Role of Hydrocortisone, Fludrocortisone in Septic Shock Role of Hydrocortisone, Fludrocortisone in Septic Shock
Twenty years after abandoning hydro/fludro for septic shock, Dr Holley will use it again, with some reservations.Medscape Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 20, 2023 Category: Consumer Health News Tags: Critical Care Viewpoint Source Type: news

Sacré bleu! Pharmacies warn of shortage of bed bug bite treatment amid fears over French invasion
Hydrocortisone cream supply is 'patchy' across England, according to Dr Leyla Hannbeck, chief executive of the Association for Independent Multiple Pharmacies. (Source: the Mail online | Health)
Source: the Mail online | Health - October 16, 2023 Category: Consumer Health News Source Type: news

Hydrocortisone Does Not Reduce 90-Day Mortality in Septic Shock
WEDNESDAY, May 31, 2023 -- For patients with septic shock, intravenous hydrocortisone does not reduce 90-day mortality when compared with placebo, according to a study published online May 22 in NEJM Evidence. Romain Pirracchio, M.D., M.P.H., Ph.D.,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 31, 2023 Category: Pharmaceuticals Source Type: news

Steroid Hydrocortisone Alone May Not Cut Death Risk From Septic Shock: Study
TUESDAY, May 23, 2023 -- A new study finds that while hydrocortisone on its own may not prevent death from sepsis, it can improve survival when combined with other steroids while eliminating the need for vasopressor drugs. Vasopressor medications... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 23, 2023 Category: General Medicine Source Type: news

Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock
Question: What is the comparative effectiveness of fludrocortisone added to hydrocortisone vs hydrocortisone alone among patients with septic shock? Findings: In this multicenter cohort study among 88 275 patients with septic shock receiving norepinephrine who initiated hydrocortisone treatment, the addition of fludrocortisone to hydrocortisone was associated with a 3.7% lower adjusted absolute risk difference in the primary composite outcome of mortality or discharge to hospice compared with initiation of hydrocortisone alone. Meaning: Among patients with septic shock receiving norepinephrine who initiated hydrocortisone ...
Source: Current Awareness Service for Health (CASH) - April 14, 2023 Category: Consumer Health News Source Type: news

Hydrocortisone Plus Fludrocortisone Superior for Septic Shock
THURSDAY, April 13, 2023 -- Among adult patients with septic shock who begin hydrocortisone treatment, the addition of fludrocortisone is superior to hydrocortisone alone, according to a study published online March 27 in JAMA Internal... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 13, 2023 Category: Pharmaceuticals Source Type: news

Combo Steroid Treatment May Work Best When Sepsis Strikes
WEDNESDAY, March 29, 2023 -- Giving patients who have septic shock a combo of two steroids could potentially be a lifesaver, according to a new study. Researchers found that patients receiving a combination of hydrocortisone and fludrocortisone had... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - March 29, 2023 Category: General Medicine Source Type: news

Hydrocortisone Linked to Lower Risk for Death in Severe Pneumonia
THURSDAY, March 23, 2023 -- For patients with severe community-acquired pneumonia admitted to the intensive care unit (ICU), hydrocortisone is associated with a lower risk for death by day 28, according to a study published online March 21 in the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 23, 2023 Category: Pharmaceuticals Source Type: news

Hydrocortisone Reduced Mortality in Patients With Severe Pneumonia
(MedPage Today) -- For patients admitted to the intensive care unit with severe community-acquired pneumonia, treatment with hydrocortisone led to a lower risk of death at 28 days versus placebo, a phase III randomized trial in France showed.... (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - March 22, 2023 Category: Infectious Diseases Source Type: news

Citrobacter freundii induces sepsis with new-onset status seizure in an adult: A case report and literature review. [Review]
RATIONALE: Sepsis with brain abscess induced by Citrobacter freundii in adults has rarely been reported and is extremely pathogenic with a high mortality rate. Early diagnosis of the infection still remains challenging. PATIENT CONCERNS: A 27-year-old woman was transferred to our emergency department for fever, status seizure and refractory hypotension. Administration of midazolam, propofol and sodium valproate could not attenuate the seizure except for the addition of vecuronium. The blood white blood cell count was 42.91 (109/L) with 80% neutrophils, and procalcitonin was 22.46ng/mL. DIAGNOSES: Both deoxyribonucleic acid...
Source: Current Awareness Service for Health (CASH) - January 26, 2023 Category: Consumer Health News Source Type: news

Therapy Monitoring in the International CAH Registry Therapy Monitoring in the International CAH Registry
Real-world data from the International CAH Registry provides insight into the variations in serum hormone measurements in relation to hydrocortisone doses.Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 17, 2022 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Hydrocortisone, Vitamin C, and Thiamine in Septic Shock Hydrocortisone, Vitamin C, and Thiamine in Septic Shock
Does this early combination therapy prove to be a safe and effective treatment option for septic shock?Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 28, 2022 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news

Vitamin C-based regimens for sepsis and septic shock: Systematic review and meta-analysis of randomized clinical trials
Conclusion: Further RCTs with higher methodological quality, an increased number of participants and assessing clinically relevant outcomes are needed to provide better decision-making guidance. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 27, 2022 Category: Consumer Health News Source Type: news

Unanswered questions on the use of hydrocortisone, ascorbic acid, and thiamine therapy in sepsis and septic shock
Conclusion: The utilization of HAT therapy for the management of sepsis and septic shock remains controversial. Hemodynamic benefits have been shown to be most pronounced when HAT therapy is initiated earlier. Future studies directed at earlier initiation may be necessary to confirm this theory. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 27, 2022 Category: Consumer Health News Source Type: news

Update on vitamin C administration in critical illness
Purpose of review: Several studies have recently explored the effects of intravenous vitamin C in sepsis. We aimed to summarize their findings to provide perspectives for future research. Recent findings: Sepsis trials examined 6 g/day of intravenous vitamin C with or without the thiamine and/or hydrocortisone compared with placebo or hydrocortisone. Network meta-analysis reported that intravenous vitamin C, thiamine, hydrocortisone, or combinations of these drugs was not proven to reduce long-term mortality. However, the component network meta-analysis suggested an association of high-dose (>6 g/day) and very-high dose v...
Source: Current Awareness Service for Health (CASH) - September 9, 2022 Category: Consumer Health News Source Type: news