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Educational video demonstrating collapsibility of the upper airway during sleep improves initial acceptance of CPAP in patients with severe obstructive sleep apnea: a retrospective study
Journal of Clinical Sleep Medicine, Ahead of Print. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - April 22, 2024 Category: Sleep Medicine Authors: Charikleia Tselepi Georgios Tsirves Konstantinos Exarhos Christos Chronis Christos Kyriakopoulos Konstantinos Tatsis Konstantinos Kostikas Athanasios Konstantinidis 1Sleep Disorders Unit, Department of Respiratory Medicine, University Hospital of Ioannina Source Type: research

Evaluating the impact of automatic positive airway pressure therapy on cardiovascular risk index and vascular behavior in patients with obstructive sleep apnea: a study on heterogeneity in the therapeutic response
Journal of Clinical Sleep Medicine, Ahead of Print. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - April 22, 2024 Category: Sleep Medicine Authors: Wenjun Zhu Lin Xiang Linna Cao Yaping Tian Wenjun Li Lirong He 1Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China 2Department of Respiratory and Sleep Medicine, Peking University P Source Type: research

Estimating the incidence of COVID-19, influenza and respiratory syncytial virus infection in three regions of Queensland, Australia, winter 2022: findings from a novel longitudinal testing-based sentinel surveillance programme
Conclusion This testing-based surveillance programme could estimate disease trends and be a useful tool in settings where testing is less common or accessible. Difficulties with recruitment meant the study was underpowered. The frontline sentinel nature of workplaces meant participants were not representative of the general population but were high-risk groups providing early warning of disease. (Source: BMJ Open)
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: May, F., Ginige, S., Firman, E., Li, Y. S., Soonarane, Y. K., Smoll, N., Hunter, I., Pery, B., Macfarlane, B., Bladen, T., Allen, T., Green, T., Walker, J., Slinko, V., Stickley, M., Khandaker, G., Anuradha, S., Wattiaux, A. Tags: Open access, Public health, COVID-19 Source Type: research

Carrageenan maintains the contractile phenotype of vascular smooth muscle cells by increasing macromolecular crowding in vitro
ConclusionsThe in vitro study showed that VSMCs can maintain the contractile phenotype by sensing changes in the crowding of the culture environment, which can be maintained by adding CR.Graphical Abstract (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 22, 2024 Category: Research Source Type: research

Comparison between high-flow nasal oxygen (HFNO) alternated with non-invasive ventilation (NIV) and HFNO and NIV alone in patients with COVID-19: a retrospective cohort study
ConclusionsIn patients with COVID-19, NIV alternating with HFNO was associated with a higher rate of IMV independent of the presence of comorbidities, chest CT score and SpO2/FiO2.Trial registration ClinicalTrials.gov identifier: NCT05579080. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 22, 2024 Category: Research Source Type: research

Concentrations of dehydroepiandrosterone-sulphate (DHEA-S) in people with cystic fibrosis on and off elexacaftor-tezacaftor-ivacaftor
Cystic fibrosis (CF) is a multi-system disorder caused by defects in the CF trans-membrane conductance regulator. As people with CF (pwCF) lead longer and healthier lives, the impact of steroid hormones on their health has become increasingly important. DHEA-S and its potential implications on the health of adults with CF has not been well-explored. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 22, 2024 Category: Respiratory Medicine Authors: Shadaan Abid, Lauren Shaffer, Andrew Bayat, Minjae Lee, Ashley Keller, Raksha Jain Tags: Short Communication Source Type: research

Optimal Inhalation Profile of Pressurized Metered Dry Powder Inhaler Using a Valved Holding Chamber: A Dynamic Analysis
Journal of Aerosol Medicine and Pulmonary Drug Delivery, Ahead of Print. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - April 22, 2024 Category: Respiratory Medicine Authors: Tetsuri Kondo Toshimori Tanigaki Makoto Hibino Shigeto Horiuchi Kazunari Maeda Shunichi Tobe Riko Kamada Shigehiro Watanabe Source Type: research

Blood Urea Nitrogen to Serum Albumin Ratio as a New Indicator of Disease Severity and Prognosis in Idiopathic Pulmonary Artery Hypertension
This study investigated the associations between BAR and functional status, echocardiographic findings, hemodynamics, and long-term outcomes among patients with IPAH. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 22, 2024 Category: Respiratory Medicine Authors: Sicheng Zhang, Luyang Gao, Zhihui Zhao, Qing Zhao, Tao Yang, Qixian Zeng, Yi Zhang, Xin Li, Zhihua Huang, Anqi Duan, Qin Luo, Zhihong Liu Source Type: research

GLP-1 Receptor Agonist Use and Risk of Postoperative Complications
This cohort study evaluates the risk of postoperative respiratory complications among patients with diabetes undergoing surgery who had vs those who had not a prescription fill for glucagon-like peptide 1 receptor agonists. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 22, 2024 Category: General Medicine Source Type: research

Rising incidence of severe maxillofacial space infections in Germany
ConclusionsSevere MSI are a growing challenge in German health care especially among elderly patients over 80  years.Clinical relevanceSevere MSI is a promising target for prevention. There should be more focus in primary dental and medical care especially in groups depending on social support. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 22, 2024 Category: Dentistry Source Type: research

Genomic characterization of human respiratory syncytial virus circulating in Islamabad, Pakistan, during an outbreak in 2022-2023
In this study, conducted at the National Institute of Health, Islamabad, during an outbreak of human respiratory syncytial virus (hRSV) from December 2022 to January 2023, the first whole-genome sequences of hRSV isolates from Islamabad, Pakistan, were determined. Out of 10 positive samples, five were sequenced, revealing the presence of two genotypes: RSV-A (GA2.3.5, ON1 strain) and RSV-B (GB5.0.5.a, BA-10 strain). A rare non-synonymous substitution (E232G) in G the protein and N276S in the F protein were found in RSV-A. In RSV-B, the unique mutations K191R, Q209R, and I206M were found in the F protein. These mutations co...
Source: Archives of Virology - April 22, 2024 Category: Virology Source Type: research

Bioinformatics and system biology approaches to determine the connection of SARS-CoV-2 infection and intrahepatic cholangiocarcinoma
ConclusionThis study is expected to provide valuable references and potential drugs for future research and treatment of COVID-19 and ICC. (Source: PLoS One)
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Xinyi Zhou Source Type: research

Respiratory drive: a journey from health to disease
AbstractRespiratory drive is defined as the intensity of respiratory centers output during the breath and is primarily affected by cortical and chemical feedback mechanisms. During the involuntary act of breathing, chemical feedback, primarily mediated through CO2, is the main determinant of respiratory drive. Respiratory drive travels through neural pathways to respiratory muscles, which execute the breathing process and generate inspiratory flow (inspiratory flow-generation pathway). In a healthy state, inspiratory flow-generation pathway is intact, and thus respiratory drive is satisfied by the rate of volume increase, ...
Source: Journal of Intensive Care - April 22, 2024 Category: Intensive Care Source Type: research

Systemic inflammation and delirium during critical illness
ConclusionMarkers of inflammation and possibly endogenous anticoagulant activity are associated with delirium and coma during critical illness. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - April 22, 2024 Category: Intensive Care Source Type: research

Rapidly improving ARDS differs clinically and biologically from persistent ARDS
Rapidly improving acute respiratory distress syndrome (RIARDS) is an increasingly appreciated subgroup of ARDS in which hypoxemia improves within 24 h after initiation of mechanical ventilation. Detailed clini... (Source: Critical Care)
Source: Critical Care - April 22, 2024 Category: Intensive Care Authors: Patricia L. Valda Toro, Andrew Willmore, Nelson E. Wu, Kevin L. Delucchi, Alejandra Jauregui, Pratik Sinha, Kathleen D. Liu, Carolyn M. Hendrickson, Aartik Sarma, Lucile P. A. Neyton, Aleksandra Leligdowicz, Charles R. Langelier, Hanjing Zhuo, Chayse Jone Tags: Research Source Type: research