Prognosis of pathogen-proven acute respiratory distress syndrome diagnosed from a protocol that includes bronchoalveolar lavage: a retrospective observational study
ConclusionsOur diagnostic protocol, which included early initiation of BAL, enabled diagnosing pathogen-proven ARDS in 71% of ARDS patients. These patients were significantly associated with higher hospital survival rates. The diagnostic accuracy of our diagnostic protocol, which includes BAL, remains unclear. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 22, 2020 Category: Intensive Care Source Type: research
Author ’s response to letter “Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients”
AbstractWe are appreciative to Dr. Jouffroy and Pr. Vivien for their responses and insights, and we agree with their words about the controversial aspect timing to antibiotic administration. Nevertheless, we stand firmly that it is not just about the time of administration of antimicrobials, but the early recognition and the comprehensive approach to recognize the most severe patients. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 22, 2020 Category: Intensive Care Source Type: research
Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients
AbstractIn a recent report, Asc.ar et al. describes the impossibility to demonstrate a significant association between early antibiotic therapy administration and mortality in sepsis patients. Nevertheless, we believe that some methodological issues deserve their conclusions. First, the objective of the authors of an early antibiotic therapy may be ambitious considering practical daily emergency department limitation. Second, most of patients included in the study appear to suffer from sepsis and not from septic shock, which limits the impact of an early and aggressive management. At last, more than a single intervention s...
Source: Journal of Intensive Care - July 21, 2020 Category: Intensive Care Source Type: research
The association between low pH value and unfavorable neurological outcome among the out-of-hospital cardiac arrest patient treated by extra-corporeal CPR: sensitivity analysis
AbstractThis is the response to the comment from Dr. Romain Jouffroy and his colleague, on the manuscript “Association between low pH and unfavorable neurological outcome among out-of-hospital cardiac arrest patients treated by extracorporeal CPR: a prospective observational cohort study in Japan”. We performed sensitivity analysis based on the comment from them. It indicated that the results of pri mary analysis were robust even in considering their criticism. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 21, 2020 Category: Intensive Care Source Type: research
Effect of oxygenation modalities among patients with postoperative respiratory failure: a pairwise and network meta-analysis of randomized controlled trials
ConclusionsAmong patients with post-operative respiratory failure, HFNC and NIV were associated with significantly reduced rates of intubation and ICU-acquired infections compared with standard oxygen. Moreover, NIV was associated with reduced mortality in comparison with standard oxygen. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 16, 2020 Category: Intensive Care Source Type: research
The First Impact Factor - Journal of Intensive Care
(Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 16, 2020 Category: Intensive Care Source Type: research
D-dimer as a biomarker for disease severity and mortality in COVID-19 patients: a case control study
ConclusionsD-dimer is commonly elevated in patients with COVID-19. D-dimer levels correlate with disease severity and are a reliable prognostic marker for in-hospital mortality in patients admitted for COVID-19. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 9, 2020 Category: Intensive Care Source Type: research
Comment on “volume-outcome relationship on survival and cost benefits in severe burn injury: a retrospective analysis of a Japanese nationwide administrative database” (Endo et al., Journal of Intensive Care 2019)
AbstractThis is a critical comment on the paper by Endo et al. on the volume-outcome relationship on survival and cost benefits in severe burn injury which addresses biases related to patient transfer and burn severity assessment. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 7, 2020 Category: Intensive Care Source Type: research
Reply to the comment by Osuka et al.
AbstractPatient transfer between hospitals can be one of the biases when evaluating the hospital performance in severe burn care. Optimal handling of such a population is challenging in the analysis of an inpatient database not specialized for burn due to the lack of detailed information. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 7, 2020 Category: Intensive Care Source Type: research
Efficacy and safety of tranexamic acid administration in traumatic brain injury patients: a systematic review and meta-analysis
ConclusionsTXA treatment demonstrated a tendency to reduce head trauma-related deaths in the TBI population, with no significant incidence of thromboembolic events. TXA treatment may therefore be suggested in the initial TBI care. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 2, 2020 Category: Intensive Care Source Type: research
Development of a nomogram to predict 30-day mortality of patients with sepsis-associated encephalopathy: a retrospective cohort study
ConclusionsSAE is related to increased 30-day mortality of patients with sepsis. The nomogram presents excellent performance in predicting 30-day risk of mortality in SAE patients, which can be used to evaluate the prognosis of patients with SAE and may be more beneficial once specific treatments towards SAE are developed. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 1, 2020 Category: Intensive Care Source Type: research
Use of glucocorticoids in patients with acute respiratory distress syndrome: a meta-analysis and trial sequential analysis
ConclusionAmong patients with ARDS, use of glucocorticoids is associated with a significant reduction in mortality and duration of mechanical ventilation, without increased risk of hospital-acquired infections. However, based on a trial sequential analysis, these findings may be secondary to a false-positive (type I) error. Further studies are needed for a firm conclusion with guarding against possible statistical errors. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - June 29, 2020 Category: Intensive Care Source Type: research
Epidemiology of sepsis and septic shock in intensive care units between sepsis-2 and sepsis-3 populations: sepsis prognostication in intensive care unit and emergency room (SPICE-ICU)
ConclusionsMost patients with infection admitted to ICU meet sepsis-2 and sepsis-3 criteria. However, in-hospital mortality did not occur if patients did not meet any criteria. Better criteria might be developed by better selection and combination of elements in both definitions.Trial registrationUMIN000027452 (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - June 29, 2020 Category: Intensive Care Source Type: research
Early prediction of high flow nasal cannula therapy outcomes using a modified ROX index incorporating heart rate
ConclusionWhile validation studies are required, the ROX-HR index appears to be a promising tool for early identification of treatment failure in patients initiated on HFNC for acute hypoxemic respiratory failure or as a preventative treatment after a planned extubation. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - June 21, 2020 Category: Intensive Care Source Type: research
Association between low pH and unfavorable neurological outcome among out-of-hospital cardiac arrest patients treated by extracorporeal CPR: do not dismiss confounders!
AbstractRecently, Okada et al. reported an association between low pH value before the implementation of extracorporeal cardiopulmonary resuscitation (ECPR) and 1-month unfavorable neurological outcome among out-of-hospital cardiac arrest (OHCA) patients treated with ECPR.Nevertheless, we believe that some methodological flaws deserve their conclusions.The time duration between OHCA occurrence and blood gas analysis (BGA), a major confounder for misinterpretation, was not taken into account. It is not reported whether the result of BGA analysis was considered and/or treated, and if ECPR implementation decision had been inf...
Source: Journal of Intensive Care - June 21, 2020 Category: Intensive Care Source Type: research
