Extra-pulmonary manifestations of COPD and the role of pulmonary rehabilitation: a symptom-centered approach.
Authors: Machado A, Marques A, Burtin C Abstract Introduction: Chronic obstructive pulmonary disease (COPD) is a complex and heterogenous disease that is associated with a range of respiratory and non-respiratory symptoms, which highly contribute to the daily burden of the disease. Symptoms burden remains high despite optimal bronchodilator therapy, but pulmonary rehabilitation (PR) is an effective intervention to improve patients' symptoms. A comprehensive interdisciplinary approach within the framework of a PR program is warranted to tackle these complex symptoms and their consequences. Areas covered: This narrat...
Source: Expert Review of Respiratory Medicine - November 24, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Management of COVID-19 from the pulmonologist's perspective: a narrative review.
Authors: Kumar S, Mehta S, Sarangdhar N, Ray A, Sinha S, Wig N Abstract Introduction: The COVID-19 pandemic has provided global challenges to healthcare facilities in ensuring delivery of care to patients. Tremendous international collaboration has enabled swift formulation of evidence-based guidelines that aim to clarify day-to-day issues faced by physicians and other healthcare providers on the frontlines. Areas Covered: In order to provide answers to the common questions and dilemmas faced by physicians and policy makers, especially those handling pulmonary manifestations of COVID-19, the authors made of list of...
Source: Expert Review of Respiratory Medicine - November 21, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

An effective drug against COVID-19: reality or dream?
Authors: Yaghoubi A, Amel Jamehdar S, Movaqar A, Milani N, Soleimanpour S Abstract INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is well known as a novel member of the coronavirus family which caused a sudden outbreak of Coronavirus disease 2019 (COVID-19) in Wuhan, China that quickly developed into a global pandemic. No effective approaches are found as yet for the therapy and epidemiological control of this new virus. For this purpose, we searched the literature in PubMed, Scopus, Web of Knowledge, Google Scholar, and MeSH, from all years of study until 23rd of October 2020, for artic...
Source: Expert Review of Respiratory Medicine - November 21, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Assessment and treatment of airflow obstruction in patients with Chronic Obstructive Pulmonary Disorder: a guide for the clinician.
The objective assessment of airflow obstruction is mandatory to make a diagnosis of COPD, but the prevalent disease sustaining the disorder should also be investigated to select a targeted therapy, because main determinants of airflow obstruction can be different in COPD patients and may differently respond to treatment. PMID: 33215956 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - November 21, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

COPD in Biomass exposed nonsmokers: a different phenotype.
Authors: Jindal S, Jindal A Abstract INTRODUCTION: Chronic obstructive pulmonary disease, most commonly caused by tobacco smoking, is increasingly reported in nonsmoking patients exposed to domestic combustion of biomass fuels. This is particularly common among rural women in the low- and middle-income countries. It is highly likely that the disease in these patients is a different clinical phenotype. AREAS COVERED: This manuscript covers epidemiological and clinical aspects of biomass-exposed COPD and also dwells upon its different phenotypic characteristics. EXPERT OPINION: Chronic obstructive pulmonary d...
Source: Expert Review of Respiratory Medicine - November 18, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Chest radiographs may assist in predicting the outcome in the early phase of Covid-19. UK district general hospital experience of Covid-19 first wave.
Conclusions: In this small retrospective study, our results suggest features of chest radiographs at presentation may provide a helpful tool for prognostication. In environments with constrained computed tomography (CT) imaging with serial chest radiographs could be a cost-effective tool in the assessment of Covid-19 patients. PMID: 33191824 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - November 18, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Functional tests associated with sarcopenia in moderate chronic obstructive pulmonary disease.
Conclusion: Functional tests, especially 30STS and SPPB, are simple and affordable tools for screening sarcopenia in COPD with moderate obstruction. PMID: 33197358 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - November 18, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Reduced risk of COVID-19 hospitalization in asthmatic and COPD patients: a benefit of inhaled corticosteroids?
Authors: Rogliani P, Lauro D, di Daniele N, Chetta A, Calzetta L Abstract BACKGROUND: The comorbidities and clinical signs of coronavirus disease 2019 (COVID-19) patients have been reported mainly as descriptive statistics, rather than quantitative analysis even in very large investigations. The aim of this study was to identify specific patients' characteristics that may modulate the risk of COVID-19 hospitalization. RESEARCH DESIGN AND METHODS: A pooled analysis was performed on high-quality epidemiological studies to quantify the prevalence (%) of comorbidities and clinical signs in hospitalized COVID-19 pat...
Source: Expert Review of Respiratory Medicine - November 17, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Mesenchymal stromal cells for acute respiratory distress syndrome (ARDS), sepsis and COVID 19 infection: optimising the therapeutic potential.
Authors: Gorman E, Millar J, McAuley D, O'Kane C Abstract Introduction: Mesenchymal stromal (stem) cell (MSC) therapies are emerging as a promising therapeutic intervention in patients with Acute Respiratory Distress Syndrome (ARDS) and sepsis due to their reparative, immunomodulatory, and antimicrobial properties. Areas covered: This review provides an overview of Mesenchymal Stromal Cells (MSCs) and their mechanisms of effect in ARDS and sepsis. The preclinical and clinical evidence to support MSC therapy in ARDS and sepsis is discussed. The potential for MSC therapy in COVID-19 ARDS is discussed with insights fr...
Source: Expert Review of Respiratory Medicine - November 13, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Lung function parameters among Australian Aboriginal "Apparently Healthy" Adults: an Australian Caucasian and Global Lung Function Initiative (GLI-2012) various ethnic norms comparative study.
Conclusions: Australian Aboriginal adults had 20% lower values for FVCandFEV1 but nearly preserved absolute FEV1/FVC in comparison to Australian Caucasians. The GLI-2012 spirometric norms do not appear to fit for Australian Aboriginal adults regardless of which ethnicity options selected, including "others/mixed". PMID: 33166208 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - November 11, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Chronic obstructive pulmonary disease in HIV.
Authors: Byanova KL, Kunisaki KM, Vasquez J, Huang L Abstract Introduction: Chronic obstructive pulmonary disease (COPD) is more prevalent in people with HIV (PWH) than in the general population and leads to an increased burden of morbidity and mortality in this population. The mechanisms behind COPD development and progression in PWH are not fully elucidated, and there are no PWH-specific guidelines for COPD management. Areas covered: The goal of this broad narrative review is to review the epidemiology of COPD in PWH globally, highlight proposed pathways contributing to increased COPD prevalence and progression i...
Source: Expert Review of Respiratory Medicine - November 11, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Multidisciplinary consensus on inhaled therapy in asthma.
CONCLUSIONS: The experts endorse the main guidelines recommendations; however, do not fully agree on recent GINA recommendations about the treatment of the initial steps of the disease. The experts value positively the differential characteristics of BAI over other devices. PMID: 33170733 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - November 11, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

The role of peripheral muscle fatigability on exercise intolerance in COPD.
Authors: Marillier M, Bernard AC, Verges S, Neder JA Abstract INTRODUCTION: Exercise limitation in chronic obstructive pulmonary disease (COPD) is multi-factorial; however, growing evidence indicates that muscle dysfunction may contribute in some patients. AREAS COVERED: This work outlines current evidence for and against increased peripheral muscle fatigability in COPD through a comprehensive review of relevant literature available on PubMed/MEDLINE until May 2020. The authors first discuss key methodological issues relative to muscle fatigue assessment by non-volitional techniques, particularly magnetic stimu...
Source: Expert Review of Respiratory Medicine - November 7, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Role of acute exacerbations in skeletal muscle impairment in COPD patients.
This report includes a review of both clinical and pre-clinical peer-reviewed literature of the past 20 years found in PubMed providing a comprehensive view on the role of AECOPD in muscle dysfunction in COPD, the putative underlying mechanisms and the treatment perspectives. EXPERT OPINION: The contribution of AECOPD and its recurrent nature to muscle impairment in COPD cannot be ignored and can be attributed to the acutely intensifying and converging disease-related drivers of muscle deterioration, in particular disuse, systemic inflammation and corticosteroid treatment. The search for novel treatment options should ...
Source: Expert Review of Respiratory Medicine - November 4, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Clinical progression and changes of chest CT findings among asymptomatic and pre-symptomatic patients with SARS-CoV-2 infection in Wuhan, China.
Authors: Yang R, Gui X, Gao S, Ke H, Xiong Y Abstract OBJECTIVES: To analyze characteristics of asymptomatic/pres-ymptomatic patients with SARS-CoV-2 infection. METHODS: Chest computed tomography(CT), indicators for organ and coagulation function, inflammation cytokines, of asymptomatic/pre-symptomatic patients with SARS-CoV-2 infection were retrospectively analyzed in Zhongnan Hospital of Wuhan University from 20 December 2019, to 8 March 2020. RESULTS: The proportion of normal chest CT in asymptomatic and pre-symptomatic patients with SARS-CoV-2 infection were 35.4% (17/48) and 3.3%(2/61), respectively (P
Source: Expert Review of Respiratory Medicine - November 4, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Clinical features associated with a doctor-diagnosis of bronchiectasis in the Severe Asthma Network in Italy (SANI) registry.
Authors: Malipiero G, Paoletti G, Blasi F, Paggiaro P, Senna G, Latorre M, Caminati M, Carpagnano GE, Crimi N, Spanevello A, Aliberti S, Canonica GW, Heffler E Abstract BACKGROUND: Several severe asthma comorbidities and have been identified. One of the emerging comorbidities is bronchiectasis. We evaluated the frequency of bronchiectasis on severe asthma in a real life setting, by analyzing the data collected by the "Severe Asthma Network Italy" (SANI) registry. METHODS: SANI registry encompasses demographic, clinical, functional and inflammatory data of Italian severe asthmatics. Data obtained by th...
Source: Expert Review of Respiratory Medicine - October 28, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Understanding rare infections post-lung transplantation.
This article will review the epidemiology, clinical presentation, diagnostic and therapeutic management of certain rarely reported viral, fungal, bacterial and parasitic infections in lung transplant recipients. EXPERT OPINION: Once the most frequent infections are excluded, clinical suspicion combined with molecular diagnostic methods such as targeted and broad-spectrum PCRs can allow diagnosis of a rare infection. A multidisciplinary team, including transplant pulmonologists, transplant infectious diseases specialists, microbiologists and pathologists is essential for prompt diagnosis and optimal therapeutic manageme...
Source: Expert Review of Respiratory Medicine - October 28, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Our current understanding of and approach to the management of lung cancer with pulmonary hypertension.
Authors: Dauriat G, LePavec J, Pradere P, Savale L, Fabre D, Fadel E Abstract INTRODUCTION: Lung cancer is a frequent pathology for which the best curative treatment is pulmonary resection. Pulmonary arterial hypertension is a rare disease but pulmonary hypertension associated with parenchymal disease or left heart disease is frequently observed in these patients. The diagnosis of pulmonary hypertension before lung resection makes the perioperative management of these patients more difficult and sometimes leads to rejecting patients for surgery. AREAS COVERED: We performed a review of literature on PubMed on Pu...
Source: Expert Review of Respiratory Medicine - October 28, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Influenza and pneumonia-attributed deaths among cancer patients in the United States; a population-based study.
Authors: Abdel-Rahman O Abstract OBJECTIVE: To assess the patterns and trends of influenza and pneumonia-attributed deaths among cancer patients in the United States. METHODS: Surveillance, Epidemiology and End Results (SEER) database was accessed and cancer patients diagnosed 1975-2016 who have been included in the SEER-9 registries were included. The primary endpoint of the study is standardized mortality rate (SMR; calculated as observed/Expected (O/E) ratio for death from influenza and pneumonia among cancer patients). Competing risk analysis was additionally conducted to evaluate the impact of age on influ...
Source: Expert Review of Respiratory Medicine - October 28, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Understanding hydrogen sulfide signaling in neonatal airway disease.
Authors: Schiliro M, Bartman CM, Pabelick CM Abstract INTRODUCTION: Airway dysfunction leading to chronic lung disease is a common consequence of premature birth and mechanisms responsible for early and progressive airway remodeling are not completely understood. Current therapeutic options are only partially effective in reducing the burden of neonatal airway disease and premature decline of lung function. The gasotransmitter hydrogen sulfide (H2S) has been recently recognized for its therapeutic potential in lung diseases. AREAS COVERED: Contradictory to its well-known toxicity at high concentrations, H2S has...
Source: Expert Review of Respiratory Medicine - October 24, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Clinical characteristics of COVID-19 patients with HIV coinfection in Wuhan, China.
CONCLUSION: Lower level of CD4+ T lymphocyte counts caused by HIV infection itself might be one of reasons for relatively weak ability to produce SARS-CoV-2 specific antibodies. The effects of anti-HIV drugs in prevention and treatment of COVID-19 appears to be limited, which needs further observations to confirmed. PMID: 33074039 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - October 22, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Advances in understanding of mechanisms related to increased cardiovascular risk in COPD.
Authors: Rogliani P, Ritondo BL, Laitano R, Chetta A, Calzetta L Abstract INTRODUCTION: Chronic obstructive pulmonary disease (COPD) represents a serious global health issue that is commonly associated with cardiovascular (CV) disease (CVD). The close relationship between COPD and CVD could be explained by different factors, first and foremost a chronic low-grade systemic inflammation implicated in the pathogenesis of both diseases and several stimuli enhancing the inflammatory processes and causing a mixed condition with worse outcomes than either disorder alone. AREAS COVERED: The present narrative review con...
Source: Expert Review of Respiratory Medicine - October 22, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

An update on current treatment strategies for managing bronchiolitis obliterans syndrome after lung transplantation.
Authors: Arjuna A, Olson MT, Walia R, Bremner RM, Smith MA, Mohanakumar T Abstract INTRODUCTION: Bronchiolitis obliterans syndrome (BOS), a subtype of chronic lung allograft dysfunction, is quite common, with up to half of all lung recipients developing BOS within five years of transplantation. Preventive efforts are aimed at alleviating known risk factors of BOS development, while the primary goal of treatment is to delay the irreversible, fibrotic airway changes and progressive loss of lung function. AREAS COVERED: This narrative review will briefly discuss the updated definition, clinical presentation, patho...
Source: Expert Review of Respiratory Medicine - October 21, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Post COVID-19 bronchiectasis: a potential epidemic within a pandemic.
Authors: José RJ, Manuel A, Gibson-Bailey K, Lee L PMID: 33054432 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - October 21, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Association of mild cognitive impairment and characteristic of COPD and overall health status in a cohort study.
Authors: Yohannes AM, Eakin MN, Holbrook JT, Sugar EA, Henderson R, Baker AM, Casper AS, Kaminsky DA, Rea AL, Mathews AM, Que LG, Ramsdell JW, Gerald LB, Wise RA, Hanania NA Abstract OBJECTIVES: We evaluated risk factors and demographic characteristics associated with mild cognitive impairment (MCI) in patients with COPD. METHODS: We analyzed data on 220 individuals with COPD enrolled in a cohort study designed to evaluate anxiety conducted at 16 clinical centers. Cognitive impairment was assessed with the Montreal Cognitive Assessment (MoCA), a cutoff score of 26 defined normal cognition and a score of 18-25 d...
Source: Expert Review of Respiratory Medicine - October 21, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Masks in COVID-19: let's unmask the evidence.
Authors: De Silva AP, Niriella MA, de Silva JH Abstract INTRODUCTION: One of the main issues in the novel coronavirus 2019 (COVID- 19) pandemic has been the lack of uniformity of recommendations for the usage of face masks. AREAS COVERED: While Asian countries started using masks early during the epidemic, most Western countries were slow to do so. To avoid such situations, clear guidelines, need to be established, not only regarding the use of masks but also the type of mask to suit different situations. In this article, we will examine the types of masks and review the recommendations for their use based on t...
Source: Expert Review of Respiratory Medicine - October 21, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Right ventricular dysfunction in patients with non-severe idiopathic pulmonary fibrosis: a cross-sectional prospective single-center study.
CONCLUSIONS: RV dysfunction was detected in 37% of non-advanced IPF patients and early recognition was only possible using speckle-tracking echocardiography. Special attention should be given to these patients as RV dysfunction is suggestive of worse prognosis. These patients could benefit from new specific drugs or even oxygen therapy for transitory hypoxia. PMID: 33070645 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - October 21, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Tuberculosis related stigma in India: roadblocks and the way forward.
Authors: Thomas BE, Stephen A PMID: 33021117 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - October 8, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Social determinants of tuberculosis: context, framework and the way forward to ending TB in India.
We examined the role of social determinants in two key pathways - the pathway of TB causation and its outcomes, and the care cascade for patients with TB, and its consequences. We reviewed the most important social determinants of TB including poverty, membership of certain castes and indigenous population, undernutrition and poor access to healthcare, especially in rural areas. EXPERT OPINION: We suggest that TB elimination will require an optimal mix of enhanced biomedical and social interventions. TB elimination strategy in India needs a pro-poor model of patient -centred care inclusive of nutritional, psycho-social...
Source: Expert Review of Respiratory Medicine - October 6, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Lung MRI to predict lack of response to treatment in interstitial lung disease: initial observations on SSFSE/PROPELLER T2 mismatch.
CONCLUSIONS: SSFSE-PROPELLER T2 match/mismatch was predictive of treatment response status in this group of ILD patients. PMID: 32993387 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - October 2, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Exposure to cleaning products and childhood asthma: more than just a link?
Authors: Parks J, Takaro TK PMID: 32990115 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - October 1, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Recent developments in the pathobiology of lung myofibroblasts.
This article reviewed the most recent progresses, mainly within the last five years, on the definition, origin, activity regulation and targeting of lung myofibroblasts in lung fibrosis. We did a literature search on PubMed using the keywords below from the dates 2010 to 2020. EXPERT OPINION: With the improved cell lineage characterization and the advent of scRNA-seq, the field is having much better picture of the lung myofibroblast origin and mesenchymal heterogeneity. Additionally, cellular metabolism has emerged as a key regulation of lung myofibroblast pathogenic phenotype and is a promising therapeutic target for ...
Source: Expert Review of Respiratory Medicine - September 29, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Using forced vital capacity (FVC) in the clinic to monitor patients with idiopathic pulmonary fibrosis (IPF): pros and cons.
Authors: Nathan SD, Wanger J, Zibrak JD, Wencel ML, Burg C, Stauffer JL Abstract INTRODUCTION: Forced vital capacity (FVC) decline is predictive of mortality in patients with idiopathic pulmonary fibrosis (IPF) and has been used as a clinical trial endpoint to define disease progression. How to interpret FVC findings in an individual patient with IPF in the real-world setting amid uncertainty about the measurement accuracy and variability has not been well established. AREAS COVERED: This review highlights the challenges and limitations of using FVC in the clinic to monitor disease progression in patients with ...
Source: Expert Review of Respiratory Medicine - September 29, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Multidrug-resistant tuberculosis in children and adolescents: current strategies for prevention and treatment.
Authors: Seddon JA, Johnson S, Palmer M, van der Zalm MM, Lopez-Varela E, Hughes J, Schaaf HS Abstract Introduction An estimated 30,000 children develop multidrug-resistant (MDR) tuberculosis (TB) each year, with only a small proportion diagnosed and treated. This field has historically been neglected due to a perception that children with MDR-TB are challenging to diagnose and treat. Diagnostic and therapeutic developments in adults have improved paediatric management, yet further paediatric-specific research and wider implementation of evidence-based practices are required. Areas covered This review combines the ...
Source: Expert Review of Respiratory Medicine - September 25, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Reported quality of life in countries with cases of COVID19: a systematic review.
Authors: Melo-Oliveira ME, Sá-Caputo D, Bachur JA, Paineiras-Domingos LL, Sonza A, Lacerda AC, Mendonça V, Seixas A, Taiar R, Bernardo-Filho M Abstract INTRODUCTION: Considering the relevance of the Quality of life (QoL) and the consequences of the 2019 new coronavirus disease (COVID-19) due to the social distancing, this systematic review aimed to summarize effects of the COVID-19 in the QoL of the studied populations. AREAS COVERED: Four databases, the methodological quality and the risk of bias in selected publications were investigated. Seven thousand and fifty-one individuals from Italy, Saud...
Source: Expert Review of Respiratory Medicine - September 22, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

TB Free India by 2025: Hype or Hope.
Authors: Sachdeva KS PMID: 32951482 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - September 22, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Acute oxygen therapy: a cross-sectional study of prescribing practices at an English Hospital immediately before COVID-19 pandemic.
CONCLUSION: We present real-world practice in naturalistic settings, immediately before pandemic-lockdown. Enhanced compliance is advocated to reduce risks of harm and mortality. PMID: 32945710 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - September 21, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

The predictive value of neutrophil-to-lymphocyte ratio for chronic obstructive pulmonary disease: a systematic review and meta-analysis.
Authors: Guo R, Li J, Ma X, Pan L Abstract OBJECTIVES: To assess the role of neutrophil to lymphocyte ratio (NLR) on the progression and prognosis of chronic obstructive pulmonary disease (COPD) through meta-analytic approach. METHODS: The electronic databases of PubMed, EmBase, and the Cochrane library were systematically searched for eligible studies throughout May 2020. The pooled weighted mean differences (WMDs) and odds ratios (ORs) with 95% confidence intervals (CIs) were estimated for continuous and categorical variables using random-effects model. RESULTS: A total of 18 studies involved 9,704 partic...
Source: Expert Review of Respiratory Medicine - September 19, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Plethysmographic data and profile of North-African patients with severe obstructive sleep apnea treated with continuous positive airway pressure.
CONCLUSION: The plethysmographic profile of OSA patients was dominated by the presence of an RVD. PMID: 32938253 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - September 19, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Clinical evaluation of Shufeng Jiedu Capsules combined with umifenovir (Arbidol) in the treatment of common-type COVID-19: a retrospective study.
Authors: Chen J, Lin S, Niu C, Xiao Q Abstract OBJECTIVE: To understand the clinical effectiveness and safety of Shufeng Jiedu Capsules combined with umifenovir (Arbidol) in the treatment of common-type COVID-19. METHODS: A retrospective cohort study was used to analyze the case data of 200 inpatients diagnosed with common-type COVID-19 at Wuhan Hospital. Participants were divided into a control group and an experimental group. The control group was treated with Arbidol hydrochloride capsules while the experimental group was treated with combination Arbidol hydrochloride capsules and Shufeng Jiedu Capsules (SFJ...
Source: Expert Review of Respiratory Medicine - September 19, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

The effect of teach-back training intervention of breathing exercise on the level of dyspnea, six-minutes walking test and FEV1/FVC ratio in patients with chronic obstructive pulmonary disease; a randomized controlled trial.
Authors: Hasanpour Dehkordi A, Ebrahimi-Dehkordi S, Banitalebi-Dehkordi F, Salehi Tali S, Kheiri S, Soleimani Babadi A Abstract BACKGROUND: Chronic obstructive pulmonary disease (COPD) is an irreversible pulmonary obstruction. Respiratory exercise training by a feedback-based model besides the routine managements have been considered to perform. RESEARCH DESIGN AND METHODS: Eighty exacerbated COPD patients with informed consent were divided to the control group(n=40) received the routine approach and the intervention group(n=40) received a teach-back training method (TBTM)of respiratory exercise including diaph...
Source: Expert Review of Respiratory Medicine - September 16, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Diagnostic approaches in COVID-19: clinical updates.
Authors: Asrani P, Eapen MS, Chia C, Haug G, Weber HC, Hassan I, Sohal SS Abstract INTRODUCTION: COVID-19 is a recent emerging pandemic whose prognosis is still unclear. Diagnostic tools are the main players that not only indicate a possible infection but can further restrict the transmission and can determine the extent to which disease progression would occur. AREAS COVERED: In this paper, we have performed a narrative and critical review on different technology-based diagnostic strategies such as molecular approaches including real-time reverse transcriptase, serological testing through enzyme-linked immunos...
Source: Expert Review of Respiratory Medicine - September 16, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Role of fever and ambient temperature in COVID-19.
Authors: Gul MH, Htun ZM, Inayat A PMID: 32901576 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - September 11, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Acute respiratory distress syndrome (ARDS) caused by the novel coronavirus disease (COVID-19): a practical comprehensive literature review.
Authors: Montenegro F, Unigarro L, Paredes G, Moya T, Romero A, Torres L, López JC, González FEJ, Del Pozo G, López-Cortés A, Diaz AM, Vasconez E, Cevallos-Robalino D, Lister A, Ortiz-Prado E Abstract INTRODUCTION: The exponential growth of SARS-CoV-2 virus transmission during the first months of 2020 has placed substantial pressure on most health systems around the world. The complications derived from the novel coronavirus disease (COVID-19) vary due to comorbidities, sex and age, with more than 50% of the patients requiring some level of intensive care developing acute respiratory dis...
Source: Expert Review of Respiratory Medicine - September 11, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

An update on the role of chronic rhinosinusitis with nasal polyps as a co-morbidity in severe asthma.
Authors: Castagnoli R, Licari A, Brambilla I, Tosca M, Ciprandi G, Marseglia GL Abstract INTRODUCTION: Chronic rhinosinusitis and asthma are heterogeneous diseases with complex pathogenesis. The presence of chronic rhinosinusitis with nasal polyps has been associated with increased asthma exacerbation frequency and may represent a predictor of future exacerbations in severe asthma. AREAS COVERED: This review provides the clinician with an overview of the prevalence and clinical impact of the chronic rhinosinusitis with nasal polyps in severe asthma and summarizes recommended therapeutic approaches, including in...
Source: Expert Review of Respiratory Medicine - September 3, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Effects of anemia on the survival of patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis.
CONCLUSION: The current systematic review and meta-analysis provides evidence regarding the detrimental consequences of anemia on the morbidity and mortality of patients with COPD. PMID: 32869670 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - September 2, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Vapour for lung volume reduction; pros and cons.
Authors: Zarogoulidis P, Hohenforst-Schmidt W, Huang H, Sapalidis K, Kosmidis C, Tryfon S, Vagionas A, Tsakiridis K, Drevelegas K, Freitag L Abstract INTRODUCTION: Bronchoscopic lung volume reduction (BLVR) is a novel approach for treatment of emphysema. Several techniques are available to accomplish BLVR including Bronchoscopic Vapour Thermal Ablation (BVTA). This technique is easy to perform and considered safe due to its gradual effect. We discuss BTVA in detail in this editorial.Areas covered: We discuss our experience with BTVA in detail including patient selection, equipment, procedure, post-procedural care a...
Source: Expert Review of Respiratory Medicine - September 2, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Evaluating triple ICS/LABA/LAMA therapies for COPD patients: a network meta-analysis of ETHOS, KRONOS, IMPACT, and TRILOGY studies.
CONCLUSION: Triple ICS/LABA/LAMA FDC and dual LABA/LAMA or ICS/LABA FDCs are characterized by specific efficacy/safety profiles in agreement with the level of blood eosinophil count at baseline. PMID: 32856967 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - August 30, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Endobronchial valve therapy for severe emphysema: an overview of valve-related complications and its management.
Authors: Koster TD, Klooster K, Ten Hacken NHT, van Dijk M, Slebos DJ Abstract INTRODUCTION: Bronchoscopic lung volume reduction treatment with one-way valves is an effective guideline treatment option for patients with severe emphysema. However, important challenges and adverse reactions may occur after treatment. AREAS COVERED: This review summarizes the complications after endobronchial and intrabronchial valve treatment that have been described by the currently published randomized controlled trials and other relevant papers regarding the complications and its management. In case there was no relevant liter...
Source: Expert Review of Respiratory Medicine - August 29, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Bronchoalveolar lavage: role in the evaluation of pulmonary interstitial disease.
Authors: Hogea SP, Tudorache E, Pescaru C, Marc M, Oancea C Abstract INTRODUCTION: Bronchoalveolar lavage (BAL), a noninvasive, well-tolerated procedure is an important diagnostic tool that can facilitate the diagnosis of various lung diseases. This procedure allows the assessment of large alveolar compartments, by providing cells as well as non-cellular constituents from the lower respiratory tract. Alterations in BAL fluid and cells ratio reflects pathological changes in the lung parenchyma. In some cases, clinicians use BAL as a differential diagnosis guide for interstitial lung disease. AREAS COVERED: In th...
Source: Expert Review of Respiratory Medicine - August 29, 2020 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research