The obesity paradox in critically ill patients: a causal learning approach to a casual finding
While obesity confers an increased risk of death in the general population, numerous studies have reported an association between obesity and improved survival among critically ill patients. This contrary find... (Source: Critical Care)
Source: Critical Care - August 5, 2020 Category: Intensive Care Authors: Alexander Decruyenaere, Johan Steen, Kirsten Colpaert, Dominique D. Benoit, Johan Decruyenaere and Stijn Vansteelandt Tags: Research Source Type: research

Plasma exchange in critically ill COVID-19 patients
(Source: Critical Care)
Source: Critical Care - August 4, 2020 Category: Intensive Care Authors: Christian Morath, Markus A. Weigand, Martin Zeier, Claudius Speer, Shilpa Tiwari-Heckler and Uta Merle Tags: Research Letter Source Type: research

Compared to NIPPV, HFNC is more dangerous regarding aerosol dispersion and contamination of healthcare personnel: we are not sure
(Source: Critical Care)
Source: Critical Care - August 4, 2020 Category: Intensive Care Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels Tags: Letter Source Type: research

Correction to: Urine cell cycle arrest biomarkers distinguish poorly between transient and persistent AKI in early septic shock: a prospective, multicenter study
An amendment to this paper has been published and can be accessed via the original article. (Source: Critical Care)
Source: Critical Care - August 4, 2020 Category: Intensive Care Authors: Dimitri Titeca-Beauport, Delphine Daubin, Ly Van Vong, Guillaume Belliard, C édric Bruel, Sami Alaya, Karim Chaoui, Maud Andrieu, Isabelle Rouquette-Vincenti, Frederic Godde, Michel Pascal, Momar Diouf, Christophe Vinsonneau, Kada Klouche and Julien Maiz Tags: Correction Source Type: research

Serum levels of receptor-interacting protein kinase-3 in patients with COVID-19
(Source: Critical Care)
Source: Critical Care - August 4, 2020 Category: Intensive Care Authors: Hideta Nakamura, Takeshi Kinjo, Wakako Arakaki, Kazuya Miyagi, Masao Tateyama and Jiro Fujita Tags: Research Letter Source Type: research

Chest physiotherapy improves lung aeration in hypersecretive critically ill patients: a pilot randomized physiological study
Besides airway suctioning, patients undergoing invasive mechanical ventilation (iMV) benefit of different combinations of chest physiotherapy techniques, to improve mucus removal. To date, little is known abou... (Source: Critical Care)
Source: Critical Care - August 3, 2020 Category: Intensive Care Authors: Federico Longhini, Andrea Bruni, Eugenio Garofalo, Chiara Ronco, Andrea Gusmano, Gianmaria Cammarota, Laura Pasin, Pamela Frigerio, Davide Chiumello and Paolo Navalesi Tags: Research Source Type: research

ACEI/ARB therapy in COVID-19: the double-edged sword of ACE2 and SARS-CoV-2 viral docking
(Source: Critical Care)
Source: Critical Care - July 31, 2020 Category: Intensive Care Authors: Chidinma L. Onweni, Yu Shrike Zhang, Thomas Caulfield, Christopher E. Hopkins, De Lisa Fairweather and William D. Freeman Tags: Research Letter Source Type: research

Association between delirium in the intensive care unit and subsequent neuropsychiatric disorders
Patients in the intensive care unit (ICU) are known to be at increased risk of developing delirium, but the risk of subsequent neuropsychiatric disorders is unclear. We therefore sought to examine the associat... (Source: Critical Care)
Source: Critical Care - July 31, 2020 Category: Intensive Care Authors: Kyla N. Brown, Andrea Soo, Peter Faris, Scott B. Patten, Kirsten M. Fiest and Henry T. Stelfox Tags: Research Source Type: research

Development of a work of breathing scale and monitoring need of intubation in COVID-19 pneumonia
(Source: Critical Care)
Source: Critical Care - July 31, 2020 Category: Intensive Care Authors: Mylene Apigo, Jeffrey Schechtman, Nyembezi Dhliwayo, Mohammed Al Tameemi and Ra úl J. Gazmuri Tags: Research Letter Source Type: research

Prediction of the development of acute kidney injury following cardiac surgery by machine learning
Cardiac surgery –associated acute kidney injury (CSA-AKI) is a major complication that results in increased morbidity and mortality after cardiac surgery. Most established prediction models are limited to the a... (Source: Critical Care)
Source: Critical Care - July 31, 2020 Category: Intensive Care Authors: Po-Yu Tseng, Yi-Ting Chen, Chuen-Heng Wang, Kuan-Ming Chiu, Yu-Sen Peng, Shih-Ping Hsu, Kang-Lung Chen, Chih-Yu Yang and Oscar Kuang-Sheng Lee Tags: Research Source Type: research

Artificial neural networks improve early outcome prediction and risk classification in out-of-hospital cardiac arrest patients admitted to intensive care
Pre-hospital circumstances, cardiac arrest characteristics, comorbidities and clinical status on admission are strongly associated with outcome after out-of-hospital cardiac arrest (OHCA). Early prediction of ... (Source: Critical Care)
Source: Critical Care - July 30, 2020 Category: Intensive Care Authors: Jesper Johnsson, Ola Bj örnsson, Peder Andersson, Andreas Jakobsson, Tobias Cronberg, Gisela Lilja, Hans Friberg, Christian Hassager, Jesper Kjaergard, Matt Wise, Niklas Nielsen and Attila Frigyesi Tags: Research Source Type: research

Efficacy of convalescent plasma for the treatment of severe influenza
Convalescent plasma administration may be of clinical benefit in patients with severe influenza, but reports on the efficacy of this therapy vary. (Source: Critical Care)
Source: Critical Care - July 29, 2020 Category: Intensive Care Authors: Zhiheng Xu, Jianmeng Zhou, Yongbo Huang, Xuesong Liu, Yonghao Xu, Sibei Chen, Dongdong Liu, Zhimin Lin, Xiaoqing Liu and Yimin Li Tags: Research Source Type: research

Early administration of glucocorticoid for thyroid storm: analysis of a national administrative database
Thyroid storm is a life-threatening disease with a mortality rate of over 10%. Although glucocorticoids have been recommended as a treatment option for thyroid storm, supportive evidence based on a large-scale... (Source: Critical Care)
Source: Critical Care - July 29, 2020 Category: Intensive Care Authors: Atsushi Senda, Akira Endo, Hisateru Tachimori, Kiyohide Fushimi and Yasuhiro Otomo Tags: Research Source Type: research

Identification of focal ARDS using PF ratio: a cross-sectional study
(Source: Critical Care)
Source: Critical Care - July 29, 2020 Category: Intensive Care Authors: Kay Choong See, Juliet Sahagun and Juvel Taculod Tags: Research Letter Source Type: research

Allocation of the ICU wards according to the patient ’s infection condition: a measure to improve antibiotic resistance
(Source: Critical Care)
Source: Critical Care - July 29, 2020 Category: Intensive Care Authors: Yefei Zhan, Peifu Chen, Jieqiong Chen, Hua Wang, Zhaojun Xu and Yu Chen Tags: Research Letter Source Type: research

Patients with emm1/T1 serotype invasive group A streptococci infections demonstrated more renal failure than patients with other serotypes: perhaps we should consider some confounders
(Source: Critical Care)
Source: Critical Care - July 29, 2020 Category: Intensive Care Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels Tags: Letter Source Type: research

Age, sex, and comorbidities predict ICU admission or mortality in cases with SARS-CoV2 infection: a population-based cohort study
(Source: Critical Care)
Source: Critical Care - July 28, 2020 Category: Intensive Care Authors: Filipe S. Cardoso, Ana L. Papoila, Rita S á Machado and Pedro Fidalgo Tags: Research Letter Source Type: research

Pooled prevalence of deep vein thrombosis among coronavirus disease 2019 patients
(Source: Critical Care)
Source: Critical Care - July 28, 2020 Category: Intensive Care Authors: Ying Wang, Li Shi, Haiyan Yang, Guangcai Duan and Yadong Wang Tags: Research Letter Source Type: research

Airway pressure morphology and respiratory muscle activity during end-inspiratory occlusions in pressure support ventilation
The driving pressure of the respiratory system is a valuable indicator of global lung stress during passive mechanical ventilation. Monitoring lung stress in assisted ventilation is indispensable, but achievin... (Source: Critical Care)
Source: Critical Care - July 28, 2020 Category: Intensive Care Authors: Stella Soundoulounaki, Evangelia Akoumianaki, Eumorfia Kondili, Emmanouil Pediaditis, Georgios Prinianakis, Katerina Vaporidi and Dimitris Georgopoulos Tags: Research Source Type: research

Cardiac injury associated with severe disease or ICU admission and death in hospitalized patients with COVID-19: a meta-analysis and systematic review
Cardiac injury is now a common complication of coronavirus disease (COVID-19), but it remains unclear whether cardiac injury-related biomarkers can be independent predictors of mortality and severe disease dev... (Source: Critical Care)
Source: Critical Care - July 28, 2020 Category: Intensive Care Authors: Xinye Li, Xiandu Pan, Yanda Li, Na An, Yanfen Xing, Fan Yang, Li Tian, Jiahao Sun, Yonghong Gao, Hongcai Shang and Yanwei Xing Tags: Research Source Type: research

Plasma lipid profiling for the prognosis of 90-day mortality, in-hospital mortality, ICU admission, and severity in bacterial community-acquired pneumonia (CAP)
Pneumonia is the most common cause of mortality from infectious diseases, the second leading cause of nosocomial infection, and the leading cause of mortality among hospitalized adults. To improve clinical man... (Source: Critical Care)
Source: Critical Care - July 27, 2020 Category: Intensive Care Authors: Mohammad M. Banoei, Hans J. Vogel, Aalim M. Weljie, Sachin Yende, Derek C. Angus and Brent W. Winston Tags: Research Source Type: research

Provision of ECPR during COVID-19: evidence, equity, and ethical dilemmas
The use of extracorporeal cardiopulmonary resuscitation (ECPR) to restore circulation during cardiac arrest is a time-critical, resource-intensive intervention of unproven efficacy. The current COVID-19 pandem... (Source: Critical Care)
Source: Critical Care - July 27, 2020 Category: Intensive Care Authors: Elliott Worku, Denzil Gill, Daniel Brodie, Roberto Lorusso, Alain Combes and Kiran Shekar Tags: Viewpoint Source Type: research

Inhibiting IL-6 in COVID-19: we are not sure
(Source: Critical Care)
Source: Critical Care - July 27, 2020 Category: Intensive Care Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels Tags: Letter Source Type: research

Incidence and mortality of pulmonary embolism in COVID-19: a systematic review and meta-analysis
(Source: Critical Care)
Source: Critical Care - July 27, 2020 Category: Intensive Care Authors: Shu-Chen Liao, Shih-Chieh Shao, Yih-Ting Chen, Yung-Chang Chen and Ming-Jui Hung Tags: Research Letter Source Type: research

Lactate dehydrogenase elevations is associated with severity of COVID-19: a meta-analysis
(Source: Critical Care)
Source: Critical Care - July 24, 2020 Category: Intensive Care Authors: Xiao-Yun Chen, Ming-Yao Huang, Zheng-wei Xiao, Sheng Yang and Xiang-Qi Chen Tags: Research Letter Source Type: research

Response to “Body temperature correlates with mortality in COVID-19 patients”
(Source: Critical Care)
Source: Critical Care - July 24, 2020 Category: Intensive Care Authors: Anne M. Drewry, Richard Hotchkiss and Erik Kulstad Tags: Letter Source Type: research

Willingness to attend cardiopulmonary resuscitation training and the associated factors among adults in China
(Source: Critical Care)
Source: Critical Care - July 23, 2020 Category: Intensive Care Authors: Shijiao Yan, Yong Gan, Rixing Wang, Xingyue Song, Ning Zhou and Chuanzhu Lv Tags: Research Letter Source Type: research

Chlorhexidine-impregnated sponge versus chlorhexidine gel dressing for short-term intravascular catheters: which one is better?
Chlorhexidine-gluconate (CHG) impregnated dressings may prevent catheter-related bloodstream infections (CRBSI). Chlorhexidine-impregnated sponge dressings (sponge-dress) and gel dressings (gel-dress) have nev... (Source: Critical Care)
Source: Critical Care - July 23, 2020 Category: Intensive Care Authors: Niccol ò Buetti, Stéphane Ruckly, Carole Schwebel, Olivier Mimoz, Bertrand Souweine, Jean-Christophe Lucet and Jean-François Timsit Tags: Research Source Type: research

Plasma levels of soluble ACE2are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-19
(Source: Critical Care)
Source: Critical Care - July 22, 2020 Category: Intensive Care Authors: Sergey A. Kornilov, Isabelle Lucas, Kathleen Jade, Chengzhen L. Dai, Jennifer C. Lovejoy and Andrew T. Magis Tags: Research Letter Source Type: research

Automated vs. conventional ventilation in the ICU: a randomized controlled crossover trial comparing blood oxygen saturation during daily nursing procedures (I-NURSING)
Hypoxia is common during daily nursing procedures (DNPs) routinely performed on mechanically ventilated patients. The impact of automated ventilation on the incidence and severity of blood oxygen desaturation ... (Source: Critical Care)
Source: Critical Care - July 22, 2020 Category: Intensive Care Authors: Jonathan Chelly, Sandie Mazerand, Sebastien Jochmans, Claire-Marie Weyer, Franck Pourcine, Olivier Ellrodt, Nathalie Thieulot-Rolin, Jean Serbource-Goguel, Oumar Sy, Ly Van Phach Vong and Mehran Monchi Tags: Research Source Type: research

Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence
Nebulised unfractionated heparin (UFH) has a strong scientific and biological rationale and warrants urgent investigation of its therapeutic potential, for COVID-19-induced acute respiratory distress syndrome ... (Source: Critical Care)
Source: Critical Care - July 22, 2020 Category: Intensive Care Authors: Frank M. P. van Haren, Clive Page, John G. Laffey, Antonio Artigas, Marta Camprubi-Rimblas, Quentin Nunes, Roger Smith, Janis Shute, Mary Carroll, Julia Tree, Miles Carroll, Dave Singh, Tom Wilkinson and Barry Dixon Tags: Review Source Type: research

The role of occludin in vascular barrier function in vivo: do we need to re-examine?
(Source: Critical Care)
Source: Critical Care - July 22, 2020 Category: Intensive Care Authors: Ruyuan Zhang, Yiyun Liu, Dechang Chen and Yaoqing Tang Tags: Letter Source Type: research

Could the severity of COVID-19 be increased by low gastric acidity?
(Source: Critical Care)
Source: Critical Care - July 22, 2020 Category: Intensive Care Authors: Elizabeth Price Tags: Research Letter Source Type: research

Detection of IgG antibody during the follow-up in patients with COVID-19 infection
(Source: Critical Care)
Source: Critical Care - July 20, 2020 Category: Intensive Care Authors: Jiao Liu, Jun Guo, Qianghong Xu, Guolong Cai, Dechang Chen and Yanfei Shen Tags: Research Letter Source Type: research

Convalescent plasma to treat critically ill patients with COVID-19: framing the need for randomised clinical trials
(Source: Critical Care)
Source: Critical Care - July 20, 2020 Category: Intensive Care Authors: Manu Shankar-Hari, Lise Estcourt, Heli Harvala, David Roberts and David K. Menon Tags: Editorial Source Type: research

Risk of harlequin syndrome during bi-femoral peripheral VA-ECMO: should we pay more attention to the watershed or try to change the venous cannulation site?
(Source: Critical Care)
Source: Critical Care - July 20, 2020 Category: Intensive Care Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels Tags: Letter Source Type: research

Neuromuscular blocking agents (NMBA) for COVID-19 acute respiratory distress syndrome: a multicenter observational study
(Source: Critical Care)
Source: Critical Care - July 19, 2020 Category: Intensive Care Authors: Romain Courcelle, St éphane Gaudry, Nicolas Serck, Gauthier Blonz, Jean-Baptiste Lascarrou and David Grimaldi Tags: Research Letter Source Type: research

Nutrition of the COVID-19 patient in the intensive care unit (ICU): a practical guidance
Five to 10% of the coronavirus SARS-CoV-2-infected patients, i.e., with new coronavirus disease 2019 (COVID-19), are presenting with an acute respiratory distress syndrome (ARDS) requiring urgent respiratory a... (Source: Critical Care)
Source: Critical Care - July 19, 2020 Category: Intensive Care Authors: Ronan Thibault, Philippe Seguin, Fabienne Tamion, Claude Pichard and Pierre Singer Tags: Review Source Type: research

Blocking IL-1 to prevent respiratory failure in COVID-19
COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it can progress into severe pneumonia and acute respira... (Source: Critical Care)
Source: Critical Care - July 18, 2020 Category: Intensive Care Authors: Frank L. van de Veerdonk and Mihai G. Netea Tags: Review Source Type: research

Infliximab against severe COVID-19-induced cytokine storm syndrome with organ failure —a cautionary case series
(Source: Critical Care)
Source: Critical Care - July 17, 2020 Category: Intensive Care Authors: Andreas Stallmach, Andreas Kortgen, Falk Gonnert, Sina M. Coldewey, Philipp Reuken and Michael Bauer Tags: Research Letter Source Type: research

Development and validation of a risk factor-based system to predict short-term survival in adult hospitalized patients with COVID-19: a multicenter, retrospective, cohort study
Coronavirus disease 2019 (COVID-19) has become a public health emergency of global concern. We aimed to explore the risk factors of 14-day and 28-day mortality and develop a model for predicting 14-day and 28-... (Source: Critical Care)
Source: Critical Care - July 16, 2020 Category: Intensive Care Authors: Shuai Zhang, Mengfei Guo, Limin Duan, Feng Wu, Guorong Hu, Zhihui Wang, Qi Huang, Tingting Liao, Juanjuan Xu, Yanling Ma, Zhilei Lv, Wenjing Xiao, Zilin Zhao, Xueyun Tan, Daquan Meng, Shujing Zhang & hellip; Tags: Research Source Type: research

Mortality rate of acute kidney injury in SARS, MERS, and COVID-19 infection: a systematic review and meta-analysis
(Source: Critical Care)
Source: Critical Care - July 16, 2020 Category: Intensive Care Authors: Yih-Ting Chen, Shih-Chieh Shao, Edward Chia-Cheng Lai, Ming-Jui Hung and Yung-Chang Chen Tags: Research Letter Source Type: research

Chest physiotherapy improves regional lung volume in ventilated children
(Source: Critical Care)
Source: Critical Care - July 16, 2020 Category: Intensive Care Authors: Bronagh McAlinden, Suzanne Kuys, Andreas Schibler and Judith L. Hough Tags: Research Letter Source Type: research

Can levosimendan reduce ECMO weaning failure in cardiogenic shock?: a cohort study with propensity score analysis
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has been increasingly used over the last decade in patients with refractory cardiogenic shock. ECMO weaning can, however, be challenging and lead to ... (Source: Critical Care)
Source: Critical Care - July 16, 2020 Category: Intensive Care Authors: Enrique Guilherme, Matthias Jacquet-Lagr èze, Matteo Pozzi, Felix Achana, Xavier Armoiry and Jean-Luc Fellahi Tags: Research Source Type: research

The application of 6S and PDCA management strategies in the nursing of COVID-19 patients
(Source: Critical Care)
Source: Critical Care - July 16, 2020 Category: Intensive Care Authors: Wenju Wei, Sicong Wang, Hongliang Wang and Hongjia Quan Tags: Editorial Source Type: research

The prognosis of critically ill patients with invasive group A streptococcus infection
(Source: Critical Care)
Source: Critical Care - July 14, 2020 Category: Intensive Care Authors: Toshihide Izumida and Teruhiko Imamura Tags: Letter Source Type: research

Prone positioning under VV-ECMO in SARS-CoV-2-induced acute respiratory distress syndrome
(Source: Critical Care)
Source: Critical Care - July 14, 2020 Category: Intensive Care Authors: Bruno Garcia, Nicolas Cousin, Claire Bourel, Merc é Jourdain, Julien Poissy and Thibault Duburcq Tags: Research Letter Source Type: research

Atorvastatin associated with decreased hazard for death in COVID-19 patients admitted to an ICU: a retrospective cohort study
(Source: Critical Care)
Source: Critical Care - July 14, 2020 Category: Intensive Care Authors: Guillermo Rodriguez-Nava, Daniela Patricia Trelles-Garcia, Maria Adriana Yanez-Bello, Chul Won Chung, Valeria Patricia Trelles-Garcia and Harvey J. Friedman Tags: Research Letter Source Type: research

Benefit of hydrocortisone, thiamine, and vitamin C for patients with sepsis or septic shock? Too early to draw conclusions
(Source: Critical Care)
Source: Critical Care - July 14, 2020 Category: Intensive Care Authors: Rui Shi and Hongtao Tie Tags: Research Letter Source Type: research

Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation
(Source: Critical Care)
Source: Critical Care - July 14, 2020 Category: Intensive Care Authors: Marina Rieder, Tobias Wengenmayer, Dawid Staudacher, Daniel Duerschmied and Alexander Supady Tags: Research Letter Source Type: research