Comparing the efficacy and safety of formoterol/budesonide pMDI versus its mono-components and other LABA/ICS in patients with asthma
Pressurised metered dose inhalers (pMDIs) are effective drug delivery devices prescribed in obstructive airway diseases due to their convenience, portability, ease of enabling multiple doses in a single formulation, and storage in any orientation. For the management of asthma, the fixed-dose combination of a long-acting β2-agonist (LABA) and an inhaled corticosteroid (ICS) has been recommended by Global Initiative for Asthma guideline as a preferred treatment option for patients who are uncontrolled with only ICS doses. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 1, 2020 Category: Respiratory Medicine Authors: Aniruddha Mukhopadhyay, Mirna Waked, Jaideep Gogtay, Vaibhav Gaur Tags: Review article Source Type: research

Asthma rehabilitation at high vs. low altitude and its impact on exhaled nitric oxide and sensitization patterns: Randomized parallel-group trial
Allergens and pollution are reduced at high altitude. We investigated the effect of asthma rehabilitation at high altitude (HA, 3100  m) compared to low altitude (LA, 760 m) on exhaled nitric oxide (FeNO) and on specific IgE levels for house dust mites (HDM,d1) and common pollen (sx1). (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 30, 2020 Category: Respiratory Medicine Authors: Lisa Basler, St éphanie Saxer, Simon R. Schneider, Mona Lichtblau, Patrick R. Bader, Paula Appenzeller, Bermet Estebesova, Berik Emilov, Talant Sooronbaev, Carole Guillet, Peter Schmid-Grendelmeier, Konrad E. Bloch, Silvia Ulrich Source Type: research

Compliance in subcutaneous and sublingual allergen immunotherapy: A nationwide study
Allergic rhino-conjunctivitis is a highly prevalent condition. In moderate to severe cases, allergen immunotherapy (AIT) is a cost-effective therapeutic option. Previous data have reported a large difference in treatment compliance of subcutaneously (SCIT) and sublingually (SLIT) administered AIT. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 29, 2020 Category: Respiratory Medicine Authors: Morten Borg, Anders L økke, Ole Hilberg Source Type: research

Fixed-dose combination of indacaterol/glycopyrronium/mometasone furoate once-daily versus salmeterol/fluticasone twice-daily plus tiotropium once-daily in patients with uncontrolled asthma: A randomised, Phase IIIb, non-inferiority study (ARGON)
The efficacy and safety of once-daily (o.d.) fixed-dose combination of indacaterol (IND), glycopyrronium (GLY) and mometasone furoate (MF) via Breezhaler ® versus concurrent administration of salmeterol/fluticasone (SAL/FLU) twice-daily (b.i.d.) via Accuhaler®+Tiotropium (TIO) o.d. via Respimat® was evaluated in patients with uncontrolled asthma. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 26, 2020 Category: Respiratory Medicine Authors: Christian Gessner, Oliver Kornmann, Jorge Maspero, Richard van Zyl-Smit, Matthias Kr üll, Anna Salina, Pritam Gupta, Sebastien Bostel, Sebastian Fucile, Lorena Garcia Conde, Pascal Pfister Source Type: research

Usefulness of routine blood test-driven clusters for predicting acute exacerbation in patients with asthma
In this study we aimed to investigate whether routine blood test results predicted AE in asthmatics. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 26, 2020 Category: Respiratory Medicine Authors: Ji Hyun Oh, Kyung-Min Ahn, Soo Jie Chung, Ji-Su Shim, Heung-Woo Park Source Type: research

Hypersensitivity to dipyrone in aspirin-exacerbated respiratory disease patients is associated with urticaria
To phenotype patients with aspirin-exacerbated respiratory disease (AERD) according to the presence of atopy, urticaria and level of peripheral eosinophils. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 26, 2020 Category: Respiratory Medicine Authors: Rosana C âmara Agondi, Gabriella Melo Fontes Silva Dias, Joāo Paulo de Assis, Rosilane Pacheco, Jorge Kalil, Pedro Giavina-Bianchi Source Type: research

Use of corticosteroids in asthma and COPD patients with or without COVID-19
The potential detrimental effects of steroids on the immune system to fight viral infections had always been a concern for patients on long term steroids in chronic conditions. A recent warning from WHO on systemic corticosteroid use amid COVID-19 raised suspicion among public and healthcare professionals regarding the safety of steroid use during the SARS-CoV-2 pandemic. The corticosteroids (inhaled and oral) are commonly prescribed in the management of asthma and COPD patients and any unsolicited changes in medications use may lead to potentially severe exacerbations and risk patient lives. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 26, 2020 Category: Respiratory Medicine Authors: Syed Shahzad Hasan, Toby Capstick, Syed Tabish Razi Zaidi, Chia Siang Kow, Hamid A. Merchant Tags: Review article Source Type: research

New opacities in lung allograft after transbronchial cryobiopsy
The occurrence of radiological opacities post-transbronchial cryobiopsy may pose serious difficulties in differential diagnosis and management of lung allografts. This prospective study evaluated the frequency, characteristics, and evolution of new lung opacities after performing transbronchial cryobiopsy. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 25, 2020 Category: Respiratory Medicine Authors: Karina Loor, Esther Pallisa, Mario Culebras, Maria Deu, Antonio Álvarez, Irene Sansano, Cristina Berastegui, David Clofent, Eva Polverino, Javier de Gracia Source Type: research

Safe extubation during the COVID-19 pandemic
Extubation of patients with Coronavirus Disease 2019 (COVID-19) is a high risk procedure for both patients and staff. Shortages in personal protective equipment (PPE) and the high volume of contact staff have with COVID-19 patients has generated an interest in ways to reduce exposure that might be feasible especially during pandemic times and in resource limited healthcare settings. The development of portable barrier hood devices (or intubation/extubation boxes) is an area of interest for many clinicians due to the theoretical reduction in aerosolization of SARS-CoV-2, the causative virus for COVID-19. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 22, 2020 Category: Respiratory Medicine Authors: Aaron W. Kangas-Dick, Bruce Swearingen, Elias Wan, Kabu Chawla, Ory Wiesel Tags: Short review Source Type: research

Bronchial wall thickening is associated with severity of chronic rhinosinusitis
Though the relationship between chronic rhinosinusitis (CRS) and lower airway diseases is well recognized, the impact of CRS on bronchial wall structure has not been elucidated. Here, we evaluated the bronchial wall structure of CRS patients with or without diagnosed airway diseases by three-dimensional computed tomography (3D-CT). (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 22, 2020 Category: Respiratory Medicine Authors: Suguru Majima, Keiko Wakahara, Tomoko Nishio, Naoki Nishio, Masaaki Teranishi, Shingo Iwano, Akihiro Hirakawa, Naozumi Hashimoto, Michihiko Sone, Yoshinori Hasegawa Tags: Clinical Trial Paper Source Type: research

Chest X-ray features of SARS-CoV-2 in the emergency department: A multicenter experience from north Italy hospitals
To evaluate the imaging features of routine admission chest X-ray in patients referred for novel Coronavirus 2019 infection. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 22, 2020 Category: Respiratory Medicine Authors: Davide Ippolito, Cesare Maino, Anna Pecorelli, Pietro Allegranza, Cecilia Cangiotti, Carlo Capodaglio, Ilaria Mariani, Teresa Giandola, Davide Gandola, Ilaria Bianco, Maria Ragusi, Cammillo Talei Franzesi, Rocco Corso, Sandro Sironi Source Type: research

Diffusing capacity in normal-for-age spirometry and spirometric impairments, using reference equations from the global lung function initiative
Reference equations from the Global Lung Function Initiative (GLI) are now available for both spirometry and diffusion. However, respiratory phenotypes defined by GLI-based measures of diffusion have not yet been evaluated in GLI-based normal-for-age spirometry or spirometric impairments. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 21, 2020 Category: Respiratory Medicine Authors: Carlos A. Vaz Fragoso, Carolyn L. Rochester, Gail J. McAvay, Lynne Iannone, Linda S. Leo-Summers Source Type: research

Characterising the role of small airways in severe asthma using low frequency forced oscillations: A combined computational and clinical approach
Within asthma, the small airways ( ≤2 mm in diameter) play an important role in pathophysiology. Using a combined clinical-computational approach, we sought to more precisely evaluate the contribution of the small airways to deep-breath induced airway dilation (in the absence of bronchial challenge), which may be impaired in seve re asthma. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 18, 2020 Category: Respiratory Medicine Authors: Brody H. Foy, Sushiladevi Natarajan, Arham Munawar, Marcia Soares, James Thorpe, John Owers-Bradley, Salman Siddiqui Source Type: research

Ultra-low dose rituximab as add-on therapy in anti-MDA5-positive patients with polymyositis /dermatomyositis associated ILD
To evaluate the efficacy and safety of ultra-low dose (100  mg) rituximab (RTX) administration in anti-melanoma differentiation-associated gene 5 (MDA5) positive patients with polymyositis/dermatomyositis (PM/DM) associated interstitial lung disease. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 15, 2020 Category: Respiratory Medicine Authors: Meng-meng Mao, Shu Xia, Bing-peng Guo, Wei-ping Qian, Ze-xuan Zheng, Xiao-min Peng, Rong-chang Chen, Qun Luo, Qian Han Source Type: research

Prevalence of viral respiratory infections amongst asthmatics: Results of a meta-regression analysis
Viral respiratory infections (VRI) can act as triggers for acute asthma exacerbations and contribute significantly to asthma-related healthcare costs. Knowing the patterns of viruses amongst asthmatics can be useful in treating and preventing these exacerbations and help decrease the burden they impose on patients and healthcare systems. We aimed to quantify the viral prevalence in asthmatics presenting with exacerbations and identify influencing factors. A meta-analysis with a systematic search was conducted. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 15, 2020 Category: Respiratory Medicine Authors: J.J. Feddema, E. Claassen Tags: Review article Source Type: research

Volatile organic compounds associated with diagnosis and disease characteristics in asthma – A systematic review
Metabolomics refers to study of the metabolome, the entire set of metabolites produced by a biological system. The application of metabolomics to exhaled breath samples - breathomics - is a rapidly growing field with potential application to asthma diagnosis and management. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 15, 2020 Category: Respiratory Medicine Authors: Adam M. Peel, Maxim Wilkinson, Ashnish Sinha, Yoon K. Loke, Stephen J. Fowler, Andrew M. Wilson Tags: Review article Source Type: research

Non-response did not affect prevalence estimates of asthma and respiratory symptoms - results from a postal questionnaire survey of the general population
A high participation rate is warranted in order to ensure validity in surveys of the general population. However, participation rates in such studies have declined during the last decades. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 15, 2020 Category: Respiratory Medicine Authors: P. R äisänen, L. Hedman, M. Andersson, C. Stridsman, A. Lindberg, B. Lundbäck, E. Rönmark, H. Backman Source Type: research

Are there differences in muscular activation to maintain balance between individuals with chronic obstructive pulmonary disease and controls?
The mechanisms underlying impaired balance in chronic obstructive pulmonary disease (COPD) are poorly understood, which makes it difficult to choose the best therapeutic approaches. Therefore, this study aimed to investigate patters of muscular activation to maintain balance and its determinants in this population. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 14, 2020 Category: Respiratory Medicine Authors: Larissa A. de Castro, Andrea A. Morita, Walter A.S. Loyola, Rubens A. da Silva, Fabio Pitta, Eddy Krueger, Vanessa S. Probst Source Type: research

Clinical features and outcomes of asymptomatic pulmonary sarcoidosis. A comparative cohort study
To evaluate the clinical characteristics and outcomes of patients with asymptomatic pulmonary sarcoidosis (APS) detected incidentally and compare them with symptomatic non-L öfgren sarcoidosis (SnLS) patients. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 14, 2020 Category: Respiratory Medicine Authors: Adriana Iriarte, Manuel Rubio-Rivas, Nadia Villalba, Xavier Corbella, Juan Ma ñá Source Type: research

Macrolide resistant Mycobacterium avium complex pulmonary disease following clarithromycin and ethambutol combination therapy
Whether two-drug therapy (clarithromycin and ethambutol) for Mycobacterium avium complex (MAC) pulmonary disease contributes to the development of macrolide-resistant MAC is unclear. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 14, 2020 Category: Respiratory Medicine Authors: Yasuhiro Ito, Seiichi Miwa, Masahiro Shirai, Miho Kanai, Kaoru Fujita, Hisano Ohba, Eriko Iwaizumi, Tomoko Oshima, Suguru Kojima, Takafumi Suda, Hiroshi Hayakawa Source Type: research

Non-optimal methodology questions indirect treatment comparison of dupilumab vs. other biologics in severe asthma
We read with interest the article by Bateman E et al. [1] that attempted to evaluate the relative efficacies of dupilumab vs. benralizumab, mepolizumab, omalizumab, and reslizumab through an indirect treatment comparison (ITC). After careful review, we have concluded the methodology and results lack scientific robustness and credibility because individual trial and patient differences were not considered. Therefore, the conclusions drawn by the authors that “dupilumab was associated with statistically significantly lower annualized severe asthma exacerbation rates compared with benralizumab, mepolizumab, and reslizum...
Source: Respiratory Medicine - May 14, 2020 Category: Respiratory Medicine Authors: Arnaud Bourdin, Nicolas Molinari Tags: Correspondence Source Type: research

D-dimer in patients infected with COVID-19 and suspected pulmonary embolism
To analyze the risk factors for pulmonary embolism (PE) in patients infected with COVID-19. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 13, 2020 Category: Respiratory Medicine Authors: Ignasi Garcia-Oliv é, Helena Sintes, Joaquim Radua, Jorge Abad Capa, Antoni Rosell Tags: Short communication Source Type: research

A study on infectivity of asymptomatic SARS-CoV-2 carriers
We report here a case of the asymptomatic patient and present clinical characteristics of 455 contacts, which aims to study the infectivity of asymptomatic carriers. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 13, 2020 Category: Respiratory Medicine Authors: Ming Gao, Lihui Yang, Xuefu Chen, Yiyu Deng, Shifang Yang, Hanyi Xu, Zixing Chen, Xinglin Gao Source Type: research

Medication of comorbidities in females with sleep-disordered breathing during long-term CPAP therapy
Treating sleep disordered breathing (SDB) with nasal continuous positive airway pressure (CPAP) may reduce mortality, but the studies on the effect on medication use are few. Women tend to have more mild sleep apnoea and partial airway obstruction and are therefore expected to have less co-morbidity. The purpose of this study was to evaluate the effect of CPAP therapy on medication use in women as overall medication, and in different subcategories of diseases, and to evaluate the impact of nocturnal airway obstruction type as partial or complete. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 12, 2020 Category: Respiratory Medicine Authors: Miia Aro, Tarja Saaresranta, Tero Vahlberg, Ulla Anttalainen Source Type: research

Pneumocystis pneumonia after lung transplantation: A retrospective multicenter study
Lung transplantation (LT) is an identified risk factor for Pneumocystis pneumonia (PCP). However, PCP management and outcomes remain poorly described in LT recipients and PCP incidence is rarely documented in this population. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 12, 2020 Category: Respiratory Medicine Authors: Agathe Delbove, Hakim Alami, Adrien Tissot, Tristan D égot, Renan Liberge, Jean-François Mornex, Marlène Murris, Claire Dromer, Johanna Claustre, Véronique Boussaud, Olivier Brugière, Jérôme Le Pavec, Aymeric Nicolas, Isabelle Danner-Boucher, Antoi Source Type: research

Predictors of mortality in fibrosing pulmonary sarcoidosis
This study was aimed to explore the prognosis value of a panel of parameters for predicting mortality. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 11, 2020 Category: Respiratory Medicine Authors: Florence Jeny, Yurdag ül Uzunhan, Maxime Lacroix, Thomas Gille, Pierre-Yves Brillet, Annelyse Nardi, Diane Bouvry, Carole Planes, Hilario Nunes, Dominique Valeyre Source Type: research

Comparability of asthma control test scores between self and physician-administered test
The Asthma Control Test (ACT) is a tool that allows physicians to estimate the control of asthma symptoms on each patient in a quick way. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 11, 2020 Category: Respiratory Medicine Authors: Claudia Crimi, Raffaele Campisi, Alberto Noto, Sabrina Genco, Giulia Cacopardo, Santi Nolasco, Nunzio Crimi Source Type: research

Should we consider paranasal and chest computed tomography in severe asthma patients?
It is essential to recognize and treat findings that can simulate or worsen symptoms to improve asthma control and thereby to reduce costs. Guidelines highlight a paranasal (PS) and chest computed tomography (CT) scan as a tool for disease evaluation and, although they suggest its indication in patients whom presentation is atypical, there are not well-defined criteria. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 10, 2020 Category: Respiratory Medicine Authors: E. Zamarron, D. Romero, J. Fern ández-Lahera, C. Villasante, I. Pinilla, P. Barranco, J. Dominguez-Ortega, R. Álvarez-Sala Walther R Source Type: research

Susceptibility to frequent exacerbation in COPD patients: Impact of the exacerbations history, vaccinations and comorbidities?
Exacerbations are key events in the natural history of COPD, but our understanding of their longitudinal determinants remains unclear. We used data from a large observational study to test the hypothesis that vaccination status and comorbidities could be associated with the occurrence of exacerbations profile. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 10, 2020 Category: Respiratory Medicine Authors: El Hassane Ouaalaya, Laurent Falque, Jean Michel Dupis, Marielle Sabatini, Alain Bernady, Laurent Nguyen, Annaig Ozier, C écilia Nocent-Ejnaini, Frédéric Le Guillou, Mathieu Molimard, Maéva Zysman, Chantal Raherison-Semjen Source Type: research

Focus on the pulmonary involvement and genetic patterns in Birt-Hogg-Dub è syndrome: Literature review
Brit-Hogg-Dub é syndrome (BHD) is a rare disorder that is estimated to affects about 600 families in the World. The disease-causing mutations is on FLCN gene which codes for folliculin. This protein has a role in different organs as skin, kidney and lung, thanks to the interaction with type I and II cadherins, R hoA activity and the regulation of AMPK, mTORC1 pathways and cell adhesion.The aim of our study is to focus on the manifestation of the syndrome, especially the pulmonary involvement, then on genetical analysis and on the available treatments. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 6, 2020 Category: Respiratory Medicine Authors: Valentina Marziali, Georgeos Geropoulos, Luca Frasca, Filippo Longo, Davide Patrini, Nikolaos Panagiotopoulos, Pierfilippo Crucitti Tags: Review article Source Type: research

Diagnoses and management of adult cough: An Indian Environmental Medical Association (EMA) position paper
Cough is a common yet distressing symptom that results in significant health care costs from outpatient visits and related consultations. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 5, 2020 Category: Respiratory Medicine Authors: Shankar PS, Krishnaprasad K, Bendre S, Behera D, Mirchandani L, Awad NT, Prasad R, Bhargava S, Sharma OP, Jindal SK Tags: Review article Source Type: research

Easy measurement of health related quality of life in patients with cystic fibrosis by the COPD assessment test (CAT) - A pilot study
Quality of life (QOL) is an important patient-related outcome (PRO) in patients with cystic fibrosis (CF). There are several QOL questionnaires like the “Cystic Fibrosis Questionnaire Revised” (CFQ-R) or the “St George's Respiratory Questionnaire” (SGRQ) that are well validated in CF. The aim of the study was to evaluate whether the easily applicable “COPD assessment test” (CAT) can be used in CF patients. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 30, 2020 Category: Respiratory Medicine Authors: Julian Pott, Angelika Krill, Heinrike Wilkens, Robert Bals Source Type: research

BPI-ANCA is expressed in the airways of cystic fibrosis patients and correlates to platelet numbers and Pseudomonas aeruginosa colonization
Autoantibodies to bactericidal/permeability-increasing protein (BPI), BPI-ANCA, are often present in serum of patients with cystic fibrosis (CF), and correlate to airway colonization with Pseudomonas aeruginosa. The aim of the study was to investigate if BPI-ANCA IgA is also present in the airways of CF patients, and if its presence correlates with neutrophil counts, platelets, and P. aeruginosa DNA in sputum. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 30, 2020 Category: Respiratory Medicine Authors: Gisela Hovold, Ulrika Lindberg, Johanna Ljungberg, Oonagh Shannon, Lisa I. P åhlman Source Type: research

Pairwise indirect treatment comparison of dupilumab versus other biologics in patients with uncontrolled persistent asthma
Currently, five biologic treatment options are available for use in patients with uncontrolled persistent asthma: three interleukin (IL)-5 antagonists, which either bind to the anti-IL-5 ligand (mepolizumab, reslizumab) or to the IL-5 receptor (benralizumab);one anti-immunoglobulin E (anti-IgE) therapy (omalizumab); and one anti-IL-4/IL-13 therapy (dupilumab). To date, no comparative data from head-to-head clinical trials are available for these biologics. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 29, 2020 Category: Respiratory Medicine Authors: Eric D. Bateman, Asif H. Khan, Yingxin Xu, Patricia Guyot, Jingdong Chao, Siddhesh Kamat, Paul Rowe, Heather Burnett, Jerome Msihid, David Weinreich, Ian D. Pavord Source Type: research

Uncommon thoracic manifestations from extrapulmonary tumors: Computed tomography evaluation - Pictorial review
Although metastasis can occur at a variety of sites, pulmonary involvement is common in patients with cancer. Depending on the source and type of tumor, pulmonary metastases present with a wide range of radiologic appearances. Hematogenous dissemination through the pulmonary arteries to the pulmonary capillary network is the most common form of spread in pulmonary metastases. However, they may also reach the lung via lymphatic dissemination, secondary airway involvement, vessel tumor embolism, and direct chest invasion. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 28, 2020 Category: Respiratory Medicine Authors: Tom ás Franquet, Melissa L. Rosado-de-Christenson, Edson Marchiori, Gerald F. Abbott, Santiago Martínez-Jiménez, Laura López Tags: Review article Source Type: research

Natural history of incidental sporadic and tuberous sclerosis complex associated lymphangioleiomyomatosis
Lymphangioleiomyiomatosis (LAM) is a rare disease affecting women in childbearing age. A sporadic form (S-LAM) affecting previously healthy women, and a form associated with Tuberous Sclerosis Complex (TSC-LAM) are described. Some data suggested that TSC-LAM could be a milder disease compared to S-LAM. To investigate whether the different disease behavior is real or due to overdiagnosis of screened TSC women, we compared the natural history of S-LAM and TSC-LAM in patients with incidental diagnosis. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 28, 2020 Category: Respiratory Medicine Authors: Fabiano Di Marco, Silvia Terraneo, Ol ívia Meira Dias, Gianluca Imeri, Stefano Centanni, Rocco Rinaldo, Lisa Giuliani, Elena Lesma, Giuseppina Palumbo, Mark Wanderley, Carlos Roberto Ribeiro Carvalho, Bruno Guedes Baldi Tags: Short communication Source Type: research

Risk factors and associated outcomes of hospital readmission in COPD: A systematic review
Chronic obstructive pulmonary disease (COPD) is a leading cause of unplanned readmission. There is need to identify risk factors for, and strategies to prevent readmission in patients with COPD. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 27, 2020 Category: Respiratory Medicine Authors: Chidiamara M. Njoku, Jaber S. Alqahtani, Barbara C. Wimmer, Gregory M. Peterson, Leigh Kinsman, John R. Hurst, Bonnie J. Bereznicki Tags: Review article Source Type: research

German Respiratory Society guidelines for diagnosis and treatment of adults suffering from acute, subacute and chronic cough
The present 2019 S2k consensus guideline of the German Respiratory Society was written for pneumologists – in contrast to the more general predecessor's S3 guidelines from 2004 to 2010 –, since 2014 the German College of General Practitioners and Family Physicians (DEGAM) published their own cough guidelines.The guidelines contain 48 recommendations agreed upon the consensus and 16 statements, whic h are explained in the background text in the following nine chapters: epidemiology, physiology, classification, acute, subacute or chronic cough, diagnostics and therapy; an extra chapter was dedicated to chronic id...
Source: Respiratory Medicine - April 25, 2020 Category: Respiratory Medicine Authors: P. Kardos, Q.T. Dinh, K.-H. Fuchs, A. Gillissen, L. Klimek, M. Koehler, H. Sitter, H. Worth Tags: Review article Source Type: research

Chronic cough in Vocal Cord Dysfunction: Description of a clinical entity
Vocal Cord Dysfunction (VCD) and chronic [Reviewer 2 comment 1] cough (CC) are challenging conditions which lead to significant quality of life impairment. The underlying mechanisms are poorly understood, but laryngeal dysfunction may be common to both conditions. The aim of this study was to determine the characteristics of cough in VCD and whether patients with cough have coexisting VCD. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 25, 2020 Category: Respiratory Medicine Authors: Anne E. Vertigan, Sarah L. Kapela, Peter G. Gibson Tags: Clinical Trial Paper Source Type: research

Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?
SARS-CoV-2 is a novel virus of the Coronaviridiae family that represents a major global health issue. Mechanisms implicated in virus/host cells interaction are central for cell infection and replication that in turn lead to disease onset and local damage. To enter airway and lung epithelia, SARS-CoV-2 attaches to ACE2 receptors by spike (S) glycoproteins. Molecular mechanisms that promote interaction between SARS-CoV-2 virus and host with particular focus on virus cell entry receptor ACE2 are described. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 25, 2020 Category: Respiratory Medicine Authors: Fabio Perrotta, Maria Gabriella Matera, Mario Cazzola, Andrea Bianco Tags: Review article Source Type: research

“Current place of impulse oscillometry in the assessment of pulmonary diseases.”
In 1956, a diagnostic tool using the forced oscillation technique (FOT) was developed to examine respiratory functions. A modification of this method is impulse oscillometry (IOS). In the latter, a loudspeaker delivers to the respiratory system a regular, square pressure wave at a constant frequency from which all other individual frequencies are derived using spectral analysis. The usefulness of IOS has been examined in relation to COPD, asthma, interstitial lung diseases, obstructive sleep apnea, and other conditions. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 24, 2020 Category: Respiratory Medicine Authors: Marcin Bednarek, Marcin Grabicki, Tomasz Piorunek, Halina Batura-Gabryel Tags: Review article Source Type: research

Mid-expiratory time as a potential spirometric index of early airflow obstruction
We would like to thank Dr. Brown and Dr. Miller for their insightful commentary on forced expiratory time between 25% and 75% of forced vital capacity (FET25-75%) as it pertains to small airways disease (SAD). (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 23, 2020 Category: Respiratory Medicine Authors: Dan Hoesterey, Brian Graham, Don Tashkin, Igor Barjaktarevic Source Type: research

A case scenario study on adherence to COPD GOLD recommendations by general practitioners in a rural area of southern Italy: The “progetto PADRE”
The aim of the present study was to evaluate in a sample of 200 patients diagnosed with COPD and selected from the physician database of 15 general practices from Valle Telesina (Benevento, Italy) if the diagnostic-therapeutic algorithm adopted by GPs operating in a non-urban district in Southern Italy adhered to GOLD 2018 recommendations for COPD. Each patient underwent a specialist visit by an experienced chest physician that collected anamnesis, assessed mMRC and CAT scores, and performed a spirometry. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 23, 2020 Category: Respiratory Medicine Authors: Mauro Maniscalco, Michele Martucci, Salvatore Fuschillo, Alberto de Felice, Silvestro Ennio D'Anna, Mario Cazzola Source Type: research

Restless legs syndrome: A new comorbidity in idiopathic pulmonary fibrosis
Sleep disorders have a high prevalence among patients with idiopathic pulmonary fibrosis (IPF). The prevalence of restless legs syndrome (RLS) is not known in these patients, neither is its clinical impact as a comorbidity. We investigated the association of RLS with IPF and characterized the clinical features of RLS in a cohort of IPF patients. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 22, 2020 Category: Respiratory Medicine Authors: Francesco Varone, Ludovica Friello, Chiara Di Blasi, Giacomo Sgalla, Marco Luigetti, Bruno Iovene, Luca Richeldi, Giacomo Della Marca, Valerio Brunetti Tags: Clinical Trial Paper Source Type: research

Association between chest CT features and clinical course of Coronavirus Disease 2019
This retrospective study aims to illustrate the radiographic characteristics of Coronavirus Disease 2019 and the correlation with the clinical course. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 22, 2020 Category: Respiratory Medicine Authors: Zhibing Luo, Na Wang, Ping Liu, Qian Guo, Linyu Ran, Feilong Wang, Yuling Tang, Qiang Li Source Type: research

Diagnostic performance between CT and initial real-time RT-PCR for clinically suspected 2019 coronavirus disease (COVID-19) patients outside Wuhan, China
Chest CT is thought to be sensitive but less specific in diagnosing the 2019 coronavirus disease (COVID-19). The diagnostic value of CT is unclear. We aimed to compare the performance of CT and initial RT-PCR for clinically suspected COVID-19 patients outside the epicentre —Wuhan, China. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 21, 2020 Category: Respiratory Medicine Authors: Jian-Long He, Lin Luo, Zhen-Dong Luo, Jian-Xun Lyu, Ming-Yen Ng, Xin-Ping Shen, Zhibo Wen Source Type: research

Practical strategies for a safe and effective delivery of aerosolized medications to patients with COVID-19
The COVID-19, the disease caused by a novel coronavirus and named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly across the globe. It has caused outbreaks of illness due to person-to-person transmission of the virus mainly via close contacts and droplets produced by an infected person's cough or sneeze. Exhaled droplets from infected patients with COVID-19 can be inhaled into the lungs and leads to respiratory illness such as pneumonia and acute respiratory distress syndrome. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 21, 2020 Category: Respiratory Medicine Authors: Arzu Ari Tags: Review article Source Type: research

Correlation analysis of the severity and clinical prognosis of 32 cases of patients with COVID-19
In December 2019, the pandemic caused by a novel kind of enveloped RNA betacoronavirus took place in Wuhan, Hubei Province, China. This virus was named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1]. Also, it was declared as coronavirus disease 2019 (COVID-19) by the World Health Organization (WHO) [1]. Because of its extremely strong transmission, this virus has spread to the world in less than 3 months and infected more than 1 million patients [2]. COVID-19 has a higher mortality rate, ranging from 3% to 12% [2]. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 20, 2020 Category: Respiratory Medicine Authors: Ming Ding, Qiang Zhang, Qing Li, Ting Wu, Ying-zi Huang Source Type: research

The lived experience with pulmonary embolism: A qualitative study using focus groups
The objective of this study was to fill this gap using a qualitative research approach. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 18, 2020 Category: Respiratory Medicine Authors: Inge Kirchberger, Sarah Ruile, Jakob Linseisen, Sabine Haberl, Christine Meisinger, Thomas M. Berghaus Source Type: research

COPD exacerbation phenotypes in a real-world five year hospitalisation cohort
COPD exacerbation phenotypes have been defined in research populations by predominantly infective or inflammatory aetiology. We sought to characterise this in patients admitted to our centre. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 18, 2020 Category: Respiratory Medicine Authors: Timothy P.W. Jones, Jan Brown, John R. Hurst, Rama Vancheeswaran, Simon Brill Tags: Short communication Source Type: research