Esmolol response in septic shock patients in relation to vascular waterfall phenomenon measured by critical closure pressure and mean systemic filling pressure: a prospective observational study
ConclusionPatients with septic shock whose heart rate is greater than 95 beats/min after hemodynamic optimization were treated with esmolol, which could effectively control heart rate and reduce CI, as well as improve Pcc and increase the difference between Pcc and Pmsf (known as “vascular waterfall” phenomenon), without affecting MAP, CVP, Pmsf and arteriovenous vascular resistance, and improve the balance of oxygen supply and demand in the body. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 4, 2022 Category: Intensive Care Source Type: research
Intensive care unit versus high-dependency care unit for patients with acute heart failure: a nationwide propensity score-matched cohort study
ConclusionsCritical care in ICUs was not associated with lower in-hospital mortality than critical care in HDUs among patients with acute heart failure. However, critical care in ICUs was associated with lower in-hospital mortality than critical care in HDUs among patients receiving noninvasive ventilation and intubation. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 20, 2021 Category: Intensive Care Source Type: research
Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19
This study showed that cytotoxic Th1 and CD8 T cells are recruited to the peripheral blood long after recovery from COVID-19. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 20, 2021 Category: Intensive Care Source Type: research
Ultrafiltration in Japanese critically ill patients with acute kidney injury on renal replacement therapy
AbstractA recent worldwide survey indicates an international diversity in net ultrafiltration (UFNET) practices for the treatment of fluid overload in critically ill patients with acute kidney injury (AKI) requiring renal replacement therapy (RRT). The sub-analysis of the survey has demonstrated that maximum doses of furosemide used before determination of diuretic resistance are lower in Japan than those prescribed worldwide and UFNET is lower but is initiated earlier. In contrast, the interval during which practitioners evaluate fluid balance is longer. The characterization of RRT in critically ill patients in Japan shou...
Source: Journal of Intensive Care - December 20, 2021 Category: Intensive Care Source Type: research
Hydrocortisone, ascorbic acid, and thiamine (HAT) for sepsis and septic shock: a meta-analysis with sequential trial analysis
ConclusionsThe HAT combination improves the SOFA score in the first 72 h and reduces the duration of vasopressors in patients with sepsis. Given the minor mean difference of the change in SOFA score, the mortality benefit has not been observed.Trial registrationPROSPERO, CRD42020203166. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 18, 2021 Category: Intensive Care Source Type: research
Blood purification could tackle COVID-19?
AbstractCoronavirus disease 2019 (COVID-19) threatened human lives worldwide since first reported. The current challenge for global intensivists is to establish an effective treatment for severe COVID-19. Blood purification has been applied to the treatment of various critical illnesses. Theoretically, its technique also has an enormous possibility of treating severe COVID-19 in managing inflammatory cytokines and coagulopathy. Recent clinical studies have revealed the positive clinical effect of therapeutic plasma exchange. Other studies have also indicated the considerable potential of other blood purification techniques...
Source: Journal of Intensive Care - December 11, 2021 Category: Intensive Care Source Type: research
Automated alert and activation of medical emergency team using early warning score
ConclusionsAfter implementing an automated alert and activation system, the time from deterioration to MET activation was shortened and clinical outcomes were improved in hospitalized patients. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 7, 2021 Category: Intensive Care Source Type: research
Letter the editor: serious methodological concerns about a recently published meta-analysis on oxygen therapy
AbstractIn a recent paper, Chen et al. report the findings of a systematic review with meta-analysis concerning conservative versus conventional oxygen therapy for critically ill patients. We wish to commend the authors for their interest in the matter. However, the authors appear to misquote findings, fail to report results for all specified analyses, do not identify all relevant trials, have post hoc changed the eligibility criteria, and have seemingly switched directions of effects in analyses of secondary outcomes. These issues have led to incorrect conclusions concerning the effects of targeted oxygen therapy in criti...
Source: Journal of Intensive Care - December 7, 2021 Category: Intensive Care Source Type: research
Non-invasive detection of a femoral-to-radial arterial pressure gradient in intensive care patients with vasoactive agents
ConclusionNIBR-APG assessment can be used to detect a significant FR-APG which occur in one in every five critically ill patients requiring vasoactive agents. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - November 27, 2021 Category: Intensive Care Source Type: research
Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis
ConclusionThe present study suggested a negative association between uUMOD and AKI especially in children and surgical patients. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - November 15, 2021 Category: Intensive Care Source Type: research
Association between intensive care unit admission of a patient and mental disorders in the spouse: a retrospective matched-pair cohort study
ConclusionsSpouses of patients who were admitted to the ICU had a slightly higher risk of mental disorders within 6 months than spouses of patients who were not admitted to the ICU. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - October 29, 2021 Category: Intensive Care Source Type: research
The association between culture positivity and long-term mortality in critically ill surgical patients
ConclusionsWe linked two databases to identify that a positive culture during admission was independently correlated with increased long-term mortality in critically ill surgical patients. Our findings highlight the need for vigilance among patients with a positive culture during admission, and more studies are warranted to validate our findings and to clarify underlying mechanisms. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - October 26, 2021 Category: Intensive Care Source Type: research
Age moderates the relationships between obesity, glucose variability, and intensive care unit mortality: a retrospective cohort study
ConclusionsWith increasing age, the association between BMI and mortality becomes stronger and the association between glucose variability and mortality becomes weaker. Future studies should investigate the underlying mechanisms of such phenomenon and the causal relationship between obesity, GV, and ICU mortality. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - October 26, 2021 Category: Intensive Care Source Type: research
Cerebral autoregulation in anoxic brain injury patients treated with targeted temperature management
ConclusionsCAR is frequently altered in cardiac arrest survivors treated by TTM. Altered CAR during normothermia was independently associated with poor outcome. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - October 26, 2021 Category: Intensive Care Source Type: research
Paradox of trimethylamine-N-oxide, the impact of malnutrition on microbiota-derived metabolites and septic patients
ConclusionPlasma TMAO concentration was inversely associated with non-CV death among extremely ill septic patients, which could be characterized as TMAO paradox. For septic patients, the impact of malnutrition reflected by circulating TMAO levels was greater than its pro-inflammatory nature. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - October 21, 2021 Category: Intensive Care Source Type: research
