Interleukin-26 is a promising biomarker of sepsis but is it always reliable?
(Source: Critical Care)
Source: Critical Care - December 6, 2019 Category: Intensive Care Authors: Patrick M. Honore, Aude Mugisha, Leonel Barreto Gutierrez, Sebastien Redant, Keitiane Kaefer, Andrea Gallerani and David De Bels Tags: Letter Source Type: research

Risk factors for the development of acute respiratory distress syndrome in mechanically ventilated adults in Peru: a multicenter observational study
Clinical and epidemiological differences between acute respiratory distress syndrome (ARDS) that presents at the initiation of mechanical ventilation [MV] (ARDS at MV onset) and that which develops during the ... (Source: Critical Care)
Source: Critical Care - December 6, 2019 Category: Intensive Care Authors: Ena Gupta, Shakir Hossen, Matthew R. Grigsby, Phabiola Herrera, Rollin Roldan, Enrique Paz, Amador A. Jaymez, Eduardo E. Chirinos, Jose Portugal, Rocio Quispe, Roy G. Brower and William Checkley Tags: Research Source Type: research

Epidemiology and prognosis of anti-infective therapy in the ICU setting during acute pancreatitis: a cohort study
Recent international guidelines for acute pancreatitis (AP) recommend limiting anti-infective therapy (AIT) to cases of suspected necrotizing AP or nosocomial extrapancreatic infection. Limited data are availa... (Source: Critical Care)
Source: Critical Care - December 5, 2019 Category: Intensive Care Authors: Philippe Montravers, Elie Kantor, Jean-Michel Constantin, Jean-Yves Lefrant, Thomas Lescot, Nicolas Nesseler, Catherine Paugam, Matthieu Jabaudon and Herv é Dupont Tags: Research Source Type: research

Cortisol total/CRP ratio for the prediction of hospital-acquired pneumonia and initiation of corticosteroid therapy in traumatic brain-injured patients
To propose a combination of blood biomarkers for the prediction of hospital-acquired pneumonia (HAP) and for the selection of traumatic brain-injured (TBI) patients eligible for corticosteroid therapy for the ... (Source: Critical Care)
Source: Critical Care - December 5, 2019 Category: Intensive Care Authors: Marwan Bouras, Antoine Roquilly, Pierre-Joachim Mah é, Raphaël Cinotti, Mickaël Vourc’h, Bastien Perrot, Kalyane Bach-Ngohou, Damien Masson and Karim Asehnoune Tags: Research Source Type: research

Expiratory flow limitation in intensive care: prevalence and risk factors
Expiratory flow limitation (EFL) is characterised by a markedly reduced expiratory flow insensitive to the expiratory driving pressure. The presence of EFL can influence the respiratory and cardiovascular func... (Source: Critical Care)
Source: Critical Care - December 5, 2019 Category: Intensive Care Authors: Carlo Alberto Volta, Francesca Dalla Corte, Riccardo Ragazzi, Elisabetta Marangoni, Alberto Fogagnolo, Gaetano Scaramuzzo, Domenico Luca Grieco, Valentina Alvisi, Chiara Rizzuto and Savino Spadaro Tags: Research Source Type: research

A meta-analysis of the effects of therapeutic hypothermia in adult patients with traumatic brain injury
Therapeutic hypothermia management remains controversial in patients with traumatic brain injury. We conducted a meta-analysis to evaluate the risks and benefits of therapeutic hypothermia management in patien... (Source: Critical Care)
Source: Critical Care - December 5, 2019 Category: Intensive Care Authors: Hanbing Chen, Fei Wu, Penglei Yang, Jun Shao, Qihong Chen and Ruiqiang Zheng Tags: Review Source Type: research

The prognostic value of serum procalcitonin measurements in critically injured patients: a systematic review
Major trauma is associated with high incidence of septic complications and multiple organ dysfunction (MOD), which markedly influence the outcome of injured patients. Early identification of patients at risk o... (Source: Critical Care)
Source: Critical Care - December 3, 2019 Category: Intensive Care Authors: Aziza N. AlRawahi, Fatma A. AlHinai, Christopher J. Doig, Chad G. Ball, Elijah Dixon, Zhengwen Xiao and Andrew W. Kirkpatrick Tags: Research Source Type: research

Temporal trends in the use of targeted temperature management after cardiac arrest and association with outcome: insights from the Paris Sudden Death Expertise Centre
Recent doubts regarding the efficacy may have resulted in a loss of interest for targeted temperature management (TTM) in comatose cardiac arrest (CA) patients, with uncertain consequences on outcome. We aimed... (Source: Critical Care)
Source: Critical Care - December 3, 2019 Category: Intensive Care Authors: Jean-Baptiste Lascarrou, Florence Dumas, Wulfran Bougouin, Richard Chocron, Frankie Beganton, Stephane Legriel, Nadia Aissaoui, Nicolas Deye, Lionel Lamhaut, Daniel Jost, Antoine Vieillard-Baron, Eloi Marijon, Xavier Jouven and Alain Cariou Tags: Research Source Type: research

Cumulative fluid accumulation is associated with the development of acute kidney injury and non-recovery of renal function: a retrospective analysis
Acute kidney injury (AKI) is common in patients in the intensive care unit (ICU) and may be present on admission or develop during ICU stay. Our objectives were (a) to identify factors independently associated... (Source: Critical Care)
Source: Critical Care - December 3, 2019 Category: Intensive Care Authors: Jing Zhang, Siobhan Crichton, Alison Dixon, Nina Seylanova, Zhiyong Y. Peng and Marlies Ostermann Tags: Research Source Type: research

Mechanical ventilation in patients with acute ischaemic stroke: from pathophysiology to clinical practice
Most patients with ischaemic stroke are managed on the ward or in specialty stroke units, but a significant number requires higher-acuity care and, consequently, admission to the intensive care unit. Mechanica... (Source: Critical Care)
Source: Critical Care - December 2, 2019 Category: Intensive Care Authors: Chiara Robba, Giulia Bonatti, Denise Battaglini, Patricia R. M. Rocco and Paolo Pelosi Tags: Review Source Type: research

Ultrasound-based clinical profiles for predicting the risk of intradialytic hypotension in critically ill patients on intermittent dialysis: a prospective observational study
This study was aimed to determine whether different predialysis ult... (Source: Critical Care)
Source: Critical Care - December 2, 2019 Category: Intensive Care Authors: Rogerio da Hora Passos, Juliana Caldas, Joao Gabriel Rosa Ramos, Erica Batista dos Santos Galv ão de Melo, Michel Por Deus Ribeiro, Maria Fernanda Coelho Alves, Paulo Benigno Pena Batista, Octavio Henrique Coelho Messeder, Augusto Manoel de Carvalho de F Tags: Research Source Type: research

The early change of SOFA score as a prognostic marker of 28-day sepsis mortality: analysis through a derivation and a validation cohort
Since the Sepsis-3 criteria, change in Sequential Organ Failure Assessment (SOFA) score has become a key component of sepsis identification. Thus, it could be argued that reversal of this change ( ΔSOFA) may refle... (Source: Critical Care)
Source: Critical Care - November 29, 2019 Category: Intensive Care Authors: Eleni Karakike, Evdoxia Kyriazopoulou, Iraklis Tsangaris, Christina Routsi, Jean-Louis Vincent and Evangelos J. Giamarellos-Bourboulis Tags: Research Source Type: research

Levosimendan in the light of the results of the recent randomized controlled trials: an expert opinion paper
Despite interesting and unique pharmacological properties, levosimendan has not proven a clear superiority to placebo in the patient populations that have been enrolled in the various recent multicenter random... (Source: Critical Care)
Source: Critical Care - November 29, 2019 Category: Intensive Care Authors: Bernard Cholley, Bruno Levy, Jean-Luc Fellahi, Dan Longrois, Julien Amour, Alexandre Ouattara and Alexandre Mebazaa Tags: Review Source Type: research

How I search for a sepsis source
(Source: Critical Care)
Source: Critical Care - November 29, 2019 Category: Intensive Care Authors: Jan J. De Waele and Yasser Sakr Tags: Editorial Source Type: research

Murine sepsis phenotypes and differential treatment effects in a randomized trial of prompt antibiotics and fluids
Clinical and biologic phenotypes of sepsis are proposed in human studies, yet it is unknown whether prognostic or drug response phenotypes are present in animal models of sepsis. Using a biotelemetry-enhanced,... (Source: Critical Care)
Source: Critical Care - November 28, 2019 Category: Intensive Care Authors: Christopher W. Seymour, Samantha J. Kerti, Anthony J. Lewis, Jason Kennedy, Emily Brant, John E. Griepentrog, Xianghong Zhang, Derek C. Angus, Chung-Chou H. Chang and Matthew R. Rosengart Tags: Research Source Type: research

Colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia (Magic Bullet study): an investigator-driven, open-label, randomized, noninferiority controlled trial
Colistin is recommended in the empirical treatment of ventilator-associated pneumonia (VAP) with a high prevalence of carbapenem-resistant gram-negative bacilli (CR-GNB). However, the efficacy and safety of co... (Source: Critical Care)
Source: Critical Care - November 28, 2019 Category: Intensive Care Authors: Jos é M. Cisneros, Clara María Rosso-Fernández, Cristina Roca-Oporto, Gennaro De Pascale, Silvia Jiménez-Jorge, Esteban Fernández-Hinojosa, Dimitrios K. Matthaiou, Paula Ramírez, Ramón Ortiz Díaz-Miguel, Angel Estella, Massimo Antonelli, George Di Tags: Research Source Type: research

The SOFA score —development, utility and challenges of accurate assessment in clinical trials
The Sequential Organ Failure Assessment or SOFA score was developed to assess the acute morbidity of critical illness at a population level and has been widely validated as a tool for this purpose across a ran... (Source: Critical Care)
Source: Critical Care - November 27, 2019 Category: Intensive Care Authors: Simon Lambden, Pierre Francois Laterre, Mitchell M. Levy and Bruno Francois Tags: Review Source Type: research

Early vs. late coronary angiography in cardiac arrest improves survival and preserves renal function: some confounding factors to consider
(Source: Critical Care)
Source: Critical Care - November 27, 2019 Category: Intensive Care Authors: S ébastien Redant, Yael Langman, Xavier Beretta-Piccoli, David De Bels, Rachid Attou and Patrick M. Honore Tags: Letter Source Type: research

Increased β-Lactams dosing regimens improve clinical outcome in critically ill patients with augmented renal clearance treated for a first episode of hospital or ventilator-acquired pneumonia: a before and after study
Augmented renal clearance (ARC) is recognized as a leading cause of β-lactam subexposure when conventional dosing regimens are used. The main objective was to compare the clinical outcome of ARC patients treat... (Source: Critical Care)
Source: Critical Care - November 27, 2019 Category: Intensive Care Authors: C édric Carrié, Grégoire Chadefaux, Noémie Sauvage, Hugues de Courson, Laurent Petit, Karine Nouette-Gaulain, Bruno Pereira and Matthieu Biais Tags: Research Source Type: research

A comparison of clinical paediatric guidelines for hypotension with population-based lower centiles: a systematic review
In this study, we aim to identify evidence-based reference values for low blood pressure and to compare these with existing definitions for systolic hyp... (Source: Critical Care)
Source: Critical Care - November 27, 2019 Category: Intensive Care Authors: Nienke N. Hagedoorn, Joany M. Zachariasse and Henriette A. Moll Tags: Research Source Type: research

Oral mucositis as a pathway for fatal outcome among critically ill patients exposed to chlorhexidine: post hoc analysis of a randomized clinical trial
(Source: Critical Care)
Source: Critical Care - November 27, 2019 Category: Intensive Care Authors: Wanessa Teixeira Bellissimo-Rodrigues, Mayra Gon çalves Menegueti, Leandro Dorigan de Macedo, Anibal Basile-Filho, Roberto Martinez and Fernando Bellissimo-Rodrigues Tags: Research Letter Source Type: research

Value of respiratory variation of aortic peak velocity in predicting children receiving mechanical ventilation: a systematic review and meta-analysis
Accurate volume assessment is crucial in children under fluid therapy. Over the last decade, respiratory variation of aortic peak velocity ( △VPeak) has been applied in intensive care unit and surgeries to help... (Source: Critical Care)
Source: Critical Care - November 22, 2019 Category: Intensive Care Authors: Xiaoying Wang, Lulu Jiang, Shuai Liu, Yali Ge and Ju Gao Tags: Research Source Type: research

In-line filtration of intravenous infusion may reduce organ dysfunction of adult critical patients
The potential harmful effects of particle-contaminated infusions for critically ill adult patients are yet unclear. So far, only significant improved outcome in critically ill children and new-borns was demons... (Source: Critical Care)
Source: Critical Care - November 22, 2019 Category: Intensive Care Authors: Elke Schmitt, Patrick Meybohm, Eva Herrmann, Karin Ammersbach, Raphaela Endres, Simone Lindau, Philipp Helmer, Kai Zacharowski and Holger Neb Tags: Research Source Type: research

Outcomes of Stenotrophomonas maltophilia hospital-acquired pneumonia in intensive care unit: a nationwide retrospective study
There is little descriptive data on Stenotrophomonas maltophilia hospital-acquired pneumonia (HAP) in critically ill patients. The optimal modalities of antimicrobial therapy remain to be determined. Our objectiv... (Source: Critical Care)
Source: Critical Care - November 21, 2019 Category: Intensive Care Authors: Philippe Guerci, Hugo Bellut, Mokhtar Mokhtari, Julie Gaudefroy, Nicolas Mongardon, Claire Charpentier, Guillaume Louis, Parvine Tashk, Cl ément Dubost, Stanislas Ledochowski, Antoine Kimmoun, Thomas Godet, Julien Pottecher, Jean-Marc Lalot, Emmanuel Nov Tags: Research Source Type: research

Continual measurement of arterial dP/dtmax enables minimally invasive monitoring of left ventricular contractility in patients with acute heart failure
Continuous, reliable evaluation of left ventricular (LV) contractile function in patients with advanced heart failure requiring intensive care remains challenging. Continual monitoring of dP/dtmax from the arteri... (Source: Critical Care)
Source: Critical Care - November 21, 2019 Category: Intensive Care Authors: Petr Ostadal, Dagmar Vondrakova, Andreas Kr üger, Marek Janotka and Jan Naar Tags: Research Source Type: research

Derivation and validation of an easy-to-compute trauma score that improves prognostication of mortality or the Trauma Rating Index in Age, Glasgow Coma Scale, Respiratory rate and Systolic blood pressure (TRIAGES) score
Multiple trauma scores have been developed and validated, including the Revised Trauma Score (RTS) and the Mechanism, Glasgow Coma Scale, Age, and Arterial Pressure (MGAP) score. However, these scores are comp... (Source: Critical Care)
Source: Critical Care - November 21, 2019 Category: Intensive Care Authors: Atsushi Shiraishi, Yasuhiro Otomo, Shunsuke Yoshikawa, Koji Morishita, Ian Roberts and Hiroki Matsui Tags: Research Source Type: research

Association between hospital mortality and inspiratory airway pressures in mechanically ventilated patients without acute respiratory distress syndrome: a prospective cohort study
Higher inspiratory airway pressures are associated with worse outcomes in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). This relationship, however, has not been well inv... (Source: Critical Care)
Source: Critical Care - November 21, 2019 Category: Intensive Care Authors: Sarina K. Sahetya, Christopher Mallow, Jonathan E. Sevransky, Greg S. Martin, Timothy D. Girard, Roy G. Brower and William Checkley Tags: Research Source Type: research

Effects of inspiratory flow on lung stress, pendelluft, and ventilation heterogeneity in ARDS: a physiological study
High inspiratory flow might damage the lungs by mechanisms not fully understood yet. We hypothesized that increasing inspiratory flow would increase lung stress, ventilation heterogeneity, and pendelluft in AR... (Source: Critical Care)
Source: Critical Care - November 21, 2019 Category: Intensive Care Authors: Alessandro Santini, Tommaso Mauri, Francesca Dalla Corte, Elena Spinelli and Antonio Pesenti Tags: Research Source Type: research

Respective contribution of intensive care unit-acquired limb muscle and severe diaphragm weakness on weaning outcome and mortality: a post hoc analysis of two cohorts
Intensive care unit (ICU)-acquired weakness (ICU-AW) and ICU-acquired diaphragm dysfunction (ICU-DD) occur frequently in mechanically ventilated (MV) patients. It is unknown whether they have different risk fa... (Source: Critical Care)
Source: Critical Care - November 21, 2019 Category: Intensive Care Authors: Martin Dres, Boris Jung, Nicolas Molinari, Federico Manna, Bruno-Pierre Dub é, Gerald Chanques, Thomas Similowski, Samir Jaber and Alexandre Demoule Tags: Research Source Type: research

Beneficial effects of early empirical administration of appropriate antimicrobials on survival and defervescence in adults with community-onset bacteremia
Bloodstream infections are associated with high morbidity and mortality, both of which contribute substantially to healthcare costs. The effects of early administration of appropriate antimicrobials on the pro... (Source: Critical Care)
Source: Critical Care - November 20, 2019 Category: Intensive Care Authors: Ching-Chi Lee, Chung-Hsun Lee, Chao-Yung Yang, Chih-Chia Hsieh, Hung-Jen Tang and Wen-Chien Ko Tags: Research Source Type: research

Implementation of earlier antibiotic administration in patients with severe sepsis and septic shock in Japan: a descriptive analysis of a prospective observational study
Time to antibiotic administration is a key element in sepsis care; however, it is difficult to implement sepsis care bundles. Additionally, sepsis is different from other emergent conditions including acute co... (Source: Critical Care)
Source: Critical Care - November 19, 2019 Category: Intensive Care Authors: Toshikazu Abe, Shigeki Kushimoto, Yasuharu Tokuda, Gary S. Phillips, Andrew Rhodes, Takehiro Sugiyama, Akira Komori, Hiroki Iriyama, Hiroshi Ogura, Seitaro Fujishima, Atsushi Shiraishi, Daizoh Saitoh, Toshihiko Mayumi, Toshio Naito, Kiyotsugu Takuma, Taka Tags: Research Source Type: research

Translational medicine between human and veterinary emergency and critical care medicine: a story meant to have a happy ending
(Source: Critical Care)
Source: Critical Care - November 19, 2019 Category: Intensive Care Authors: Nuno M. F élix, K. Gommeren and S. Boysen Tags: Editorial Source Type: research

The IES-R remains a core outcome measure for PTSD in critical illness survivorship research
(Source: Critical Care)
Source: Critical Care - November 19, 2019 Category: Intensive Care Authors: Megan M. Hosey, O. Joseph Bienvenu, Victor D. Dinglas, Alison E. Turnbull, Ann M. Parker, Ramona O. Hopkins, Karin J. Neufeld and Dale M. Needham Tags: Letter Source Type: research

Noninvasive ventilation in patients with acute respiratory distress syndrome
(Source: Critical Care)
Source: Critical Care - November 15, 2019 Category: Intensive Care Authors: Kailei Du Tags: Letter Source Type: research

A significant p value is not equivalent to the superiority of one test index over another
(Source: Critical Care)
Source: Critical Care - November 15, 2019 Category: Intensive Care Authors: Qiaoying Ji and Weimin Li Tags: Letter Source Type: research

Extracorporeal membrane oxygenation in Pneumocystis jirovecii pneumonia: outcome in HIV and non-HIV patients
(Source: Critical Care)
Source: Critical Care - November 14, 2019 Category: Intensive Care Authors: Jonathan Rilinger, Dawid L. Staudacher, Siegbert Rieg, Daniel Duerschmied, Christoph Bode and Tobias Wengenmayer Tags: Research Letter Source Type: research

Left ventricular wall findings in non-electrocardiography-gated contrast-enhanced computed tomography after extracorporeal cardiopulmonary resuscitation
This study examined left ventricular wall CE... (Source: Critical Care)
Source: Critical Care - November 14, 2019 Category: Intensive Care Authors: Kazuhiro Sugiyama, Masamichi Takahashi, Kazuki Miyazaki, Takuto Ishida, Mioko Kobayashi and Yuichi Hamabe Tags: Research Source Type: research

Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis
Sepsis is an increasingly significant challenge throughout the world as one of the major causes of patient morbidity and mortality. Central to the host immunologic response to sepsis is the increase in circula... (Source: Critical Care)
Source: Critical Care - November 13, 2019 Category: Intensive Care Authors: McKenzie K. Hollen, Julie A. Stortz, Dijoia Darden, Marvin L. Dirain, Dina C. Nacionales, Russell B. Hawkins, Michael C. Cox, Maria-Cecilia Lopez, Jaimar C. Rincon, Ricardo Ungaro, Zhongkai Wang, Quran Wu, Babette Brumback, Marie-Pierre L. Gauthier, Micha Tags: Research Source Type: research

Attainment of therapeutic vancomycin level within the first 24  h: Authors' response
(Source: Critical Care)
Source: Critical Care - November 13, 2019 Category: Intensive Care Authors: Jo ão Pedro Baptista, Jason A. Roberts, Eduardo Sousa, Ricardo Freitas, Nuno Devesa and Jorge Pimentel Tags: Letter Source Type: research

Exogenous vasopressin dose-dependently modulates gastric microcirculatory oxygenation in dogs via V1A receptor
Hypercapnia improves gastric microcirculatory oxygenation ( μHbO2) and increases vasopressin plasma levels, whereas V1A receptor blockade abolishes the increase of μHbO2. The aim of this study was to evaluate the ... (Source: Critical Care)
Source: Critical Care - November 12, 2019 Category: Intensive Care Authors: Richard Truse, Steven Grewe, Anna Herminghaus, Jan Schulz, Andreas P. M. Weber, Tabea Mettler-Altmann, Inge Bauer, Olaf Picker and Christian Vollmer Tags: Research Source Type: research

Long-term cognitive impairment after acute respiratory distress syndrome: a review of clinical impact and pathophysiological mechanisms
Acute respiratory distress syndrome (ARDS) survivors experience a high prevalence of cognitive impairment with concomitantly impaired functional status and quality of life, often persisting months after hospit... (Source: Critical Care)
Source: Critical Care - November 12, 2019 Category: Intensive Care Authors: Cina Sasannejad, E. Wesley Ely and Shouri Lahiri Tags: Review Source Type: research

Early lactate measurement is associated with better outcomes in septic patients with an elevated serum lactate level
The optimal timing of lactate measurement for septic patients in the intensive care unit (ICU) remains controversial, and whether initiating and repeating the lactate measurement earlier could make a differenc... (Source: Critical Care)
Source: Critical Care - November 11, 2019 Category: Intensive Care Authors: Hui Chen, Chenyan Zhao, Yao Wei and Jun Jin Tags: Research Source Type: research

Effects of a swallowing and oral care intervention for patients following endotracheal extubation: a pre- and post-intervention study
For patients who survive a critical illness and have their oral endotracheal tube removed, dysphagia is highly prevalent, and without intervention, it may persist far beyond hospital discharge. This pre- and p... (Source: Critical Care)
Source: Critical Care - November 9, 2019 Category: Intensive Care Authors: Chung-Pei Wu, Yu-Juan Xu, Tyng-Guey Wang, Shih-Chi Ku, Ding-Cheng Chan, Jang-Jaer Lee, Yu-Chung Wei, Tzu-Yu Hsiao and Cheryl Chia-Hui Chen Tags: Research Source Type: research

Effect of tranexamic acid on mortality in patients with haemoptysis: a nationwide study
Although tranexamic acid is widely used in patients with haemoptysis, whether it improves mortality has not been well investigated. The aim of this study was to evaluate the effect of tranexamic acid on in-hos... (Source: Critical Care)
Source: Critical Care - November 6, 2019 Category: Intensive Care Authors: Takahiro Kinoshita, Hiroyuki Ohbe, Hiroki Matsui, Kiyohide Fushimi, Hiroshi Ogura and Hideo Yasunaga Tags: Research Source Type: research

Low-flow assessment of current ECMO/ECCO2R rotary blood pumps and the potential effect on hemocompatibility
Extracorporeal carbon dioxide removal (ECCO2R) uses an extracorporeal circuit to directly remove carbon dioxide from the blood either in lieu of mechanical ventilation or in combination with it. While the potenti... (Source: Critical Care)
Source: Critical Care - November 6, 2019 Category: Intensive Care Authors: Sascha Gross-Hardt, Felix Hesselmann, Jutta Arens, Ulrich Steinseifer, Leen Vercaemst, Wolfram Windisch, Daniel Brodie and Christian Karagiannidis Tags: Research Source Type: research

Obituary: Professor Claude Martin
(Source: Critical Care)
Source: Critical Care - November 6, 2019 Category: Intensive Care Authors: Marc Leone and Jean-Louis Vincent Tags: Editorial Source Type: research

A novel non-invasive method to detect excessively high respiratory effort and dynamic transpulmonary driving pressure during mechanical ventilation
Excessive respiratory muscle effort during mechanical ventilation may cause patient self-inflicted lung injury and load-induced diaphragm myotrauma, but there are no non-invasive methods to reliably detect ele... (Source: Critical Care)
Source: Critical Care - November 6, 2019 Category: Intensive Care Authors: Michele Bertoni, Irene Telias, Martin Urner, Michael Long, Lorenzo Del Sorbo, Eddy Fan, Christer Sinderby, Jennifer Beck, Ling Liu, Haibo Qiu, Jenna Wong, Arthur S. Slutsky, Niall D. Ferguson, Laurent J. Brochard and Ewan C. Goligher Tags: Research Source Type: research

High-flow nasal cannula oxygen therapy versus conventional oxygen therapy in patients after planned extubation
(Source: Critical Care)
Source: Critical Care - November 5, 2019 Category: Intensive Care Authors: Meng-Si Luo, Guan-Jiang Huang and Lun Wu Tags: Letter Source Type: research

Caution should be taken when using electronic health record database
(Source: Critical Care)
Source: Critical Care - November 5, 2019 Category: Intensive Care Authors: Lina Wang and Xiaoming Wu Tags: Letter Source Type: research

NT-proBNP levels might predict outcomes in severe sepsis, but renal function cannot be ignored
(Source: Critical Care)
Source: Critical Care - November 4, 2019 Category: Intensive Care Authors: Jiarong Ye, Qianrong Liang and Xiaotu Xi Tags: Letter Source Type: research