Corrigendum to “Healthcare costs of the SATisfaction and adherence to COPD treatment (SAT) study follow-up” [Respir. Med. 153 (2019) 68–75]
The authors regret that the affiliations of two authors were incorrectly reported. The right affiliation of Fabiano di Marco is: “Department of Health Science, University of Milan, Respiratory Unit, Pope John XXIII Hospital, Bergamo, Italy”; the right affiliation of Pierachille Santus is: “Department of Biomedical and Clinical Sciences (DIBIC), University of Milan, Milan, Italy”. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 13, 2019 Category: Respiratory Medicine Authors: Angelo G. Corsico, Fulvio Braido, Marco Contoli, Fabiano Di Marco, Paola Rogliani, Carla Scognamillo, Irene Olivi, Pierachille Santus, Nicola Scichilone, Carlo Lazzaro Source Type: research

Bendopnoea in exercise limited patients with COPD
Dyspnoea on bending over (bendopnoea) is most commonly associated with systolic heart failure. COPD patients often also complain of bendopnoea but little is known about this symptom in this patient group. We objectively assessed 44 COPD patients attending pulmonary rehabilitation for bendopnoea in a tertiary referral centre to determine the potential mechanism and clinical implications of this symptom. Bendopnoea was assessed by timing the duration of onset to breathlessness on bending forward at the waist for 30  s. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 12, 2019 Category: Respiratory Medicine Authors: Melissa J. McDonnell, Niamh Duignan, Chistina D. Campbell, Robert M. Rutherford Tags: Short communication Source Type: research

Extrapulmonary associations of health status in severe asthma and bronchiectasis: Comorbidities and functional outcomes
Severe asthma and bronchiectasis are heterogeneous diseases that contribute to disability beyond the pulmonary system. The magnitude of the impact that these extrapulmonary features has on health-related quality of life (HRQoL) is unknown. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 12, 2019 Category: Respiratory Medicine Authors: Laura Cordova-Rivera, Peter G. Gibson, Paul A. Gardiner, Sarah A. Hiles, Vanessa M. McDonald Source Type: research

The natural course of lung function decline in asbestos exposed subjects with pleural plaques and asbestosis
While there is a good knowledge of the natural course of lung function in interstitial lung diseases (ILD) like idiopathic lung fibrosis (IPF), many ambiguities remain in patients with asbestosis. Therefore, we evaluated the change in lung function in asbestos exposed subjects with pleural plaques and asbestosis and analysed corresponding morphology of computer tomography of the thorax. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 12, 2019 Category: Respiratory Medicine Authors: M. Barnikel, P.M. Million, H. Knoop, J. Behr Source Type: research

Corrigendum to “Factors associated with pulmonary hypertension and long-term survival in bronchiectasis subjects” [Respir. Med. (2016) 119 109–114]
This study is supported by Hacettepe Universiw Scientific Research Projects Coordination Unit. Project Number: 010 D02 101  011–83 and Project ID:85. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 11, 2019 Category: Respiratory Medicine Authors: Serpil Öcal, Oytun Portakal, Arslan Öcal, Ahmet Uğur Demir, Arzu Topeli, Lütfi Çöplü Source Type: research

Tiotropium in asthma: From bench to bedside
Tiotropium is a long-acting muscarinic antagonist approved for maintenance treatment of asthma in children, adolescents, and adults in the United States, and recommended as add-on treatment for uncontrolled asthma despite treatment with inhaled corticosteroids and/or long-acting beta-2 agonists. This review traces the journey of tiotropium from its historical origins through early preclinical testing to human clinical trials and real-life studies. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 11, 2019 Category: Respiratory Medicine Authors: Lyndon Mansfield, Jonathan A. Bernstein Tags: Review article Source Type: research

Increased prevalence of exercise-induced airway symptoms – A five-year follow-up from adolescence to young adulthood
Exercise-induced airway symptoms are common in adolescents. Little is known about the development of symptoms from adolescence to early adulthood. Therefore, we studied the prevalence, incidence, and remission of exercise-induced airway symptoms (including wheeze, cough, chest and throat tightness, hoarseness, and stridor) in adolescents, over a five-year period. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 11, 2019 Category: Respiratory Medicine Authors: Henrik Johansson, Katarina Norlander, Andrei Malinovschi Source Type: research

Mucoid Pseudomonas aeruginosa alters sputum viscoelasticity in patients with non-cystic fibrosis bronchiectasis
and aim: Pseudomonas aeruginosa could acquire a mucoid phenotype due to mutations in mucA (mucoid Pseudomonas aeruginosa - mPA) that is a hallmark of poor prognosis in patients with bronchiectasis. Despite the higher prevalence of Pseudomonas aeruginosa in bronchiectasis, how mPA and non-mucoid Pseudomonas aeruginosa (non-mPA) phenotypes could affect viscoelastic properties of sputum is unknown. Our aim was to determine the relationship between Pseudomonas aeruginosa phenotypes isolation, the viscoelastic properties of sputum and the clinical outcomes in patients with bronchiectasis. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 11, 2019 Category: Respiratory Medicine Authors: Victoria Alcaraz-Serrano, Laia Fern ández-Barat, Giulia Scioscia, Joan Llorens-Llacuna, Elena Gimeno-Santos, Beatriz Herrero-Cortina, Nil Vàzquez, Jordi Puig de la Bellacasa, Albert Gabarrús, Rosanel Amaro-Rodriguez, Rosario Menendez, Antoni Torres Source Type: research

Correspondence for "clinical epidemiology of familial sarcoidosis: A systematic literature review"
We have read the very interesting article titled “Clinical epidemiology of familial sarcoidosis: a systematic literature review” by Drs. Terwiel and van Moorsel published recently in in Respiratory medicine [1]. The work was based on the very stringent selection of 27 articles out of a total of 459 published on sarcoidosis in order to obtain a high level of statistical quality in the evaluation of the prevalence of familial forms. This review took into account all articles published until March 2018, date of submission to Respiratory Medicine. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 10, 2019 Category: Respiratory Medicine Authors: Alain Calender, Dominique Valeyre, Dominique Israel-Biet, Yves Pacheco Tags: Correspondence Source Type: research

The relation of environmental tobacco smoke (ETS) to chronic bronchitis and mortality over two decades
Our aim was to describe how the prevalence of subjects exposed to environmental tobacco smoke (ETS) has changed from 1992 to 2012 in Finland. We also investigated the association between ETS and chronic bronchitis and cause-specific and all-cause mortality. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 10, 2019 Category: Respiratory Medicine Authors: Margit K. Pelkonen, Tiina K. Laatikainen, Pekka Jousilahti Source Type: research

Combined effects of lung function, blood gases and kidney function on the exacerbation risk in stable COPD: Results from the COSYCONET cohort
Alterations of acid-base metabolism are an important outcome predictor in acute exacerbations of COPD, whereas sufficient metabolic compensation and adequate renal function are associated with decreased mortality. In stable COPD there is, however, only limited information on the combined role of acid-base balance, blood gases, renal and respiratory function on exacerbation risk grading. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 10, 2019 Category: Respiratory Medicine Authors: F.C. Trudzinski, K. Kahnert, C.F. Vogelmeier, P. Alter, F. Seiler, S. F ähndrich, H. Watz, T. Welte, T. Speer, S. Zewinger, F. Biertz, H.-U. Kauczor, R.A. Jörres, R. Bals, COSYCONET consortium Source Type: research

Age- and gender-specific incidence of new asthma diagnosis from childhood to late adulthood
Asthma is currently divided into different phenotypes, with age at onset as a relevant differentiating factor. In addition, asthma with onset in adulthood seems to have a poorer prognosis, but studies investigating age-specific incidence of asthma with a wide age span are scarce. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 8, 2019 Category: Respiratory Medicine Authors: Jasmin Honkam äki, Hanna Hisinger-Mölkänen, Pinja Ilmarinen, Päivi Piirilä, Leena E. Tuomisto, Heidi Andersen, Heini Huhtala, Anssi Sovijärvi, Helena Backman, Bo Lundbäck, Eva Rönmark, Lauri Lehtimäki, Hannu Kankaanranta Source Type: research

Effect of mepolizumab in severe eosinophilic asthma according to omalizumab eligibility
Patients with severe asthma can present with overlapping eosinophilic and allergic phenotypes, which makes it challenging when deciding which biologic therapy is most appropriate to reduce exacerbations and help achieve asthma control. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 8, 2019 Category: Respiratory Medicine Authors: Marc Humbert, Frank C. Albers, Daniel J. Bratton, Steven W. Yancey, Mark C. Liu, Soichiro Hozawa, Jean-Pierre Llanos, Namhee Kwon Source Type: research

Blood eosinophil count and GOLD stage predict response to maintenance azithromycin treatment in COPD patients with frequent exacerbations
Maintenance treatment with macrolides are useful in preventing COPD exacerbations. We investigated which characteristics of COPD patients with frequent exacerbations predicted the best response to maintenance treatment with azithromycin. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 8, 2019 Category: Respiratory Medicine Authors: Remco S. Djamin, Mona Bafadhel, Sevim Uzun, Richard Russell, Anton A.M. Ermens, Rene Kerstens, Joachim G.J.V. Aerts, Ian D. Pavord, Menno M. van der Eerden Source Type: research

Lung function deterioration predicts elevated troponin levels in apparently healthy individuals throughout a 5-year follow-up
Lung function is inversely associated with coronary heart disease and cardiovascular disease. High-sensitive cardiac troponin T (hs-cTnT) was recently found to represent early subclinical cardiac disease even in healthy individuals. We explored the inter-relationship between lung function and hs-cTnT and the changes over time in these two measurements. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 6, 2019 Category: Respiratory Medicine Authors: Mor Krubiner, Udi Shapira, David Zeltser, Itzhak Shapira, Shlomo Berliner, Shani Shenhar-Tsarfaty, Ori Rogowski, Amir Bar-Shai Source Type: research

Patient journey and treatment patterns in adults with IPF based on health care data in Sweden from 2001 to 2015
For patients with idiopathic pulmonary fibrosis (IPF), there is limited real-world data on patient journey and treatment patterns. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 5, 2019 Category: Respiratory Medicine Authors: C. Magnus Sk öld, Lisen Arnheim-Dahlström, Karen Bartley, Christer Janson, Klaus-Uwe Kirchgaessler, Aaron Levine, Giovanni Ferrara Source Type: research

Connective tissue disease-associated interstitial lung disease and outcomes after hospitalization: A cohort study
The impact of hospitalization on patient outcomes is increasingly recognized and considered in the prognostication of many pulmonary disorders. We sought to evaluate the impact of hospitalization on survival in connective tissue disease-interstitial lung disease (CTD-ILD) patients. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 3, 2019 Category: Respiratory Medicine Authors: Ankush P. Ratwani, Kareem I. Ahmad, Scott D. Barnett, Steven D. Nathan, A. Whitney Brown Source Type: research

Risk of bleeding in patients undergoing pulmonary procedures on antiplatelet or anticoagulants: A systematic review
As many as 25% of all patients undergoing invasive pulmonary procedures are receiving at least one antiplatelet or anticoagulant agent. For those undergoing elective procedures, the decision-making process is uncomplicated and the procedure may be postponed until the antiplatelet or anticoagulant agent may be safely held. However, many invasive pulmonary procedures are semi-elective or emergent in nature in which case a risk-benefit calculation and discussion occur between the provider and patient or surrogate decision-maker. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 2, 2019 Category: Respiratory Medicine Authors: D.D. Herman, C.C. Thomson, S. Brosnhan, R. Patel, Trosini-Desert, S. Bilaceroglu, J.T. Poston, M. Liberman, P.L. Shah, D.E. Ost, R. Chatterjee, G.C. Michaud Tags: Review article Source Type: research

A mesh nebulizer is more effective than jet nebulizer to nebulize bronchodilators during non-invasive ventilation of subjects with COPD: A randomized controlled trial with radiolabeled aerosols
Beneficial effects from non-invasive ventilation (NIV) in acute COPD are well-established, but the impact of nebulization during NIV has not been well described. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 30, 2019 Category: Respiratory Medicine Authors: Valdecir Castor Galindo-Filho, Luciana Alcoforado, Catarina Rattes, Dulciane Nunes Paiva, Simone Cristina Soares Brand ão, James B. Fink, Armèle Dornelas de Andrade Source Type: research

Autoantibody status is not associated with change in lung function or survival in patients with idiopathic pulmonary fibrosis
This study aimed to determine the relationship between serologic status, lung function decline and survival. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 29, 2019 Category: Respiratory Medicine Authors: Gillian C. Goobie, Chelsea A. Ford-Sahibzada, Marvin J. Fritzler, Kerri A. Johannson, Charlene D. Fell Source Type: research

TRIPLE inhaled therapy in COPD patients: Determinants of prescription in primary care
To assess the incidence and determinants of the triple inhaled therapy in chronic obstructive pulmonary disease (COPD) primary care patients. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 29, 2019 Category: Respiratory Medicine Authors: Davide L. Vetrano, Alberto Zucchelli, Elisa Bianchini, Claudio Cricelli, Alessio Piraino, Marco Zibellini, Alberto Ricci, Graziano Onder, Francesco Lapi Source Type: research

Revefenacin, a once-daily, lung-selective, long-acting muscarinic antagonist for nebulized therapy: Safety and tolerability results of a 52-week phase 3 trial in moderate to very severe chronic obstructive pulmonary disease
The objective was to characterize the safety profile of revefenacin 88 μg and 175 μg over 52 weeks of treatment. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 28, 2019 Category: Respiratory Medicine Authors: James F. Donohue, Edward Kerwin, Sanjay Sethi, Brett Haumann, Srikanth Pendyala, Lorna Dean, Chris N. Barnes, Edmund J. Moran, Glenn Crater Source Type: research

Healthcare costs of the SATisfaction and adherence to COPD treatment (SAT) study follow-up
Chronic obstructive pulmonary disease (COPD) is characterised by recurring exacerbations. We estimated the costs of healthcare resources for COPD management funded by the Italian National Healthcare Service (INHS) for one year. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 28, 2019 Category: Respiratory Medicine Authors: Angelo G. Corsico, Fulvio Braido, Marco Contoli, Fabiano Di Marco, Paola Rogliani, Carla Scognamillo, Irene Olivi, Pierachille Santus, Nicola Scichilone, Carlo Lazzaro Source Type: research

Influence of frequency and amplitude on the mucus viscoelasticity of the novel mechano-acoustic Frequencer ™
Cystic fibrosis affects 1/3200 Caucasians. This genetic disease disturbs the ion and water homeostasis across epithelia, thus rendering mucus more viscous and harder to expel. Conventional treatments rely on the clapping method coupled with postural drainage. Despite the effectiveness of these procedures, they are invasive and enervating. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 27, 2019 Category: Respiratory Medicine Authors: Dalma Schieppati, R émi Germon, Federico Galli, Marco Giulio Rigamonti, Marta Stucchi, Daria Camilla Boffito Source Type: research

Device-handling study of a novel breath-actuated inhaler, Synchrobreathe ®, versus a pMDI
Synchrobreathe ®, a new-generation, novel breath-actuated inhaler (BAI) can address the key issues arising during the use of both pressurised metered dose inhalers ([pMDIs]; hand-breath coordination) and dry powder inhalers ([DPIs]; high inspiratory flow required) with respect to optimal drug deposition. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 27, 2019 Category: Respiratory Medicine Authors: Santhalingam Balamurugan, Komal Kirti Apte, Bhanu Pratap Singh, Ashish Kumar Deb, Chandrahas Deshmukh, Kinjal Modi, Ajay Godse, Raja Dhar, Keya Rani Lahiri, Virendra Singh, Hiren Pandya, Sujeet Rajan, Abhijit Vaidya, Vaibhav Gaur, Jaideep Gogtay Source Type: research

Bone mineral density and associated fractures in COPD patients: The role of inflammation and pulmonary rehabilitation
We read the paper of Kameyama N et al. about factors associated with rapid bone mineral density (BMD) decline among COPD patients [1]. Osteoporosis is highly prevalent in COPD and associated with several adverse outcomes [2]; thus, investigating the characteristics of patients with rapid BMD decline and associated fractures, might offer further insight into modifying factors of these complications. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 26, 2019 Category: Respiratory Medicine Authors: Afroditi K. Boutou, Maria Papathanassiou, Adamantios Chloros Tags: Correspondence Source Type: research

Long-term treatment with human immunoglobulin for antisynthetase syndrome-associated interstitial lung disease
Interstitial lung disease-associated antisynthetase syndrome (AS-ILD) carries significant morbidity and mortality. Corticosteroids and immunosuppressive drugs are the mainstay of treatment. Human immunoglobulin (IVIg), an immunomodulator without immunosuppressive properties, is effective in myositis but the evidence supporting its use in ILD is scarce. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 20, 2019 Category: Respiratory Medicine Authors: J.A. Huapaya, Robert Hallowell, L. Silhan, I. Pinal-Fernandez, Maria Casal-Dominguez, C. Johnson, J. Albayda, J.J. Paik, C.T. Lin, A. Hussien, A.L. Mammen, L. Christopher-Stine, S.K. Danoff Source Type: research

Targeting quality of life in asthmatic children: The MyTEP pilot randomized trial
Quality of life (QoL) is an important outcome in the management of children with asthma. Mobile Health (m-Health) and Therapeutic Education Programs (TEPs) are increasingly recognized as essential components of pediatric asthma management to improve disease outcomes. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 17, 2019 Category: Respiratory Medicine Authors: Laura Montalbano, Giuliana Ferrante, Giovanna Cilluffo, Manuel Gentile, Marco Arrigo, Dario La Guardia, Mario Allegra, Velia Malizia, Rosalia Paola Gagliardo, Matteo Bonini, Stefania La Grutta Source Type: research

Coexistence of obstructive sleep apnea and telomerase activity, concentration of selected adipose tissue hormones and vascular endothelial function in patients with arterial hypertension
The aim of the present study was to determine the effect of obstructive sleep apnea (OSA) with hypertension on telomerase activity, visfatin and adipsine concentration in the blood and vascular endothelial function assessed by ultrasound measured flow-mediated dilatation of the brachial artery (FMD). (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 17, 2019 Category: Respiratory Medicine Authors: Helena Martynowicz, Olga Kornafel-Flak, Dominika Urbanik, Łukasz Łaczmański, Małgorzata Sobieszczańska, Grzegorz Mazur, Rafał Poręba, Paweł Gać Source Type: research

Screening sarcoidosis patients for cardiac sarcoidosis: What the data really show
Cardiac sarcoidosis is a major cause of death in sarcoidosis patients. In most series, cardiac sarcoidosis is second only to pulmonary sarcoidosis in causes of death related to sarcoidosis [1], although cardiac sarcoidosis has been found to be the leading cause of death in some reports [2,3]. More importantly, the deaths from cardiac sarcoidosis may occur suddenly and early after diagnosis, relating to the development of a small focus of granulomatous inflammation in a strategically vulnerable portion of the cardiac conduction system. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 16, 2019 Category: Respiratory Medicine Authors: Marc A. Judson Tags: Editorial Source Type: research

Impact of pharmaceutical care in the improvement of medication adherence and quality of life for COPD patients in Vietnam
Medication adherence is an important factor in the management of chronic obstructive pulmonary disease (COPD). However, the rate of non-adherence to medications is high in COPD and is associated with worsened clinical outcomes and health-related quality of life for patients. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 14, 2019 Category: Respiratory Medicine Authors: Tu-Son Nguyen, Thi Lien Huong Nguyen, Thi Thuy Van Pham, Susan Hua, Quy Chau Ngo, Shu Chuen Li Source Type: research

Correspondence for “Clinical epidemiology of familial sarcoidosis: A systematic literature review”
It is with great interest that we read the article titled “Clinical epidemiology of familial sarcoidosis: A systematic literature review” by Drs. Terwiel and van Moorsel published recently in Respiratory Medicine [1]. Their systematic review on familial sarcoidosis highlights the great heterogeneity in familial disease prevalence and in familial relati ve risks among published studies. They also emphasize the high heritability (>60%) of sarcoidosis. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 13, 2019 Category: Respiratory Medicine Authors: Marios Rossides, Johan Grunewald, Anders Eklund, Susanna Kullberg, Johan Askling, Elizabeth V. Arkema Tags: Correspondence Source Type: research

Monoclonal antibodies for severe asthma: Pharmacokinetic profiles
Several monoclonal antibodies (mAbs) (omalizumab, mepolizumab, reslizumab, benralizumab, and dupilumab) are currently approved for the treatment of severe asthma. They have complex pharmacokinetic profiles. These profiles are unique in that they are dependent on their structure as well as can be markedly influenced by the biology of their target antigen, but their general behaviour can still be considered a class property, similar to their endogenous IgG counterpart. They cannot be administered by oral route, have a slow distribution into tissue, are metabolized to peptides and amino acids in several tissues but are protec...
Source: Respiratory Medicine - May 13, 2019 Category: Respiratory Medicine Authors: Maria Gabriella Matera, Luigino Calzetta, Paola Rogliani, Mario Cazzola Tags: Review article Source Type: research

Subfreezing air as a cough trigger and multiple triggers are strongly associated with the presence of asthma in chronic cough
Management of chronic cough relies on the recognition of cough background disorders. It is not known whether certain cough triggers are associated with specific background disorders. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 11, 2019 Category: Respiratory Medicine Authors: Heikki O. Koskela, Anne M. L ätti, Juha Pekkanen Source Type: research

Interrelational changes in the epidemiology and clinical features of nontuberculous mycobacterial pulmonary disease and tuberculosis in a referral hospital in Japan
The incidence of nontuberculous mycobacterial pulmonary disease (NTM-PD) is increasing, while that of tuberculosis (TB) is decreasing in many industrialized countries, including Japan. However, the long-term evaluation of clinico-epidemiological features of NTM-PD in relation to TB are limited. We aimed to clarify the long-term changes in the epidemiology and clinical features of NTM-PD in relation to those of TB at a nationally-designated TB center in Japan. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 8, 2019 Category: Respiratory Medicine Authors: Koji Furuuchi, Kozo Morimoto, Takashi Yoshiyama, Yoshiaki Tanaka, Keiji Fujiwara, Masao Okumura, Kiyohiko Izumi, Yuji Shiraishi, Satoshi Mitarai, Hideo Ogata, Atsuyuki Kurashima, Kozo Yoshimori, Ken Ohta, Hajime Goto, Yuka Sasaki Source Type: research

Combined effect of central obesity and urinary PAH metabolites on lung function: A cross-sectional study in urban adults
Central obesity and polycyclic aromatic hydrocarbons (PAHs) exposure were reported as independent risk factors for lung function decline. However, the interaction between central obesity and PAHs exposure on lung function is still unclear. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 6, 2019 Category: Respiratory Medicine Authors: Ge Mu, Yun Zhou, Jixuan Ma, Yanjun Guo, Lili Xiao, Min Zhou, Limin Cao, Wei Li, Bin Wang, Jing Yuan, Weihong Chen Source Type: research

Comparison of the novel CompEx asthma exacerbation endpoint to the ATS/ERS adapted moderate/severe asthma exacerbation definition used in the MITRA trial
One of the main goals of asthma treatment is the prevention of recurrent exacerbations that progressively increase the symptoms of the disease and require a change in treatment [1]. However, severe asthma exacerbations are not frequent events, and high numbers of patients are necessary to assess the clinical effect of a treatment aiming at minimizing or lowering the number of recurrent severe asthma exacerbations. A novel asthma exacerbation endpoint (CompEx) was recently suggested by Fuhlbrigge et al. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 1, 2019 Category: Respiratory Medicine Authors: G öran Eriksson, Hendrik Nolte, Christian Ljørring, Bente Riis, Johann Christian Virchow Tags: Short communication Source Type: research

Comparison of anti-aminoacyl-tRNA synthetase antibody-related and idiopathic non-specific interstitial pneumonia
The objective of this study was to evaluate the clinical differences between patients with ARS-NSIP and idiopathic NSIP (I –NSIP). (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 1, 2019 Category: Respiratory Medicine Authors: Sachiko Shioya, Takeshi Masuda, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Taku Nakashima, Shintaro Miyamoto, Tadashi Senoo, Hiroshi Iwamoto, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori Source Type: research

A review of the burden and management of mild asthma in adults — Implications for clinical practice
Mild asthma is present in 50 –75% of patients with asthma and is defined by the Global Initiative for Asthma as asthma that can be well controlled with low-intensity treatments (Steps 1 and 2). Despite this definition, ‘mild’ asthma is often not well controlled in reality, and can have a significant impact on an individua l's symptom burden and quality of life.We performed a PubMed literature search to investigate the burden of ‘mild’ asthma in the lives of patients, including future risk and asthma control, and the current management strategies. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 1, 2019 Category: Respiratory Medicine Authors: Aruni Mulgirigama, Neil Barnes, Monica Fletcher, S øren Pedersen, Emilio Pizzichini, Ioanna Tsiligianni Tags: Review article Source Type: research

Increase in blood eosinophils during follow-up is associated with lung function decline in adult asthma
Asthma is associated with accelerated rate of lung function (FEV1) decline. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 30, 2019 Category: Respiratory Medicine Authors: Sophie Graff, Sophie Demarche, Monique Henket, Virginie Paulus, Renaud Louis, Florence Schleich Tags: Clinical Trial Paper Source Type: research

Sputum biomarkers during aspirin desensitization in nonsteroidal anti-inflammatory drugs exacerbated respiratory disease
Aspirin desensitization (AD) is an effective and safe therapeutic option for patients with nonsteroidal anti-inflammatory drugs (NSAIDs)-exacerbated respiratory disease (N-ERD). The mechanisms driving its beneficial effects remain poorly understood. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 30, 2019 Category: Respiratory Medicine Authors: Katarzyna Ewa Tyrak, Izabela Kupry ś-Lipińska, Ewa Czarnobilska, Bogdan Jakieła, Kinga Pajdzik, Adam Ćmiel, Hanna Plutecka, Mateusz Koziej, Aleksandra Gawrońska, Ewa Konduracka, Piotr Kuna, Marek Sanak, Lucyna Mastalerz Tags: Clinical Trial Paper Source Type: research

Asthma as aetiology of bronchiectasis in Finland
By definition bronchiectasis (BE) means destructed structure of normal bronchus as a consequence of frequent bacterial infections and inflammation. In many senses, BE is a neglected orphan disease. A recent pan-European registry study, EMBARC, has been set up in order to better understand its pathophysiology, better phenotype patients, and to individualize their management. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 30, 2019 Category: Respiratory Medicine Authors: Jarkko M äntylä, Witold Mazur, Tanja Törölä, Paula Bergman, Tuomas Saarinen, Paula Kauppi Source Type: research

Risk factors for lung cancer in COPD – results from the Bergen COPD cohort study
COPD patients have an increased risk of developing lung cancer, but the underlying mechanisms are poorly understood. We aimed to identify risk factors for lung cancer in patients from the Bergen COPD Cohort Study. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 29, 2019 Category: Respiratory Medicine Authors: Gunnar R. Huseb ø, Rune Nielsen, Jon Hardie, Per Sigvald Bakke, Lorena Lerner, Corina D'Alessandro-Gabazza, Jeno Gyuris, Esteban Gabazza, Pål Aukrust, Tomas Eagan Source Type: research

Use of aclidinium did not increase the risk of death in a noninterventional cohort study in the Clinical Practice Research Datalink (CPRD), United Kingdom
Aclidinium bromide is an inhaled long-acting muscarinic antagonist (LAMA). Although the initial potential increased cardiovascular and mortality risk among users of tiotropium has been ruled out by several observational studies, and clinical trials, there are still concerns related to the use of newer LAMA medications. The current study aimed to evaluate the risk of death among users of aclidinium and other LAMAs. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 26, 2019 Category: Respiratory Medicine Authors: Cristina Rebordosa, Jaume Aguado, Estel Plana, Steven Thomas, Ana Frances, Alejhandra Lei, Esther Garc ía-Gil, Javier Nuevo, Susana Perez-Gutthann, Jordi Castellsague Source Type: research

Association between exhaled nitric oxide and nasal polyposis in severe asthma
Although several contributions exist on the role of fractional exhaled NO (FeNO) in diagnosis and management of asthma, no studies have analysed the association between FeNO in patients with severe asthma and nasal polyposis. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 25, 2019 Category: Respiratory Medicine Authors: Mauro Maniscalco, Cecilia Calabrese, Maria D'Amato, Pietro Guida, Antonio Molino, Maria Aliani, Renato De Tullio, Mariapia Foschino Barbaro, Fabio Luigi Massimo Ricciardolo, Giovanna Elisiana Carpagnano Source Type: research

Risk factors for respiratory tract bacterial colonization in adults with neuromuscular or neurological disorders and chronic tracheostomy
The aim of this study was to describe the endotracheal respiratory flora in a population of adults suffering from neuromuscular or neurological disorders requiring a long-term tracheostomy and to identify risk factors for colonization. We conducted a prospective and single-center observational study among patients with chronic tracheostomy admitted for planned respiratory assessment between February 2015 and December 2016. Data were collected from patient interview and medical charts with a standardized questionnaire. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 24, 2019 Category: Respiratory Medicine Authors: Margaux Lepainteur, Adam Ogna, Bernard Clair, Aur élien Dinh, Catherine Tarragon, Hélène Prigent, Benjamin Davido, Frédéric Barbot, Isabelle Vaugier, Muriel Afif, Anne-Laure Roux, Martin Rottman, David Orlikowski, Jean-Louis Herrmann, Djillali Annane Source Type: research

Pirfenidone in patients with idiopathic pulmonary fibrosis and more advanced lung function impairment
Patients with idiopathic pulmonary fibrosis (IPF) demonstrate a range of lung function impairment. However, the efficacy of antifibrotics compared with placebo has not been assessed in patients with more advanced disease. This post-hoc analysis investigated the efficacy and safety of pirfenidone versus placebo in patients with IPF and more advanced lung function impairment, defined as percent predicted forced vital capacity (%FVC)   (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 24, 2019 Category: Respiratory Medicine Authors: Steven D. Nathan, Ulrich Costabel, Carlo Albera, J ürgen Behr, Wim A. Wuyts, Klaus-Uwe Kirchgaessler, John L. Stauffer, Elizabeth Morgenthien, Willis Chou, Susan L. Limb, Paul W. Noble Source Type: research

Economic burden of incident interstitial lung disease (ILD) and the impact of comorbidity on costs of care
Evidence about the economic burden related to interstitial lung diseases (ILDs) and the cost-driving factors is sparse. In the knowledge that distinct comorbidities affect the clinical course of ILDs, our study investigates their impact on costs of care within first year after diagnosis. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 22, 2019 Category: Respiratory Medicine Authors: Anna Lena Frank, Michael Kreuter, Larissa Schwarzkopf Source Type: research

Serum CXCL11 correlates with pulmonary outcomes and disease burden in sarcoidosis
Sarcoidosis is a systemic granulomatous disease of unknown etiology that affects the lungs in 90% of patients, but has a wide range of disease manifestations and outcomes including chronic and progressive courses. Noninvasive biomarkers are needed to assess these outcomes and guide decisions for long term monitoring and treatment. Interferon-gamma (IFN- γ)-inducible chemotactic cytokines (chemokines), CXCL9, CXCL10 and CXCL11, show promise in this regard because they have been implicated in the pathogenesis of and reflect the burden of granulomatous inflammation. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 16, 2019 Category: Respiratory Medicine Authors: Nicholas K. Arger, Melissa Ho, Prescott G. Woodruff, Laura L. Koth Source Type: research

Late presentation of acute hypercapnic respiratory failure carries a high mortality risk in COPD patients treated with ward-based NIV
This study investigated the relationship between time from hospital presentation to diagnosis of AHRF and in-hospital mortality. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 14, 2019 Category: Respiratory Medicine Authors: Samuel P. Trethewey, Ross G. Edgar, Julien Morlet, Rahul Mukherjee, Alice M. Turner Tags: Clinical Trial Paper Source Type: research