Disease diagnosis and severity classification in pulmonary fibrosis using carbonyl volatile organic compounds in exhaled breath

Pathophysiological conditions underlying pulmonary fibrosis remain poorly understood. Exhaled breath volatile organic compounds (VOCs) have shown promise for lung disease diagnosis and classification. In particular, carbonyls are a byproduct of oxidative stress, associated with fibrosis in the lungs. To explore the potential of exhaled carbonyl VOCs to reflect underlying pathophysiological conditions in pulmonary fibrosis, this proof-of-concept study tested the hypothesis that volatile and low abundance carbonyl compounds could be linked to diagnosis and associated disease severity.

Source: Respiratory Medicine - January 18, 2024 Category: Respiratory Medicine Authors: Matthew J. Taylor, Corey P. Chitwood, Zhenzhen Xie, Hunter A. Miller, Victor H. van Berkel, Xiao-An Fu, Hermann B. Frieboes, Sally A. Suliman Tags: Original Research Source Type: research