Circadian misalignment proxies, BMI, and chronic conditions: the role for weekday to weekend sleep differences
ConclusionsOur findings, which demonstrate that even a slight weekend sleep extension and variability of just 1 h is associated with higher values of BMI, suggest incorporating measures for sleep consistency and regularity into clinical protocols and public health guidelines to prevent and treat obesity and related diseases. (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 16, 2024 Category: Respiratory Medicine Source Type: research
Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants
SARS-CoV-2 infection of the upper airway and the subsequent immune response are early, critical factors in COVID-19 pathogenesis. By studying infection of human biopsies in vitro and in a hamster model in vivo, we demonstrated a transition in nasal tropism from olfactory to respiratory epithelium as the virus evolved. Analyzing each variant revealed that SARS-CoV-2 WA1 or Delta infect a proportion of olfactory neurons in addition to the primary target sustentacular cells. The Delta variant possessed broader cellular invasion capacity into the submucosa, while Omicron displayed enhanced nasal respiratory infection and longe...
Source: Journal of Clinical Investigation - April 15, 2024 Category: Biomedical Science Authors: Mengfei Chen, Andrew Pekosz, Jason S. Villano, Wenjuan Shen, Ruifeng Zhou, Heather Kulaga, Zhexuan Li, Amy Smith, Asiana Gurung, Sarah E. Beck, Kenneth W. Witwer, Joseph L. Mankowski, Murugappan Ramanathan Jr, Nicholas R. Rowan, Andrew P. Lane Source Type: research
People with complicated pregnancies may suffer health problems, die early
Preterm births are a well-known hazard for babies—who can require months and sometimes years of extra care—but far less attention is paid to the people who deliver them. Now, a new analysis of more than 2 million pregnancies over 4 decades finds those parents need consideration, too: Even years later, people who experienced some common pregnancy complications had a higher risk of death.
“We are starting to understand that pregnancy complications … are windows into longer term complications,” says Cynthia Gyamfi-Bannerman, a maternal fetal medicine specialist at the University of California San Diego who was...
Source: Science of Aging Knowledge Environment - April 15, 2024 Category: Geriatrics Source Type: research
COVID-19 presenting with nystagmus
Arch Soc Esp Oftalmol. 2021 Apr;96(4):224-226. doi: 10.1016/j.oftal.2020.09.008. Epub 2020 Nov 6.ABSTRACTThis case reports a 20-year-old female patient who was in northern Italy when the state of emergency was declared on the 31st of January 2020, developing 15 days after return to Spain upper respiratory symptoms characterized by fever, headache and anosmia that was treated as sinusitis. Three weeks later presented with dizziness and an intermittent horizontal nystagmus with rotatory component. Otorhinolaryngology and neurological examination including MRI were normal. COVID-19 IgG antibodies where positive. In the contex...
Source: Archivos de la Sociedad Espanola de Oftalmologia - April 15, 2024 Category: Opthalmology Authors: E Garc ía-Romo R Blanco C Nicholls A Hern ández-Tejero B Fern ández-de-Arévalo Source Type: research
Traffic-related air pollution in marginalized neighborhoods: a community perspective
CONCLUSIONS: Guided by the perspectives of NYC community scientists, this contemporary review of toxicological and epidemiological studies considers how the exposome could lead to disproportionate exposures and health effects in underserved populations.PMID:38618680 | DOI:10.1080/08958378.2024.2331259 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - April 15, 2024 Category: Respiratory Medicine Authors: Rahanna N Khan Antonio F Saporito Jania Zenon Lael Goodman Judith T Zelikoff Source Type: research
