Abnormalities on baseline chest imaging are risk factors for immune checkpoint inhibitor associated pneumonitis
Chronic lung disease is a proposed risk factor for immune checkpoint inhibitor pneumonitis (ICI-pneumonitis); however, data is sparse regarding the impact of pre-existing lung disease and baseline chest imaging abnormalities on the risk of developing ICI-pneumonitis. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 27, 2023 Category: Respiratory Medicine Authors: Danielle Stahlbaum, Renea Jablonski, Mary E. Strek, Christine M. Bestvina, Mei-Yin Polley, Pankti Reid Tags: Original Research Source Type: research
Artificial intelligence in respiratory therapy: Opportunities and ethical challenges
Artificial Intelligence (AI) is transforming the healthcare industry, including respiratory therapy. AI-powered tools such as predictive analytics and machine learning algorithms have the potential to enhance patient outcomes and improve the efficiency of care delivery [1 –3]. However, the increasing use of AI in respiratory therapy also poses ethical challenges that need to be addressed [4–6]. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 26, 2023 Category: Respiratory Medicine Authors: Prakasini Satapathy, Bijaya K. Padhi, Noor Ali AL-Khathlan Tags: Correspondence Source Type: research
Clinical outcomes of transbronchial cryobiopsy using a 1.1-mm diameter cryoprobe for peripheral lung lesions - A prospective pilot study
Transbronchial cryobiopsy (TBCB) is a novel technique for the diagnosis of peripheral lung lesions (PLLs). We aim to evaluate the clinical outcomes of TBCB using a new 1.1-mm diameter cryoprobe for the diagnosis of PLLs. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 25, 2023 Category: Respiratory Medicine Authors: Soo Han Kim, Jeongha Mok, Saerom Kim, Wan Ho Yoo, Eun-Jung Jo, Mi-Hyun Kim, Kwangha Lee, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee, Jung Seop Eom Tags: Original Research Source Type: research
Analysis of inflammatory protein profiles in the circulation of COVID-19 patients identifies patients with severe disease phenotypes
The coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) can present with a broad range of clinical manifestations, ranging from asymptomatic to severe multiple organ failure. The severity of the disease can vary depending on factors such as age, sex, ethnicity, and pre-existing medical conditions. Despite multiple efforts to identify reliable prognostic factors and biomarkers, the predictive capacity of these markers for clinical outcomes remains poor. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 24, 2023 Category: Respiratory Medicine Authors: Nick Keur, Maria Saridaki, Isis Rica ño-Ponce, Mihai G. Netea, Evangelos J. Giamarellos-Bourboulis, Vinod Kumar Tags: Original Research Source Type: research
Potential applications of P2X3 receptor antagonists in the treatment of refractory cough
Refractory chronic cough is defined as a clinical condition in which the cause of the cough remains unclear after comprehensive examination and treatment, or the cause is clear but symptomatic treatment is ineffective. Patients with refractory chronic cough experience a variety of physiological and psychological issues that significantly lower their quality of life and place a significant socio-economic burden on society. As a result, research both domestically and internationally has turned heavily toward these patients. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 24, 2023 Category: Respiratory Medicine Authors: Baiyi Yi, Shengyuan Wang, Wanzhen Li, Xianghuai Xu, Li Yu Tags: Review article Source Type: research
Exercise oscillatory ventilation in patients with coexisting chronic obstructive pulmonary disease and heart failure: Clinical implications
Exercise oscillatory ventilation (EOV) is considered an important variable for predicting poor prognosis in patients with heart failure (HF) with reduced left ventricular ejection fraction (HFrEF). However, there are no studies evaluating EOV presence in the coexistence chronic obstructive pulmonary disease (COPD) and HFrEF. Aims: I) To compare the clinical characteristics of participants with coexisting HFrEF-COPD with and without EOV during cardiopulmonary exercise testing (CPET); and II) to identify the impact of EOV on mortality during follow-up for 35 months. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 23, 2023 Category: Respiratory Medicine Authors: C ássia da Luz Goulart, Rebeca Nunes Silva, Piergiuseppe Agostoni, Frits M.E. Franssen, Jonathan Myers, Ross Arena, Audrey Borghi-Silva Tags: Original Research Source Type: research
Emphysema and interstitial lung disease in systemic sclerosis-related pulmonary hypertension
Pulmonary hypertension (PH) is a major cause of morbidity and mortality among patients with systemic sclerosis (SSc) [1]. Patients with SSc-PH and concomitant interstitial lung disease (ILD) have worse clinical outcomes compared to those with SSc-PH, alone [2 –4]. In patients with increasing ILD severity, as assessed by forced vital capacity (FVC), there is a trend toward increased all-cause mortality [5]. Common in restrictive lung diseases including ILD [5], reduced FVC also occur in obstructive lung diseases, including chronic obstructive pulmonary disease (COPD), which can also affect SSc patients. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 17, 2023 Category: Respiratory Medicine Authors: Jasmine Vakhshoorzadeh, Justin K. Lui, Ruchika A. Sangani, Marcin A. Trojanowski, Andreea M. Bujor, Michael P. LaValley, Elizabeth S. Klings Tags: Short communication Source Type: research
Mild asthma: Lessons learned and remaining questions
Patients living with mild disease represent the largest proportion of asthma patients. There are significant challenges in proposing a definition that would best describe these patients, while also accurately identifying at-risk individuals. Current literature suggests considerable inflammatory and clinical heterogeneity within this group. Research has shown that these patients are at risk of poor control, exacerbations, lung function decline, and death. Despite conflicting data on its prevalence, eosinophilic inflammation appears to be a predictor of poorer outcomes in mild asthma. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 14, 2023 Category: Respiratory Medicine Authors: Arjun Mohan, Njira L. Lugogo Tags: Original Research Source Type: research
Structural changes in lung morphology detected by MRI after modulating therapy with elexacaftor/tezacaftor/ivacaftor in adolescent and adult patients with cystic fibrosis
Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) improves CFTR function in cystic fibrosis (CF) patients homozygous or heterozygous for F508del mutation. The aim of the study was to evaluate the response to ELX/TEZ/IVA treatment both clinically and morphologically in terms of bronchiectasis, bronchial wall thickening, mucus plugging, abscess and consolidations. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 13, 2023 Category: Respiratory Medicine Authors: Valentina Fainardi, Kaltra Skenderaj, Andrea Ciuni, Gianluca Milanese, Michela Deolmi, Francesco Longo, Cinzia Spaggiari, Nicola Sverzellati, Susanna Esposito, Giovanna Pisi Tags: Original Research Source Type: research
Efficacy and safety of antifibrotic agents in the treatment of CTD-ILD and RA-ILD: A systematic review and meta-analysis
This study aimed to investigate the efficacy and safety of antifibrotic agents in the treatment of CTD-ILD and RA-ILD. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 12, 2023 Category: Respiratory Medicine Authors: Mei Yang, Yan-Qing Wu, Xue-Mei Liu, Chen Zhao, Ting Li, Ting-Qian Li, Xia-Wei Zhang, Hong-Li Jiang, Bing Mao, Wei Liu Source Type: research
Bronchial thermoplasty improves cough hypersensitivity and cough in severe asthmatics
Cough is a troublesome symptom of asthma because it is associated with disease severity and poor asthma control. Bronchial thermoplasty (BT) may be effective in improving cough severity and cough-related quality of life in severe uncontrolled asthma. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 10, 2023 Category: Respiratory Medicine Authors: Hirono Nishiyama, Yoshihiro Kanemitsu, Johsuke Hara, Kensuke Fukumitsu, Norihisa Takeda, Ryota Kurokawa, Keima Ito, Tomoko Tajiri, Satoshi Fukuda, Takehiro Uemura, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Masaya Takemura, Akio Niimi Tags: Original Research Source Type: research
Approach to non-type 2 asthma
Asthma is a common respiratory disease which is estimated to effect up to 262 million worldwide by Global Burden of Disease collaboration report of 2019 [1]. It continues to be a major contributor of the global economic burden of healthcare related costs and approximately 1000 people die from asthma every day [1]. Effective management of asthma requires a personalized plan of care which includes addressing triggers, patient education, lung function monitoring, and both pharmacological and non-pharmacological management. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 9, 2023 Category: Respiratory Medicine Authors: Muhammad Adrish, Praveen Akuthota Tags: Original Research Source Type: research
Lung abscess: Clinical characteristics of 222 Danish patients diagnosed from 2016 to 2021
This study described the clinical presentation of LA, treatment duration and mortality in a contemporary Danish population. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 9, 2023 Category: Respiratory Medicine Authors: Jakob Kirkegaard Vaarst, S øren Sperling, Victor Naestholt Dahl, Andreas Fløe, Christian Borbjerg Laursen, Tina Noerregaard Gissel, Pia Holland Gjoerup, Elisabeth Bendstrup Tags: Original Research Source Type: research
Serum IgA levels for predicting the development of rapidly progressive interstitial lung disease in dermatomyositis
Some patients with dermatomyositis (DM) can develop rapidly progressive interstitial lung disease (RPILD) that is resistant to treatment and life-threatening. Convenient and practical predictive factors for the development of RPILD are currently lacking. We aimed to identify independent risk factors for RPILD in patients with DM. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 9, 2023 Category: Respiratory Medicine Authors: Haoru Zhang, Renge Liang, Xin Yuan, Zemao Zheng, Weinan Lai Tags: Original Research Source Type: research
How risky is it to remove an airway stent?
Airway stent removal has traditionally been associated with a high complication rate. Most studies on stent removal are over a decade old, prior to newer anti-cancer therapies, and by including non-contemporary and uncovered metal stents, may not reflect the current practices. We review our experience at Mount Sinai Hospital to report outcomes of stent removal with more contemporary practices. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 8, 2023 Category: Respiratory Medicine Authors: Bertin D. Salguero, Abhinav Agrawal, Christian M. Lo Cascio, Matsuo So, Udit Chaddha Tags: Short communication Source Type: research
