Risk factors for arterial catheter failure and complications during critical care hospitalisation: a secondary analysis of a multisite, randomised trial
ConclusionsAC failure is common with ultrasound-guided insertion associated with lower failure rates.Trial registration Australian New Zealand Clinical Trial Registry (ACTRN 12610000505000); date registered: 18 June 2010. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - March 8, 2024 Category: Intensive Care Source Type: research

From bedside to recovery: exercise therapy for prevention of post-intensive care syndrome
ConclusionPICS is a growing global healthcare concern. This review aims to guide clinicians, researchers, policymakers, and healthcare providers in utilising ET as a therapeutic and preventive measure for patients during and after an ICU admission to address this problem. An improved understanding of the effectiveness of ET and the clinical and research gaps that needs to be urgently addressed will greatly assist clinicians in their efforts to rehabilitate ICU survivors, improving patients ’ quality of survival and helping them return to their normal lives after hospital discharge. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - February 29, 2024 Category: Intensive Care Source Type: research

Unit-to-unit transfer due to shortage of intensive care beds in Sweden 2015 –2019 was associated with a lower risk of death but a longer intensive care stay compared to no transfer: a registry study
ConclusionsIntensive care unit-to-unit transfer due to shortage of bed capacity as compared to no transfer during a 5-year period preceding the COVID-19 pandemic in Sweden was associated with lower risk of death within 90  days but with longer stay in intensive care. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - February 27, 2024 Category: Intensive Care Source Type: research

Exploring the therapeutic role of early heparin administration in ARDS management: a MIMIC-IV database analysis
ConclusionThis research highlights that early prophylactic administration of heparin may substantially lower mortality in ARDS patients. These findings underscore the potential of heparin as a key component in the management of ARDS, offering a new perspective and novel strategies for clinical treatment. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - February 26, 2024 Category: Intensive Care Source Type: research

Development and validation of a nomogram to predict the risk of sepsis-associated encephalopathy for septic patients in PICU: a multicenter retrospective cohort study
ConclusionsThe novel nomogram and online calculator showed performance in predicting the morbidity of SAE in patients with sepsis admitted to the PICU, thereby potentially assisting clinicians in the early detection and intervention of SAE. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - February 20, 2024 Category: Intensive Care Source Type: research

External validation of the HACOR score and ROX index for predicting treatment failure in patients with coronavirus disease 2019 pneumonia managed on high-flow nasal cannula therapy: a multicenter retrospective observational study in Japan
ConclusionsIn COVID-19 patients receiving HFNC therapy in Japan, the predictive performance of the HACOR score and ROX index at the 2-h time-point may be inadequate. Furthermore, clinicians should be mindful of time-point scores owing to the variation of the models ’ predictive performance with the time-point.Trial registration UMIN (registration number: UMIN000050024, January 13, 2023) (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - February 15, 2024 Category: Intensive Care Source Type: research

Association between regional critical care capacity and the incidence of invasive mechanical ventilation for coronavirus disease 2019: a population-based cohort study
ConclusionsThe results of prefecture-level analyses demonstrate that increased numbers of ICU beds, resource-rich ICU beds, and intensivists are associated with the incidence of invasive mechanical ventilation among patients recently diagnosed with COVID-19 during the pandemic. These findings have important implications for healthcare policymakers, aiding in efficiently allocating critical care resources during crises, particularly in regions with limited ICU bed capacities.Registry and the registration no. of the study/trial The approval date of the registry was August 20, 2020, and the registration no. of the study was l...
Source: Journal of Intensive Care - January 30, 2024 Category: Intensive Care Source Type: research

Chest CT findings in severe acute respiratory distress syndrome requiring V-V ECMO: J-CARVE registry
ConclusionsTraction bronchiectasis and subcutaneous emphysema increased the risk of 90-day in-hospital mortality in patients with severe ARDS who required V-V ECMO. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 26, 2024 Category: Intensive Care Source Type: research

Efficacy of permissive underfeeding for critically ill patients: an updated systematic review and trial sequential meta-analysis
ConclusionsPermissive underfeeding may reduce ICU mortality in critically ill patients and help to shorten mechanical ventilation duration, but the overall mortality is not improved. Owing to the sample size and patient heterogeneity, the conclusions still need to be verified by well-designed, large-scale RCTs.Trial Registration The protocol for our meta-analysis and systematic review was registered and recorded in PROSPERO (registration no. CRD42023451308). Registered 14 August 2023 (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 23, 2024 Category: Intensive Care Source Type: research

Limitation of life sustaining measures in neurocritical care: sex, timing, and advance directive
ConclusionsIn patients receiving LLST, the presence of an AD was associated with an increase of early LLST, but not with an increased in-hospital mortality. This supports the notion that the presence of an AD is primarily an expression of the patients ’ will but does not per se predestine the patient for an unfavorable outcome. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 16, 2024 Category: Intensive Care Source Type: research

Post-intensive care syndrome follow-up system after hospital discharge: a narrative review
ConclusionsThis narrative review aimed to summarize the PICS follow-up system after hospital discharge and provide a comprehensive approach for the prevention and treatment of PICS. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 12, 2024 Category: Intensive Care Source Type: research

Development of quality indicators for palliative care in intensive care units and pilot testing them via electronic medical record review
ConclusionsThe QI set, developed using the modified Delphi method and tested using EMR data, provided a tool for assessing the quality of palliative care in ICUs. In the two ICUs considered in this study, aspects of the palliative care process with a low performance frequency were identified, and further national surveys were recommended. It is necessary to conduct ongoing surveys at more facilities to improve the quality of palliative care in ICUs. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 9, 2024 Category: Intensive Care Source Type: research

Mechanical circulatory support in cardiogenic shock
AbstractCardiogenic shock is a complex and diverse pathological condition characterized by reduced myocardial contractility. The goal of treatment of cardiogenic shock is to improve abnormal hemodynamics and maintain adequate tissue perfusion in organs. If hypotension and insufficient tissue perfusion persist despite initial therapy, temporary mechanical circulatory support (t-MCS) should be initiated. This decade sees the beginning of a new era of cardiogenic shock management using t-MCS through the accumulated experience with use of intra-aortic balloon pump (IABP) and venoarterial extracorporeal membrane oxygenation (VA...
Source: Journal of Intensive Care - December 19, 2023 Category: Intensive Care Source Type: research

Higher levels of circulating desphospho-uncarboxylated matrix Gla protein over time are associated with worse survival: the prospective Maastricht Intensive Care COVID cohort
ConclusionICU mortality in COVID-19 patients was associated with higher dp-ucMGP levels over 4 weeks, independent of age, gender, and APACHE II score, and not explained by inflammation, renal function, history of coumarin use, and CAC score. No association with PE was observed. At ETI, higher levels of dp-ucMGP were associated with higher OR for both ICU and six month mortality in crude and adjusted modes, although not statistically significantly. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 18, 2023 Category: Intensive Care Source Type: research

Functional intervention following cardiac surgery to prevent postoperative delirium in older patients (FEEL WELL study)
ConclusionsResults of the study imply that a multisensory stimulation done on the first 3 days after planned cardiac surgery can reduce the incidence and duration of postoperative delirium in older patients. Influence of the treatment on the incidence of delirium in other patient groups, the length of stay in the intensive care unit, and patients ´ postoperative pain should be confirmed in further clinical studies.Trial registration: DRKS, DRKS00026909. Registered 28 October 2021, Retrospectively registered,https://drks.de/search/de/trial/DRKS00026909. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 13, 2023 Category: Intensive Care Source Type: research