The minimal important difference of the constant work rate cycle test in severe COPD
The Constant Work Rate Cycle Test (CWRT) is a commonly used and sensitive test to detect treatment success in patients with Chronic Obstructive Pulmonary Disease (COPD). Earlier, the Minimal Important Difference (MID) of the CWRT was estimated at 101 s (or 34%) change from baseline based on one well executed study. However, this study was performed in a population of patients with mild-to-moderate COPD, and we have learned that MIDs might be quite different in patients with severe COPD. Therefore, we aimed to establish the MID of the CWRT in patients with severe COPD. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 21, 2023 Category: Respiratory Medicine Authors: Marieke C. van der Molen, Dirk-Jan Slebos, Sonja W.S. Augustijn, Huib A.M. Kerstjens, Jorine E. Hartman Tags: Original Research Source Type: research
Validity and clinical applicability of the 60-second sit-to-stand test in people with acute exacerbations of COPD
The 60-s sit-to-stand test (60STS) is a simple and increasingly popular test of physical function, however evidence to support its appropriateness for assessing people with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is lacking. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 20, 2023 Category: Respiratory Medicine Authors: Olivia McDonald, Luke Perraton, Christian Osadnik Tags: Original Research Source Type: research
Severity and phenotypes of dyspnea in asthma: Impact of comorbidities
Dyspnea is a common but non-specific symptom of asthma, which in particular may be related to anxiety and hyperventilation syndrome, two frequent comorbidities of asthma. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 20, 2023 Category: Respiratory Medicine Authors: Awa Bousso, Celine Chuffart, Maxime Leroy, Alice Gicquello, Aurelie Cottereau, Florence Hennegrave, Antoine Beurnier, Thomas Stoup, Sophie Pereira, Capucine Morelot-Panzini, Camille Taille, Nathalie Bautin, Stephanie Fry, Thierry Perez, Gilles Garcia, Cec Tags: Original Research Source Type: research
Validity and clinical applicability of the 60-secondecond sit-to-stand test in people with acute exacerbations of COPD
The 60-second sit-to-stand test (60STS) is a simple and increasingly popular test of physical function, however evidence to support its appropriateness for assessing people with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is lacking. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 20, 2023 Category: Respiratory Medicine Authors: Olivia McDonald, Luke Perraton, Christian Osadnik Tags: Original Research Source Type: research
Clinical characteristics of chronic obstructive pulmonary disease in never-smokers: A systematic review
Chronic Obstructive Pulmonary Disease (COPD) is the third cause of death worldwide. While tobacco smoking is a key risk factor, COPD also occurs in never-smokers (NS). However, available evidence on risk factors, clinical characteristics, and natural history of the disease in NS is scarce. Here, we perform a systematic review of the literature to better describe the characteristics of COPD in NS. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 19, 2023 Category: Respiratory Medicine Authors: Carlota Rodr íguez García, Alberto Ruano-Ravina, Mónica Pérez Ríos, Lucía Martín Gisbert, Leonor Varela-Lema, Cristina Candal-Pedreira, Cristina Represas-Represas, Julia Rey-Brandariz, Luis Valdés-Cuadrado, Alvar Agustí Source Type: research
Association of age with computed tomography airway tree morphology in male and female never smokers without lung disease history
Sex and aging may affect the airway tree structure in patients with airway diseases and even healthy subjects. Using chest computed tomography (CT), this study sought to determine whether age is associated with airway morphological features differently in healthy males and females. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 15, 2023 Category: Respiratory Medicine Authors: Satoru Terada, Naoya Tanabe, Tomoki Maetani, Yusuke Shiraishi, Ryo Sakamoto, Hiroshi Shima, Tsuyoshi Oguma, Atsuyasu Sato, Megumi Kanasaki, Izuru Masuda, Susumu Sato, Toyohiro Hirai Tags: Original Research Source Type: research
High risk lung nodule: A multidisciplinary approach to diagnosis and management
Pulmonary nodules are often discovered incidentally during CT scans performed for other reasons. While the vast majority of nodules are benign, a small percentage may represent early-stage lung cancer with the potential for curative treatments. With the growing use of CT for both clinical purposes and lung cancer screening, the number of pulmonary nodules detected is expected to increase substantially. Despite well-established guidelines, many nodules do not receive proper evaluation due to a variety of factors, including inadequate coordination of care and financial and social barriers. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 13, 2023 Category: Respiratory Medicine Authors: Babith J. Mankidy, GhasemiRad Mohammad, Kelly Trinh, Anoop P. Ayyappan, Quillan Huang, Steven Bujarski, Mohammad S. Jafferji, Ravi Ghanta, Alexander N. Hanania, Donald R. Lazarus Tags: Review article Source Type: research
Rheumatoid arthritis associated interstitial lung disease: Trends in epidemiology and mortality in Ontario from 2000-2018
The epidemiology and mortality of rheumatoid arthritis related interstitial lung disease (RA-ILD) have not been described in Canada. Our aim was to describe recent trends in RA-ILD prevalence, incidence, and mortality in Ontario, Canada. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 12, 2023 Category: Respiratory Medicine Authors: Lee Fidler, Jessica Widdifield, Jolene H. Fisher, Shane Shapera, Andrea S. Gershon Tags: Original Research Source Type: research
A practical approach to pseudoexudative pleural effusions
Light's criteria falsely label a significant number of effusions as exudates. Such exudative effusions with transudative etiologies are referred to as “pseduoexudates”. In this review, we discuss a practical approach to correctly classify an effusion that may be a pseudoexudate. A PubMed search yielded 1996 manuscripts between 1990 and 2022. Abstracts were screened and 29 relevant studies were included in this review article. Common etiologies for pseudoexudates include diuretic therapy, traumatic pleural taps, and coronary artery bypass grafting. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 10, 2023 Category: Respiratory Medicine Authors: Gaurav Mohan, Poorva Bhide, Abhinav Agrawal, Viren Kaul, Udit Chaddha Source Type: research
Correspondence regarding the paper “Laorden D, Zamarrón E, Romero D, Domínguez-Ortega J, Villamañán E, Losantos I, Gayá F, Quirce S, Álvarez-Sala R. evaluation of FEOS score and super-responder criteria in a real-life cohort treated with anti-IL5/IL5R. Respir. Med. 2023; 211: 107216”
We have read with great interest the recent study by Laorden et al., “Evaluation of FEOS score and super-responder criteria in a real-life cohort treated with anti-IL5/IL5R” [1]. While their study provides valuable insights into using the FEOS score proposed by Perez de Llano et al. [2] and super-responder criteria defined by Upham et al. [3], some points require further analysis. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 9, 2023 Category: Respiratory Medicine Authors: Miguel Estrav ís, Jacqueline Pérez-Pazos, Maria J. Martin, Jacinto Ramos-González, María Gil-Melcón, Cristina Martín-García, Asunción García-Sánchez, Catalina Sanz, Ignacio Dávila Tags: Correspondence Source Type: research
The association between MUC5AC and MUC5B genes expression and remodeling progression in severe neutrophilic asthma: A direct relationship
This study investigates the expression of MUC5AC and MUC5B at mRNA levels on asthma severity and airway wall thickness in severe neutrophilic asthmatic patients. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 3, 2023 Category: Respiratory Medicine Authors: Amirhossein Mohajeri Khorasani, Bita Mohammadi, Mohammad Reza Saghafi, Samane Mohamadi, Shadi Ghaffari, Majid Mirsadraee, Mohammad Reza Khakzad Tags: Original Research Source Type: research
There is still no established and accepted definition of COPD
The treatment of any patient is strictly related to the diagnosis of his/her disease, an evident axiom that can, however, find complex application when identifying the condition is not easy because its definition is not univocal, varying over time. This necessarily leads to underestimating or overestimating the presence of the disease to be treated, with an evident impact on the treatment to be used. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 2, 2023 Category: Respiratory Medicine Authors: Mario Cazzola, Francesco Blasi Tags: Short communication Source Type: research
Lung parenchymal abnormalities and outcomes in hospitalized patients with COVID 19 pneumonia: A positive message from a prospective hospital-based longitudinal study for future considerations
Pulmonary fibrosis is one of the commonly reported sequelae with varying frequencies among the survivors of COVID-19. [1 –3] While parenchymal lung abnormalities (PLA) on High Resolution Computed Tomography (HRCT) scan in patients with COVID-19 pneumonia with varying periods of follow up have been reported, pulmonary consequences are clinically significant for the potential of therapeutic intervention and highlighte d as a key research priority [4,5]. We undertook a prospective observational study in RT-PCR confirmed adult (>18 years) COVID-19 patients hospitalized from June –September 2020 at a tertiary care hospita...
Source: Respiratory Medicine - April 29, 2023 Category: Respiratory Medicine Authors: Bornali Datta, Ashish Kumar Prakash, Kavitha Yaddanapudi, Kulbir Ahlawat, Jaya Prasad Tripathy, Pinky Goyal, Anand Jaiswal, Padam Singh, Sudhakar Pipavath, Ganesh Raghu Tags: Short communication Source Type: research
Cardiopulmonary exercise testing applied to respiratory medicine: Myths and facts
Cardiopulmonary exercise testing (CPET) remains poorly understood and, consequently, largely underused in respiratory medicine. In addition to a widespread lack of knowledge of integrative physiology, several tenets of CPET interpretation have relevant controversies and limitations which should be appropriately recognized. With the intent to provide a roadmap for the pulmonologist to realistically calibrate their expectations towards CPET, a collection of deeply entrenched beliefs is critically discussed. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 24, 2023 Category: Respiratory Medicine Authors: J. Alberto Neder Source Type: research
Reviewer Thank You
(Source: Respiratory Medicine)
Source: Respiratory Medicine - April 21, 2023 Category: Respiratory Medicine Source Type: research
