Lacosamide dosing in patients receiving continuous renal replacement therapy
ConclusionsVolume of distribution, total clearance, CRRT clearance and body weight were significantly contributed to lacosamide dosing. Clinical validation of the finding is strongly indicated. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - November 9, 2023 Category: Intensive Care Source Type: research
A deep learning model for predicting multidrug-resistant organism infection in critically ill patients
ConclusionsThis study confirmed nine independent risk factors for MDRO infection. The BPNN model performed well and was potentially used to predict MDRO infection in ICU patients. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - November 9, 2023 Category: Intensive Care Source Type: research
Efficacy of therapeutic drug monitoring-based antibiotic regimen in critically ill patients: a systematic review and meta-analysis of randomized controlled trials
ConclusionTDM-based regimens had no significant efficacy for clinical or pharmacological outcomes. Further studies with other achievable targets and well-defined outcomes are required.Trial registration: Clinical trial registration; PROSPERO (https://www.crd.york.ac.uk/prospero/), registry number: CRD 42022371959. Registered 24 November 2022. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - November 8, 2023 Category: Intensive Care Source Type: research
Japanese Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients 2023 (J-ReCIP 2023)
AbstractProviding standardized, high-quality rehabilitation for critically ill patients is a crucial issue. In 2017, the Japanese Society of Intensive Care Medicine (JSICM) promulgated the “Evidence-Based Expert Consensus for Early Rehabilitation in the Intensive Care Unit” to advocate for the early initiation of rehabilitations in Japanese intensive care settings. Building upon this seminal work, JSICM has recently conducted a rigorous systematic review utilizing the Grading of R ecommendations, Assessment, Development, and Evaluation (GRADE) methodology. This endeavor resulted in the formulation of Clinical Practice ...
Source: Journal of Intensive Care - November 7, 2023 Category: Intensive Care Source Type: research
Trends in massive transfusion practice for trauma in Japan from 2011 to 2020: a nationwide inpatient database study
ConclusionsThis study demonstrated a declining trend in the incidence and a rise in higher FFP-to-RBC ratios in massive transfusion in association with patient outcomes for trauma from 2011 to 2020 in Japan. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - October 18, 2023 Category: Intensive Care Source Type: research
Polymyxin B-immobilised fibre column treatment for acute exacerbation of idiopathic pulmonary fibrosis patients with mechanical ventilation: a nationwide observational study
ConclusionsIn AE-IPF patients using mechanical ventilation, the treatment outcome was not significantly better for PMX combined with high-dose mPSL than for high-dose mPSL alone. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - October 11, 2023 Category: Intensive Care Source Type: research
Role of the interstitium during septic shock: a key to the understanding of fluid dynamics?
ConclusionsWe aimed at reviewing the literature and summarizing the current knowledge along these specific axes, as well as methodological aspects related to interstitium exploration. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - October 10, 2023 Category: Intensive Care Source Type: research
Long-term prognostic significance of gasping in out-of-hospital cardiac arrest patients undergoing extracorporeal cardiopulmonary resuscitation: a post hoc analysis of a multi-center prospective cohort study
ConclusionsGasping during resuscitation is a favorable factor in patients with refractory VF/pVT. Patients with refractory VF/pVT with continuously preserved gasping during EMS transportation to the hospital are expected to have more favorable outcomes. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - October 6, 2023 Category: Intensive Care Source Type: research
A novel method for diaphragm-based electrode belt position of electrical impedance tomography by ultrasound
ConclusionsThe diaphragm-based EIT-belt position by ultrasound was feasible and resulted in different belt positions compared to the conventional position in > 50% of the examined subjects, especially in patients with higher BMI. Further study is required to validate the impact on EIT images with this novel method on clinical management. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - September 25, 2023 Category: Intensive Care Source Type: research
High driving pressure ventilation induces pulmonary hypertension in a rabbit model of acute lung injury
ConclusionsA rabbit model of ventilation-induced pulmonary hypertension in ALI was successfully established. Our results open a new research direction investigating the exact role of ferroptosis in ventilation-induced pulmonary hypertension in ALI. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - September 25, 2023 Category: Intensive Care Source Type: research
Ultrasonographic evaluation of the diaphragm in critically ill patients to predict invasive mechanical ventilation
ConclusionsIn this study, RDE had a good ability to predict the need for IMV in critically ill patients. The optimal RDE cutoff value was 1.2 cm. Its benefit in patient management requires further investigation. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - September 19, 2023 Category: Intensive Care Source Type: research
Association between diaphragmatic dysfunction after adult cardiovascular surgery and prognosis of mechanical ventilation: a retrospective cohort study
ConclusionsDiaphragmatic dysfunction after adult cardiovascular surgery was significantly associated with longer duration of mechanical ventilation and higher reintubation. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - September 12, 2023 Category: Intensive Care Source Type: research
Comparison of balanced and unbalanced crystalloids as resuscitation fluid in patients treated for cardiogenic shock
ConclusionsIn patients with cardiogenic shock, use of balanced crystalloids was associated with a similar all-cause mortality at 30 days but a lower rate of new onset of renal replacement therapy. In the subgroup of patients after OHCA with severe shock, use of balanced crystalloids was associated with a higher mortality than saline.Trial registration: LMUshock registry (WHO International Clinical Trials Registry Platform Number DRKS00015860). (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - September 6, 2023 Category: Intensive Care Source Type: research
Ability of the respiratory ECMO survival prediction (RESP) score to predict survival for patients with COVID-19 ARDS and non-COVID-19 ARDS: a single-center retrospective study
AbstractThe respiratory ECMO survival prediction (RESP) score is used to predict survival for patients managed with extracorporeal membrane oxygenation (ECMO), but its performance in patients with Coronavirus Disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is unclear. We evaluated the ability of the RESP score to predict survival for patients with both non-COVID 19 ARDS and COVID-19 ARDS managed with ECMO at our institution. Receiver operating characteristic area under the curve (AUC) analysis found the RESP score reasonably predicted survival in patients with non-COVID-19 ARDS (AUC 0.76, 95% CI 0.68 –...
Source: Journal of Intensive Care - September 1, 2023 Category: Intensive Care Source Type: research
Effect of a music intervention on anxiety in adult critically ill patients: a multicenter randomized clinical trial
ConclusionsAnxiety levels in this ICU population were low, and music during 3 days did not decrease anxiety. This study indicates that efficacy of music is context and intervention-dependent, given previous evidence showing decreased anxiety.Trial registration Netherlands Trial Register: NL8595, Registered, 1 April 2020. ClinicalTrials.gov ID: NCT04796389, Registered retrospectively, 12 March 2021 (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - August 17, 2023 Category: Intensive Care Source Type: research
