Development and validation of an online model to predict critical COVID-19 with immune-inflammatory parameters
ConclusionsThe developed online prediction model SPMCIIP is hopeful to facilitate intensive monitoring and early intervention of high risk of critical illness in COVID-19 patients.Trial registrationThis study was retrospectively registered in the Chinese Clinical Trial Registry (ChiCTR2000032161).Graphical abstracthelper lymphocytvevv (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - February 18, 2021 Category: Intensive Care Source Type: research
Development and validation of the predictive risk of death model for adult patients admitted to intensive care units in Japan: an approach to improve the accuracy of healthcare quality measures
ConclusionsModel 3 showed good performance and can be adopted as the JROD model for monitoring quality of care in an ICU, although further investigation of the clinical validity of outlier detection is required. This update method may also be useful in other settings. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - February 15, 2021 Category: Intensive Care Source Type: research
Oxygen administration for patients with ARDS
AbstractAcute respiratory distress syndrome (ARDS) is a fatal condition with insufficiently clarified etiology. Supportive care for severe hypoxemia remains the mainstay of essential interventions for ARDS. In recent years, adequate ventilation to prevent ventilator-induced lung injury (VILI) and patient self-inflicted lung injury (P-SILI) as well as lung-protective mechanical ventilation has an increasing attention in ARDS.Ventilation-perfusion mismatch may augment severe hypoxemia and inspiratory drive and consequently induce P-SILI. Respiratory drive and effort must also be carefully monitored to prevent P-SILI. Airway ...
Source: Journal of Intensive Care - February 6, 2021 Category: Intensive Care Source Type: research
Prediction of patients requiring intensive care for COVID-19: development and validation of an integer-based score using data from Centers for Disease Control and Prevention of South Korea
ConclusionsAn integer-based scoring system was developed for predicting patients with COVID-19 requiring intensive care, with high performance. This system may aid decision support for prioritizing the patient for hospitalization and intensive care, particularly in a situation with limited medical resources. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 29, 2021 Category: Intensive Care Source Type: research
Self-citation policies and journal self-citation rate among Critical Care Medicine journals
ConclusionsA limited number of CCM journals have policies for limiting A-SC, and these have higher IF. The J-SC rate among CCM journals is highly variable and higher in “topic-specific” interest CCM journals. Excluding self-referencing practice from scientific metrics calculation could be valuable to tackle this scientific malpractice. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 26, 2021 Category: Intensive Care Source Type: research
The discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine?
AbstractThe acute respiratory distress syndrome (ARDS) is a severe lung disorder with a high morbidity and mortality which affects all age groups. Despite active research with intense, ongoing attempts in developing pharmacological agents to treat ARDS, its mortality rate remains unaltered high and treatment is still only supportive. Over the years, there have been many attempts to identify meaningful subgroups likely to react differently to treatment among the heterogenous ARDS population, most of them unsuccessful. Only recently, analysis of large ARDS cohorts from randomized controlled trials have identified the presenc...
Source: Journal of Intensive Care - January 21, 2021 Category: Intensive Care Source Type: research
Advanced echocardiographic phenotyping of critically ill patients with coronavirus-19 sepsis: a prospective cohort study
ConclusionsIn this comprehensive hemodynamic evaluation in critically ill COVID-19 septic patients, we identified four homogeneous and coherent clusters with a good feasibility. AMI was common and associated with alteration of LV and RV functions. Echocardiographic assessment had a clinical impact on patient management in most cases. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 20, 2021 Category: Intensive Care Source Type: research
The effect of incorporating an arterial pH target during apnea test for brain death determination
ConclusionImplementing a BD criteria requiring both arterial pH and PaCO2 thresholds reduced the total number of positive ATs; these inconclusive cases would have required longer duration of AT to reach both targets, repeated ATs, or ancillary studies to confirm BD. The impact of this on the overall number BD declarations requires further research. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 20, 2021 Category: Intensive Care Source Type: research
Community-acquired and hospital-acquired respiratory tract infection and bloodstream infection in patients hospitalized with COVID-19 pneumonia
ConclusionsCommunity-acquired viral and bacterial infections were rare among COVID-19 pneumonia patients. By contrast, hospital-acquired bacterial or fungal infections were frequently complicating the course among ICU patients. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 18, 2021 Category: Intensive Care Source Type: research
The effect of vitamin K on prothrombin time in critically ill patients: an observational registry study
ConclusionIn critically ill patients with a PT-INR of 1.3 –1.9, the administration of vitamin K resulted in a slightly larger decrease of PT-INR 12–36 h after administration compared to controls. Future studies should focus on identifying which patient populations may benefit most from vitamin K administration as well as whether vitamin K could be a better alternative than plasma or prothrombin complex concentrate to improve PT-INR before non-emergent invasive procedures. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 18, 2021 Category: Intensive Care Source Type: research
Left and right ventricular longitudinal strains are associated with poor outcome in COVID-19: a systematic review and meta-analysis
ConclusionThis study shows that lower LV-GLS and RV-LS measurements were associated with poor outcome in patients with COVID-19.Trial registrationPROSPEROCRD42020221144 (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 12, 2021 Category: Intensive Care Source Type: research
Music Use for Sedation in Critically ill Children (MUSiCC trial): a pilot randomized controlled trial
ConclusionsThis pilot RCT has demonstrated the feasibility of a music medicine intervention in critically ill children. The study has also provided the necessary information to plan a larger trial. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 12, 2021 Category: Intensive Care Source Type: research
Energy expenditure and indirect calorimetry in critical illness and convalescence: current evidence and practical considerations
AbstractThe use of indirect calorimetry is strongly recommended to guide nutrition therapy in critically ill patients, preventing the detrimental effects of under- and overfeeding. However, the course of energy expenditure is complex, and clinical studies on indirect calorimetry during critical illness and convalescence are scarce. Energy expenditure is influenced by many individual and iatrogenic factors and different metabolic phases of critical illness and convalescence. In the first days, energy production from endogenous sources appears to be increased due to a catabolic state and is likely near-sufficient to meet ene...
Source: Journal of Intensive Care - January 12, 2021 Category: Intensive Care Source Type: research
Machine learning-based prediction models for accidental hypothermia patients
ConclusionThis multi-center retrospective cohort study indicated that machine learning-based prediction models could accurately predict in-hospital mortality in validation cohort among the accidental hypothermia patients. These models might be able to support physicians and patient ’s decision-making. However, the applicability to clinical settings, and the actual clinical utility is still unclear; thus, further prospective study is warranted to evaluate the clinical usefulness. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 9, 2021 Category: Intensive Care Source Type: research
Psychological effects of remote-only communication among reference persons of ICU patients during COVID-19 pandemic
ConclusionRPs experienced psychological distress and reported that being an RP in a remote-only communication context was a specific responsibility and qualified it as an overall negative experience.Trial registrationNCT04385121. Registered 12 May 2020.https://clinicaltrials.gov/. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 9, 2021 Category: Intensive Care Source Type: research
