Is Autonomic Activation a Middleman Between Obstructive Sleep Apnea Syndrome and Psoriasis?
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Psoriasis Is Associated With a Higher Prevalence of Obstructive Sleep Apnea and Restless Legs Syndrome: A Possible Indication of Autonomic Activation in Psoriasis
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Inflammation, Sleep and ADHD
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Sleep Disorders and Attention Deficit: A Consequence of Proinflammatory State?
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Good Night, Sleep Tight, Bed Bugs Continue to Bite
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Transient Central Sleep Apnea Runs Triggered by Disorder of Arousal in a Child
We report the case of a 5-year-old girl with frequent nocturnal episodes of disorder of arousal (confusional arousals, sleep terrors, and sleep walking), occurring at the end of periods of slow wave sleep, followed by return to sleep accompanied by the occurrence of periodic breathing with a run of approximately 10 to 20 central events. The duration of the central events and oxyhemoglobin desaturation were both maximum at the beginning of each run and became progressively less prominent with the development of the sequences. Night episodes disappeared with bedtime clonazepam but behavioral problems occurred as a paradoxica...
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Obstructive Sleep Apnea in a Severely Obese Child With Combined Central Sleep Apnea and Sleep-Related Hypoventilation Disorder Caused by a Medullary Tumor
A medullary tumor is a relatively rare disease that causes severe and complicated respiratory disorders, including sleep-related breathing disorders, due to dysregulation of respiratory control. A severely obese 12-year-old male was admitted to our hospital for worsening dyspnea and received a diagnosis of type II respiratory failure. Although obstructive sleep apnea (OSA) and/or obesity hypoventilation syndrome were suspected, a polysomnogram obtained during a nap (nap study) revealed central sleep apnea (CSA) and sleep-related hypoventilation disorder (SRHD) in addition to OSA. Brain magnetic resonance imaging showed a m...
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

A Novel Artificial Neural Network Based Sleep-Disordered Breathing Screening Tool
Conclusions:The results of this study suggested that the ANN based SDB screening tool can be used to identify the presence or absence of SDB. Future validation should be performed in other populations to determine the practicability of this screening tool in sleep clinics and other at-risk populations.Citation:Li A, Quan SF, Silva GE, Perfect MM, Roveda JM. A novel artificial neural network based sleep-disordered breathing screening tool.J Clin Sleep Med. 2018;14(6):1063–1069. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Validation of the Sleep-Wake Scoring of a New Wrist-Worn Sleep Monitoring Device
Conclusions:The kappa statistic for MC is consistent with a high level of agreement with PSG. Overall, the reliability of MC compared to PSG scoring was slightly more favorable than that of AW. Findings suggest that MC provides reliable sleep-wake scoring during a nocturnal sleep period for good sleepers.Citation:Pigeon WR, Taylor M, Bui A, Oleynk C, Walsh P, Bishop TM. Validation of the sleep-wake scoring of a new wrist-worn sleep monitoring device.J Clin Sleep Med. 2018;14(6):1057–1062. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Position Paper for the Treatment of Nightmare Disorder in Adults: An American Academy of Sleep Medicine Position Paper
Introduction:Nightmare disorder affects approximately 4% of adults, occurring in isolation or as part of other disorders such as posttraumatic stress disorder (PTSD), and can significantly impair quality of life. This paper provides the American Academy of Sleep Medicine (AASM) position regarding various treatments of nightmare disorder in adults.Methods:A literature search was performed based upon the keywords and MeSH terms from the Best Practice Guide for the Treatment of Nightmare Disorder in Adults that was published in 2010 by the AASM. The search used the date range March 2009 to August of 2017, and sought to find a...
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Sleep Duration and Hypertension: Analysis of > & nbsp;700,000 Adults by Age and Sex
The objective of this study was to evaluate the cross-sectional relationship between sleep duration and hypertension in a large, nationally-representative dataset that spans 10 years. This analysis may provide detailed information with high resolution about how sleep duration is related to hypertension and how this differs by demographic group.Methods:Data were aggregated from the 2013 Behavioral Risk Factor Surveillance System (n = 433,386) and the combined 2007–2016 National Health Interview Surveys (n = 295,331). These data were collected by the Centers for Disease Control and Prevention from nationally-representa...
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Change is the Only Constant in Life (and in Sleep Medicine)
This article will provide a brief update describing how the AASM board of directors has responded to my challenge and capitalized on change in the areas of the physician pipeline, patient access, advocacy, new technology and strategic research. Change is inevitable and often beyond our control, but how we anticipate and respond to change is entirely within our power. As sleep specialists, it is our responsibility not only to respond to change so that we can deliver the best possible care for our patients, but also to be the leading voice for change so that we all achieve better health through optimal sleep.Citation:Rosen I...
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Insomnia in the Elderly: A Review
Conclusions:The most important aspect in evaluation of insomnia is detailed history taking and thorough physical examination. Nonpharmacological treatment options have favorable and enduring benefits compared to pharmacological therapy.Citation:Patel D, Steinberg J, Patel P. Insomnia in the elderly: a review.J Clin Sleep Med. 2018;14(6):1017–1024. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Cost-Effectiveness Analysis of the DiagnOSAS Screening Tool Compared With Polysomnography Diagnosis in Dutch Primary Care
This study's objective was to investigate the cost-effectiveness of DiagnOSAS, a screening tool that strives to facilitate fast and well-informed referral to hospitals and sleep clinics for diagnosis, in The Netherlands.Methods:A Markov model was constructed to assess cost-effectiveness in men aged 50 years. The diagnostic process of OSA was simulated with and without DiagnOSAS, taking into account the occurrence of hazardous OSA effects: car accidents, myocardial infarction, and stroke. The cost-effectiveness of“DiagnOSAS Strategy” and a“Rapid Diagnosis Scenario,” in which time to diagnosis was hal...
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Snore Sound Analysis Can Detect the Presence of Obstructive Sleep Apnea Specific to NREM or REM Sleep
Conclusions:Snore sounds carry sufficient information to detect the presence of OSA during NREM and REM sleep. Because the methods used include technology that is fully automated and sensors that do not have a physical connection to the patient, it has potential for OSA screening in the home environment. The accuracy of the method can be improved by developing sex-specific models.Citation:Akhter S, Abeyratne UR, Swarnkar V, Hukins C. Snore sound analysis can detect the presence of obstructive sleep apnea specific to NREM or REM sleep.J Clin Sleep Med. 2018;14(6):991–1003. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

High Negative Predictive Value of Normal Body Mass Index for Obstructive Sleep Apnea in the Lateral Sleeping Position
This study comprises a retrospective and prospective part run on groups of 1,181 and 821 consecutive patients, respectively. All had been referred to the university-based sleep laboratory because of suspected OSA and underwent polysomnography.Results:In the retrospective study, areas under the receiver operating characteristic curves for normal BMI at AHI≥ 5 and AHI≥ 15 events/h were found to be larger in the lateral sleeping positing than supine: 0.79 versus 0.69 and 0.80 versus 0.68, respectively (P
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

A Community-Based Study of Sleep and Cognitive Development in Infants and Toddlers
Conclusions:Frequent nighttime awakenings are associated with poor cognitive functions in toddlers. Meanwhile, a nonlinear association between nighttime awakenings and cognitive performance was found among infants. The findings provide a developmental context for the effect of sleep on cognitive abilities in young children. Further longitudinal studies and interventional studies on the effects of parent-based sleep-focused intervention on cognitive abilities among young children are warranted.Citation:Sun W, Li SX, Jiang Y, Xu X, Spruyt K, Zhu Q, Tseng C, Jiang F. A community-based study of sleep and cognitive development ...
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Obstructive Sleep Apnea and Sleep Architecture in Adolescents With Severe Obesity: Effects of a 9-Month Lifestyle Modification Program Based on Regular Exercise and a Balanced Diet
The objectives of this study were to investigate the effects of long-term physical exercise combined with a balanced diet on sleep architecture, sleep duration, and OSA in adolescents with severe obesity.Methods:This interventional study was conducted in a nursing institution. Participants were aged 14.6± 1.2 years with obesity (body mass index (BMI) = 40.2± 6.5 kg/m2). At admission and at 9 months, participants underwent ambulatory polysomnography and incremental maximal exercise testing to determine cardiorespiratory fitness.Results:Twenty-four subjects completed the study. Analyses were performed on the wh...
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Sleep-Related Attentional Bias for Faces Depicting Tiredness in Insomnia: Evidence From an Eye-Tracking Study
Conclusions:Individuals with insomnia display an attentional bias toward tired faces, more specifically for the eye region compared to normal sleepers. These findings contribute to our understanding of face perception in insomnia and provide more objective support for cognitive models of insomnia, suggesting that individuals with insomnia selectively attend to faces for tiredness cues.Citation:Akram U, Robson A, Ypsilanti A. Sleep-related attentional bias for faces depicting tiredness in insomnia: evidence from an eye-tracking study.J Clin Sleep Med. 2018;14(6):959–965. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Continuous Positive Airway Pressure Treatment May Improve Optic Nerve Function in Obstructive Sleep Apnea: An Electrophysiological Study
Conclusions:This study documented that CPAP therapy significantly improves VEP in patients with OSA who are adherent to the treatment. We hypothesize that CPAP treatment, minimizing the metabolic, inflammatory and ischemic consequences of OSA, may normalize the altered VEP responses in patients with OSA by restoring and preserving optic nerve function.Citation:Liguori C, Placidi F, Palmieri MG, Izzi F, Ludovisi R, Mercuri NB, Pierantozzi M. Continuous positive airway pressure treatment may improve optic nerve function in obstructive sleep apnea: an electrophysiological study.J Clin Sleep Med. 2018;14(6):953–958. (Sou...
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

The Differential Effects of Regular Shift Work and Obstructive Sleep Apnea on Sleepiness, Mood and Neurocognitive Function
Conclusions:Shift workers and patients with OSA had similar sleepiness and mood deficits relative to healthy individuals. However, only the patients with OSA showed deficits on vigilance and neurocognitive function relative to healthy individuals. These findings suggest that distinct causes of sleep disturbance likely result in different patterns of neurobehavioral dysfunction.Citation:Cori JM, Jackson ML, Barnes M, Westlake J, Emerson P, Lee J, Galante R, Hayley A, Wilsmore N, Kennedy GA, Howard M. The differential effects of regular shift work and obstructive sleep apnea on sleepiness, mood and neurocognitive function.J ...
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Insomnia Symptoms Among Female Veterans: Prevalence, Risk Factors, and the Impact on Psychosocial Functioning and Health Care Utilization
Conclusions:Sleep problems are common among female veterans (47.39%) despite limited diagnosis of sleep disorders (0.90%). Eight unique subgroups of female veterans with both low and high insomnia symptoms were observed. These subgroups differed in terms of psychosocial functioning and health care utilization, with those with depression, posttraumatic stress disorder, and pain having the poorest outcomes. These results shed light on the prevalence of insomnia symptoms experienced among female veterans and the effect on psychosocial functioning and health care utilization. Results can inform targeted detection and customize...
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Rebuttal to Javaheri, Brown and Khayat
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Rebuttal to Naughton
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

CON: Persistent Central Sleep Apnea/Hunter-Cheyne-Stokes Breathing, Despite Best Guideline-Based Therapy of Heart Failure With Reduced Ejection Fraction, Is Not a Compensatory Mechanism and Should Be Suppressed
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

PRO: Persistent Central Sleep Apnea/Hunter-Cheyne-Stokes Breathing, Despite Best Guideline-Based Therapy of Heart Failure With Reduced Ejection Fraction, Is a Compensatory Mechanism and Should Not Be Suppressed
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Too Little, but Still Great?
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - June 14, 2018 Category: Sleep Medicine Source Type: research

Effective Treatment of Insomnia With Mirtazapine Attenuates Concomitant Suicidal Ideation
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

The Case for Membership in the AMA
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

The Effects of Sildenafil on the Respiratory System of Patients With Obstructive Sleep Apnea and Erectile Dysfunction
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

The Longest Obstructive Apnea You Have Ever Seen: A Patient With New-Onset Autonomic Dysfunction
We present a case of a 70-year-old woman who had experienced cardiac arrest four times related to hypoxic events due to the apparent sudden onset of obstructive sleep apnea (OSA) in the setting of AD. The episodes of OSA were profoundly prolonged and a tracheostomy was ultimately needed due to the inability of positive airway pressure therapy with supplemental oxygen to control events. We think that this case is unique because of the extreme duration of the obstructive apneas (up to 233.8 seconds), which almost certainly reflects lack of protective autonomic control in terminating these events.Citation:Aulakh PK, Westerman...
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Violent Parasomnia With Recurrent Biting and Surgical Interventions: Case Report and Differential Diagnosis
A case is reported of recurrent, injurious self-biting during sleep, requiring surgical interventions, in a 55-year-old obese man with a 20-year history of violent complex parasomnia, with greatly increased frequency and severity of episodes induced by work stress during the preceding 3 years. After clinical evaluation and overnight, hospital-based video-polysomnography, the cause of the chronic injurious parasomnia was deemed to be a non-rapid eye movement (NREM) sleep parasomnia comorbid with severe obstructive sleep apnea. Therapy with bedtime clonazepam and bilevel positive airway pressure was effective, with injurious...
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Stevens-Johnson Syndrome After Armodafinil Use
We present the case of a 21-year-old woman in whom Stevens-Johnson syndrome (SJS) developed after initiation of armodafinil. Although this rare and life-threatening reaction is listed on armodafinil's label, no cases have been reported in the literature. This case, in addition to an update of the drug's label after post-marketing research, both support the link between armodafinil and SJS. Providers should maintain a high clinical suspicion for SJS when starting therapy to minimize associated morbidity and mortality by discontinuing armodafinil at the onset of first symptoms.Citation:Holfinger S, Roy A, Schmidt M. Stevens-...
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Value and Payment in Sleep Medicine
This article places the value of clinical sleep medicine services in historical context and presents a vision for the value-based sleep of the future. First, the history of value and payment in sleep medicine is reviewed from the early days of the field, to innovative disruption, to the widespread adoption of home sleep apnea testing. Next, the importance of economic perspective is discussed, with emphasis on cost containment and cost-shifting between payers, employers, providers, and patients. Specific recommendations are made for sleep medicine providers and the field at large to maximize the perceived value of sleep. Fi...
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Consumer Sleep Technology: An American Academy of Sleep Medicine Position Statement
Consumer sleep technologies (CSTs) are widespread applications and devices that purport to measure and even improve sleep. Sleep clinicians may frequently encounter CST in practice and, despite lack of validation against gold standard polysomnography, familiarity with these devices has become a patient expectation. This American Academy of Sleep Medicine position statement details the disadvantages and potential benefits of CSTs and provides guidance when approaching patient-generated health data from CSTs in a clinical setting. Given the lack of validation and United States Food and Drug Administration (FDA) clearance, CS...
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Prevalence of Obstructive Sleep Apnea in Children With Down Syndrome: A Meta-Analysis
Conclusions:OSA is highly prevalent in children with Down syndrome. Prevalence of moderate to severe OSA is higher in younger age.Citation:Lee CF, Lee CH, Hsueh WY, Lin MT, Kang KT. Prevalence of obstructive sleep apnea in children with Down syndrome: a meta-analysis.J Clin Sleep Med. 2018;14(5):867–875. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Sleep Duration Interacts With Lifestyle Risk Factors and Health Status to Alter Risk of All-Cause Mortality: The Rural Chinese Cohort Study
Study Objectives:Many studies suggest an association of both short and long sleep duration with all-cause mortality, but the effect of co-occurrence of sleep duration and other lifestyle risk factors or health status remains unclear.Methods:A total of 17,184 participants aged 18 years or older from rural areas of China were examined at baseline from 2007 to 2008 and followed up from 2013 to 2014. Cox proportional hazard models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI).Results:During 6-year follow-up, we identified 1,101 deaths. The multivariable-adjusted mortality risk was significantly h...
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Characterizing Decisional Conflict for Caregivers of Children With Obstructive Sleep Apnea Without Tonsillar Hypertrophy
This study comprised children evaluated in the multidisciplinary upper airway center at the Cincinnati Children's Hospital Medical Center from December 2014 to May 2016. Caregivers were asked to complete surveys (Pediatric Quality of Life Inventory 4.0 [PedsQL], OSA-18, Epworth Sleepiness Scale, Family Impact Questionnaire, Decisional Conflict Scale, CollaboRATE scale, and SURE questionnaire) during a clinic visit. Polysomnography data were collected. Analysis included Kruskal-Wallis, Wilcoxon rank-sum, and regression testing.Results:Caregivers of 76 children participated; 16 (21.1%) had high DC. There were no significant ...
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Ability of the Multisensory Jawbone UP3 to Quantify and Classify Sleep in Patients With Suspected Central Disorders of Hypersomnolence: A Comparison Against Polysomnography and Actigraphy
This study included 43 patients who completed polysomnography (PSG) and a Multiple Sleep Latency Test (MSLT) with concurrent wrist-worn JB3 and Actiwatch 2 (AW2) recordings for comparison. Mean differences in nocturnal sleep architecture variables were compared using Bland-Altman analysis. Sensitivity, specificity, and accuracy were derived for both devices relative to PSG. Ability of the JB3 to detect sleep onset rapid eye movement periods (SOREMPs) during MSLT naps was also quantified.Results:JB3 demonstrated a significant overestimation of total sleep time (39.6 min,P
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Lack of Worsening of Sleep-Disordered Breathing After Recurrent Stroke in the BASIC Project
Conclusions:In this within-subject, longitudinal study, neither severity nor prevalence of SDB worsened after recurrent stroke.Citation:Brown DL, Li C, Sánchez BN, Dunietz GL, Chervin RD, Case E, Garcia NM, Lisabeth LD. Lack of worsening of sleep-disordered breathing after recurrent stroke in the BASIC project.J Clin Sleep Med. 2018;14(5):835–839. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Differentiating Single and Multiple Suicide Attempters: What Nightmares Can Tell Us That Other Predictors Cannot
Conclusions:Inconsistent with past research, this study showed that nightmare frequency, and not nightmare chronicity or severity/distress, differentiated between single and multiple suicide attempters. This outcome suggests that the number of nightmares experienced may be more pertinent in predicting repeat suicide attempts than their duration or perceived severity. Study limitations include a cross-sectional design, a convenience sampling approach, a lack of control for previous treatment or length of time since last attempt, and a retrospective nightmare measure.Citation:Speed KJ, Drapeau CW, Nadorff MR. Differentiating...
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Change in Cognition and Other Non-Motor Symptoms With Obstructive Sleep Apnea Treatment in Parkinson Disease
Conclusions:CPAP treatment of OSA in PD is associated with improved overall non-motor symptoms, sleep quality, anxiety, and global cognitive function over a 12-month period.Citation:Kaminska M, Mery VP, Lafontaine AL, Robinson A, Benedetti A, Gros P, Kimoff RJ. Change in cognition and other non-motor symptoms with obstructive sleep apnea treatment in Parkinson disease.J Clin Sleep Med. 2018;14(5):819–828. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Prevalence, Associated Clinical Features, and Impact on Continuous Positive Airway Pressure Use of a Low Respiratory Arousal Threshold Among Male United States Veterans With Obstructive Sleep Apnea
Study Objectives:Determine the prevalence of, and clinical features associated with, a low respiratory arousal threshold (ArTH) among patients with obstructive sleep apnea (OSA), and to assess whether a low ArTH is associated with reduced long-term CPAP use.Methods:Cross-sectional and longitudinal analyses were performed in an observational study conducted among 940 male Veterans with OSA. Data for clinical characteristics, polysomnography characteristics, and long-term (5± 2 years) CPAP use were obtained from clinical records. Logistic regression was used to assess the associations between low ArTH and clinical fea...
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Exosomal Cargo Properties, Endothelial Function and Treatment of Obesity Hypoventilation Syndrome: A Proof of Concept Study
Conclusions:Circulating exosomes facilitate important intercellular signals that modify endothelial phenotype, and thus emerge as potential fundamental contributors in the context of OSA/OHS-related endothelial dysfunction. Exosomes may not only provide candidate biomarkers, but are also a likely and plausible mechanism toward OSA/OHS-induced cardiovascular disease.Clinical Trial Registration:Registry: ClinicalTrials.gov, Title: AVAPS-AE Efficacy Study, URL:https://clinicaltrials.gov/ct2/show/NCT01368614, Identifier: NCT01368614Citation:Bhattacharjee R, Khalyfa A, Khalyfa AA, Mokhlesi B, Kheirandish-Gozal L, Almendros I, P...
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Clinical Reproducibility of the Epworth Sleepiness Scale for Patients With Suspected Sleep Apnea
Conclusions:In a clinical obstructive sleep apnea referral population, the ESS score was variable when administered sequentially. Given this variability the ESS should not be used as the sole tool to prioritize patients for obstructive sleep apnea assessment.Commentary:A commentary on this article appears in this issue on page 711.Citation:Campbell AJ, Neill AM, Scott DA. Clinical reproducibility of the Epworth Sleepiness Scale for patients with suspected sleep apnea.J Clin Sleep Med. 2018;14(5):791–795. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Executive and Visuospatial Dysfunction in Patients With Primary Restless Legs Syndrome/Willis-Ekbom Disease: Study of a Chinese Population
Study Objectives:The aim of the study was to investigate the cognitive function of patients with primary restless legs syndrome/Willis-Ekbom disease (RLS/ WED) in a Chinese population.Methods:A total of 40 patients with RLS/WED who were drug naïve and 40 controls, matched by age, sex, and educational level, were evaluated by cognitive function assessments, including the Chinese version of the Mini-Mental State Examination (MMSE-C), clock drawing test (CDT), Auditory Verbal Learning Test (AVLT), Rey-Osterrieth Complex Figure Test (CFT), and Stroop Color Word Test (SCWT).Results:Patients with RLS/WED showed worse perfor...
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Insomnia and Nightmares as Markers of Risk for Suicidal Ideation in Young People: Investigating the Role of Defeat and Entrapment
Conclusions:Taken together, these findings provide novel insights into the psychological mechanisms linking sleep disturbance and suicidality by highlighting the role of defeat and entrapment. Clinically, these findings have the potential to improve suicide risk assessment and prevention in young people experiencing difficulties with their sleep.Citation:Russell K, Rasmussen S, Hunter SC. Insomnia and nightmares as markers of risk for suicidal ideation in young people: investigating the role of defeat and entrapment.J Clin Sleep Med. 2018;14(5):775–784. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Risk of Nephrolithiasis in Patients With Sleep Apnea: A Population-Based Cohort Study
Study Objectives:To delineate the relationship between sleep apnea and subsequent risk of nephrolithiasis.Methods:We conducted a retrospective cohort analysis of a general population sample from Taiwan National Health Insurance Research Database (NHIRD) from January 1, 2000 to December 31, 2012. Patients with sleep apnea without prior diagnosis of nephrolithiasis (n = 7,831) were identified and subsequent development of nephrolithiasis was compared to an age- and sex-matched control group (n = 31,293) without sleep apnea. The Cox proportional hazard regression models were used to evaluate the association between sleep apne...
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Lack of Resilience Is Related to Stress-Related Sleep Reactivity, Hyperarousal, and Emotion Dysregulation in Insomnia Disorder
Conclusions:Subjects with insomnia showed low resilience, which was related to high stress-related sleep reactivity, emotional dysregulation, and hyperarousal. If resilience helps to minimize the extent of pathogenesis in the developmental process, an early identification of vulnerable candidates should be useful for preventing insomnia development and maintenance.Commentary:A commentary on this article appears in this issue on page 709.Citation:Palagini L, Moretto U, Novi M, Masci I, Caruso D, Drake CL, Riemann D. Lack of resilience is related to stress-related sleep reactivity, hyperarousal, and emotion dysregulation in ...
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research

Obstructive Sleep Apnea is an Independent Risk Factor for Hospital Readmission
This study seeks to characterize the relationship between readmissions and obstructive sleep apnea (OSA). A better understanding of this relationship could be utilized to develop preventative measures and reduce readmission rates.Methods:A retrospective review of patients discharged over a 24-month period to a Department of Defense hospital was conducted. Medical records review provided demographic data, presence of OSA and comorbid diseases, and whether readmission occurred within 30 days of discharge. Statistical analysis assessed risk factors for readmission, and multivariate analysis was performed. Next, 125 readmitted...
Source: Journal of Clinical Sleep Medicine : JCSM - May 15, 2018 Category: Sleep Medicine Source Type: research