Preface
The past decade has seen large shifts in our approach to asthma, with the achievement of many advances in our understanding of its underlying mechanisms and the development of new approaches to its diagnosis and treatment. Indeed, much has changed from our new understanding of disease heterogeneity and related comorbid conditions, to the use of variable dosing of inhaled steroids and reliever combination therapies and to the development of targeted biologics. In this special issue of Respiratory Medicine entitled “Innovations in Asthma”, several publications highlight innovations that are at the forefront of asthma res...
Source: Respiratory Medicine - July 13, 2023 Category: Respiratory Medicine Authors: Zuzana Diamant, Sven F. Seys, Linda Rogers, Nicola A. Hanania Tags: Editorial Source Type: research
Prolonged-release pirfenidone in patients with pulmonary fibrosis as a phenotype of post-acute sequelae of COVID-19 pneumonia. Safety and efficacy
One of the major concerns with post-acute sequelae of COVID-19 (PASC) is the development of pulmonary fibrosis, for which no approved pharmacological treatments exist. Therefore, the primary aim of this open-label study was to evaluate the safety and the potential clinical efficacy of a prolonged-release pirfenidone formulation (PR-PFD) in patients having PASC-pulmonary fibrosis. (Source: Respiratory Medicine)
Source: Respiratory Medicine - July 12, 2023 Category: Respiratory Medicine Authors: R.H. Sansores, A. Ram írez-Venegas, F. Montiel-Lopez, S. Domínguez-Arellano, L.F. Alva-Lopez, R. Falfán-Valencia, G. Pérez-Rubio, E. Olaya-López, E.O. Zavaleta-Martínez, S. Aguilar-Medina, J.C. Escobar-Alvarado, J.L. Poo, M.G. Matera, M. Cazzola Tags: Original Research Source Type: research
Novel pneumonia score based on a machine learning model for predicting mortality in pneumonia patients on admission to the intensive care unit
Scores for predicting the long-term mortality of severe pneumonia are lacking. The purpose of this study is to use machine learning methods to develop new pneumonia scores to predict the 1-year mortality and hospital mortality of pneumonia patients on admission to the intensive care unit (ICU). (Source: Respiratory Medicine)
Source: Respiratory Medicine - July 12, 2023 Category: Respiratory Medicine Authors: Bin Wang, Yuanxiao Li, Ying Tian, Changxi Ju, Xiaonan Xu, Shufen Pei Tags: Original Research Source Type: research
Effect of bronchial thermoplasty on static and dynamic lung compliance and resistance in patients with severe persistent asthma
Bronchial thermoplasty (BT) reduces severity and frequency of bronchoconstriction and symptoms in severe, persistent asthmatics although it is usually not associated with change in spirometric variables. Other than spirometry. there are almost no data on changes in lung mechanics following BT. (Source: Respiratory Medicine)
Source: Respiratory Medicine - July 8, 2023 Category: Respiratory Medicine Authors: Ahmet Baydur, Richard Barbers, Darren May Tags: Original Research Source Type: research
Home-based pulmonary rehabilitation for adults with severe asthma exposed to psychosocial chronic stressors
To evaluate the effects of a home-based pulmonary rehabilitation (PR) programme on hyperventilation symptoms, anxiety and depressive symptoms, general fatigue, health-related quality of life (HRQoL) and exercise capacity in adults with severe asthma who have been exposed to psychosocial chronic stressors. (Source: Respiratory Medicine)
Source: Respiratory Medicine - July 7, 2023 Category: Respiratory Medicine Authors: Sarah Gephine, St éphanie Fry, Emilie Margoline, Alice Gicquello, Cécile Chenivesse, Jean-Marie Grosbois Tags: Original Research Source Type: research
Bronchial thermoplasty attenuates bronchodilator responsiveness
This study was designed to address this question. (Source: Respiratory Medicine)
Source: Respiratory Medicine - July 6, 2023 Category: Respiratory Medicine Authors: Cyndi Henry, Sabrina Biardel, Magali Boucher, Krystelle Godbout, Jamila Chakir, Andr éanne Côté, Michel Laviolette, Ynuk Bossé Tags: Original Research Source Type: research
Severe asthma clinical remission after biologic treatment with anti-IL4/IL13: A real-life experience
Dupilumab, a fully human anti-interleukin-4/interleukin-13 monoclonal antibody, has shown efficacy in many aspects of Type-2 severe asthma management. Currently, we lack real-life studies addressing the achievment of clinical remission in patients treated with this biologic. (Source: Respiratory Medicine)
Source: Respiratory Medicine - July 6, 2023 Category: Respiratory Medicine Authors: Andrea Portacci, Ilaria Iorillo, Vitaliano Nicola Quaranta, Leonardo Maselli, Ernesto Lulaj, Enrico Buonamico, Silvano Dragonieri, Giovanna Elisiana Carpagnano Tags: Original Research Source Type: research
STOP-Bang for OSA screening in patients with pulmonary hypertension
Obstructive sleep apnea (Source: Respiratory Medicine)
Source: Respiratory Medicine - July 5, 2023 Category: Respiratory Medicine Authors: Thomas H. Fox, Michael Lanasa, Lesley Ann Saketkoo, Shigeki Saito, Bennett P. deBoisblanc, Matthew R. Lammi Tags: Short communication Source Type: research
Angiographic classification of pulmonary vascular lesion in Takayasu arteritis: A cohort study
Percutaneous transluminal pulmonary angioplasty (PTPA) can significantly improve the haemodynamics and prognosis of patients with Takayasu arteritis and pulmonary artery involvement. However, the choice of PTPA is mainly based on clinical experience. We aim to classify pulmonary artery lesions in Takayasu arteritis according to pulmonary angiogram and evaluate the PTPA success rate and technical difficulty of different types of lesions. (Source: Respiratory Medicine)
Source: Respiratory Medicine - July 2, 2023 Category: Respiratory Medicine Authors: Tao Yang, Xin Li, Qin Luo, Qing Zhao, Qixian Zeng, Yi Zhang, Anqi Duan, Zhihua Huang, Meixi Hu, Changming Xiong, Zhihui Zhao, Zhihong Liu Tags: Original Research Source Type: research
Underdiagnosis and misclassification of COPD in Sweden – A Nordic Epilung study
The prevalence of COPD tends to level off in populations with decreasing prevalence of smoking but the extent of underdiagnosis in such populations needs further investigation. (Source: Respiratory Medicine)
Source: Respiratory Medicine - July 2, 2023 Category: Respiratory Medicine Authors: Malin Axelsson, Helena Backman, Bright I. Nwaru, Caroline Stridsman, Lowie Vanfleteren, Linnea Hedman, P äivi Piirilä, Juuso Jalasto, Arnulf Langhammer, Hannu Kankaanranta, Madeleine Rådinger, Linda Ekerljung, Eva Rönmark, Anne Lindberg Tags: Original Research Source Type: research
Comment on: Identifying responders and exploring mechanisms of action of the endobronchial coil treatment for emphysema
I have read the article titled “Identifying responders and exploring the mechanism of action of endobronchial coil treatment for Emphysema” by Jorine E. Hartman et al. [1] I would like to express my appreciation for its informative and well-structured nature. I agree with the conclusion that patients suffering from emphysema can benefit significantly from endobronchial coil treatment, primarily through the reduction of static hyperinflation, which leads to improvements in airway resistance and dynamic lung mechanics. (Source: Respiratory Medicine)
Source: Respiratory Medicine - July 1, 2023 Category: Respiratory Medicine Authors: Bakht Muhammad Tags: Correspondence Source Type: research
Dyspnea-induced Limitation (DYSLIM), a new self-administered concise questionnaire to evaluate dyspnea-related activity limitation in chronic respiratory diseases
Few questionnaires are available for routine assessment of dyspnea. The study aimed to design a self-administered questionnaire assessing the impact of chronic dyspnea on daily activities, named DYSLIM (Dyspnea-induced Limitation). (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 30, 2023 Category: Respiratory Medicine Authors: T. Perez, N. Roche, H. Nunes, P.R. Burgel, A. Chaouat, P. Surpas, F. Herengt, G. Garcia, J.M. Grosbois, S. Stelianides, Ph de Rigal, Ph Gu érin, B. Arnould, J. Coste Tags: Original Research Source Type: research
Efficacy of mometasone/indacaterol/glycopyrronium in patients with inadequately controlled asthma with respect to baseline eosinophil count: Post hoc analysis of IRIDIUM study
Baseline characteristics could potentially guide asthma treatments. We evaluated whether baseline eosinophil levels affect the efficacy of mometasone/indacaterol/glycopyrronium (MF/IND/GLY) in patients with inadequately controlled asthma. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 29, 2023 Category: Respiratory Medicine Authors: Konstantinos Kostikas, Jorge F. Maspero, Kenneth R. Chapman, Karen Mezzi, Xavier Jaumont, David Lawrence, Richard van Zyl-Smit Tags: Original Research Source Type: research
Differential impacts between fat mass index and fat-free mass index on patients with COPD
Differences in the clinical impacts of fat mass index (FMI) and fat-free mass index (FFMI) remain unclear in patients with chronic obstructive pulmonary disease (COPD). We hypothesized that FMI and FFMI have different impacts on 1) emphysema and 2) pulmonary function and health-related quality of life of COPD patients. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 28, 2023 Category: Respiratory Medicine Authors: Takashi Shimada, Shotaro Chubachi, Shiro Otake, Kaori Sakurai, Mamoru Sasaki, Hiroaki Iijima, Naoya Tanabe, Kazuya Tanimura, Kaoruko Shimizu, Toru Shirahata, Masaru Suzuki, Susumu Sato, Hidetoshi Nakamura, Koichiro Asano, Koichi Fukunaga Tags: Original Research Source Type: research
Abnormalities on baseline chest imaging are risk factors for immune checkpoint inhibitor associated pneumonitis
Chronic lung disease is a proposed risk factor for immune checkpoint inhibitor pneumonitis (ICI-pneumonitis); however, data is sparse regarding the impact of pre-existing lung disease and baseline chest imaging abnormalities on the risk of developing ICI-pneumonitis. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 27, 2023 Category: Respiratory Medicine Authors: Danielle Stahlbaum, Renea Jablonski, Mary E. Strek, Christine M. Bestvina, Mei-Yin Polley, Pankti Reid Tags: Original Research Source Type: research
