The role of nitric oxide in pleural disease
Nitric oxide (NO) regulates various physiological and pathophysiological functions in the lungs. However, there is much less information about the effects of NO in the pleura. The present review aimed to explore the available evidence regarding the role of NO in pleural disease. NO, has a double-edged role in the pleural cavity. It is an essential signaling molecule mediating various physiological cell functions such as lymphatic drainage of the serous cavities, the immune response to intracellular multiplication of pathogens, and downregulation of neutrophil migration, but also induces genocytotoxic and mutagenic effects ...
Source: Respiratory Medicine - February 23, 2021 Category: Respiratory Medicine Authors: Ourania S. Kotsiou, Konstantinos I. Gourgoulianis, Sotirios G. Zarogiannis Tags: Review article Source Type: research

Emergency Department admission and hospitalization for COPD Exacerbation and Particulate Matter short-term exposure in Brescia, a highly polluted town in Northern Italy
Short-term exposure to high Particulate Matter (PM) concentrations worsens several respiratory conditions. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 16, 2021 Category: Respiratory Medicine Authors: Laura Pini, Jordan Giordani, Giulia Gardini, Carlo Concoreggi, Alessandro Pini, Elisa Perger, Enrico Vizzardi, Danilo Di Bona, Carlo Cappelli, Manuela Ciarfaglia, Claudio Tantucci Tags: Original Research Source Type: research

Intravenous prostacyclin-analogue therapy in pulmonary arterial hypertension – a review of the past, present and future
Therapy with intravenous prostacyclin analogues in patients with pulmonary arterial hypertension (PAH) has been established for decades and is an integral component of the current guidelines for the treatment of pulmonary hypertension.Initially, these drugs were infused by external pump systems via tunnelled right atrial catheters with the need for cooling and frequent exchange of drug reservoirs. Associated complications included, among others, catheter-related infections.More recently, fully implantable pump systems have been developed with drug reservoirs that are filled transcutaneously, allowing intervals between refi...
Source: Respiratory Medicine - February 16, 2021 Category: Respiratory Medicine Authors: Beate Stubbe, Christian F. Opitz, Michael Halank, Dirk Habedank, Ralf Ewert Tags: Original Research Source Type: research

COPD prevalence in smokers with stable ischemic heart disease: a cross-sectional study in Tunisia
Chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IHD) are common causes of mortality worldwide, with shared risk factors. COPD continues to be largely underdiagnosed and undertreated, especially in patients with IHD. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 15, 2021 Category: Respiratory Medicine Authors: Ferdaous Yangui, Amany Touil, Saoussen Antit, Lilia Zakhama, Mohamed Ridha Charfi Tags: Original Research Source Type: research

Predictors of starting antimicrobial treatment in patients with nontuberculous mycobacterial lung disease in the Italian scenario: a SITA GIOVANI-IRENE promoted web-survey
The disease burden due to nontuberculous mycobacteria is growing worldwide, consequently to improved diagnostic abilities and an increase in the individuals at risk. Uncertainties exist about the right moment on which start treatment. We investigated the clinical features associated with starting an antimicrobial treatment in patients with nontuberculous mycobacterial lung disease among Italian physicians involved in the field. We found that in real life predictors of starting antimicrobial treatment are quite adherent to international guidelines, with some uncertainties regarding the implication of immunosuppressive drugs...
Source: Respiratory Medicine - February 15, 2021 Category: Respiratory Medicine Authors: Andrea Lombardi, Marta Colaneri, Margherita Sambo, Angela Di Matteo, Paolo Sacchi, Massimiliano Fabbiani, Luigi Codecasa, Stefano Aliberti, Francesco Blasi, Alessandra Bandera, Raffaele Bruno, Andrea Gori Tags: Short communication Source Type: research

Cavity formation and its predictors in noncavitary nodular bronchiectatic Mycobacterium avium complex pulmonary disease
The temporal dynamics of cavity formation in patients with the noncavitary nodular bronchiectatic (NC-NB) form of Mycobacterium avium complex pulmonary disease (MAC-PD) have not yet been well described. We aimed to investigate the development of new cavities in the NC-NB form of MAC-PD. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 13, 2021 Category: Respiratory Medicine Authors: Dong-Woo Han, Kyung-Wook Jo, Ock-Hwa Kim, Tae Sun Shim Source Type: research

Using the Medication Adherence Reasons Scale (MAR-Scale) in Asthma and Chronic Obstructive Pulmonary Disease to Determine the Extent and Identify the Reasons for Non-adherence
The objectives of this study were to determine the extent of non-adherence with asthma and COPD medicines and to describe the reasons for non-adherence in these conditions. Materials and Methods: Data from the National Health and Wellness Study (NHWS), a self-administered, annual, internet-based cross-sectional survey of US adults from 2018 was used. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 11, 2021 Category: Respiratory Medicine Authors: Elizabeth J. Unni, Shaloo Gupta, Nikoletta Sternbach Tags: Original Research Source Type: research

Aspergillus isolation in nontuberculous mycobacterial pulmonary disease: associated with antimycobacterial treatment initiation but not response
Chronic pulmonary aspergillosis is a serious complication of nontuberculous mycobacterial pulmonary disease (NTM-PD), and diagnosis remains challenging. The present study examined associations between the respiratory isolation of Aspergillus and the clinical characteristics and treatment outcomes of patients with NTM-PD. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 11, 2021 Category: Respiratory Medicine Authors: Daan Raats, Sharina M.S. Aldhaheri, Theodore K. Marras, Mahtab Mehrabi, Sarah K. Brode Tags: Original Research Source Type: research

The Use of Oxygen Hoods in Patients Failing on Conventional High-flow Oxygen Delivery Systems, the Effects on Oxygenation, Mechanical Ventilation and Mortality Rates in Hypoxic Patients with COVID-19. A Prospective Controlled Cohort Study
Efforts to meet increased oxygen demands in COVID-19 patients are a priority in averting mechanical ventilation (MV), associated with high mortality approaching 76.4 – 97.2%. Novel methods of oxygen delivery could mitigate that risk. Oxygen hoods/helmets may improve: O2-saturation (SaO2), reduce in-hospital mechanical ventilation and mortality rates, and reduce length of hospitalization in hypoxic Covid-19 patients failing on conventional high-flow oxygen deli very systems. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 11, 2021 Category: Respiratory Medicine Authors: David Dayya, Owen J. O ’Neill, Tracy Feiertag, Ritzel Tuazon-Boer, John Sullivan, Lubiha Perez, Sandrah Gurash, Matthew Eaton, Taylor Bodley, Joanne Marker, Elizabeth Smykowski, T. Hall Source Type: research

Comparative analysis between available challenge tests in the Hyperventilation Syndrome
dysfunctional breathing (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 11, 2021 Category: Respiratory Medicine Authors: Angelica Tiotiu, Iulia Ioan, Mathias Poussel, Cyril Schweitzer, Sophia Abdel Kafi Tags: Original Research Source Type: research

A Comprehensive Assessment of Environmental Exposures and the Medical History Guides Multidisciplinary Discussion in Interstitial Lung Disease
Multidisciplinary discussion (MDD) is widely recommended for patients with interstitial lung disease (ILD), but published primary data from MDD has been scarce, and factors influencing MDD other than chest computed tomography (CT) and lung histopathology interpretations have not been well-described. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 10, 2021 Category: Respiratory Medicine Authors: Neal Dodia, Diana Amariei, Blaine Kenaa, Doug Corwin, Lydia Chelala, E. James Britt, Ashutosh Sachdeva, Irina G. Luzina, Jeffrey D. Hasday, Nirav G. Shah, Sergei P. Atamas, Teri J. Franks, Allen P. Burke, Stella E. Hines, Jeffrey R. Galvin, Nevins W. Todd Tags: Original Research Source Type: research

Cost-effectiveness of sustained-release morphine for refractory breathlessness in COPD: a randomized clinical trial
Chronic breathlessness is a frequent symptom in advanced Chronic Obstructive Pulmonary Disease (COPD) and has major impact on quality of life, daily activities and healthcare utilization. Morphine is used as palliative treatment of chronic breathlessness. The aim is to analyze cost-effectiveness of regular, low-dose morphine in patients with advanced COPD from a healthcare and societal perspective. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 9, 2021 Category: Respiratory Medicine Authors: Cornelia A. Verberkt, Marieke H.J. van den Beuken-van Everdingen, Carmen D. Dirksen, Jos M.G.A. Schols, Emiel F.M. Wouters, Daisy J.A. Janssen Source Type: research

Geographical and socioeconomic differences in compliance with and access to allergen immunotherapy in Denmark
Allergen immunotherapy (AIT) is a cost-effective treatment option in moderate-severe allergic rhino-conjunctivitis. Inequality in access to AIT and variation in compliance related to socioeconomic status or geographical location have not been described previously. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 6, 2021 Category: Respiratory Medicine Authors: Morten Borg, Anders L økke, Ole Hilberg Tags: Original Research Source Type: research

Factors Associated With Delayed Viral Shedding In COVID-19 Infected Patients: A Retrospective Small-scale Study
The outbreak of COVID-19 has caused ever-increasing attention and public panic all over the world. Until now, data are limited about the risk factors to virus shedding in COVID-19 infected patients. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 6, 2021 Category: Respiratory Medicine Authors: Hui-ru Cao, Xin-yun Zhu, Lin Zhou, Hua Zhang, Bin-bin Gu, Wei Tang, Jian Ding, Jianan Huang, Xing-hua Shen, Cheng Chen Source Type: research

Optimizing Routine Screening for Cardiac Sarcoidosis through Use of Commonly Available Studies
This study suggests that the HRS guidelines lack sensitivity to effectively screen for CS and that a modified screening model which includes ARM may be more effective. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 5, 2021 Category: Respiratory Medicine Authors: Arthur W. Holtzclaw, Zorana Mrsic, Tyler L. Church, John N. Shumar, Robert A. Liotta, Saira N. Aslam, Joseph R. Fontana, Joel A. Nations, Angeline Lazarus, Robert F. Browning, Aaron B. Holley, John H. Sherner, Sean A. McKay Tags: Original Research Source Type: research

Incidence of pulmonary embolism in patients with NON-INVASIVE respiratory support during COVID-19 OUTBREAK
While the incidence of thrombotic complications in critically ill patients is very high, in patients under non-invasive respiratory support (NIS) is still unknown. The specific incidence of thrombotic events in each of the clinical scenarios within the broad spectrum of severity of COVID-19, is not clearly established, and this has not allowed the implementation of thromboprophylaxis or anticoagulation for routine care in COVID-19. Patients admitted in a semi-critical unit treated initially with NIS, especially Continuous-Positive Airway Pressure (CPAP), were included in the study. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 3, 2021 Category: Respiratory Medicine Authors: Jose Gregorio Gonz ález-García, Sergi Pascual-Guardia, Ricardo J. Aguilar Colindres, Pilar Ausín Herrero, Mariela Alvarado Miranda, Mariela Arita Guevara, Diana Badenes Bonet, Salome Bellido Calduch, Oswaldo A. Caguana Vélez, Cinta Cumpli Gargallo, Ma Tags: Short communication Source Type: research

Reduction of bronchial response to mannitol after partial switch from conventional tobacco to electronic cigarette consumption
Regarding the multiple health effects of e-cigarettes, there are insufficient data on potential effects on bronchial reactivity (BHR). In the present study, we assessed the impact of a switch from conventional to e-cigarettes on BHR under realistic conditions over a period of 3 months. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 1, 2021 Category: Respiratory Medicine Authors: R üther Tobias, Kahnert Kathrin, Mader Madeleine, Rabenstein Andrea, Falkai Peter, Fischer Elke, Pogarell Oliver, Jörres Rudolf A Tags: Original Research Source Type: research

Colchicine and SARS-CoV-2: Management of the Hyperinflammatory State
The global COVID-19 pandemic is currently underway. In December 2020, the European Agency of Medicine (EMA) licensed the first Sars-CoV-2 vaccine. Therapeutic management of the COVID-19 positive patient should primarily aim to avoid the severe complications and organ injury caused by generalized inflammation caused by a cytokine storm and occurring in the most severe stages of viral infection. Current knowledge of the pathophysiological mechanisms of SARS- CoV-2 suggests a central role for exaggerated activation of the innate immune system as an important contributor to the adverse outcomes of COVID-19. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 31, 2021 Category: Respiratory Medicine Authors: A. Vitiello, F. Ferrara, Francesco Ferrara Tags: Review article Source Type: research

Characteristics and outcomes in hospitalized COVID-19 patients during the first 28 days of the spring and autumn pandemic waves in Milan: an observational prospective study
The therapeutic approach to COVID-19 and healthcare system preparedness improved during 2020. We compared characteristics and outcomes of hospitalized COVID-19 patients during the first 28 days of the March and October pandemic waves in Milan, Italy. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 30, 2021 Category: Respiratory Medicine Authors: Dejan Radovanovic, Stefano Pini, Elisa Franceschi, Marica Pecis, Andrea Airoldi, Maurizio Rizzi, Pierachille Santus Tags: Short communication Source Type: research

A Comparison of Characteristics and Outcomes of Patients with Community-Acquired and Hospital-Acquired COVID-19 in the United Kingdom: An Observational Study
Reports comparing the characteristics of patients and their clinical outcomes between community-acquired (CA) and hospital-acquired (HA) COVID-19 have not yet been reported in the literature. We aimed to characterise and compare clinical, biochemical and haematological features, in addition to clinical outcomes, between these patients. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 28, 2021 Category: Respiratory Medicine Authors: Haaris A. Shiwani, Muhammad Bilal, Muhammad U. Shahzad, Alson Rodrigues, Jehad A. Suliman, Muhammad Soban, Shahzeb Mirza, Nicoleta Lotca, Mohammed R. Ruslan, Danyal Memon, Muhammad A. Arshad, Kiran Fatima, Asma Kamran, Emmanuel E. Egom, Abdul Aziz Tags: Original Research Source Type: research

Cardiovascular safety of mometasone/indacaterol and mometasone/indacaterol/glycopyrronium once-daily fixed-dose combinations in asthma
To evaluate cardiovascular safety of two new inhaled fixed-dose combinations for treatment of asthma: (i) the inhaled corticosteroid/long-acting beta2-agonist (ICS/LABA) mometasone furoate/indacaterol acetate (MF/IND), (ii) the ICS/LABA/long-acting muscarinic antagonist (LAMA) MF/IND/glycopyrronium bromide (GLY). (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 27, 2021 Category: Respiratory Medicine Authors: Emil Scosyrev, Richard van Zyl-Smit, Huib Kerstjens, Christian Gessner, Oliver Kornmann, Devendra Jain, Elodie Aubrun, Peter D ’Andrea, Motoi Hosoe, Abhijit Pethe, Dominic Brittain Tags: Original Research Source Type: research

Long-Term Exposure to Fine Particulate Matter and Hospitalization in COVID-19 Patients
Ecological evidence suggests that exposure to air pollution affects coronavirus disease 2019 (COVID-19) outcomes. However, no individual-level study has confirmed the association to date. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 25, 2021 Category: Respiratory Medicine Authors: Angelico Mendy, Xiao Wu, Jason L. Keller, Cecily S. Fassler, Senu Apewokin, Tesfaye B. Mersha, Changchun Xie, Susan M. Pinney Tags: Short communication Source Type: research

Idiopathic Pulmonary Fibrosis and Gastroesophageal Reflux Disease: A Population-Based, Case-Control Study
This study aimed to determine whether patients with IPF were more likely to have GERD compared with age- and sex-matched controls who either had 1) interstitial lung disease (ILD) other than IPF or 2) no diagnosed lung disease (population control). (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 21, 2021 Category: Respiratory Medicine Authors: Misbah Baqir, Amit Vasirreddy, Ann N. Vu, Teng Moua, Alanna M. Chamberlain, Ryan D. Frank, Jay H. Ryu Tags: Original Research Source Type: research

Transitions Between COPD Groups: A Cross-sectional Study in Turkey
Introduction: Since GOLD 2017 separates spirometry results from ‘ABCD’ groups, there have been some changes to the stages of COPD patients. Our aim was to investigate the shifts in COPD groups after GOLD 2017.Methods: COPD patients from outpatient clinics of 3 hospitals in Turkey were stratified into old and new ABCD groups according to exacerbation history, mMRC evaluation and spirometry results for both GOLD 2011 and 2017 assessments. Treatment protocols were also evaluated if they were suitable for both classifications. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 21, 2021 Category: Respiratory Medicine Authors: P.A. Turan, O. Turan, F. G üldaval, C. Anar, G. Polat, M. Buyuksirin Tags: Original Research Source Type: research

Assessment of pinch force strength in patients with pulmonary arterial hypertension in the era of AOS ® dry powder inhaler based therapies
Over the last two decades treatment options have drastically improved for patients with pulmonary arterial hypertension (PAH). In the recent times, there is renewed interest in dry powder inhaler (DPI) based inhaled therapies in the treatment of PAH. PAH patients are well known to have respiratory and other muscle weakness either related to the disease itself or due to the underlying diseases like connective tissue disease (CTD). CTD PAH patients are at particular disadvantage as there is a concern if they have enough strength to press the buttons on the inhaler device, needed to pierce the drug capsule inside the device. ...
Source: Respiratory Medicine - January 13, 2021 Category: Respiratory Medicine Authors: Sandeep Sahay, Royanne Holy, Shirley Lyons, Edwin Parsley, Mari Maurer, Jeffry Weers Tags: Short communication Source Type: research

Effect of patient immunodeficiencies on the diagnostic performance of serological assays to detect Aspergillus-specific antibodies in chronic pulmonary aspergillosis
Prevalence of chronic pulmonary aspergillosis (CPA) is ∼3 million patients worldwide, and detection of Aspergillus-specific antibody is a critical diagnostic component. Some patients with CPA have subtle immune deficits possibly contributing to poor Aspergillus antibody production and false negative results. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 11, 2021 Category: Respiratory Medicine Authors: Elizabeth Stucky Hunter, Bayu Wilopo, Malcolm D. Richardson, Chris Kosmidis, David W. Denning Source Type: research

Pneumococal Community-Acquired Pneumonia in the Intensive Care Unit: Azithromycin Remains Protective Despite Macrolide Resistance
Streptococcus pneumoniae (SP) remains the leading pathogen in community-acquired pneumonia (CAP). Despite the increasing prevalence of macrolide resistance in SP, guidelines recommend the use of macrolides as part of a combination regiment for intensive care unit (ICU) patients with CAP. We sought to describe if macrolide resistance effects outcomes in SP CAP in the ICU and if macrolides remain associated with a mortality advantage in an era of greater resistance. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 8, 2021 Category: Respiratory Medicine Authors: Andrew F. Shorr, James Simmons, Nicolas Hampton, Scott T. Micek, Marin H. Kollef Tags: Original Research Source Type: research

Mortality and morbidity in children with asthma: A nationwide study in Korea
This study aimed to estimate asthma mortality and morbidity and determine to what extent asthma contributes to childhood mortality in Korea. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 7, 2021 Category: Respiratory Medicine Authors: In Suk Sol, Haerin Jang, Juhwan Noh, Soo Yeon Kim, Min Jung Kim, Yoon Hee Kim, Changsoo Kim, Myung Hyun Sohn, Kyung Won Kim Tags: Original Research Source Type: research

Reliability of automatic detection of AHI during positive airway pressure treatment in obstructive sleep apnea patients: A “real-life study”
Automatic event detection (AED) of residual apnea-hypopnea index (AHI) by ventilators is a current practice in sleep and mechanical ventilation Units but this methodology has not been validated in an unselected population of OSA patients. Aim of the present study was to assess in a “real-life” condition the reliability of AED during PAP therapy by the in-built software compared to full polysomnography during follow-up. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 7, 2021 Category: Respiratory Medicine Authors: F. Fanfulla, N. D ’Artavilla Lupo, A. Malovini, S. Arcovio, A. Prpa, M.P. Mogavero, C. Pronzato, Maria R. Bonsignore Source Type: research

Early life growth and associations with lung function and bronchial hyperresponsiveness at 11-years of age
Low birthweight and being born small-for-gestational age (SGA) are linked to asthma and impaired lung function. Particularly, poor intrauterine growth followed by rapid catch-up growth during childhood may predispose for respiratory disease. Bronchial hyperresponsiveness (BHR) is an essential feature of asthma, but how foetal and early childhood growth are associated with BHR is less studied. Our hypothesis was that children born SGA or with accelerated early life growth have increased BHR and altered lung function at 11-years of age. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 7, 2021 Category: Respiratory Medicine Authors: Ingvild Bruun Mikalsen, Thomas Halvorsen, Petur Benedikt Juliusson, Maria Magnus, Wenche Nystad, Trine Stensrud, Ketil St ørdal, Maria Vollsæter, Knut Øymar Tags: Original Research Source Type: research

Asthmatic children are at a high risk of respiratory morbidity Mortality and morbidity in children with asthma: A nationwide study in Korea
This study aimed to estimate asthma mortality and morbidity and determine to what extent asthma contributes to childhood mortality in Korea. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 7, 2021 Category: Respiratory Medicine Authors: In Suk Sol, Haerin Jang, Juhwan Noh, Soo Yeon Kim, Min Jung Kim, Yoon Hee Kim, Changsoo Kim, Myung Hyun Sohn, Kyung Won Kim Tags: Original Research Source Type: research

Interventional and pharmacological management of chronic thromboembolic pulmonary hypertension
This article reviews the current management of CTEPH. The standard of care in CTEPH is pulmonary endarterectomy (PEA). However, up to 40% of patients with CTEPH are ineligible for PEA, and up to 51% develop persistent/recurrent PH after PEA. Riociguat is currently the only medical therapy licensed for treatment of inoperable or persistent/recurrent CTEPH after PEA based on the results of the Phase III CHEST-1 study. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 5, 2021 Category: Respiratory Medicine Authors: Hossein-Ardeschir Ghofrani, Andrea M. D ’Armini, Nick H. Kim, Eckhard Mayer, Gérald Simonneau Tags: Review article Source Type: research

High Expression of mTOR Signaling in granulomatous lesions is not predictive for the Clinical Course of Sarcoidosis
Sarcoidosis is a systemic granulomatous disease with a variable clinical presentation and disease course. There is still no reliable biomarker available, which assists in the diagnosis or prediction of the clinical course. According to a murine model, the expression level of the metabolic checkpoint kinase mechanistic target of Rapamycin complex 1 (mTORC1) in granulomas of sarcoidosis patients may be used as a clinical biomarker. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 5, 2021 Category: Respiratory Medicine Authors: Alex Pizzini, Hannes Bacher, Magdalena Aichner, Alexander Franchi, Kathrin Watzinger, Ivan Tancevski, Thomas Sonnweber, Birgit Mosheimer-Feistritzer, Christina Duftner, Bettina Zelger, Johannes Pallua, Susanne Sprung, Thomas Weichart, Bernhard Zelger, G Source Type: research

Suggestions for lung function testing in the context of COVID-19
The 2019 coronavirus disease (COVID-19) pandemic is currently a challenge worldwide. Due to the characteristics of lung function tests, the risk of cross infection may be high between health care workers and patients. The role of lung function testing is well defined for the diagnosis of various diseases and conditions. Lung function tests are also indispensable in evaluating the response to medical treatment, in monitoring patient respiratory and systemic pathologies, and in evaluating preoperative risk in cardiothoracic and major abdominal surgeries. (Source: Respiratory Medicine)
Source: Respiratory Medicine - December 30, 2020 Category: Respiratory Medicine Authors: Milanese Manlio, Corsico Angelo Guido, Bellofiore Salvatore, Carrozzi Laura, Di Marco Fabiano, Iovene Bruno, Richeldi Luca, Sanna Antonio, Santus Pierachille, Schisano Mario, Scichilone Nicola, Vancheri Carlo, Cerveri Isa, SIP (Italian Respiratory Society Tags: Review article Source Type: research

Non-invasive Ventilation at Home Improves Survival and Decreases Healthcare Utilization in Medicare Beneficiaries with Chronic Obstructive Pulmonary Disease with Chronic Respiratory Failure
We examined the association between NIVH and survival, hospitalizations, and emergency room (ER) use in COPD-CRF Medicare beneficiaries. (Source: Respiratory Medicine)
Source: Respiratory Medicine - December 29, 2020 Category: Respiratory Medicine Authors: William D. Frazier, Richard Murphy, Emma van Eijndhoven Source Type: research

Serum angiotensin converting enzyme elevation in association with artificial stone silicosis
.Silicosis is a rapidly emerging major health concern for workers in the artificial stone benchtop industry. The association between serum angiotensin converting enzyme (sACE) levels and artificial stone silicosis is unknown. (Source: Respiratory Medicine)
Source: Respiratory Medicine - December 24, 2020 Category: Respiratory Medicine Authors: R.F. Hoy, J. Hansen, D.C. Glass, C. Dimitriadis, F. Hore-Lacy, M.R. Sim Tags: Short communication Source Type: research

Pseudomonas Aeruginosa Associated with Severity of Non-cystic Fibrosis Bronchiectasis Measured by the Modified Bronchiectasis Severity Score (BSI) and the FACED: the US Bronchiectasis and NTM Research Registry (BRR) Study
Non-cystic fibrosis bronchiectasis (NCFB) is characterized by dilated bronchi, poor mucus clearance and susceptibility to bacterial infection. Pseudomonas aeruginosa (PA) is one of the most frequently isolated pathogens in patients with NCFB. The purpose of this study was to evaluate the association between presence of PA and disease severity in patients within the US Bronchiectasis and Nontuberculous mycobacteria (NTM) Research Registry (BRR). (Source: Respiratory Medicine)
Source: Respiratory Medicine - December 23, 2020 Category: Respiratory Medicine Authors: Radmila Choate, Timothy R. Aksamit, David Mannino, Doreen Addrizzo-Harris, Alan Barker, Ashwin Basavaraj, Charles L. Daley, M. Leigh Anne Daniels, Edward Eden, Angela DiMango, Kevin Fennelly, David E. Griffith, Margaret M. Johnson, Michael R. Knowles, Pam Source Type: research

Updated prevalence, predictors and treatment outcomes for bronchiolitis obliterans syndrome after allogeneic stem cell transplantation
Bronchiolitis obliterans syndrome (BOS) after allogeneic haemopoietic stem cell transplant (HSCT) is an under-recognised and difficult to treat disease. This occurs in the context of limited clinical research and inconsistent diagnostic criteria. (Source: Respiratory Medicine)
Source: Respiratory Medicine - December 23, 2020 Category: Respiratory Medicine Authors: Jonathan Pham, Jhanavi Rangaswamy, Sharon Avery, Brigitte Borg, Catherine Martin, Maitri Munsif, Tiffany Lin, Eli Dabscheck Source Type: research

Poor outcome of SARS-CoV-2 infection in patients with severe asthma on biologic therapy
It is unclear whether asthma and asthma medications increase or decrease the risk of severe COVID-19, and this is particularly true for patients with severe asthma receiving biologics. (Source: Respiratory Medicine)
Source: Respiratory Medicine - December 22, 2020 Category: Respiratory Medicine Authors: Katrien Eger, Simone Hashimoto, Gert Jan Braunstahl, Anneke ten Brinke, Kornelis W. Patberg, Annelies Beukert, Frank Smeenk, Simone van der Sar –van der Brugge, Els J.M. Weersink, Elisabeth H. Bel Source Type: research

Risk of Incident Dementia and Cognitive Impairment in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Large UK Population-based Study
Although cognitive impairment and dementia are common comorbidities in patients with chronic obstructive pulmonary disease (COPD), estimates of incidence following a diagnosis of COPD are inconclusive. (Source: Respiratory Medicine)
Source: Respiratory Medicine - December 22, 2020 Category: Respiratory Medicine Authors: R.A. Siraj, T.M. McKeever, J.E. Gibson, A.L. Gordon, C.E. Bolton Tags: Original Research Source Type: research

Falls prevalence and risk factors in people with chronic obstructive pulmonary disease: A systematic review
Falls are frequent in people with chronic obstructive pulmonary disease (COPD) and related to increased morbidity, mortality, and health care costs in older adults. This systematic review aims to synthesise the falls outcomes and to examine risk factors for falls in the COPD literature. (Source: Respiratory Medicine)
Source: Respiratory Medicine - December 9, 2020 Category: Respiratory Medicine Authors: Cristino C. Oliveira, Raquel Annoni, Annemarie L. Lee, Jennifer McGinley, Louis B. Irving, Linda Denehy Tags: Review article Source Type: research

Specific pathogens as predictors of poor long-term prognosis after hospital discharge for community-acquired pneumonia
Some studies have reported that long-term prognosis after pneumonia is poor. Our aim was to determine predictors of long-term outcomes with special attention to community-acquired pneumonia (CAP) etiology. (Source: Respiratory Medicine)
Source: Respiratory Medicine - December 6, 2020 Category: Respiratory Medicine Authors: Yuto Akiyama, Takashi Ishiguro, Ryuji Uozumi, Takashi Nishida, Yoichi Kobayashi, Noboru Takayanagi Tags: Original Research Source Type: research

Multiple breath washout: A noninvasive tool for identifying lung disease in symptomatic military deployers
Military deployments to austere environments since November 9, 2001 may put “deployers” at risk for respiratory disease. Sensitive, noninvasive tools for detecting large and small airways injury are needed to identify early disease and help inform management for this at-risk population. (Source: Respiratory Medicine)
Source: Respiratory Medicine - December 5, 2020 Category: Respiratory Medicine Authors: Lauren M. Zell-Baran, Silpa D. Krefft, Camille M. Moore, Jenna Wolff, Richard Meehan, Cecile S. Rose Source Type: research

Plasma proteomics and lung function in four community-based cohorts
Underlying mechanism leading to impaired lung function are incompletely understood. (Source: Respiratory Medicine)
Source: Respiratory Medicine - December 5, 2020 Category: Respiratory Medicine Authors: Andreas Rydell, Christoph Nowak, Christer Janson, Karin Lisspers, Bj örn Ställberg, David Iggman, Jerzy Leppert, Pär Hedberg, Johan Sundström, Erik Ingelsson, Lars Lind, Johan Ärnlöv Source Type: research

Inhaled tobramycin for chronic infection with pseudomonas aeruginosa in non-cystic fibrosis bronchiectasis: A systematic review and meta-analysis
Non-cystic fibrosis bronchiectasis (NCFBE) is a chronic and progressive disease characterized by the permanent destruction of small and mid-sized airways. Many patients are chronically colonized by Pseudomona aueruginosa, for which oral antibiotics are given. Evidence to support the use of inhaled antibiotics is contradictory. (Source: Respiratory Medicine)
Source: Respiratory Medicine - December 5, 2020 Category: Respiratory Medicine Authors: Saveria Sangiovanni, Eliana I. Morales, Liliana Fern ández-Trujillo Source Type: research

Measuring vital capacity in amyotrophic lateral sclerosis: Effects of interfaces and reproducibility
Deterioration of vital capacity (VC) in amyotrophic lateral sclerosis (ALS) signifies disease progression and indicates need for non-invasive ventilation. Weak facial muscles consequent to ALS, with resulting poor mouth seal, may interfere with the accuracy of VC measurements. (Source: Respiratory Medicine)
Source: Respiratory Medicine - December 3, 2020 Category: Respiratory Medicine Authors: Giulia Michela Pellegrino, Giuseppe Francesco Sferrazza Papa, Stefano Centanni, Massimo Corbo, David Kvarnberg, Martin J. Tobin, Franco Laghi Source Type: research

Impact of patients ’ perception of COPD and treatment on adherence and health-related quality of life in real-world: Study in 53 community pharmacies
Patient adherence to treatment in chronic obstructive pulmonary disease (COPD) is essential to optimize disease management. We aimed to assess the impact of patients ’ perception of their treatment and disease on adherence and Health-Related Quality of Life (HRQL) in patients attending a community pharmacy, where usually subjects have a better condition than those in clinical settings. (Source: Respiratory Medicine)
Source: Respiratory Medicine - December 3, 2020 Category: Respiratory Medicine Authors: E. L ópez-Pintor, J. Grau, I. González, MCQuesada JA. Bernal-Soriano, B. Lumbreras Source Type: research

Riociguat treatment in patients with pulmonary arterial hypertension: Final safety data from the EXPERT registry
The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension following Phase 3 randomized trials. The EXPosurE Registry RiociguaT in patients with pulmonary hypertension (EXPERT) study was designed to monitor the long-term safety of riociguat in clinical practice. (Source: Respiratory Medicine)
Source: Respiratory Medicine - December 2, 2020 Category: Respiratory Medicine Authors: Marius M. Hoeper, Miguel-Angel Gomez Sanchez, Marc Humbert, David Pittrow, G érald Simonneau, Henning Gall, Ekkehard Grünig, Hans Klose, Michael Halank, David Langleben, Repke J. Snijder, Pilar Escribano-Subias, Lisa M. Mielniczuk, Tobias J. Lange, Jean Source Type: research

The detrimental qualitative and quantitative alterations of circulating endothelial progenitor cells in patients with bronchiectasis
Bronchiectasis is an independent risk factor for cardiovascular disease (CVD)and cardiac dysfunction. Endothelial progenitor cells (EPCs) play a crucial role in maintaining endothelial function, and is inversely correlated with cardiovascular risk factors or cardiac dysfunction. However, the relationship between EPCs and bronchiectasis is unknown. (Source: Respiratory Medicine)
Source: Respiratory Medicine - November 30, 2020 Category: Respiratory Medicine Authors: Yangli Liu, Xinyan Huang, Dubo Chen, Fengjia Chen, Chengqiang Mo, Yubiao Guo, Canmao Xie, Gexiu Liu, Haitao Zeng, Yunwei Sun, Zhen Yang Source Type: research

Pulmonary function and health-related quality of life after COVID-19 pneumonia
Background.The COVID-19 pandemic has led to many cases of pneumonia with extensive lung abnormalities on CT-scans. The consequences of COVID-19 pneumonia on survivors ’ pulmonary function and quality of life are unknown. The purpose of this study is to examine the impact of COVID-19 pneumonia on pulmonary function, health-related quality of life (HRQoL) and perceived dyspnoea.Methods.A prospective longitudinal cohort study regarding patients discharged from our hospital after PCR-proven, non-critical COVID-19 pneumonia was conducted. (Source: Respiratory Medicine)
Source: Respiratory Medicine - November 29, 2020 Category: Respiratory Medicine Authors: S. van der Sar - van der Brugge, S. Talman, LJM Boonman-de Winter, M. de Mol, E. Hoefman, R.W. van Etten, I.C. De Backer Tags: Short communication Source Type: research