Scoping review on diagnostic criteria and investigative approach in sepsis of unknown origin in critically ill patients
ConclusionsUniversally accepted diagnostic criteria for SUO was not found. Prospective studies on investigative processes in critically ill patients managed as SUO across different healthcare settings are needed to understand the epidemiology and inform the diagnostic criteria required to diagnose SUO. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - September 11, 2022 Category: Intensive Care Source Type: research

Difference between 5A score and the HOPE score
AbstractRecently, a letter to the editor was published to comment on the 5A score which is the prediction model for accidental hypothermia patients comparing the HOPE score. In this letter, we responded to the comments to clarify the difference between the 5A score and the HOPE score. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - September 9, 2022 Category: Intensive Care Source Type: research

Association between ICU admission during off-hours and in-hospital mortality: a multicenter registry in Japan
ConclusionsICU admissions during off-hours were associated with lower in-hospital mortality in Japan. These results were against our expectations and raised some concerns for a possible imbalance between ICU staffing and workload during office-hours. Further studies with a sufficient dataset required for comparing with other countries are warranted in the future. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - September 5, 2022 Category: Intensive Care Source Type: research

Association between histological diaphragm atrophy and ultrasound diaphragm expiratory thickness in ventilated patients
ConclusionsDiaphragm atrophy and thickness reduction is associated to MV. While a lower Tdi in diaphragm ultrasound is a good tool for diagnosing atrophy, normal or increased Tdi cannot rule atrophy out showing that both parameters should not be considered as synonymous. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - August 19, 2022 Category: Intensive Care Source Type: research

Post-resuscitation diastolic blood pressure is a prognostic factor for outcomes of cardiac arrest patients: a multicenter retrospective registry-based analysis
ConclusionWe found that DBP after resuscitation can predict outcomes, as a higher DBP level correlated with cardiogenic cardiac arrest. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - August 6, 2022 Category: Intensive Care Source Type: research

Pharmacotherapy consideration of thrombolytic medications in COVID-19-associated ARDS
ConclusionsInhaled or intravenous administration of thrombolytics appears to be a salvage therapy for severe ARDS associated with COVID-19 by prompt attenuation of lung injury. Considering the pathogenesis of COVID-19-related ARDS and mechanism of action of thrombolytic agents, thrombolytics appear attractive options in stable patients without contraindications. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 30, 2022 Category: Intensive Care Source Type: research

Outcome prediction for hypothermic patients in cardiac arrest
AbstractThe 5A score predicts in-hospital mortality of patients suffering from accidental hypothermia, including those not in cardiac arrest. The HOPE score was specifically developed to predict survival for the subgroup of hypothermic patients in cardiac considered for extracorporeal life support rewarming. The C-statistic in the external validation study of the HOPE score was 0.825 (95% CI: 0.753 –0.897), confirming its excellent discrimination. In addition, its good calibration allows for a reliable interpretation of the corresponding survival probability after rewarming. The HOPE score should be used for predicting o...
Source: Journal of Intensive Care - July 28, 2022 Category: Intensive Care Source Type: research

Association of multiple sclerosis with mortality in sepsis: a population-level analysis
ConclusionsMS was associated with lower short-term mortality among septic patients, with findings consistent among the subset with septic shock. Among septic patients admitted to ICU, MS was not associated with mortality. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 25, 2022 Category: Intensive Care Source Type: research

Intensive care unit versus high-dependency care unit admission on mortality in patients with septic shock: a retrospective cohort study using Japanese claims data
ConclusionsAn association was observed between ICU admission and lower 30-day mortality in patients with septic shock. These findings could provide essential insights for building a more appropriate treatment system. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 22, 2022 Category: Intensive Care Source Type: research

Tracheostomy decannulation protocol in patients with prolonged tracheostomy referred to a rehabilitation hospital: a prospective cohort study
ConclusionsA standardized tracheostomy decannulation protocol implemented by a pulmonary rehabilitation team is associated with successful tracheostomy decannulation in patients with prolonged tracheostomy. Not every tracheostomy patient must undergo upper airway endoscopy before decannulation. Tolerance of speaking valve continuously for 4  h can be used as an alternative means for tube occlusion. A swallow assessment was used to evaluate the feeding mode and did not affect the final decision to decannulate.Trial registration: 2018bkky-121. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 16, 2022 Category: Intensive Care Source Type: research

Temporal trends of medical cost and cost-effectiveness in sepsis patients: a Japanese nationwide medical claims database
ConclusionsWe demonstrated an improvement in annual cost-effectiveness in patients with sepsis between 2010 and 2017. The annual trend of reduced costs was consistent after adjustment with the confounders altering hospital expenses. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 14, 2022 Category: Intensive Care Source Type: research

ARDS Clinical Practice Guideline 2021
ConclusionsThis article is a translated summary of the full version of the ARDS Clinical Practice Guideline 2021 published in Japanese (URL:https://www.jsicm.org/publication/guideline.html). The original text, which was written for Japanese healthcare professionals, may include different perspectives from healthcare professionals of other countries. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - July 8, 2022 Category: Intensive Care Source Type: research

Calculated left ventricular outflow tract diameter for critically ill patients
In this study, the measured LVOTd was compared with the expected LVOTd when estimated using an existing formula in 1177 critically ill patients. We show that estimated LVOTd based on baseline data can aid when obtaining LVOTd is difficult or impossible and simplified estimation based on a formula may allow for more reliable and accessible measurement of cardiac output. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - June 21, 2022 Category: Intensive Care Source Type: research

Extracorporeal cardiopulmonary resuscitation with temperature management could improve the neurological outcomes of out-of-hospital cardiac arrest: a retrospective analysis of a nationwide multicenter observational study in Japan
ConclusionWithin patients who underwent ECPR following OHCA, ECPR with TTM could show the potential of improvement in the neurological outcomes, compared to ECPR without TTM. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - June 17, 2022 Category: Intensive Care Source Type: research

Construction of a predictive model and prognosis of left ventricular systolic dysfunction in patients with sepsis based on the diagnosis using left ventricular global longitudinal strain
ConclusionSepsis patients with left ventricular systolic dysfunction had a higher risk of death and atrial fibrillation. Hs-TnI, PCT, Lac, and NT-proBNP were independent risk factors of LVSD, and the LVSD predictive model constructed using these factors showed good diagnostic performance.Trial registration: Chinese Clinical Trial Registry No: ChiCTR2000032128. Registered on 20 April 2020,http://www.chictr.org.cn/showproj.aspx?proj=52531. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - June 15, 2022 Category: Intensive Care Source Type: research