Exercise training initiated early during hospitalisation in individuals with chronic obstructive pulmonary disease is safe and improves exercise capacity and physical function at hospital discharge: A systematic review and meta-analysis
Earlier reviews of exercise in people during exacerbation of chronic obstructive pulmonary disease (COPD) included studies where exercise training was initiated late during hospital admission or shortly following hospital discharge. Our question was: in adults hospitalised with an exacerbation of COPD, does initiating exercise training early during an admission versus not initiating exercise training during admission, change outcomes measured at discharge? (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 31, 2024 Category: Respiratory Medicine Authors: Yuin Lai, Vinicius Cavalheri, Abbey Sawyer, Kylie Hill Source Type: research
Severity of bronchiectasis predicts use of and adherence to high frequency chest wall oscillation therapy - Analysis from the United States Bronchiectasis and NTM research registry
High frequency chest wall oscillation (HFCWO) is a form of airway clearance therapy that has been available since the mid-1990s and is routinely used by patients suffering from retained pulmonary secretions. Patients with cystic fibrosis (CF), neuromuscular disease (NMD), and other disorders, including bronchiectasis (BE) and COPD (without BE), are commonly prescribed this therapy. Limited evidence exists describing HFCWO use in the BE population, its impact on long-term management of disease, and the specific patient populations most likely to benefit from this therapy. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 31, 2024 Category: Respiratory Medicine Authors: Ashwin Basavaraj, Radmila Choate, Brian C. Becker, Timothy R. Aksamit, Mark L. Metersky, Bronchiectasis and NTM Research Registry Investigators Tags: Original Research Source Type: research
Secondary Analysis of Fluids and Catheters Treatment Trial (FACTT) data reveal poor clinical outcomes in acute respiratory distress syndrome patients with diabetes
Conflicting reports exist about the link between diabetes mellitus (DM) and acute respiratory distress syndrome (ARDS). Our study examines the impact of pre-existing DM on ARDS patients within the Fluid and Catheter Treatment Trial (FACTT). (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 27, 2024 Category: Respiratory Medicine Authors: Abdulaziz H. Alanazi, Sultan Almuntashiri, Andrea Sikora, Duo Zhang, Payaningal R. Somanath Tags: Original Research Source Type: research
Rapid review of ventilator-induced diaphragm dysfunction
Ventilator-induced diaphragm dysfunction is gaining increased recognition. Evidence of diaphragm weakness can manifest within 12 h to a few days after the initiation of mechanical ventilation. Various noninvasive and invasive methods have been developed to assess diaphragm function. The implementation of diaphragm-protective ventilation strategies is crucial for preventing diaphragm injuries. Furthermore, diaphragm neurost imulation emerges as a promising and novel treatment option. In this rapid review, our objective is to discuss the current understanding of ventilator-induced diaphragm dysfunction, diagnostic approac...
Source: Respiratory Medicine - January 27, 2024 Category: Respiratory Medicine Authors: Huimin Wu, Bobby Chasteen Source Type: research
The diagnostic value of bronchial provocation testing combined with fractional exhaled nitric oxide (FeNO) in children with chest tightness-variant asthma (CTVA)
Chest tightness-variant asthma (CTVA) is a novel atypical asthma characterized by chest tightness as the sole or primary symptom. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 27, 2024 Category: Respiratory Medicine Authors: Tengteng Zhang, Lijuan Xu, Yingqian Zhang, Lina Zhen Tags: Original Research Source Type: research
Dupilumab sustains lung function improvements in patients with moderate-to-severe asthma
TRAVERSE (NCT02134028), a phase 3 open-label extension study, assessed dupilumab safety and efficacy in patients with asthma aged ≥12 years who completed a previous dupilumab asthma study. This analysis evaluated changes in multiple lung function parameters in patients with moderate-to-severe asthma with elevated type 2 biomarkers (baseline eosinophils ≥150 cells·μL−1 or fractional exhaled nitric oxide [FeNO] ≥25 p pb) who completed QUEST (parent study) and 2 years of dupilumab treatment in TRAVERSE. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 23, 2024 Category: Respiratory Medicine Authors: Alberto Papi, Mario Castro, Jonathan Corren, Ian D. Pavord, Yuji Tohda, Arman Altincatal, Nami Pandit-Abid, Elizabeth Laws, Bolanle Akinlade, Leda P. Mannent, Rebecca Gall, Juby A. Jacob-Nara, Yamo Deniz, Paul J. Rowe, David J. Lederer, Megan Hardin Tags: Original Research Source Type: research
Prognostic impact of chronic obstructive pulmonary disease in patients with heart failure with mildly reduced ejection fraction
The aging population has led to a significant increase in heart failure (HF) patients. Related to demographic changes, the burden with comorbidities was shown to increase in patients with HF. Whereas chronic obstructive pulmonary disease (COPD) was yet demonstrated to be associated with adverse outcomes in patients with HF, the prognostic impact of COPD in HF with mildly reduced ejection fraction (HFmrEF) has not yet been clarified. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 23, 2024 Category: Respiratory Medicine Authors: Felix Lau, Tobias Schupp, Alexander Schmitt, Marielen Reinhardt, Noah Abel, Mohammad Abumayyaleh, Kathrin Weidner, Daniel Duerschmied, Mohamed Ayoub, Kambis Mashayekhi, Muharrem Akin, Niklas Ayasse, Ibrahim Akin, Michael Behnes Tags: Original Research Source Type: research
Effectiveness of omalizumab across different dosing regimens in patients with moderate-to-severe allergic asthma
For patients with moderate-to-severe persistent allergic asthma, omalizumab is approved for subcutaneous administration according to a recommended dosing table based on weight and total immunoglobulin E (IgE) level. The aim of this analysis was to assess asthma outcomes including quality of life in patients with allergic asthma initiated on omalizumab in the PROSPERO trial; patients were stratified by where their IgE and body weight fell on the approved dosing table. Patient groups were defined as Inside Dosing Table: patients whose IgE and weight fell within the approved dosing table (n = 506); Insufficient Data to R...
Source: Respiratory Medicine - January 20, 2024 Category: Respiratory Medicine Authors: Nicole M. Chase, Monica Littlejohn, Cecile T.J. Holweg, Lauren A. Millette, Arpamas Seetasith, John W. Steinke, Benjamin L. Trzaskoma, Nicola A. Hanania, Thomas B. Casale Tags: Short communication Source Type: research
Obstructive sleep related breathing disorders and cardiometabolic risk factors – A Portuguese birth cohort
Pediatric obstructive sleep related breathing disorders (SRBD) are an important under-diagnosed health problem with associated cardiometabolic comorbidities, demonstrated with polysomnographic studies in selected samples. Our main goal was to assess the prevalence of SRBD in a population-based cohort and to analyze its association with cardiometabolic risk factors, in general and by sex. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 19, 2024 Category: Respiratory Medicine Authors: Mariana Costa, Liane Correia-Costa, Ana Cristina Santos, In ês Azevedo Tags: Original Research Source Type: research
Disease diagnosis and severity classification in pulmonary fibrosis using carbonyl volatile organic compounds in exhaled breath
Pathophysiological conditions underlying pulmonary fibrosis remain poorly understood. Exhaled breath volatile organic compounds (VOCs) have shown promise for lung disease diagnosis and classification. In particular, carbonyls are a byproduct of oxidative stress, associated with fibrosis in the lungs. To explore the potential of exhaled carbonyl VOCs to reflect underlying pathophysiological conditions in pulmonary fibrosis, this proof-of-concept study tested the hypothesis that volatile and low abundance carbonyl compounds could be linked to diagnosis and associated disease severity. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 18, 2024 Category: Respiratory Medicine Authors: Matthew J. Taylor, Corey P. Chitwood, Zhenzhen Xie, Hunter A. Miller, Victor H. van Berkel, Xiao-An Fu, Hermann B. Frieboes, Sally A. Suliman Tags: Original Research Source Type: research
Hypouricemia as a novel predictor of mortality in anti-MDA5 positive dermatomyositis patients with ILD: A retrospective cohort study
Anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis (MDA5+ DM) is a unique subtype of idiopathic inflammatory myopathy (IIM) that is associated with rapidly progressive interstitial lung disease (RPILD) and high mortality. This retrospective study aimed to identify predictors of mortality and discover novel easily detectable indicators. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 14, 2024 Category: Respiratory Medicine Authors: Hongjiang Liu, Bo Chen, Yixue Guo, Huan Liu, Jingjing Ran, Ruiting Liu, Geng Yin, Qibing Xie Tags: Original Research Source Type: research
Small airways in asthma: From inflammation and pathophysiology to treatment response
Summary: Small airways play a crucial role in asthma. The current review provides an overview of the physiology of the small airways, the most widely used pulmonary function tests to assess small airway function and the results of asthma treatments on small airways function, inflammation, and remodelling. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 13, 2024 Category: Respiratory Medicine Authors: Anastasia Siora, Angelos Vontetsianos, Nikolaos Chynkiamis, Christina Anagnostopoulou, Konstantinos Bartziokas, Nektarios Anagnostopoulos, Nikoletta Rovina, Petros Bakakos, Andriana I. Papaioannou Source Type: research
The interplay between obesity and blood neutrophils in adult-onset asthma
Obesity is an established risk factor for the development of asthma in adults [1], often associated with a type-2 low phenotype [2]. Further, obese individuals with asthma have poorer asthma control and prognosis than non-obese individuals with asthma [2 –4]. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 10, 2024 Category: Respiratory Medicine Authors: Helena Backman, Sofia Winsa Lindmark, Linnea Hedman, Hannu Kankaanranta, Katja Warm, Anne Lindberg, Apostolos Bossios, Eva R önmark, Caroline Stridsman Tags: Short communication Source Type: research
Comparison of clinical remission criteria for severe asthma patients receiving biologic therapy
The concept of remission on biological treatment has been suggested as a therapeutic target for patients with severe asthma, composed of 1. no chronic use of systemic steroids, 2. no exacerbations, 3. minimal symptoms, and 4. optimized lung function, for a significant time. However, the criteria for remission are not clearly defined. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 8, 2024 Category: Respiratory Medicine Authors: Anna Breslavsky, Ahsen Al Qaied, Philip Tsenter, Nikita Mukaseev, Mohamed Alamor, Keren Cohen-Hagai, Ori Wand Tags: Original Research Source Type: research
Tiotropium reduces clinically important deterioration in patients with mild-to-moderate chronic obstructive pulmonary disease: A post hoc analysis of the Tie-COPD study
Clinically important deterioration (CID) is a composite endpoint used to holistically assess the complex progression of chronic obstructive pulmonary disease (COPD). Tiotropium improves lung function and reduces the rate of COPD exacerbations in patients with COPD of Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 1 (mild) or 2 (moderate). However, whether tiotropium reduces CID risk in patients with mild-to-moderate COPD remains unclear. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 8, 2024 Category: Respiratory Medicine Authors: Fan Wu, Cuiqiong Dai, Yumin Zhou, Zhishan Deng, Zihui Wang, Xiaochen Li, Shuyun Chen, Weijie Guan, Nanshan Zhong, Pixin Ran Tags: Original Research Source Type: research
