Effectiveness of systemic thrombolysis on clinical outcomes in high-risk pulmonary embolism patients with venoarterial extracorporeal membrane oxygenation: a nationwide inpatient database study
ConclusionsSystemic thrombolysis was not associated with reduced in-hospital mortality or increased major bleeding in the high-risk PE patients receiving VA-ECMO. However, systemic thrombolysis with monteplase was associated with increased major bleeding. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - February 6, 2023 Category: Intensive Care Source Type: research
Predictive value of soluble CD59 for poor 28-day neurological prognosis and all-cause mortality in patients after cardiopulmonary resuscitation: a prospective observatory study
ConclusionsThe elevated serum level of sCD59 was positively correlated with disease severity after ROSC. Moreover, serum sCD59 could have good predictive values for the poor 28-day neurological prognosis and all-cause mortality in patients after ROSC. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - February 2, 2023 Category: Intensive Care Source Type: research
Mortality analysis among sepsis patients in and out of intensive care units using the Japanese nationwide medical claims database: a study by the Japan Sepsis Alliance study group
ConclusionsHerein, using the nationwide medical claims database, we demonstrated that ICU admission was potentially associated with decreasing in-hospital mortality among sepsis patients. Further investigations are warranted to validate these results and elucidate the mechanisms favoring ICU management on clinical outcomes. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 7, 2023 Category: Intensive Care Source Type: research
Clinical effectiveness of tigecycline in combination therapy against nosocomial pneumonia caused by CR-GNB in intensive care units: a retrospective multi-centre observational study
ConclusionsIn this retrospective observational study that included ICU-admitted patients with nosocomial pneumonia caused by tigecycline-susceptible CR-GNB, mostly CRAB, tigecycline as part of a combination treatment regimen was associated with lower clinical failure and all-cause mortality rates. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 3, 2023 Category: Intensive Care Source Type: research
Timing of tracheostomy and patient outcomes in critically ill patients requiring extracorporeal membrane oxygenation: a single-center retrospective observational study
ConclusionsThe timing of tracheostomy in patients requiring ECMO was significantly associated with patient outcomes in a time-dependent manner. Further investigation is warranted to determine the optimal timing of tracheostomy in terms of mortality. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 30, 2022 Category: Intensive Care Source Type: research
Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study
ConclusionsHigher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury.Trial registration Clinicaltrials.gov NCT02010073 (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 25, 2022 Category: Intensive Care Source Type: research
Prognostic significance of delirium subtypes in critically ill medical and surgical patients: a secondary analysis of a prospective multicenter study
ConclusionsPatients with mixed delirium had the most unfavourable outcomes, including higher mortality, compared with no delirium. These differences argue for distinguishing delirium subtypes in clinical practice and future research.Trial registration ClinicalTrials.gov NCT01952899. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 20, 2022 Category: Intensive Care Source Type: research
Comment on: Post ‑resuscitation diastolic blood pressure is a prognostic factor for outcomes of cardiac arrest patients
(Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 8, 2022 Category: Intensive Care Source Type: research
Intensive care unit versus high-dependency care unit admission on mortality in patients with septic shock: let ’s think to the survival chain concept for septic shock
(Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 5, 2022 Category: Intensive Care Source Type: research
Impact of the COVID-19 pandemic on critical care utilization in Japan: a nationwide inpatient database study
ConclusionsThe ICU and HDU bed capacity did not increase while their bed occupancy decreased during the COVID-19 pandemic in Japan. There was no change in clinicians ’ decision-making to forego ICU/HDU care for selected patients, and there was no progress in the centralization of critically ill COVID-19 patients. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 2, 2022 Category: Intensive Care Source Type: research
The revised recommendation for administering vitamin C in septic patients: the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020
AbstractGiven the available clinical evidence through the literature search when the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 was being created, we suggested administering vitamin C to such patients. Recently, several randomized control trials have been published, some of which suggested the harmful effect of vitamin C in terms of mortality or persistent organ dysfunction. Therefore, we performed updated systematic reviews and meta-analyses. Accordingly, we revised our recommendation as “We suggest against administering vitamin C to septic patients (GRADE 2D: certainty of evide...
Source: Journal of Intensive Care - November 29, 2022 Category: Intensive Care Source Type: research
Short- versus long-course antibiotic therapy for sepsis: a post hoc analysis of the nationwide cohort study
ConclusionsThe 28-day mortality was significantly lower in the short-course group, even though there was a higher rate of re-initiated antibiotics in the short course. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - October 29, 2022 Category: Intensive Care Source Type: research
The cardioprotective and anti-inflammatory effect of inhaled nitric oxide during Fontan surgery in patients with single ventricle congenital heart defects: a prospective randomized study
ConclusionsNO inhaled into the oxygenator during CPB can improve short-term clinical outcomes. It shortens intubation time and intensive care time. It reduces inflammatory response, improves myocardial and lung protection, and diminishes metabolic stress in patients with a single ventricle undergoing Fontan surgery.Trial registration number: The trial was preregistered, supervised, and supported by The Polish National Science Center (NCN/01/B/NZ5/04246). (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - October 13, 2022 Category: Intensive Care Source Type: research
Correction: Intensive care unit versus high-dependency care unit admission on mortality in patients with septic shock: a retrospective cohort study using Japanese claims data
(Source: Journal of Intensive Care)
Source: Journal of Intensive Care - October 12, 2022 Category: Intensive Care Source Type: research
Prone positioning in ARDS patients supported with VV ECMO, what we should explore?
ConclusionFor patients with ARDS supported with VV ECMO, the potential effects of prone positioning have yet to be clarified. Ensuring an optimal strategy, especially an individualized plan for prone positioning therapy during VV ECMO, is particularly challenging and requires further research. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - October 4, 2022 Category: Intensive Care Source Type: research
