is a risk factor for asthma in both atopic and non-atopic individuals. Exposure or sensitization to moulds are a risk factor for severe asthma and/or exacerbations in children. There appears to be a causal relationship between exposure and asthma. This link seems less significant in adults. However, in a...
Source: Revue des Maladies Respiratoires - July 17, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Therapeutic adherence in chronic obstructive pulmonary disease: A literature review].
CONCLUSIONS: Despite major therapeutic progress, the essential problems of COPD management remain. While the treatment armamentarium has expanded in recent years, there is still a great deal of work to be done in simplifying treatment regimens, improving the administration of these treatments and motivating patients to be compliant with them. This review also highlights the need for better physician-patient communication. PMID: 31300244 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - July 14, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Diffuse infiltrative lung disease, pericarditis, pleural effusion and ceritinib hypersensitivity].
We describe the case of a patient who was treated with ceritinib as a third line approach for a metastatic lung adenocarcinoma with ROS1 rearrangement. After two months, the patient developed acute respiratory distress with pericarditis and pleurisy. A hypersensitivity reaction was suggested and supported by favorable clinical and radiological outcomes within three days following ceritinib discontinuation and systemic corticosteroid introduction. Pleural effusion, pericarditis and diffuse pulmonary infiltration associated to ceritinib have not often been described previously. Despite few data of pulmonary toxicity related ...
Source: Revue des Maladies Respiratoires - July 11, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Recommendations for best practice in the management of venous thromboembolic disease in adults. Long version].
Authors: Sanchez O, Benhamou Y, Bertoletti L, Constans J, Couturaud F, Delluc A, Elias A, Fischer AM, Frappé P, Gendron N, Girard P, Godier A, Gut-Gobert C, Laporte S, Mahé I, Mauge L, Meneveau N, Meyer G, Mismetti P, Parent F, Pernod G, Quéré I, Revel MP, Roy PM, Salaün PY, Smadja DM, Sevestre MA PMID: 31280989 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - July 11, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Exposure of vapers to formaldehyde and acrolein: A systematic review].
CONCLUSION: In the current state of knowledge, we must continue to support and help smokers to quit smoking, and for those who are engaged in a harm reduction approach, to minimize the duration of their electronic cigarette use. PMID: 31285084 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - July 11, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[The plethysmographic reference equations established for adult natives of Eastern Algeria are not applicable to natives of Northern Algeria].
CONCLUSION: The RE-EA are not applicable in adult natives of Northern Algeria. PMID: 31285085 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - July 11, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Feasibility and benefits of training to screen for chronic obstructive pulmonary disease].
CONCLUSION: These results encourage both holding and following up such sessions. The specialized professional environment ensures knowledge updates and offers subsequent assistance. Further improving these sessions will increase their benefits in terms of diagnosis, treatment, and health economy. PMID: 31279593 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - July 8, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Emergency room management of patients with lung cancer and organ failure].
CONCLUSION: In the majority of cases, the decision on the intensity of care to be provided to patients with lung cancer and organ failure was made in a collective manner. PMID: 31255316 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - July 1, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Adolescent obstructive sleep apnoea syndrome: Characteristics and treatment].
Authors: Nguyen XL, Briffod J, Couloigner V, Darqué F, Kerbrat JB, Vecchierini MF Abstract Although the prevalence of the obstructive sleep apnoea syndrome (OSAS) is high in adolescents, studies pertaining to adolescent OSAS are less numerous than childhood studies. Cases of adolescent OSAS may consist of residual OSAS after adenotonsillectomy, but most often are de novo cases. Major pathophysiological factors are weight excess or even high-grade obesity, and the association of upper airway narrowing and tonsillar hypertrophy (pharyngeal, palatal or even lingual). ENT and systematic orthodontic assessments a...
Source: Revue des Maladies Respiratoires - July 1, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Stretching and chylothorax].
CONCLUSION: Following a literature review, similar cases with the same clinical presentation were found. Combined treatment with thoracic drainage and medium chain triglyceride diet was effective in drying up the effusions. Our diagnosis was a diagnosis of exclusion. It is important to exclude a medical cause by thorough investigation. PMID: 31235335 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - June 28, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Trends of lung cancer mortality among employed men according to their occupation].
The objective of this article is to describe the changes in lung cancer mortality among employed men over the period 1976-2005, according to their activity sector and socio-professional categories. This work was done as part of the Cosmop monitoring program. The socio-professional data come from the DADS panel constituted by INSEE. For each person of the panel, the vital status was searched until 2005 by matching the national file of medical causes of death managed by Inserm's CépiDC (Epidemiological Center for Mortality by Medical Causes). The results show large disparities in mortality among male employees by acti...
Source: Revue des Maladies Respiratoires - June 28, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Lung metastases of pancreatic adenocarcinoma: Watch for the second train!]
We report the case of a 37-year-old female patient, without past medical history, with multicystic lung disease in a context of chronic abdominal pain, fatigue and weight loss. After several months of diagnostic delay, pathological examination of surgical lung biopsies led to the diagnosis of secondary deposits of pancreatic cancer. The clinical and radiogical situation deteriorated quickly with the development of alveolar consolidation and Aspergillus superinfection was then diagnosed. This case illustrates the value of an early decision to undertake surgical lung biopsy in the work-up of multicystic lung disease when can...
Source: Revue des Maladies Respiratoires - June 25, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Smoking cessation: How can we involve patients better in treatment choice?]
This article summarizes current knowledge in this field and its application to the process of smoking cessation. Shared decision making in smoking cessation is illustrated by a decision aid created to facilitate the choice between different smoking cessation medications. PMID: 31221484 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - June 23, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Endoscopic lung volume reduction for emphysema].
Authors: Mal H, Bunel V, Marceau A, Dombret MC, Debray MP, Crestani B Abstract Lung hyperinflation which is a hallmark of advanced emphysema plays a major role in the exertional dyspnoea experienced by patients. This has led to the development of surgical lung volume reduction which, though effective, is also associated with significant morbidity and mortality. The goal of endoscopic lung volume reduction which has developed over several years is to decrease hyperinflation without exposing patients to the risks of surgery. Several endoscopic techniques have been assessed by high quality controlled studies: airway b...
Source: Revue des Maladies Respiratoires - June 20, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[What are the special features of the treatment of venous thombo-embolic disease in the course of pregnancy and post-partum?]
Authors: Mahé I, Parent F, Sanchez O, pour le groupe de travail Recommandations de bonne pratique pour la prise en charge de la MVTE PMID: 31208886 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - June 20, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Postoperative complications after major lung resection].
CONCLUSION: Major lung resection has benefited from minimally invasive approaches and fast track to surgery. However, it is important to note the occurrence of new and specific complications related to those news surgical access. PMID: 31208887 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - June 20, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Quality criteria for the transition to adult care in French CF centers - results from the SAFETIM APP study?]
CONCLUSION: The transition processes in place in CFRCs can be improved by implementing the use of these quality criteria systematically. PMID: 31208888 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - June 20, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Behavioral and cognitive therapies in smoking cessation: What tools for the pulmonologist?]
Authors: Guichenez P, Underner M, Perriot J Abstract Behavioral therapies have been developed from Pavlov and Skinner's theories on learning. They have been enriched with knowledge about the processing of information, a process organizing the perception of events. For these two reasons they are called behavioral and cognitive therapies (CBT). CBTs take place in four stages: therapeutic alliance, functional analysis, behavioral and cognitive methods, and evaluation. Seven techniques allow the pulmonologist to increase motivation in patients, particularly at the contemplation stage: the motivational interviewing, the...
Source: Revue des Maladies Respiratoires - June 18, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Hypersensitivity pneumonitis presenting as acute respiratory distress syndrome].
CONCLUSION: The diagnosis of hypersensitivity pneumonitis should be considered in similar cases. Treatment is based mainly on removing exposure to the causative antigen. PMID: 31202600 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - June 18, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Relationship between vaping and smoking among 15-year-olds in high school. Results of a descriptive cross-sectional and monocentric observational study conducted in the metropolitan area of Saint- √Čtienne].
This study focuses on the prevalence of electronic cigarette use among teenagers and its connection with the consumption of tobacco. METHODS: A cross-sectional and monocentric study was conducted in the spring of 2018 and included 1435 students (15-16years old) from the metropolitan area of Saint-Étienne in France. RESULTS: Nearly half of the adolescents experimented with e-cigarettes (50.30%) or tobacco (50.40%). Nearly a quarter are vapers (23.60%) or smokers (28.20%), with low daily use (3.65% for vaping and 9.40% for smoking). In regard to the link between smoking and vaping, 64.85% of adolescents are &q...
Source: Revue des Maladies Respiratoires - June 18, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Management of non-small cell lung cancer patients harboring activating mutations and CNS progression].
Authors: Rouviere D, Veillon R, Chaltiel L, Simonneau Y, Filleron T, Milia J, Guibert N, Melloni B, Raherisson C, Didier A, Mazieres J Abstract The central nervous system (CNS), through carcinomatous meningitis or solid brain metastases, is the most common site of recurrence in non-small cell lung cancers (NSCLC) with activating mutations. Our retrospective study describes the population of patients with CNS metastases of NSCLC harboring activating mutation with targeted therapy (EGFR, ALK, BRAF, HER2) in 4 French regional reference hospitals. 60 patients were analyzed. The proposed treatments were heterogeneous an...
Source: Revue des Maladies Respiratoires - June 18, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Lung abscess: Diagnosis and management].
Authors: Feki W, Ketata W, Bahloul N, Ayadi H, Yangui I, Kammoun S Abstract Lung abscesses are necrotic cavitary lesions of the lung parenchyma. They are usually caused by anaerobic bacteria or mixed flora and typically occur after aspiration. Primary lung abscesses occur in previously healthy patients with no underlying medical disorders and are usually solitary. Secondary lung abscesses occur in patients with underlying or predisposing conditions and may be multiple. The initial diagnosis is usually made by chest radiography showing a lung cavity with an air-fluid level. Typically, the cavity wall is thick and ir...
Source: Revue des Maladies Respiratoires - June 18, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Spontaneous lung volume reduction following pneumonia in a patient with emphysema].
CONCLUSION: Rarely, emphysematous bullae resolve following infections. Further studies of the mechanisms involved in these natural regressions may be of interest in the development of new therapeutics. PMID: 31202604 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - June 18, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Second- or third-line treatment with erlotinib in EGFR wild-type non-small cell lung cancer: Real-life data].
Authors: Debieuvre D, Moreau L, Coudert M, Locher C, Asselain B, Coëtmeur D, Dayen C, Goupil F, Martin F, Brun P, De Faverges G, Hauss PA, Gally S, Ben Hadj Yahia B, Grivaux M Abstract INTRODUCTION: The benefit of tyrosine kinase inhibitors for patients with an EGFR wild-type non-small cell lung cancer (NSCLC) remains controversial. METHODS: The survival of patients with an EGFR wild-type NSCLC who received second- or third-line erlotinib treatment was assessed using real-life data that had been collected in a prospective, national, multicenter, non-interventional cohort study. RESULTS: Data from 274 p...
Source: Revue des Maladies Respiratoires - June 18, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Cardiopulmonary exercise testing for the diagnosis of unexplained dyspnea: a review of 194 cases].
CONCLUSIONS: CPET may greatly facilitate the diagnosis of unexplained dyspnoea. More than 50% of the dyspnoea cases examined here were due to deconditioning or hyperventilation syndrome and would benefit from a simple pulmonary rehabilitation program. PMID: 31204232 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - June 18, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Uncontrolled occupational asthma: Talking about comorbidities].
CONCLUSIONS: As with all cases of severe asthma, the assessment of comorbidities must be systematic in the presence of an occupational asthma which persists after the cessation of the occupational exposure. The management of these comorbidities can lead to an improvement in asthma control and severity. PMID: 31204233 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - June 18, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Prevalence and control of asthma among medical students at Parakou, Benin].
CONCLUSION: Clinical manifestations of asthma are frequent among medical students at Parakou. Some are not well controlled, suggesting a need for greater awareness and an improvement in clinical follow-up. PMID: 31204234 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - June 18, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Asthma and cocaine use].
CONCLUSION: Cocaine use may be responsible for asthma onset, acute asthma exacerbations (which may require intubation and invasive ventilation) or death related to asthma. Cocaine use must be systematically considered in the case of asthma exacerbation and practitioners must help cocaine users to stop their consumption. PMID: 31201016 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - June 17, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Medical thoracoscopy in respiratory medicine: The Li ège University Hospital experience].
CONCLUSION: Medical thoracoscopy is a safe, well-tolerated procedure with high accuracy in the diagnostic and therapeutic management of pleural disease. PMID: 31030998 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - May 1, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Pulmonary function testing of dyspnea complaint by the pulmonologist].
Authors: Delclaux C, Laveneziana P, Garcia G, Ninot G, Roche N, Morelot-Panzini C, groupe Dyspnée de la SPLF Abstract Dyspnea results from an imbalance between ventilatory demand (linked to CO2 production, PaCO2 set-point and wasted ventilation-physiological dead space) and ventilatory capacity (linked to passive-compliance, resistance-and active-respiratory muscles-components of the respiratory system). Spirometry and static lung volumes investigate ventilatory capacity only. Ventilatory demand (increased for instance in all pulmonary vascular diseases due to increased physiological dead space) is not evalu...
Source: Revue des Maladies Respiratoires - April 25, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[The GLORI-COPD score: detection of COPD patients at risk of complications].
CONCLUSION: The score was an acceptable screening tool to identify COPD patients with high risk of complications. Nevertheless, validation needs be performed in a larger population to allow its use in primary care. PMID: 31010752 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 25, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Asthma control in adult Algerian patients. Comparison with other North African and Middle-East countries].
CONCLUSION: Poor control of asthma is still observed in Algeria despite a high level of specialist involvement. Except for adherence, known predictive factors of poor asthma control have been observed. Quality improvement training of health care professionals and patient education are probably the main issues to be addressed. PMID: 31010753 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 25, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Erratum to "A case report of an adult with bronchial mould infection complicated by purulent pleurisy" [Rev. Mal. Respir. 36 (2019) 63-68]].
[Erratum to "A case report of an adult with bronchial mould infection complicated by purulent pleurisy" [Rev. Mal. Respir. 36 (2019) 63-68]]. Rev Mal Respir. 2019 Apr 19;: Authors: Mbaye FBR, Ouethy Nguessie M, Cissé MF, Diémé MJ, Kombila UD, Thiam K, Kane YD, Kane M, Touré NO PMID: 31010754 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 25, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Early determinants of chronic obstructive pulmonary disease: Lung regeneration, a new therapeutic target?]
Authors: Zysman M, Ribeiro Baptista B, Essari LA, Giffard C, Chabot F, Epaud R, Lanone S, Boczkowski J, Boyer L Abstract Chronic obstructive pulmonary disease, a disease of increasing incidence, is related mainly to smoking. Although symptoms only appear at adulthood, the disease can develop from early life events. For example, bronchopulmonary dysplasia, which occurs in preterm infants, is characterized by airspace enlargement and could lead to late lung consequences. Once the lesions are established, no curative treatment is available. Stimulating lung regeneration from endogenous stem cells is therefore an excit...
Source: Revue des Maladies Respiratoires - April 25, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[The current situation with sputum positive pulmonary tuberculosis in Niamey (Niger)].
Authors: Assao Neino MM, Gagara Issoufou MA, Ouédraogo AR, Marcellin KA, Maizoumbou DA, Mamadou S Abstract Tuberculosis is a major public health problem and the main reason for hospital admission in developing countries. No study of tuberculosis has been undertaken in the pulmonary/tuberculosis service of Lamordé National Hospital in Niamey since its foundation in April 2009. The aim of our study is to assess the current situation of sputum positive new and relapsed cases of tuberculosis and to determine their epidemiological, clinical and therapeutic profiles. It comprised a retrospective four-year s...
Source: Revue des Maladies Respiratoires - April 25, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[The GLI-2012 reference values for forced spirometry accurately portray the European and French population].
Authors: de Broucker V, Edmé JL, Plantier L, Hulo S, Groupe Fonction de la SPLF PMID: 31010757 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 25, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Therapeutic options for oligoprogressive non-small cell lung cancer].
Authors: Gustin P, Botticella A, Tselikas L, Mercier O, Le Péchoux C, Levy A Abstract Lung cancer is the leading cause of cancer-related mortality and more than half of the cases are diagnosed at a metastatic stage. Major progress in terms of systemic treatments has been achieved in recent decades. Access to new anti-PD-(L) 1 immunotherapies and targeted therapies for non-small cell lung cancer (NSCLC) with oncogenic addiction such as EGFR mutation or ALK rearrangement have led to improved outcomes. Patients with limited progression of their disease during systemic treatment may be a particular subgroup. Thi...
Source: Revue des Maladies Respiratoires - April 25, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[New insights in the pathogenesis of pulmonary arterial hypertension].
Authors: Bordenave J, Tu L, Savale L, Huertas A, Humbert M, Guignabert C Abstract Pulmonary arterial hypertension (PAH) is a severe and incurable cardiopulmonary disorder. Research from the past 10 years illustrates the complex and multifactorial aspects of PAH pathophysiology. Furthermore, latest advances in the field have led to a better understanding of the key components underlying this inadequate accumulation of pulmonary vascular cells within the pulmonary arterial walls, leading to pulmonary vascular remodelling. Among the underlying molecular and cellular mechanisms, pulmonary endothelial dysfunction, alter...
Source: Revue des Maladies Respiratoires - April 25, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Hypersensitivity pneumonitis in children].
Authors: Soumagne T, Dalphin ML, Dalphin JC Abstract Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by an immune response to a variety of antigens to which patients have been previously sensitised. It can occur at any age. In children, it is a rare disease, probably under-diagnosed, with an estimated prevalence of 4 per million. The paediatric forms are not really different from those of adults but present some particularities. Avian exposure is by far the most frequent cause of HP, accounting for nearly two-thirds of cases. Although there is no current recommendation for the diagnosis of ...
Source: Revue des Maladies Respiratoires - April 25, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Phenotypical plasticity and targeted therapies in non-small cell lung carcinomas].
Authors: Da Silva J, Dalstein V, Polette M, Nawrocki-Raby B Abstract Lung cancer is the most diagnosed and deathly type of cancer worldwide. It has a poor prognosis because of a late diagnosis, high metastatic potential and resistance to conventional therapies. Since the 2000s, the emergence of targeted therapies has improved patients' outcomes. However, these therapies concern only a small proportion of patients, selected by the presence of molecular biomarkers that indicate the targeting relevance. Here, we discuss the possibility that new phenotypical biomarkers could be predictive factors for targeted therapies...
Source: Revue des Maladies Respiratoires - April 25, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Smoking cessation: A challenge for cardiologists and pulmonologists].
Authors: Thomas D Abstract In addition to public health measures that need to be strongly supported politically, smoking is also a major medical issue. Tobacco dependence is a chronic disease, and, given its extremely addictive nature, treatment for tobacco dependence must be addressed actively by all health professionals. Because smoking is a major contributor to many of the pathologies their specialties address, cardiologists and pulmonologists must be at the forefront of this care. In this review we analyse the current state of smoking cessation treatment and its inadequacies, the limiting impact that doctors' o...
Source: Revue des Maladies Respiratoires - April 24, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Fundamental research in Pulmonology: Progress in 2018].
Authors: Vachier I, Crestani B, Frossard N, Maitre B, Roche N PMID: 31006578 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 24, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Selection of lung transplant candidates in France in 2019].
CONCLUSION: These new recommendations, close to French practices, help clinicians to find the right time for referral of patients to transplantation centers. This is crucial for the prognosis of lung transplantation. PMID: 31006579 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 24, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Allergen-derived peptide: A promising approach in asthma].
Authors: Klein M, Magnan A, Bouchaud G Abstract Severe asthma required high dose of corticosteroids combined with biotherapies to control more or less asthma symptoms and lead to the decrease of patients' quality of life on long term. Recent studies show that hypoallergenic peptides derived from allergen can prevent airway hyperresponsiveness, decrease Th2 response and also allergen-specific IgE in mouse models of allergic asthma. Even if some peptides mechanisms remain unknown, their fast efficacy with low doses of allergens make peptide immunotherapy a new promising approach in allergic asthma. PMID: 31006580...
Source: Revue des Maladies Respiratoires - April 24, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[A truly silent interstitial lung disease].
Authors: Vandevelde C, Rombaut C, Rémy-Jardin M, Wallaert B PMID: 31006581 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 24, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Severe pneumonia and acute respiratory distress syndrome: Implication of unconventional T cells].
Authors: Jouan Y, Si-Tahar M, Paget C Abstract Pneumonia is frequently complicated by occurrence of acute respiratory distress syndrome (ARDS), consequently to dysregulated inflammatory response. However, mechanisms driving this dysregulation are poorly understood. To address this, "unconventional T-cells (UTC)" -γδT, NKT and MAIT cells- appear to be relevant targets due to their key role in orchestrating anti-microbial immune response in the lung. Thus, using an experimental and translational approach, we test the hypothesis that a tight regulation of UTC is mandatory to fine-tune host respon...
Source: Revue des Maladies Respiratoires - April 22, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Different approaches to chest drainage in the management of primary spontaneous pneumothorax].
Authors: Carnot N, Dupuis M, Pontier S, Laborde F, Brouchet L, Didier A Abstract Drainage of primary spontaneous pneumothorax (PSP) may be managed by different techniques and with different types of drain. It is mainly performed in the pneumology department or in the emergency department. The aim of the study was to evaluate the factors that influence the success of PSP drainage. This retrospective, monocentric study performed in University Hospital of Toulouse, included patients with a first episode of PSP requiring drainage. The primary outcome was the rate of success according to the techniques of drainage. Data...
Source: Revue des Maladies Respiratoires - April 22, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Transbronchial cryobiopsy in diffuse interstitial lung diseases].
CONCLUSION: A prospective randomized study is needed to evaluate the technique in France in order to specify its diagnostic performance and its safety profile in comparison to SLB. PMID: 31005425 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 22, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Factors associated with poor acceptance of illness in patients with COPD].
CONCLUSION: The greater the handicap of the disease, the greater is the difficulty in accepting the disease by the patient. The doctor could have an impact in improving the therapeutic education and involving the family in the patient's care. PMID: 30956003 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 9, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research