The higher the better? Defining the optimal beta-lactam target for critically ill patients to reach infection resolution and improve outcome

ConclusionAchieving the target 100% fT>MIC leads to faster infection resolution in the critically ill. However, there was no benefit for patients who reached the highest target of 100% fT>4xMIC, although the mortality rate was higher possibly due to confounding effects. In conclusion, we recommend the target 100% fT>MIC<4xMIC for critically ill patients.Trial registrationNCT03985605
Source: Journal of Intensive Care - Category: Intensive Care Source Type: research