Perspective: The Long-Term Effects of Light Exposure on Establishment of Newborn Circadian Rhythm
Development of newborns continues postnatally. Evidence has accumulated on the early life programming effects of light exposure on the maturing visual axis and the developing circadian rhythm. Consideration of the effects of light at night and insufficient light during the day should occur when giving anticipatory guidance in the care of newborn infants. Long-term health consequences of light imprinting may occur with inappropriate light-dark environments during the newborn period.Citation:Yates J. The long-term effects of light exposure on establishment of newborn circadian rhythm.J Clin Sleep Med. 2018;14(10):1829–...
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Increasing the Visibility of Dental Sleep Disorders
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

PAP Treatment for Patients Who Have Had a Stroke
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Let's Get It Right This Time: Controversies and Now Redacted 2018 AHA Stroke Guidelines
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Can Sleep Problems Have a Negative Impact on Falls in Older People?
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Obstructive Sleep Apnea and Stroke
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Twitter Discussions from a Respirology Journal Club: Role of Positive Airway Pressure Therapy for Obstructive Sleep Apnea in Patients With Stroke
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Medical Cannabis, Synthetic Marijuana Extracts, and Obstructive Sleep Apnea
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Stop the Attack on Minnesota's Courageous Stance to Allow Its Residents to Sleep Safely
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Medical Cannabis and AASM Position Statement: The Don't Ask, Don't Tell Wishing Well
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Roving Eye Movements
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Two Cases of Sleep-Related Eating Disorder Responding Promptly to Low-Dose Sertraline Therapy
We report two cases of adult males with sleep-related eating disorder (SRED), with durations of 3 and 7 years, and without associated psychiatric history. In both cases, the use of low-dose (25 mg) sertraline taken at bedtime resulted in immediate, full and sustained resolution of symptoms at the latest follow-ups. The sertraline efficacy was of particular benefit for the patient reported on in case 2 who was a commercial airline pilot subjected to a highly restricted list of Federal Aviation Administration-approved medications. Risk factors for SRED included smoking cessation and work-related stress in case 1, and a histo...
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Tachypnea Seen During Positive Airway Pressure Titration Studies: A Case Series of Four Patients
We report a case series of four patients where tachypnea was observed during positive airway titration studies, double the baseline breathing rate (tachypnea range 46–68 breaths/min). It happened mainly during non-rapid eye movement to rapid eye movement sleep transitions without significant changes in oxygen saturation or signs of autonomic hyperactivity such as an increased heart rate. The increased respiratory rate may be a normal physiological extreme outlier seen during phasic rapid eye movement sleep triggered by high pressure ventilation and it may also indicate underlying ventilatory instability, making patie...
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Treatment of Comorbid Obstructive Sleep Apnea by Upper Airway Stimulation Results in Resolution of Debilitating Symptoms of Restless Legs Syndrome
An association between restless legs syndrome (RLS) and obstructive sleep apnea (OSA) has been suggested for decades but has been questioned in recent years given the apparently similar prevalence of RLS among patients with OSA and the general population. Still, marked improvement in symptoms of RLS has been reported in patients with OSA treated with continuous positive airway pressure (CPAP). Whether the effect of OSA treatment on RLS extends to modalities of OSA treatment other than CPAP remains an open question. Here, we report the case of a patient with OSA and comorbid debilitating RLS who underwent upper airway stimu...
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

An Evaluation of the NightOwl Home Sleep Apnea Testing System
The objective of this study was to evaluate the performance of a miniaturized home sleep apnea test, called NightOwl. The system consists of a sensor placed on the fingertip and a cloud-based analytics software. The sensor acquires accelerometer and photoplethysmographic data. The software derives actigraphy from the former, and blood oxygen saturation and peripheral arterial tone, among other features, from the latter.Methods:Data of 101 participants who underwent an in-laboratory polysomnography (PSG), while wearing the NightOwl sensor, were collected. In order to establish an external benchmark, all PSG tests were edite...
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Smartphone Applications to Support Sleep Self-Management: Review and Evaluation
Conclusions:The findings suggest that few apps meet prespecified criteria for quality, content, and functionality for sleep self-management. Despite the rapid evolution of sleep self-management apps, lack of validation studies is a significant concern that limits the clinical value of these apps.Citation:Choi YK, Demiris G, Lin SY, Iribarren SJ, Landis CA, Thompson HJ, McCurry SM, Heitkemper MM, Ward TM. Smartphone applications to support sleep self-management: review and evaluation.J Clin Sleep Med. 2018;14(10):1783–1790. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Sleep Apnea Evolution and Left Ventricular Recovery After Percutaneous Coronary Intervention for Myocardial Infarction
Study Objectives:Sleep apnea is often newly diagnosed in patients presenting with ST-segment elevation myocardial infarction (STEMI). We assessed longitudinal changes in apnea-hypopnea index (AHI) and sleep apnea phenotype after STEMI and determined its association with changes in the left ventricular ejection fraction (LVEF).Methods:A total of 101 eligible patients with STEMI underwent consecutive sleep studies and echocardiographic studies within 5 days of admission and at 6-month follow-up. Sleep apnea (AHI≥ 15 events/h) was further divided into obstructive sleep apnea (OSA) or central sleep apnea (CSA).Results:Both ...
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Chronic Pain, Sleep, and Cognition in Older Adults With Insomnia: A Daily Multilevel Analysis
Conclusions:In older adults with HxCP, improving sleep may benefit lower level cognition, whereas reducing depression may affect higher level cognition. Discrepancies in sleep parameters promote assessment of objective and subjective sleep outcomes when investigating effects of insomnia on cognition.Clinical Trial Registration:Title: Intraindividual Variability in Sleep and Cognitive Performance in Older Adults (REST), Registry: ClinicalTrials.gov, Identifier: NCT02967185, URL:https://clinicaltrials.gov/ct2/show/NCT02967185Citation:Curtis AF, Williams JM, McCoy KJ, McCrae CS. Chronic pain, sleep, and cognition in older adu...
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Sleep Duration Is Associated With Testis Size in Healthy Young Men
Conclusions:There is a positive linear and a possible inverse U-shaped relationship between sleep duration and testis volume. Longitudinal or interventional studies manipulating sleep are required to better define causality, and ultimately to establish how much sleep is needed to maximize male reproductive potential.Clinical Trial Registration:Title: Hormonal Mechanisms of Sleep Restriction, Registry: ClinicalTrials.gov, Identifier: NCT02256865, URL:https://clinicaltrials.gov/ct2/show/NCT02256865Citation:Zhang W, Piotrowska K, Chavoshan B, Wallace J, Liu PY. Sleep duration is associated with testis size in healthy young me...
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Uvulopalatopharyngoplasty May Reduce the Incidence of Dementia Caused by Obstructive Sleep Apnea: National Insurance Service Survey 2007 –2014
Conclusions:Uvulopalatopharyngoplasty may have a preventive effect on dementia in patients with OSA.Citation:Cho JH, Suh JD, Han KD, Jung JH, Lee HM. Uvulopalatopharyngoplasty may reduce the incidence of dementia caused by obstructive sleep apnea: National Insurance Service Survey 2007–2014.J Clin Sleep Med. 2018;14(10):1749–1755. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Validating the Watch-PAT for Diagnosing Obstructive Sleep Apnea in Adolescents
We examined the correlation, agreement, and concordance in the apnea-hypopnea index (AHI) and minimum arterial oxygen saturation (mSaO2) between the WP200 and PSG-RRC or PSG-RRA.Results:There were high correlations (r = .945,P
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Sleep Architecture Changed Without RBD in Patients With FTDP-17
Conclusions:In FTDP-17, striatum and brainstem are the pathological lesions, which may be involved in the pathophysiology of the alterations in sleep architecture. The concrete mechanisms need further investigation.Citation:Liu J, Zhan S, Huang C, Liu Y, Liu L, Wu L, Wang Y. Sleep architecture changed without RBD in patients with FTDP-17.J Clin Sleep Med. 2018;14(10):1735–1739. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Prevalence of Sleep Disorders in Adults With Down Syndrome: A Comparative Study of Self-Reported, Actigraphic, and Polysomnographic Findings
Study Objectives:Sleep problems are often undetected in adults with Down syndrome (DS). Our objective was to determine the prevalence of sleep disorders in adults with DS through self-reported and objective sleep measures.Methods:We performed a community-based cross-sectional study of 54 adults with DS not referred for sleep disorders. Two polysomnography (PSG) sleep studies were performed. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI); daytime sleepiness was evaluated using the Epworth Sleepiness Scale (ESS) and the risk for the sleep apnea syndrome (OSA) was identified using the Berlin Quest...
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Accuracy and Reliability of Internet Resources Providing Information on Obstructive Sleep Apnea
Conclusions:Our findings suggest that most online health resources regarding OSA are not reliable and are inaccurate. Health care providers should be aware of the high variability in online information concerning OSA.Commentary:A commentary on this article appears in this issue on page 1643.Citation:Lee J, Ban WH, Park HK, Na E, Kim SK, Kang HH, Lee SH. Accuracy and reliability of internet resources providing information on obstructive sleep apnea.J Clin Sleep Med. 2018;14(10):1717–1723. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Physical Activity Following Positive Airway Pressure Treatment in Adults With and Without Obesity and With Moderate-Severe Obstructive Sleep Apnea
Conclusions:Compared to study participants without obesity and with OSA, participants with obesity and OSA had reduced PA at baseline. PA increased significantly in participants without obesity, with OSA, and who were adherent to PAP treatment. Results indicate that treatment of OSA is unlikely to be associated with a change in PA in adults with obesity and OSA and help explain the absence of weight loss following PAP treatment in adults with OSA.Clinical Trial Registration:Registry: ClinicalTrials.gov, title: The Effects of Treating Obese and Lean Patients With Sleep Apnea (PISA), identifier: NCT01578031, URL:https://clin...
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Randomized Controlled Trial of Melatonin for Sleep Disturbance in Dravet Syndrome: The DREAMS Study
Study Objectives:Dravet syndrome is a severe developmental and epileptic encephalopathy, in which 75% of patients have sleep disturbance. Melatonin is often used for sleep problems in childhood; however, there is no quality evidence supporting its use in Dravet syndrome. We hypothesized that melatonin would increase total sleep and quality of life for patients with Dravet syndrome.Methods:A double-blind crossover randomized placebo-controlled trial was conducted, comparing 6 mg regular-release melatonin to placebo for patients with Dravet syndrome and sleep disturbance. The primary outcome measure was total sleep measured ...
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Insufficient Sleep Duration Is Associated With Dietary Habits, Screen Time, and Obesity in Children
Study Objectives:To examine sleep duration and the association between insufficient sleep duration and life- style factors in a representative sample of Greek children and adolescents.Methods:Population data derived from a school-based health survey carried out in spring 2015 on 177,091 children (51% male) aged 8 to 17 years (participation rate was approximately 40% of the total population). Dietary habits, sleeping hours (weekdays and weekend), physical activity status, and sedentary activities were assessed through electronic questionnaires completed at school with assistance of teachers. Anthropometric and physical fitn...
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Defining the Core Components of a Clinical Review of People Using Continuous Positive Airway Pressure Therapy to Treat Obstructive Sleep Apnea: An International e-Delphi Study
Conclusions:We mapped 17 prioritized components to a suggested template that may support clinical reviews. Reviews should be flexible, frequently in the early stages of commencing CPAP, shifting to“on demand” and/or remote follow-up for maintenance. Our findings may inform future guideline recommendations for reviewing CPAP users.Citation:Murphie P, Little S, Paton R, McKinstry B, Pinnock H. Defining the core components of a clinical review of people using continuous positive airway pressure therapy to treat obstructive sleep apnea: an international e-Delphi study.J Clin Sleep Med. 2018;14(10):1679–1687. ...
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Use of Sedative-Hypnotics and Mortality: A Population-Based Retrospective Cohort Study
Conclusions:Based on the current study results, sedative-hypnotics were associated with an increased risk of mortality, especially in study participants who used zolpidem.Citation:Choi JW, Lee J, Jung SJ, Shin A, Lee YJ. Use of sedative-hypnotics and mortality: a population-based retrospective cohort study.J Clin Sleep Med. 2018;14(10):1669–1677. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Breathing Irregularity Is Independently Associated With the Severity of Obstructive Sleep Apnea in Patients With Multiple System Atrophy
Study Objectives:Multiple system atrophy (MSA) is a neurodegenerative disease characterized by the combination of cerebellar ataxia, parkinsonism, and autonomic disturbance. Patients with MSA frequently have sleep-disordered breathing. In some patients with MSA, central sleep apnea manifests during the disease's natural course or as a treatment effect. Breathing instability may be involved in the development of obstructive sleep apnea (OSA); therefore, we investigated whether breathing instability affects the severity of OSA in patients with MSA.Methods:Patients with MSA and a control group of individuals who were matched ...
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Effects of Increased Pharyngeal Tissue Mass Due to Fluid Accumulation in the Neck on the Acoustic Features of Snoring Sounds in Men
Conclusions:These results suggest that snoring spectral centroid can be used as a noninvasive and convenient method to assess variations in the pharyngeal tissue mass.Citation:Saha S, Moussavi Z, Hadi P, Bradley TD, Yadollahi A. Effects of increased pharyngeal tissue mass due to fluid accumulation in the neck on the acoustic features of snoring sounds in men.J Clin Sleep Med. 2018;14(10):1653–1660. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

The Effect of Sleeping Environment and Sleeping Location Change on Positive Airway Pressure Adherence
Conclusions:Frequent change in sleeping location is associated with reduced PAP adherence, independent of sociodemographic factors. This novel finding has implications for physician-patient dialogue. PAP portability considerations in device selection and design may modify adherence and potentially improve treatment outcomes. Prospective investigation is needed to confirm this finding and inform design of possible interventions.Citation:Liou HY, Kapur VK, Consens F, Billings ME. The effect of sleeping environment and sleeping location change on positive airway pressure adherence.J Clin Sleep Med. 2018;14(10):1645–1652...
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

The Internet: Sleep On It
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Sleep-Disordered Breathing in Multiple System Atrophy: Pathophysiology and New Insights for Diagnosis and Treatment
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 12, 2018 Category: Sleep Medicine Source Type: research

Dissociative Identity Disorder and Obstructive Sleep Apnea
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research

Obstructive Sleep Apnea Severity in Dissociative Identity Disorder can Vary Significantly Depending Upon the Autonomic Activation Status of the Personality That Has Executive Control
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research

Asthma Exacerbation in the Spouse of a Patient With Obstructive Sleep Apnea
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research

An Unusual Cause of Obstructive Sleep Apnea in a Man With Spinal Muscular Atrophy Type III
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research

Pseudo Status Cataplecticus in Narcolepsy Type 1
We describe a young adult with known narcolepsy type 1 who reported a marked exacerbation of her symptoms that was initially suspicious forstatus cataplecticus. Neurological evaluation, polysomnography, and additional history revealed that the spells were not consistent with cataplexy, but rather with a somatoform disorder. The case highlights the importance of considering psychosomatic factors in narcolepsy type 1 when presumed cataplexy remains suboptimally controlled despite adequate dosing with appropriate medications.Citation:Meinen CN, Smith KM, Tillema JM, Kotagal S. Pseudostatus cataplecticus in narcolepsy type 1.J...
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research

Sleep-Related Rhythmic Sound From the Vocal Cords: A Possible Atypical Form of NREM Parasomnia
Sleep-related noises may have different features and etiologies. Here we report an atypical case of an adolescent with episodes of“sleep-related vocalization” occurring every night, especially during the first part of the night. The patient had moderate mental retardation and a dysfunctional dysphonia; she had no recollection of the episodes and complained exclusively of mild excessive daytime sleepiness. A video polysomnography recording documented two typical manifestations during non-rapid eye movement (NREM) sleep, characterized by the persistence of slow waves and without any electroencephalographic or bre...
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research

Digital Health and Sleep-Disordered Breathing: A Systematic Review and Meta-Analysis
Conclusions:This study evidenced the limitations and potential use of portable devices in screening patients for SDB. Additional research should evaluate the accuracy of devices when used at home.Citation:Rosa T, Bellardi K, Viana A Jr, Ma Y, Capasso R. Digital health and sleep-disordered breathing: a systematic review and meta-analysis.J Clin Sleep Med. 2018;14(9):1605–1620. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research

Gray Matter Changes Following Cognitive Behavioral Therapy for Patients With Comorbid Fibromyalgia and Insomnia: A Pilot Study
We examined the effect of cognitive behavioral therapy for insomnia (CBT-I) and pain (CBT-P) on cortical thickness.Methods:Patients with fibromyalgia and insomnia underwent MRI before and after random assignment to CBT-I (n = 14), CBT-P (n = 16), or waitlist control (WLC; n = 7).Results:Repeated-measures analyses of variance revealed significant interactions for two regions (left lateral orbitofrontal cortex, left rostral middle frontal,Ps
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research

Total Sleep Time Interacts With Age to Predict Cognitive Performance Among Adults
Conclusions:These results extend existing data on sleep duration and cognition across the lifespan by combining in a single study the results from four specific cognitive tests, both younger and older adults, and four self-reported risk factors for cognitive impairment. Longitudinal studies with biomarkers should be undertaken to determine whether causal mechanisms, such as inflammation or amyloid buildup, account for these associations.Citation:Mohlenhoff BS, Insel PS, Mackin RS, Neylan TC, Flenniken D, Nosheny R, Richards A, Maruff P, Weiner MW. Total sleep time interacts with age to predict cognitive performance among a...
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research

Detailed Polysomnography in Australian Vietnam Veterans With and Without Posttraumatic Stress Disorder
This study aimed to objectively assess the prevalence of sleep disorders in the same cohort using detailed polysomnography (PSG).Methods:Participants from the PTSD Initiative were recruited to undergo PSG. PTSD status was determined with the Clinician Administered PTSD Scale for DSM-5 (CAPS-5). Subjective sleep information was attained via structured questionnaires. Data from single night PSG were compared between trauma-exposed VV with and without PTSD.Results:A total of 74 trauma-exposed male VV (40 with PTSD) underwent PSG (prospective n = 59, retrospective n = 15). All PSG parameters were similar between groups. No dif...
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research

Respiratory-Related Leg Movements of Sleep Are Associated With Serotonergic Antidepressants But Not Bupropion
Conclusions:The greater number of RRLMs and PLMs in the SSRI group may contribute to treatment-emergent insomnia often seen with SSRI use. Fragmented sleep and elevated autonomic nervous system activation associated with increased RRLMs in patients with OSA taking SSRIs might also limit the tolerability of antidepressant treatment, as well as increase the risk for cardiovascular disease.Citation:McCall CA, Winkelman JW. Respiratory-related leg movements of sleep are associated with serotonergic antidepressants but not bupropion.J Clin Sleep Med. 2018;14(9):1569–1576. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research

Pediatric Obstructive Sleep Apnea is Associated With Changes in the Oral Microbiome and Urinary Metabolomics Profile: A Pilot Study
Conclusions:High-throughput sequencing revealed that the oral microbiome composition and function were significantly altered in pediatric OSA. Further studies are needed to confirm and determine the mechanisms underlying these findings.Citation:Xu H, Li X, Zheng X, Xia Y, Fu Y, Li X, Qian Y, Zou J, Zhao A, Guan J, Gu M, Yi H, Jia W, Yin S. Pediatric obstructive sleep apnea is associated with changes in the oral microbiome and urinary metabolomics profile: a pilot study.J Clin Sleep Med. 2018;14(9):1559–1567. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research

Sleep-Disordered Breathing is Associated With Increased Mortality in Hospitalized Infants With Congenital Heart Disease
Study Objectives:Sleep-disordered breathing (SDB) has adverse cardiovascular effects in children and adults. In adults with cardiac disease, SDB is highly prevalent and confers increased mortality risk. It is unknown if SDB confers a similar risk in infants with congenital heart disease (CHD). We evaluated clinical and economic outcomes associated with SDB among inpatient infants with CHD in the United States from 1997–2012.Methods:This retrospective, cross-sectional study used discharge data from the Kids' Inpatient Database. Inclusion criteria included diagnosed CHD and age younger than 1 year. Exclusion criteria i...
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research

The Association Between Adherence to Positive Airway Pressure Therapy and Long-Term Outcomes in Patients With Obesity Hypoventilation Syndrome: A Prospective Observational Study
Study Objectives:To assess the role of different levels of adherence and long-term effects of positive airway pressure (PAP) therapy on gas exchange, sleepiness, quality of life, depressive symptoms, and all-cause mortality in patients with obesity hypoventilation syndrome (OHS).Methods:A total of 252 patients with newly diagnosed OHS were followed up for a minimum of 2 years after PAP initiation. PAP adherence (h/night) was monitored. Arterial blood gas samples were taken with patients being alert for more than 4 hours after morning awakening. Subjective daytime sleepiness (Epworth Sleepiness Scale [ESS]), quality of life...
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research

Insomnia and Regulation of Sleep-Wake Cycle With Drugs Among Adolescent Risky Drinkers
Study Objectives:We aimed to explore symptoms of insomnia in a group of youths characterized as engaging in risky drinking, their use of drugs as sleep/ wake aids, and the relationships between alcohol and other drug use and insomnia.Methods:Face-to-face interviews were conducted with 596 Australian 14 to 19-year-olds identified as engaging in regular risky drinking. They completed the Insomnia Severity Index and were assessed for recent alcohol and other drug use, including drugs used specifically as sleep aids or to stay awake. Alcohol-related problems, emotional distress, self-control, and working outside of traditional...
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research

Gout and the Risk of Incident Obstructive Sleep Apnea in Adults 65 Years or Older: An Observational Study
Conclusions:The independent association of gout with a twofold higher risk of OSA in older adults indicates that common mechanisms may be shared by the two conditions. More studies are needed to investigate these mechanisms further.Citation:Singh JA, Cleveland JD. Gout and the risk of incident obstructive sleep apnea in adults 65 years or older: an observational study.J Clin Sleep Med. 2018;14(9):1521–1527. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - September 14, 2018 Category: Sleep Medicine Source Type: research