Hydrocortisone, ascorbic acid, and thiamine (HAT) for sepsis and septic shock: a meta-analysis with sequential trial analysis

ConclusionsThe HAT combination improves the SOFA score in the first 72  h and reduces the duration of vasopressors in patients with sepsis. Given the minor mean difference of the change in SOFA score, the mortality benefit has not been observed.Trial registrationPROSPERO, CRD42020203166.
Source: Journal of Intensive Care - Category: Intensive Care Source Type: research