Respiratory disturbances in fibromyalgia: a systematic review and meta-analysis of case control studies
Expert Rev Respir Med. 2021 Apr 15. doi: 10.1080/17476348.2021.1918547. Online ahead of print.ABSTRACTBACKGROUND: Fibromyalgia is a debilitating syndrome characterized by diffuse and chronic musculoskeletal pain and tender points in muscles and soft tissues.OBJECTIVE: To perform a systematic review and meta-analysis of case-control studies to explore the respiratory disturbances among persons with fibromyalgia in comparison with healthy adults.STUDY APPRAISAL AND SYNTHESIS METHOD: This review was performed in accordance with PRISMA guidelines (PROSPERO; identification number CRD: 42020196835). We systematically searched se...
Source: Expert Review of Respiratory Medicine - April 15, 2021 Category: Respiratory Medicine Authors: Araceli Ortiz-Rubio Irene Torres-S ánchez Irene Cabrera-Martos Laura L ópez-López Janet Rodr íguez-Torres Mar ía Granados-Santiago Marie Carmen Valenza Source Type: research

Fixed dexmedetomidine infusion versus fixed-dose midazolam bolus as primary sedative for maintaining intra-procedural sedation during endobronchial ultrasound-guided transbronchial needle aspiration: a double blind randomized controlled trial
Conclusion: Fixed dexmedetomidine infusion statistically significantly reduced need for rescue sedation during EBUS-TBNA, and allowed slightly faster post-procedure recovery, as compared to fixed-dose midazolam bolus. However, it caused hypotension and bradycardia more frequently.Clinical trial registration: www.clinicaltrials.gov identifier is NCT02713191.PMID:33849367 | DOI:10.1080/17476348.2021.1918000 (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - April 14, 2021 Category: Respiratory Medicine Authors: Renu Kumari Kajal Jain Ritesh Agarwal Sahajal Dhooria Inderpaul Singh Sehgal Ashutosh Nath Aggarwal Source Type: research

Ventilation management in acute respiratory failure related to COVID-19 versus ARDS from another origin - a descriptive narrative review
Expert Rev Respir Med. 2021 Apr 13:1-11. doi: 10.1080/17476348.2021.1913060. Online ahead of print.ABSTRACTINTRODUCTION: It is uncertain whether ventilation in patients with acute respiratory failure related to coronavirus disease 2019 (COVID-19) differs from that in patients with acute respiratory distress syndrome (ARDS) from another origin.AREAS COVERED: We undertook two literature searches in PubMed to identify observational studies reporting on ventilation management--one in patients with acute respiratory failure related to COVID-19, and one in patients with ARDS from another origin. The searches identified 14 studie...
Source: Expert Review of Respiratory Medicine - April 13, 2021 Category: Respiratory Medicine Authors: Anissa M Tsonas Michela Botta Ary Serpa Neto Janneke Horn Frederique Paulus Marcus J Schultz Source Type: research

A multimodal approach to detect and monitor early lung disease in cystic fibrosis
Expert Rev Respir Med. 2021 Apr 12:1-12. doi: 10.1080/17476348.2021.1908131. Online ahead of print.ABSTRACTIntroduction: In the early stages, lung involvement in cystic fibrosis (CF) can be silent, with disease progression occurring in the absence of clinical symptoms. Irreversible airway damage is present in the early stages of disease; however, reliable biomarkers of early damage due to inflammation and infection that are universally applicable in day-to-day patient management have yet to be identified.Areas covered: At present, the main methods of detecting and monitoring early lung disease in CF are the lung clearance ...
Source: Expert Review of Respiratory Medicine - April 12, 2021 Category: Respiratory Medicine Authors: Pedro Mond éjar-López Alexander Horsley Felix Ratjen Silvia Bertolo Helene de Vicente Òscar Asensio de la Cruz Source Type: research

Leveraging "big data" in respiratory medicine - data science, causal inference, and precision medicine
Expert Rev Respir Med. 2021 Apr 5. doi: 10.1080/17476348.2021.1913061. Online ahead of print.NO ABSTRACTPMID:33818245 | DOI:10.1080/17476348.2021.1913061 (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - April 5, 2021 Category: Respiratory Medicine Authors: Yoshihiko Raita Carlos A Camargo Liming Liang Kohei Hasegawa Source Type: research

Bronchoscopy during the COVID-19 pandemic: effect on current practices and strategies to reduce procedure-associated transmission
Expert Rev Respir Med. 2021 Apr 2. doi: 10.1080/17476348.2021.1913058. Online ahead of print.ABSTRACTIntroduction: Bronchoscopy and related procedures have unambiguously been affected during the Corona Virus Disease 2019 (COVID-19) pandemic caused from Severe Acute Respiratory Syndrome-Corona Virus -2 (SARS COV-2). Ordinary bronchoscopy practices and lung cancer services might have changed over this pandemic and for the years to come.Areas covered: This manuscript summarizes the utility of bronchoscopy in COVID-19 patients, and the impact of the pandemic in lung cancer diagnostic services, in view of possible viral spread ...
Source: Expert Review of Respiratory Medicine - April 2, 2021 Category: Respiratory Medicine Authors: Fotios Sampsonas Loukas Kakoullis Theodoros Karampitsakos Ourania Papaioannou Matthaios Katsaras Eleni Papachristodoulou George Kyriakou Aggeliki Bellou Argyrios Tzouvelekis Source Type: research

Change in mortality rates of respiratory disease during the COVID-19 pandemic
CONCLUSION: During the pandemic, the death rate of residents decreased, especially that due to respiratory disease.PMID:33787428 | DOI:10.1080/17476348.2021.1908891 (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - March 31, 2021 Category: Respiratory Medicine Authors: Chunyan Huang Yan Lu Linchi Wang Yujie Hua Jianrong Xu Xiaolin Wei Zhengji Zhang Jun Zhang Source Type: research

The "clinically significant" bronchodilator responsiveness (BDR) in children: a comparative study between six definitions of scholarly societies and a mini-review
Expert Rev Respir Med. 2021 Mar 22. doi: 10.1080/17476348.2021.1906653. Online ahead of print.ABSTRACTOBJECTIVE: To compare the percentages of children with and without airway obstruction (obstructive and non-obstructive groups, respectively) presenting a "clinically significant" BDR according to the following definitions: GINA: FEV1 increase>12% predicted (∆Predicted), ATS/ERS: FEV1 increase ≥12% initial (∆Initial) and ∆FEV1 absolute (∆) ≥200ml and/or ∆FVCInitial ≥12% and ∆FVC ≥200ml, British thoracic society (BTS): ∆FEV1Initial ≥12%, National asthma education and prevention progr...
Source: Expert Review of Respiratory Medicine - March 22, 2021 Category: Respiratory Medicine Authors: Fatma Guezguez Hend Knaz Ichraf Anane Mohamed Bougrida Helmi Ben Saad Source Type: research

Pseudomonas aeruginosa in bronchiectasis: infection, inflammation and therapies
Expert Rev Respir Med. 2021 Mar 18. doi: 10.1080/17476348.2021.1906225. Online ahead of print.ABSTRACTINTRODUCTION: : Bronchiectasis is a chronic endobronchial suppurative disease characterized by irreversibly dilated bronchi damaged by repeated polymicrobial infections and, predominantly neutrophilic airway inflammation. Some consider bronchiectasis a syndromic consequence of several different causes whilst others view it as an individual disease entity. In most patients, identifying an underlying cause remains challenging. The acquisition and colonization of affected airways by Pseudomonas aeruginosa represents a critica...
Source: Expert Review of Respiratory Medicine - March 19, 2021 Category: Respiratory Medicine Authors: Celine Vidaillac Sanjay H Chotirmall Source Type: research

Ten things you need to know about intensive care unit management of mechanically ventilated patients with COVID-19
Expert Rev Respir Med. 2021 Mar 18. doi: 10.1080/17476348.2021.1906226. Online ahead of print.ABSTRACTThe ongoing pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed important challenges for clinicians and health care systems worldwide.Areas covered: The aim of this manuscript is to provide brief guidance for intensive care unit management of mechanically ventilated patients with COVID-19 based on the literature and our direct experience with this population. PubMed, EBSCO, and the Cochrane Library were searched up until 15th of January 2021 for relevant literature.Expert opinion: Init...
Source: Expert Review of Respiratory Medicine - March 18, 2021 Category: Respiratory Medicine Authors: Chiara Robba Denise Battaglini Lorenzo Ball Paolo Pelosi Patricia R M Rocco Source Type: research

Which one is superior in predicting 30 and 90 days mortality after COPD exacerbation: DECAF, CURB-65, PSI, BAP-65, PLR, NLR
Expert Rev Respir Med. 2021 Mar 11. doi: 10.1080/17476348.2021.1901584. Online ahead of print.ABSTRACTOBJECTIVES: The major scores associated with the mortality after COPD exacerbations were; DECAF, CURB-65, PSI and BAP-65 scores. We aimed to compare these scores in predicting 30- and 90-day mortality in patients hospitalized with exacerbation of COPD.METHODS: The data of 141 patients who were hospitalized with the diagnosis of COPD exacerbation between January 2018 and March 2019 and accepted to participate in the study were prospectively recorded.RESULTS: Age, mean modified-medical-research-council (mMRC) dyspnea score, ...
Source: Expert Review of Respiratory Medicine - March 11, 2021 Category: Respiratory Medicine Authors: Mine Gayaf G ülistan Karadeniz Filiz G üldaval G ülru Polat Merve T ürk Source Type: research

Managing thrombosis and cardiovascular complications of COVID-19: Answering the questions in COVID-19-associated coagulopathy
Expert Rev Respir Med. 2021 Mar 5. doi: 10.1080/17476348.2021.1899815. Online ahead of print.ABSTRACTINTRODUCTION: The first patients with Coronavirus disease 2019 (COVID-19) emerged at the end of 2019. This novel viral infection demonstrated unique features that include prothrombotic clinical presentations. However, one year after the first occurrence, there remain many unanswered questions. We try to address some of the important queries in this review.AREAS COVERED: We raised the following critical questions. "Why is COVID-19 so hypercoagulable?", "Why are most coagulation test results relatively normal?&...
Source: Expert Review of Respiratory Medicine - March 5, 2021 Category: Respiratory Medicine Authors: Toshiaki Iba Jerrold H Levy Jean Marie Connors Theodore E Warkentin Jecko Thachil Marcel Levi Source Type: research

Machine learning in asthma research: moving towards a more integrated approach
Expert Rev Respir Med. 2021 Feb 23. doi: 10.1080/17476348.2021.1894133. Online ahead of print.ABSTRACTINTRODUCTION: Big data are reshaping the future of medicine. The growing availability and increasing complexity of data have favoured the adoption of modern analytical and computational methodologies in every area of medicine. Over the past decades, asthma research has been characterised by a shift in the way studies are conducted and data are analysed. Motivated by the assumptions that 'data will speak for themselves', hypothesis-driven approaches have been replaced by data-driven hypotheses-generating methods to explore ...
Source: Expert Review of Respiratory Medicine - February 23, 2021 Category: Respiratory Medicine Authors: Sara Fontanella Alex Cucco Adnan Custovic Source Type: research

The triad: respiratory microbiome - virus - immune response in the pathophysiology of pulmonary viral infections.
Authors: Porto BN, Moraes TJ Abstract INTRODUCTION: The longstanding dogma that the healthy lung is sterile has been refuted by recent advances in culture-independent analyses of airway samples. The respiratory microbiome comprises all airway and lung tissue-associated microbes. These micro-organisms occur throughout the upper and lower respiratory tracts, with different populations and distinct burdens at specific sites and can be classified as pathogenic or commensals. AREAS COVERED: The majority of studies investigating the respiratory microbiome has focused on bacteria; however, emerging evidence has reveal...
Source: Expert Review of Respiratory Medicine - February 21, 2021 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research