Thromboembolic disease in COVID-19 patients: A brief narrative review
AbstractCorona virus 2 (SARS-CoV2/ Severe Acute Respiratory Syndrome Corona Virus 2) infection has emerged as a global health crisis. Incidence of thromboembolic disease is reported to be high in SARS-CoV2 disease and is seen in a multitude of organ systems ranging from cutaneous thrombosis to pulmonary embolism, stroke or coronary thrombosis sometimes with catastrophic outcomes. Evidence points towards a key role of thromboembolism, hypercoagulability and over production of proinflammatory cytokines mimicking a “cytokine storm” which leads to multiorgan failure. This brief narrative review highlights the pathophysiolo...
Source: Journal of Intensive Care - September 13, 2020 Category: Intensive Care Source Type: research
Saline versus 5% dextrose in water as a drug diluent for critically ill patients: a retrospective cohort study
ConclusionsChanging the diluent default from D5W to saline had no effect on blood glucose control and increased the incidences of hypernatremia and hyperchloremia. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - September 10, 2020 Category: Intensive Care Source Type: research
Factors associated with non-invasive mechanical ventilation failure in patients with hematological neoplasia and their association with outcomes
ConclusionThe implementation of a NIMV protocol is feasible in patients with hematological neoplasia admitted to the ICU, even though its benefits still remain to be demonstrated. NIMV failure was associated with higher SOFA and RR and more frequent sepsis, and it was also related to poor prognosis. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - September 6, 2020 Category: Intensive Care Source Type: research
Low levels of CD72 and CD100 expression on circulating lymphocytes in immunosuppressive phase of sepsis is associated with mortality in septic patients
ConclusionsOur study demonstrated that the decrease of the levels of CD72 and CD100 expression on circulating lymphocytes after 3 –4 days of sepsis had a close correlation of the 28-day mortality of septic patients. Thus, CD72 and CD100 are promising biomarkers for assessing the prognosis of patients with sepsis.Trial registrationPeripheral blood lymphocytes analysis detects CD72 and CD100 alteration in trauma patients; ChiCTR1900026367; Registered 4 October 2019;http://www.chictr.org.cn. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - September 2, 2020 Category: Intensive Care Source Type: research
Correction to: Low-chloride- versus high-chloride-containing hypertonic solution for the treatment of subarachnoid hemorrhage –related complications: The ACETatE (A low ChloriE hyperTonic solution for brain Edema) randomized trial
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - August 31, 2020 Category: Intensive Care Source Type: research
Delay in seeking treatment before emergent heart failure readmission and its association with clinical phenotype
ConclusionsMore than one in ten patients with HF readmission delay seeking treatment> 2 days after symptom onset. Patients who delayed seeking treatment showed the phenotype of chronic fluid retention, whereas those who presented to the hospital earlier had the phenotype of acute respiratory failure. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - August 25, 2020 Category: Intensive Care Source Type: research
Risk factors for complete recovery of adults after weaning from veno-venous extracorporeal membrane oxygenation for severe acute respiratory failure: an analysis from adult patients in the Extracorporeal Life Support Organization registry
ConclusionComplete recovery after veno-venous ECMO support is associated with the patient ’s baseline condition, ECMO duration, and ECMO-related complications. Respiratory ECMO should aim to increase both the survival and the quality of life after weaning from ECMO. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - August 19, 2020 Category: Intensive Care Source Type: research
Effect of renal support therapy on 5-year survival in patients discharged from the intensive care unit
ConclusionsThe impact of acute renal failure with the consequent need for RRT in patients admitted to the ICU is reflected in a decrease of approximately one quarter in 5-year survival, regardless of the different comorbidities. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - August 17, 2020 Category: Intensive Care Source Type: research
Effects of hypertonic saline versus mannitol in patients with traumatic brain injury in prehospital, emergency department, and intensive care unit settings: a systematic review and meta-analysis
ConclusionsOur findings revealed no significant difference in the all-cause mortality rates between patients receiving hypertonic saline or mannitol to control intracranial pressure. Further investigation is warranted because we only included a limited number of studies (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - August 11, 2020 Category: Intensive Care Source Type: research
Oxygen administration in patients recovering from cardiac arrest: a narrative review
AbstractHigh oxygen tension in blood and/or tissue affects clinical outcomes in several diseases. Thus, the optimal target PaO2 for patients recovering from cardiac arrest (CA) has been extensively examined. Many patients develop hypoxic brain injury after the return of spontaneous circulation (ROSC); this supports the need for oxygen administration in patients after CA. Insufficient oxygen delivery due to decreased blood flow to cerebral tissue during CA results in hypoxic brain injury. By contrast, hyperoxia may increase dissolved oxygen in the blood and, subsequently, generate reactive oxygen species that are harmful to...
Source: Journal of Intensive Care - August 11, 2020 Category: Intensive Care Source Type: research
Early steroid pulse therapy among children with influenza virus-associated encephalopathy
ConclusionsWe did not observe the effectiveness of early steroid pulse therapy on patient outcomes among children with IAE in our study population including all clinical subtypes of IAE. Further studies considering severity of illness are warranted to determine whether steroid pulse therapy is beneficial, especially for specific clinical subtypes of IAE. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - August 11, 2020 Category: Intensive Care Source Type: research
Operationalization of critical care triage during a pandemic surge using protocolized communication and integrated supportive care
AbstractTriage becomes necessary when demand for intensive care unit (ICU) resources exceeds supply. Without triage, there is a risk that patients will be admitted to the ICU in the sequence that they present, disadvantaging those who either present later or have poorer access to healthcare. Moreover, if the patients with the best prognosis are not allocated life support, there is the possibility that overall mortality will increase. Before formulating criteria, principles such as maximizing lives saved and fairness ought to have been agreed upon to guide decision-making. The triage process is subdivided into three parts, ...
Source: Journal of Intensive Care - August 5, 2020 Category: Intensive Care Source Type: research
Extracorporeal cardiopulmonary resuscitation without target temperature management for out-of-hospital cardiac arrest patients prolongs the therapeutic time window: a retrospective analysis of a nationwide multicentre observational study in Japan
ConclusionThis study revealed significant differences in the neurological outcomes between ECPR and CCPR without TTM, in patients with NLT of> 30 min. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - August 2, 2020 Category: Intensive Care Source Type: research
Histamine-2 receptor antagonists versus proton pump inhibitors for septic shock after lower gastrointestinal tract perforation: a retrospective cohort study using a national inpatient database
ConclusionsThere were no significant differences in gastrointestinal bleeding requiring endoscopic hemostasis within 28 days of admission, 28-day mortality, CDI, and hospital-acquired pneumonia between H2RA and PPI in patients with septic shock after lower gastrointestinal tract perforation. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 30, 2020 Category: Intensive Care Source Type: research
The use of automated pupillometry to assess cerebral autoregulation: a retrospective study
ConclusionsAutomated pupillometry cannot predict CAR indices such as Mxa in a heterogeneous population of critically ill patients. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 30, 2020 Category: Intensive Care Source Type: research
