Extensive cutaneous necrosis associated with cryofibrinogenemia
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 24, 2020 Category: Intensive Care Source Type: research

Uncontrolled interventions during pandemics: a missed learning opportunity?
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 23, 2020 Category: Intensive Care Source Type: research

The perceived barriers and facilitators to implementation of ECMO services in acute hospitals
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 23, 2020 Category: Intensive Care Source Type: research

Acute life-threatening toxicity from CAR T-cell therapy
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 23, 2020 Category: Intensive Care Source Type: research

Efficacy of early prone position for COVID-19 patients with severe hypoxia: a single-center prospective cohort study
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 22, 2020 Category: Intensive Care Source Type: research

Dysphagia in critical care: focus on therapeutical interventions
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 21, 2020 Category: Intensive Care Source Type: research

Pulmonary immune responses against SARS-CoV-2 infection: harmful or not?
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 17, 2020 Category: Intensive Care Source Type: research

Health-related quality of life in survivors of septic shock: 6-month follow-up from the ADRENAL trial
AbstractPurposeTo investigate the impact of hydrocortisone treatment and illness severity on health-related quality of life (HRQoL) at 6  months in septic shock survivors from the ADRENAL trial.MethodsUsing the EuroQol questionnaire  (EQ-5D-5L) at 6 months after randomization we assessed HRQoL in patient subgroups defined by hydrocortisone or placebo treatment, gender, illness severity (APACHE II 
Source: Intensive Care Medicine - July 16, 2020 Category: Intensive Care Source Type: research

Treating critically ill anaemic patients with erythropoietin: why not?
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 16, 2020 Category: Intensive Care Source Type: research

Travelling to hell and back
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 16, 2020 Category: Intensive Care Source Type: research

Prediction of outcome of nasal high flow use during COVID-19-related acute hypoxemic respiratory failure
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 15, 2020 Category: Intensive Care Source Type: research

Successful spontaneous breathing trial, early reintubation and mechanisms of weaning failure
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 13, 2020 Category: Intensive Care Source Type: research

Early bacterial co-infection in ARDS related to COVID-19
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 13, 2020 Category: Intensive Care Source Type: research

Emerging pharmacological therapies for ARDS: COVID-19 and beyond
AbstractARDS, first described in 1967, is the commonest form of acute severe hypoxemic respiratory failure. Despite considerable advances in our knowledge regarding the pathophysiology of ARDS, insights into the biologic mechanisms of lung injury and repair, and advances in supportive care, particularly ventilatory management, there remains no effective pharmacological therapy for this syndrome. Hospital mortality at 40% remains unacceptably high underlining the need to continue to develop and test therapies for this devastating clinical condition. The purpose of the review is to critically appraise the current status of p...
Source: Intensive Care Medicine - July 11, 2020 Category: Intensive Care Source Type: research

Less contact isolation is more in the ICU: pro
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 9, 2020 Category: Intensive Care Source Type: research

Serum antibody response in critically ill patients with COVID-19
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 8, 2020 Category: Intensive Care Source Type: research

Role of frailty in COVID-19 patients
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 8, 2020 Category: Intensive Care Source Type: research

Critical care journals during the COVID-19 pandemic: challenges and responsibilities
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 6, 2020 Category: Intensive Care Source Type: research

Monitoring patient –ventilator interaction by an end-expiratory occlusion maneuver
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 4, 2020 Category: Intensive Care Source Type: research

Uncharted territories: assessing cerebral vascularization in patients undergoing venoarterial extra-corporeal membrane oxygenation
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 3, 2020 Category: Intensive Care Source Type: research

Modified 4T score for heparin-induced thrombocytopenia diagnosis in VA-ECMO patients
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 1, 2020 Category: Intensive Care Source Type: research

Pseudo B-line in pneumothorax
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 1, 2020 Category: Intensive Care Source Type: research

Yesterday heroes, today plague doctors: the dark side of celebration
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 1, 2020 Category: Intensive Care Source Type: research

Rethinking the post-COVID-19 pandemic hospital: more ICU beds or smart monitoring on the wards?
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 1, 2020 Category: Intensive Care Source Type: research

Correction to: Epidemiology and patient predictors of infection and sepsis in the prehospital setting
The original version of this article unfortunately contained a mistake. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 30, 2020 Category: Intensive Care Source Type: research

The negative impact of comorbidities on the disease course of COVID-19
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 29, 2020 Category: Intensive Care Source Type: research

Epidemiology and burden of sepsis acquired in hospitals and intensive care units: a systematic review and meta-analysis
ConclusionHA sepsis is of major public health importance, and the burden is particularly high in ICUs. There is an urgent need to improve the implementation of global and local infection prevention and management strategies to reduce its high burden among hospitalized patients. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 26, 2020 Category: Intensive Care Source Type: research

Inhalational volatile-based sedation for COVID-19 pneumonia and ARDS
AbstractHospitals worldwide are experiencing a shortage in essential intravenous sedative medications. This is attributable to high number and high sedative needs of COVID-19 critical care patients with disruption of drug supply chains. Inhaled volatile anesthetic agents are an abundant resource and readily implementable solution for providing ICU sedation. Inhaled volatile agents may also provide important pulmonary benefits for COVID-19 patients with ARDS that could improve gas exchange and reduce time spent on a ventilator. We review the use of volatile agents, and provide a technical overview and algorithm for administ...
Source: Intensive Care Medicine - June 25, 2020 Category: Intensive Care Source Type: research

Rapidly scalable mechanical ventilator for the COVID-19 pandemic
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 25, 2020 Category: Intensive Care Source Type: research

Severe malaria: a micro vessel disease
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 24, 2020 Category: Intensive Care Source Type: research

Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion
ConclusionA consensus case definition of IAPA is proposed, which will facilitate research into the epidemiology, diagnosis and management of this emerging acute and severeAspergillus disease, and may be of use to study CAPA. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 22, 2020 Category: Intensive Care Source Type: research

Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis
ConclusionsCompared to results from the IHME study, we found an approximately 50% lower incidence of hospital-treated sepsis. The majority of studies included were based on administrative data, thus limiting our ability to assess temporal trends and regional differences. The incidence of sepsis remains unknown for the vast majority of LMICs, highlighting the urgent need for improved epidemiological sepsis surveillance. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 22, 2020 Category: Intensive Care Source Type: research

A multicenter national survey of children with SARS-CoV-2 infection admitted to Spanish Pediatric Intensive Care Units
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 22, 2020 Category: Intensive Care Source Type: research

Between-centre differences for COVID-19 ICU mortality from early data in England
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 22, 2020 Category: Intensive Care Source Type: research

SARS-CoV-2 viral loads and serum IgA/IgG immune responses in critically ill COVID-19 patients
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 22, 2020 Category: Intensive Care Source Type: research

Impact on 30-day survival of time taken by a critical care transport team to reach the bedside of critically ill children
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 22, 2020 Category: Intensive Care Source Type: research

Might the surviving sepsis campaign international guidelines be less confusing? Authors ’ reply
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 22, 2020 Category: Intensive Care Source Type: research

ICU beds: less is more? Not sure
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 22, 2020 Category: Intensive Care Source Type: research

Metaphor use in the ICU: rigor with words!
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 18, 2020 Category: Intensive Care Source Type: research

A clinician ’s remorse
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 18, 2020 Category: Intensive Care Source Type: research

Doctor –patient relationship at the time of COVID-19: travel notes
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 16, 2020 Category: Intensive Care Source Type: research

Pericyte alteration sheds light on micro-vasculopathy in COVID-19 infection
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 12, 2020 Category: Intensive Care Source Type: research

Acute kidney injury in critically ill patients with COVID-19
AbstractAcute kidney injury (AKI) has been reported in up to 25% of critically-ill patients with SARS-CoV-2 infection, especially in those with underlying comorbidities. AKI is associated with high mortality rates in this setting, especially when renal replacement therapy is required. Several studies have highlighted changes in urinary sediment, including proteinuria and hematuria, and evidence of urinary SARS-CoV-2 excretion, suggesting the presence of a renal reservoir for the virus. The pathophysiology of COVID-19 associated AKI could be related to unspecific mechanisms but also to COVID-specific mechanisms such as di...
Source: Intensive Care Medicine - June 12, 2020 Category: Intensive Care Source Type: research

Correction to: Contrast-enhanced ultrasound (CEUS) of the lung reveals multiple areas of microthrombi in a COVID-19 patient
The original version of this article unfortunately contained two mistakes (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 10, 2020 Category: Intensive Care Source Type: research

Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study
ConclusionADE was infrequently applied in critically ill-infected patients. The observational effect estimate on clinical cure suggested no deleterious impact of ADE compared to no-ADE. However, residual confounding is likely. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 9, 2020 Category: Intensive Care Source Type: research

Hypertonic saline for fluid resuscitation in ICU patients post-cardiac surgery (HERACLES): a double-blind randomized controlled clinical trial
ConclusionIn a monocentric prospective double-blind randomized clinical trial, we observed that hypertonic saline did not reduce the total fluid volume administered on the ICU in critically ill cardiac surgery patients. Hypertonic saline infusion was associated with timely increase in urinary output. Variations in electrolyte and acid –base homeostasis were transient, but substantial in all patients. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 9, 2020 Category: Intensive Care Source Type: research

How likely are COVID-19 interventions to benefit the sickest patients?
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 9, 2020 Category: Intensive Care Source Type: research

Severity of endothelial dysfunction is associated with the occurrence of hemorrhagic complications in COPD patients treated by extracorporeal CO 2 removal
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 9, 2020 Category: Intensive Care Source Type: research

Mesenchymal stromal cells as a salvage treatment for confirmed acute respiratory distress syndrome: preliminary data from a single-arm study
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 8, 2020 Category: Intensive Care Source Type: research

Interventions for oropharyngeal dysphagia in acute and critical care: a systematic review and meta-analysis
ConclusionThere is limited evidence for the effectiveness of swallowing treatments in the acute and critical care setting. Clinical trials consistently measuring patient-centred outcomes are needed. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 8, 2020 Category: Intensive Care Source Type: research