Management of arterial partial pressure of carbon dioxide in the first week after traumatic brain injury: results from the CENTER-TBI study
AbstractPurposeTo describe the management of arterial partial pressure of carbon dioxide (PaCO2) in severe traumatic brain-injured (TBI) patients, and the optimal target of PaCO2 in patients with high intracranial pressure (ICP).MethodsSecondary analysis of CENTER-TBI, a multicentre, prospective, observational, cohort study. The primary aim was to describe current practice in PaCO2 management during the first week of intensive care unit (ICU) after TBI, focusing on the lowest PaCO2 values. We also assessed PaCO2 management in patients with and without ICP monitoring (ICPm), and with and without intracranial hypertension. W...
Source: Intensive Care Medicine - July 24, 2021 Category: Intensive Care Source Type: research

“L’histoire se répète”, one size does not fit all
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 20, 2021 Category: Intensive Care Source Type: research

Harlequin syndrome after surgery for aortic dissection
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 20, 2021 Category: Intensive Care Source Type: research

Diagnosis and treatment of COVID-19 associated pulmonary apergillosis in critically ill patients: results from a European confederation of medical mycology registry
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 16, 2021 Category: Intensive Care Source Type: research

Poor quality data, privacy, lack of certifications: the lethal triad of new technologies in intensive care
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 15, 2021 Category: Intensive Care Source Type: research

Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial
ConclusionAmong critically ill patients with COVID-19, lopinavir-ritonavir, hydroxychloroquine, or combination therapy worsened outcomes compared to no antiviral therapy. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 12, 2021 Category: Intensive Care Source Type: research

SAPS-3 performance for hospital mortality prediction in 30,571 patients with COVID-19 admitted to ICUs in Brazil
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 10, 2021 Category: Intensive Care Source Type: research

Use of stylet and airway management procedure in critically ill patients
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 10, 2021 Category: Intensive Care Source Type: research

Diagnosis of spontaneous intestinal perforation using point of care ultrasound
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 9, 2021 Category: Intensive Care Source Type: research

The gut in COVID-19
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 8, 2021 Category: Intensive Care Source Type: research

When could airway plateau pressure above 30  cmH2O be acceptable in ARDS patients?
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 8, 2021 Category: Intensive Care Source Type: research

Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS
AbstractThe role of non-invasive respiratory support (high-flow nasal oxygen and noninvasive ventilation) in the management of acute hypoxemic respiratory failure and acute respiratory distress syndrome is debated. The oxygenation improvement coupled with lung and diaphragm protection produced by non-invasive support may help to avoid endotracheal intubation, which prevents the complications of sedation and invasive mechanical ventilation. However, spontaneous breathing in patients with lung injury carries the risk that vigorous inspiratory effort, combined or not with mechanical increases in inspiratory airway pressure, p...
Source: Intensive Care Medicine - July 7, 2021 Category: Intensive Care Source Type: research

Skin-to-skin care with sedated and ventilated mother
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 5, 2021 Category: Intensive Care Source Type: research

Do not just sit there, do something … but do no harm: the worrying aspects of COVID-19 experimental interventions
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 5, 2021 Category: Intensive Care Source Type: research

Why and how do we need comprehensive international clinical epidemiology of ARDS?
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 3, 2021 Category: Intensive Care Source Type: research

Acute kidney injury in the critically ill: an updated review on pathophysiology and management
AbstractAcute kidney injury (AKI) is now recognized as a heterogeneous syndrome that not only affects acute morbidity and mortality, but also a patient ’s long-term prognosis. In this narrative review, an update on various aspects of AKI in critically ill patients will be provided. Focus will be on prediction and early detection of AKI (e.g., the role of biomarkers to identify high-risk patients and the use of machine learning to predict AKI), as pects of pathophysiology and progress in the recognition of different phenotypes of AKI, as well as an update on nephrotoxicity and organ cross-talk. In addition, prevention...
Source: Intensive Care Medicine - July 2, 2021 Category: Intensive Care Source Type: research

Delirium in COVID-19: can we make the unknowns knowns?
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 30, 2021 Category: Intensive Care Source Type: research

The relationship between adrenocortical candidate gene expression and clinical response to hydrocortisone in patients with septic shock
ConclusionsIn patients with septic shock, there is no association between adrenocortical candidate gene expression and mortality. Patients with higher expression ofGLCCI1 who received hydrocortisone achieved shock resolution faster than those receiving placebo; conversely, patients who had higher expression of  BHSD1 who received hydrocortisone achieved shock resolution slower than those who received placebo. Variation in gene expression may be a mechanism for heterogeneity of treatment response to corticosteroids in septic shock. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 29, 2021 Category: Intensive Care Source Type: research

Secondary sclerosing cholangitis: an emerging complication in critically ill COVID-19 patients
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 29, 2021 Category: Intensive Care Source Type: research

Differential effects of prone position in COVID-19-related ARDS in low and high recruiters
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 28, 2021 Category: Intensive Care Source Type: research

Determining the optimal number of lung ultrasound zones to monitor COVID-19 patients: can we keep it ultra-short and ultra-simple?
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 26, 2021 Category: Intensive Care Source Type: research

Genome-wide association studies in ARDS: SNPing the tangled web of heterogeneity
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 26, 2021 Category: Intensive Care Source Type: research

Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis
ConclusionCAPA is a complex disease involving a continuum of respiratory colonization, tissue invasion and angioinvasive disease. Knowledge gaps including true epidemiology, optimal diagnostic work-up, management strategies and role of host-directed therapy require further study. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 23, 2021 Category: Intensive Care Source Type: research

Critical care after the COVID-19 outbreak in China: lessons and renaissance
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 22, 2021 Category: Intensive Care Source Type: research

Implementation of new ECMO centers during the COVID-19 pandemic: experience and results from the Middle East and India
AbstractPurposeExtracorporeal membrane oxygenation (ECMO) use for severe coronavirus disease 2019 (COVID-19) patients has increased during the course of the pandemic. As uncertainty existed regarding patient ’s outcomes, early guidelines recommended against establishing new ECMO centers. We aimed to explore the epidemiology and outcomes of ECMO for COVID-19 related cardiopulmonary failure in five countries in the Middle East and India and to evaluate the results of ECMO in 5 new centers.MethodsThis is a retrospective, multicenter international, observational study conducted in 19 ECMO centers in five countries in the...
Source: Intensive Care Medicine - June 22, 2021 Category: Intensive Care Source Type: research

What ’s new in intensive care: environmental sustainability
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 19, 2021 Category: Intensive Care Source Type: research

Provision of critical care in austere conditions: staff, supplies and space
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 18, 2021 Category: Intensive Care Source Type: research

Correction to: Falsifiability in medicine: what clinicians can learn from Karl Popper
A correction to this paper has been published: https://doi.org/10.1007/s00134-021-06457-4 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 17, 2021 Category: Intensive Care Source Type: research

Reducing the global burden of sepsis: a positive legacy for the COVID-19 pandemic?
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 16, 2021 Category: Intensive Care Source Type: research

Conceptual simplicity in pursuit of precision
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 16, 2021 Category: Intensive Care Source Type: research

Matters of time
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 16, 2021 Category: Intensive Care Source Type: research

Chrysalis
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 16, 2021 Category: Intensive Care Source Type: research

Thromboaspiration and fibrinolysis infusion for portomesenteric thrombosis after AstraZeneca COVID-19 vaccine administration
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 16, 2021 Category: Intensive Care Source Type: research

Correction to: Expanding controlled donation after the circulatory determination of death: statement from an international collaborative
A correction to this paper has been published: https://doi.org/10.1007/s00134-021-06435-w (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 15, 2021 Category: Intensive Care Source Type: research

High-flow oxygen during spontaneous breathing trial for patients at high risk of weaning failure
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 14, 2021 Category: Intensive Care Source Type: research

Exploring family members ’ and health care professionals’ perceptions on ICU diaries: a systematic review and qualitative data synthesis
ConclusionThis qualitative synthesis shows that family members and health care professionals consider the ICU diary a valuable intervention. It also brings evidence to challenges faced during diary writing, which should be carefully approached in order to reduce the stress associated with this process. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 12, 2021 Category: Intensive Care Source Type: research

Intracerebral Aspergillus fumigatus abscess and SARS-CoV-2
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 8, 2021 Category: Intensive Care Source Type: research

Neurological complications of COVID-19
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 7, 2021 Category: Intensive Care Source Type: research

Predictors of death and new disability after critical illness: a multicentre prospective cohort study
This study aimed to determine the prevalence and predictors of death or new disability following critical illness.MethodsProspective, multicentre cohort study conducted in six metropolitan intensive care units (ICU). Participants were adults admitted to the ICU who received more than 24  h of mechanical ventilation. The primary outcome was death or new disability at 6 months, with new disability defined by a 10% increase in the WHODAS 2.0.ResultsOf 628 patients with the primary outcome available (median age of 62 [49 –71] years, 379 [61.0%] had a medical admission and 370 (58.9%) died or developed new disab...
Source: Intensive Care Medicine - June 5, 2021 Category: Intensive Care Source Type: research

Moving from bytes to bedside: a systematic review on the use of artificial intelligence in the intensive care unit
ConclusionThe vast majority of developed ICU-AI models remain within the testing and prototyping environment; only a handful were actually evaluated in clinical practice. A uniform and structured approach can support the development, safe delivery, and implementation of AI to determine clinical benefit in the ICU. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 5, 2021 Category: Intensive Care Source Type: research

Correction to: COVID-19 in critical care: epidemiology of the first epidemic wave across England, Wales and Northern Ireland
A correction to this paper has been published: https://doi.org/10.1007/s00134-021-06413-2 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 1, 2021 Category: Intensive Care Source Type: research

Time for tocilizumab in COVID-19?
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - May 31, 2021 Category: Intensive Care Source Type: research

Pulmonary immuno-thrombosis in COVID-19 ARDS pathogenesis
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - May 30, 2021 Category: Intensive Care Source Type: research

Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial
ConclusionThe higher than expected incidence of early IAPA precludes any definite conclusion on POS prophylaxis. High mortality of early IAPA, despite timely antifungal therapy, indicates that alternative management strategies are required. After 48  h, still 11% of patients developed IAPA. As these could benefit from prophylaxis, differentiated strategies are likely needed to manage IAPA in the ICU. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - May 29, 2021 Category: Intensive Care Source Type: research

Idiopathic paroxysmal atrioventricular block
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - May 28, 2021 Category: Intensive Care Source Type: research

Maximizing first pass success when intubating the critically ill patient: use a stylet!
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - May 27, 2021 Category: Intensive Care Source Type: research

Caring for COVID-19 patients and their relatives with the ICU diary
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - May 27, 2021 Category: Intensive Care Source Type: research

Effect of the use of an endotracheal tube and stylet versus an endotracheal tube alone on first-attempt intubation success: a multicentre, randomised clinical trial in 999 patients
ConclusionsAmong critically ill adults undergoing tracheal intubation, using a stylet improves first-attempt intubation success. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - May 25, 2021 Category: Intensive Care Source Type: research

Integrative omics provide biological and clinical insights into acute respiratory distress syndrome
ConclusionOur findings suggest a novel susceptibility locus in ARDS pathophysiology that implicatesBORCS5 andDUSP16 as potentially acting in immune-inflammatory processes. This locus warrants further investigation to inform the development of therapeutic targets and clinical care strategies for ARDS, including those induced by COVID-19. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - May 25, 2021 Category: Intensive Care Source Type: research

COVID-19 and the intensive care unit: vaccines to the rescue
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - May 25, 2021 Category: Intensive Care Source Type: research