Why participation in an international clinical trial platform matters during a pandemic? Launching REMAP-CAP in Japan
AbstractREMAP-CAP, a randomized, embedded, multifactorial adaptive platform trial for community-acquired pneumonia, is an international clinical trial that is rapidly expanding its scope and scale in response to the COVID-19 pandemic. Japan is now joining REMAP-CAP with endorsement from Japanese academic societies. Commitment to REMAP-CAP can significantly contribute to population health through timely identification of optimal COVID-19 therapeutics. Additionally, it will promote the establishment of a national and global network of clinical trials to tackle future pandemics of emerging and re-emerging infectious diseases,...
Source: Journal of Intensive Care - April 14, 2021 Category: Intensive Care Source Type: research
Afterload-related cardiac performance identifies cardiac impairment and associates with outcome in patients with septic shock: a retrospective cohort study
ConclusionsOur results suggested thatACP could improve mortality predictions when compared to CI and CPI. Decreased ACP was still an independent risk factor for increased day-28 mortality. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - April 13, 2021 Category: Intensive Care Source Type: research
Association of noninvasive respiratory support with mortality and intubation rates in acute respiratory failure: a systematic review and network meta-analysis
ConclusionNPPV and HFNC use are associated with a decreased risk of endotracheal intubation; however, there are no significant differences in short-term mortality.Trial registrationPROSPERO (registration number:CRD42020139105, 01/21/2020) (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - April 12, 2021 Category: Intensive Care Source Type: research
Functional status of mechanically ventilated COVID-19 survivors at ICU and hospital discharge
ConclusionsThe majority of IMV COVID-19 survivors were not functionally independent at discharge and required significant follow-up medical care. The COVID-19 circumstance has placed constraints on access to in-hospital rehabilitation. These findings underscore the need for prospective studies to ascertain the short- and long-term sequela in COVID-19 survivors. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - March 31, 2021 Category: Intensive Care Source Type: research
What place for virtual reality in the intensive care unit during medical procedures?
AbstractIn the intensive care unit, patients are subject to discomforts and pain. Their management is essentially based on pharmacologic approaches. Immersive virtual reality could represent an adjunctive non-invasive and non-pharmacological pain control technique. It is based on real-time interaction with an artificial 360 ° immersive world using interfaces that enable physical and emotional perceptions to make the user feel better trying to reduce pain perception and to limit anxiety. Evaluation of virtual reality in intensive care unit is lacking and further studies are necessary before to introduce this alternativ e m...
Source: Journal of Intensive Care - March 26, 2021 Category: Intensive Care Source Type: research
An A-E assessment of post-ICU COVID-19 recovery
AbstractThe COVID-19 global pandemic has placed unprecedented strain on healthcare and critical care services around the world. Whilst most resources have focused on the acute phase of the disease, there is likely to be an untold burden of patients chronically affected.A wide range of sequelae contribute to post intensive care syndrome (PICS); from our current knowledge of COVID-19, a few of these have the potential to be more prevalent following critical care admission. Follow-up assessment, diagnosis and treatment in an increasingly virtual setting will provide challenges but also opportunities to develop these services....
Source: Journal of Intensive Care - March 20, 2021 Category: Intensive Care Source Type: research
Dynamic change of heart rate in the acute phase and clinical outcomes after intracerebral hemorrhage: a cohort study
ConclusionsPersistently high heart rate and higher variability in the acute phase were associated with increased risk of unfavorable functional outcome in patients with acute ICH. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - March 18, 2021 Category: Intensive Care Source Type: research
A longitudinal change of syndecan-1 predicts risk of acute respiratory distress syndrome and cumulative fluid balance in patients with septic shock: a preliminary study
ConclusionsIn our cohort of patients with septic shock, higher circulating level of Syn-1 of cardinal glycocalyx component is associated with more ARDS, cumulative positive fluid balance, and fewer VFD. Measurement of Syn-1 levels in patients with septic shock might be useful for predicting patients at high risk of ARDS. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - March 16, 2021 Category: Intensive Care Source Type: research
The author ’s response
(Source: Journal of Intensive Care)
Source: Journal of Intensive Care - March 16, 2021 Category: Intensive Care Source Type: research
A reassessment about included studies and certainty of evidence on a systematic review and meta-analysis of steroid for patients with acute respiratory distress syndrome
AbstractWe comment on the study by Hirano et al. about the effect of steroids in patients with acute respiratory distress syndrome. It might be necessary to include only the existing randomized control trials and to reassess the certainty of evidence about the primary outcomes. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - March 16, 2021 Category: Intensive Care Source Type: research
Association between physical restraint requirement and unfavorable neurologic outcomes in subarachnoid hemorrhage
ConclusionsContinuous use of physical restraint during the first 24 –72 h after admission was more significantly associated with unfavorable neurological outcomes than no physical restraint among patients with SAH during the acute phase. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - March 12, 2021 Category: Intensive Care Source Type: research
Predictors of failure with high-flow nasal oxygen therapy in COVID-19 patients with acute respiratory failure: a multicenter observational study
ConclusionsAmong adult critically ill patients with COVID-19 initially treated with HFNO, the SOFA score and the ROX index may help to identify patients with higher likelihood of intubation. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - March 5, 2021 Category: Intensive Care Source Type: research
Correction to: The discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine?
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - February 25, 2021 Category: Intensive Care Source Type: research
Prognostic value of lymphocyte counts in bronchoalveolar lavage fluid in patients with acute respiratory failure: a retrospective cohort study
ConclusionsIn the patients with ARF, ≥20% lymphocytes in BALF was associated with significantly less ventilatory support, lower mortality at both 90-day and 1-year follow-ups. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - February 23, 2021 Category: Intensive Care Source Type: research
The incidence of pulmonary thromboembolism in COVID-19 patients admitted to the intensive care unit: a meta-analysis and meta-regression of observational studies
ConclusionThe weighted average incidence of PTE remains high even after prophylactic anticoagulation. PTE is a significant complication of COVID-19 especially in critically ill patients in the ICU. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - February 22, 2021 Category: Intensive Care Source Type: research
