Brain monitoring using near-infrared spectroscopy to predict outcome after cardiac arrest: a novel phenotype in a rat model of cardiac arrest
AbstractImproving neurological outcomes after cardiac arrest (CA) is the most important patient-oriented outcome for CA research. Near-infrared spectroscopy (NIRS) enables a non-invasive, real-time measurement of regional cerebral oxygen saturation. Here, we demonstrate a novel, non-invasive measurement using NIRS, termed modified cerebral oximetry index (mCOx), to distinguish the severity of brain injury after CA. We aimed to test the feasibility of this method to predict neurological outcome after asphyxial CA in rats. Our results suggest that mCOx is feasible shortly after resuscitation and can provide a surrogate measu...
Source: Journal of Intensive Care - January 7, 2021 Category: Intensive Care Source Type: research
Characteristics and outcomes of patients admitted to adult intensive care units in Hong Kong: a population retrospective cohort study from 2008 to 2018
ConclusionsDespite relatively modest per capita health expenditure, and a small number of ICU beds per population, Hong Kong consistently provides a high-quality and efficient ICU service. Number of adult ICU admissions has increased, whilst adjusted mortality has decreased over the last decade. Although APACHE IV had good discrimination for hospital mortality, it overestimated hospital mortality of critically ill patients in Hong Kong. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 6, 2021 Category: Intensive Care Source Type: research
Occurrence and incidence rate of peripheral intravascular catheter-related phlebitis and complications in critically ill patients: a prospective cohort study (AMOR-VENUS study)
ConclusionPIVC-related phlebitis and complications were common in critically ill patients. The results suggest the importance of preventing PIVC-related complications, even in critically ill patients.Trial registrationUMIN-CTR, the Japanese clinical trial registry (registration number:UMIN000028019, July 1, 2017). (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 6, 2021 Category: Intensive Care Source Type: research
The effects of a limited infusion rate of fluid in the early resuscitation of sepsis on glycocalyx shedding measured by plasma syndecan-1: a randomized controlled trial
ConclusionsIn sepsis resuscitation, the limited rate of fluid resuscitation compared to the standard rate did not significantly reduce changes in syndecan-1 at 6 h.Trial registrationThai Clinical Trials Registry number: TCTR20181010001. Registered 8 October 2018,http://www.clinicaltrials.in.th/index.php?tp=regtrials&menu=trialsearch&smenu=fulltext&task=search&task2=view1&id=4064 (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - January 5, 2021 Category: Intensive Care Source Type: research
Correction to: Factors influencing liberation from mechanical ventilation in coronavirus disease 2019: multicenter observational study in fifteen Italian ICUs
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 17, 2020 Category: Intensive Care Source Type: research
Biological effects of the oxygen molecule in critically ill patients
AbstractThe medical use of oxygen has been widely and frequently proposed for patients, especially those under critical care; however, its benefit and drawbacks remain controversial for certain conditions. The induction of oxygen therapy is commonly considered for either treating or preventing hypoxia. Therefore, the concept of different types of hypoxia should be understood, particularly in terms of their mechanism, as the effect of oxygen therapy principally varies by the physiological characteristics of hypoxia. Oxygen molecules must be constantly delivered to all cells throughout the human body and utilized effectively...
Source: Journal of Intensive Care - December 14, 2020 Category: Intensive Care Source Type: research
Ensuring competency in focused cardiac ultrasound: a systematic review of training programs
ConclusionA short training program will allow most learners to achieve competency in detecting left ventricular systolic dysfunction and pericardial effusion by FoCUS. Additional training is necessary to ensure skill retention, improve efficiency in image acquisition, and detect other pathologies. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 11, 2020 Category: Intensive Care Source Type: research
The effect of recombinant human soluble thrombomodulin on renal function and mortality in septic disseminated intravascular coagulation patients with acute kidney injury: a retrospective study
ConclusionsAmong sepsis-induced DIC patients with AKI, rhTM administration was associated with lower dependence on RRT at ICU discharge, improvement in renal function, and lower 28-day mortality rate. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 11, 2020 Category: Intensive Care Source Type: research
Electromagnetic-guided versus endoscopic placement of post-pyloric feeding tubes: a systematic review and meta-analysis of randomised controlled trials
ConclusionsNo significant difference was found between the two groups in efficacy, safety, and costs. Further studies are needed to confirm our findings.Systematic review registrationPROSPERO (CRD42020172427) (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 10, 2020 Category: Intensive Care Source Type: research
Association between visitation restriction during the COVID-19 pandemic and delirium incidence among emergency admission patients: a single-center retrospective observational cohort study in Japan
ConclusionVisitation restriction was associated with an increased incidence of delirium in emergency inpatients. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 7, 2020 Category: Intensive Care Source Type: research
Corticosteroid treatment for early acute respiratory distress syndrome: a systematic review and meta-analysis of randomized trials
ConclusionsProlonged corticosteroid treatment in early ARDS improved the survival outcomes.Trial registrationPROSPERO,CRD42020195969 (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - December 7, 2020 Category: Intensive Care Source Type: research
Ginsenoside ameliorated ventilator-induced lung injury in rats
ConclusionsGinsenosides inhibited the inflammatory and oxidative stress response in VILI. Further studies are required on the 13 genes, including LCN2. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - November 23, 2020 Category: Intensive Care Source Type: research
The higher the better? Defining the optimal beta-lactam target for critically ill patients to reach infection resolution and improve outcome
ConclusionAchieving the target 100% fT>MIC leads to faster infection resolution in the critically ill. However, there was no benefit for patients who reached the highest target of 100% fT>4xMIC, although the mortality rate was higher possibly due to confounding effects. In conclusion, we recommend the target 100% fT>MIC<4xMIC for critically ill patients.Trial registrationNCT03985605 (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - November 23, 2020 Category: Intensive Care Source Type: research
Prevalence and prognostic value of elevated troponins in patients hospitalised for coronavirus disease 2019: a systematic review and meta-analysis
ConclusionElevated troponins were relatively common in patients hospitalised for covid-19. Troponin measurement on admission might help in risk stratification, especially in identifying patients at high risk of death when troponin levels are elevated. High-quality prospective studies are needed to validate these findings.Systematic review registrationPROSPEROCRD42020176747 (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - November 23, 2020 Category: Intensive Care Source Type: research
Upper limb muscle atrophy associated with in-hospital mortality and physical function impairments in mechanically ventilated critically ill adults: a two-center prospective observational study
ConclusionsUpper limb muscle atrophy was associated with in-hospital mortality and physical function impairments; thus, it is prudent to monitor it. (321 words)Trial registrationUMIN 000031316. Retrospectively registered on 15 February 2018. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - November 23, 2020 Category: Intensive Care Source Type: research
