When GETomics meets aging and exercise in COPD
The term GETomics has been recently proposed to illustrate that human health and disease are actually the final outcome of many dynamic, interacting and cumulative gene (G) – environment (E) interactions that occur through the lifetime (T) of the individual. According to this new paradigm, the final outcome of any GxE interactions depends on both the age of the individual at which such GxE interaction occurs as well as on the previous, cumulative history of previous GxE interactions through the induction of epigenetic changes and immune memory (both lasting overtime). (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 7, 2023 Category: Respiratory Medicine Authors: D. Pellegrino, S. Casas-Recasens, R. Faner, P. Palange, A. Agusti Tags: Review article Source Type: research
Real-world effectiveness of benralizumab in US subspecialist-treated adults with severe asthma: Findings from CHRONICLE
Patients with eosinophilic severe asthma (SA) have an increased risk of asthma exacerbations. Benralizumab is approved for eosinophilic SA, and there is great value in understanding real-world effectiveness. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 6, 2023 Category: Respiratory Medicine Authors: Reynold A. Panettieri, Njira Lugogo, Wendy C. Moore, Bradley E. Chipps, Brett Jepson, Wenjiong Zhou, Christopher S. Ambrose, Eduardo Genofre, Donna D. Carstens Tags: Original Research Source Type: research
Breathlessness and exercise performance to predict mortality in long-term oxygen therapy – The population-based DISCOVERY study
Patients with chronic respiratory failure treated with long-term oxygen therapy (LTOT) often have severe breathlessness, impaired exercise performance, and high but variable mortality that is difficult to predict. We aimed to evaluate breathlessness and exercise performance upon starting LTOT as predictors of overall and short-term mortality. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 4, 2023 Category: Respiratory Medicine Authors: Filip Bj örklund, Andreas Palm, Jwan Abdulrazak Gorani, Zainab Ahmadi, Josefin Sundh, Jenny Theorell-Haglöw, Mirjam Ljunggren, Ludger Grote, Karin Wadell, Magnus Ekström Tags: Original Research Source Type: research
Obesity associates with increased all-cause and cardiovascular mortality in adults with asthma
Asthma and obesity are prevalent conditions that are increasing worldwide. Asthma is characterized by airway inflammation and bronchial variability, while obesity is a complex metabolic disorder that poses significant morbidity and mortality risks. Obesity is a risk factor for asthma and a plethora of other non-communicable diseases. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 4, 2023 Category: Respiratory Medicine Authors: Axel Sturesson, Linnea Hedman, Caroline Stridsman, Anne Lindberg, Eva R önmark, Helena Backman Tags: Original Research Source Type: research
Prevalence of diaphragm dysfunction in patients with interstitial lung disease (ILD): The role of diaphragmatic ultrasound
Diaphragm ultrasound (DUS) has been extensively used in critically ill patients while data on outpatients with interstitial lung disease (ILD) are limited. We hypothesized that diaphragm function, assessed by ultrasound, could be impaired in patients with ILD, considering both Idiopathic Pulmonary Fibrosis (IPF) and Connective Tissue Disease (CTD-ILD), compared to healthy subjects. Moreover, this impairment could impact clinical and functional parameters. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 2, 2023 Category: Respiratory Medicine Authors: Nicol Bernardinello, Elisabetta Cocconcelli, Annalisa Boscolo, Gioele Castelli, Nicol ò Sella, Chiara Giraudo, Elisabetta Zanatta, Federico Rea, Marina Saetta, Paolo Navalesi, Paolo Spagnolo, Elisabetta Balestro Tags: Original Research Source Type: research
Multiple manifestations of uncontrolled asthma increase the risk of severe COVID-19
Asthma control is of importance when assessing the risk of severe outcomes of COVID-19. The aim of this study was to explore associations of clinical characteristics and the effect of multiple manifestations of uncontrolled asthma with severe COVID-19. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 2, 2023 Category: Respiratory Medicine Authors: Stina Selberg, Johanna Karlsson Sundbaum, Jon R. Konradsen, Helena Backman, Linnea Hedman, Anne Lindberg, Caroline Stridsman Tags: Original Research Source Type: research
Inflammatory bowel disease and asthma. Results from the RHINE study
Asthma and inflammatory bowel disease (IBD) are common inflammatory diseases. The aim of this study was to investigate the associations of IBD with asthma and respiratory symptoms. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 2, 2023 Category: Respiratory Medicine Authors: Marta A. Kisiel, Martin Sedvall, Andrei Malinovschi, Karl A. Franklin, Thorarinn Gislason, Vivi Shlunssen, Ane Johansson, Lars Modig, Rain Jogi, Mathias Holm, Cecilia Svanes, Louise Lindholdt, Marie Carlson, Christer Janson Tags: Original Research Source Type: research
Failing categorization of severe COVID-19 ARDS into ventilatory subphenotypes studied via the clinical-histopathologic relationship
This study aimed to assess the correlation between mechanoelastic ventilatory features and lung histopathologic findings in critically ill patients who died because of CARDS. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 30, 2023 Category: Respiratory Medicine Authors: Riccardo Colombo, Maddalena Alessandra Wu, Davide Ottolina, Tommaso Fossali, Jonathan Montomoli, Gianluca Lopez, Emanuele Catena, Manuela Nebuloni, Luigi Sacco Hospital COVID-19 ARDS Study Group Tags: Original Research Source Type: research
Short-term and long-term effects of cesarean section on asthma and wheezing: A cohort study and meta-analysis
To describe the short-term and long-term effects of cesarean section on childhood asthma and wheezing. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 29, 2023 Category: Respiratory Medicine Authors: Yuxiu Liang, Jiatao Zhang, Shuoxin Bai, Shang Du, Xiwei Yang, Zhiping Wang Tags: Original Research Source Type: research
Letter to the editor in response to Hoskote “Corrected formula for rectangular area ratio (RAR), a parameter used to quantify airflow limitation on expiratory flow-volume curves” Respiratory Medicine 2022; 204: 107032
In 2010 we published original research in Respiratory Medicine that used the Rectangular Area Ratio (RAR) of the spontaneous expiratory flow-volume curve to characterize the dynamic development of concavity during ramp-incremental exercise in COPD patients [1]. Development of concavity, as identified by an RAR (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 29, 2023 Category: Respiratory Medicine Authors: Janos Porszasz, Chu-Yi Wang, Carrie Ferguson, Shuyi Ma, Michele Girardi, William W. Stringer Tags: Correspondence Source Type: research
Mediastinal Paraganglioma: A retrospective analysis of 51 cases
This study aimed to better characterize the presenting features and relevant aspects in optimizing the diagnosis and treatment of mediastinal paragangliomas. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 28, 2023 Category: Respiratory Medicine Authors: Amjad N. Kanj, William F. Young, Jay H. Ryu Tags: Original Research Source Type: research
Development of a diagnostic score using FeNO and symptoms to predict asthma
Fractional exhaled nitric oxide (FeNO) is known as effective for ruling-in asthma. The diagnostic value might be increased in combination with clinical signs and symptoms (CSS). The aim was to develop a new model for ruling-in and ruling-out asthma. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 28, 2023 Category: Respiratory Medicine Authors: Benjamin Brunn, Alexander Hapfelmeier, Rudolf A. J örres, Konrad Schultz, Antonius Schneider Tags: Original Research Source Type: research
Comparing bronchial thermoplasty with biologicals for severe asthma: Systematic review and network meta-analysis
Bronchial thermoplasty (BT) has shown favorable safety and efficacy in several randomized controlled trials (RCTs), but has not been directly compared to biological therapies. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 28, 2023 Category: Respiratory Medicine Authors: Khi Yung Fong, Joseph J. Zhao, Nicholas L. Syn, Parameswaran Nair, Yiong Huak Chan, Pyng Lee Tags: Original Research Source Type: research
Bacterial load and related innate immune response in the bronchi of rapid decliners with chronic obstructive pulmonary disease
Characterization of COPD patients with rapid lung functional decline is of interest for prognostic and therapeutic reasons. We recently reported an impaired humoral immune response in rapid decliners. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 26, 2023 Category: Respiratory Medicine Authors: Silvestro Ennio D'Anna, Francesca Dossena, Isabella Gnemmi, Paola Brun, Antonio Spanevello, Vitina Carriero, Francesca Bertolini, Mauro Maniscalco, Fabio LM. Ricciardolo, Bruno Balbi, Antonino Di Stefano Tags: Original Research Source Type: research
Degradation of neuromuscular junction contributes to muscle weakness but not physical compromise in chronic obstructive pulmonary disease patients taking lipids-lowering medications
The relevant data about the effects and the associated mechanisms of statins on muscle strength and physical capacity is inconsistent. We investigated the potential contribution of neuromuscular junction (NMJ) degradation to muscle weakness and physical compromise in patients with chronic obstructive pulmonary disease (COPD) on statins. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 26, 2023 Category: Respiratory Medicine Authors: Rizwan Qaisar, Asima Karim, Tahir Muhammad, Shaea A. Alkahtani, Hossam Kamli, Firdos Ahmad Tags: Original Research Source Type: research
