Utility of the Enhanced Liver Fibrosis score as a blood biomarker of pulmonary fibrosis secondary to SARS-CoV-2 pneumonia
SARS-CoV-2 pneumonia can lead to several sequelae, among them, pulmonary fibrosis. The Enhanced Liver Fibrosis (ELF) score is a panel of serum markers of liver fibrosis. We aimed to describe the utility of the ELF score as a biomarker of pulmonary fibrosis secondary to COVID-19 pneumonia. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 23, 2023 Category: Respiratory Medicine Authors: Alexa N úñez, Cristina Aljama, Cristina Esquinas, Gerard Orriols, Pablo Gabriel-Medina, Georgina Farago, Galo Granados, Francisco Rodriguez-Frias, Mònica Pons, Marc Miravitlles, Miriam Barrecheguren Tags: Original Research Source Type: research
Minimal effective dose of maintenance steroid therapy for relapse of cryptogenic organizing pneumonia
Long-term maintenance steroid therapy (MST) is frequently required for repeated relapses of cryptogenic organizing pneumonia (COP); however, the optimal minimal dose has not been clarified. Therefore, this study evaluated the minimal MST dose required to prevent repeated relapses and identify relapse predictors. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 17, 2023 Category: Respiratory Medicine Authors: Kenichiro Atsumi, Kakeru Hisakane, Erika Mikami, Takahiro Suzuki, Satoru Matsuki, Masahiro Seike, Takashi Hirose Tags: Original Research Source Type: research
Risk and outcomes of COVID-19 in patients with oxygen-dependent chronic respiratory failure – a national cohort study
We aimed to evaluate cumulative occurrence and impact of COVID-19 in patients with chronic respiratory failure (CRF) treated with long-term oxygen therapy (LTOT). (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 17, 2023 Category: Respiratory Medicine Authors: Josefin Sundh, Andreas Palm, Mirjam Ljunggren, Össur Ingi Emilsson, Ludger Grote, Sara Cajander, Huiqi Li, Fredrik Nyberg, Magnus Ekström Tags: Original Research Source Type: research
Prevalence of dyspnea in general adult populations: A systematic review and meta-analysis
and objectives: Dyspnea is a commonly described symptom in various chronic and acute conditions. Despite its frequency, relatively little is known about the prevalence and assessment of dyspnea in general populations. The aims of this review were: 1) to estimate the prevalence of dyspnea in general adult populations; 2) to identify associated factors; and 3) to identify used methods for dyspnea assessment. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 16, 2023 Category: Respiratory Medicine Authors: Alexander M üller, Tobias Mraz, Emiel FM. Wouters, Sander MJ. van Kuijk, André FS. Amaral, Robab Breyer-Kohansal, Marie-Kathrin Breyer, Sylvia Hartl, Daisy JA. Janssen Source Type: research
Impulse oscillometry defined small airway dysfunction in asthmatic patients with normal spirometry: Prevalence, clinical associations, and impact on asthma control
The small-airway dysfunction (SAD), detected with impulse oscillometry (IOS) methods, has been recently better characterized in patients with asthma. However, little is known about SAD in asthmatic patients with normal spirometry (NS). (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 16, 2023 Category: Respiratory Medicine Authors: Marcello Cottini, Benedetta Bondi, Diego Bagnasco, Fulvio Braido, Giovanni Passalacqua, Anita Licini, Carlo Lombardi, Alvise Berti, Pasquale Comberiati, Massimo Landi, Enrico Heffler, Giovanni Paoletti Tags: Original Research Source Type: research
Is the diagnostic yield of mediastinal lymph node cryobiopsy (cryoEBUS) better for diagnosing mediastinal node involvement compared to endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)? A systematic review
New tools such as cryobiopsy of mediastinal lymph nodes (cryoEBUS) have been described to improve the diagnostic usefulness of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). The literature suggests that this novel procedure could be associated with greater diagnostic usefulness than conventional EBUS-TBNA. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 12, 2023 Category: Respiratory Medicine Authors: Maribel Botana-Rial, Irene Lojo-Rodr íguez, Virginia Leiro-Fernández, Cristina Ramos-Hernández, Almudena González-Montaos, Luis Pazos Area, Manuel Núñez-Delgado, Alberto Fernández-Villar Source Type: research
Asthma in the era of COVID-19
Since its global invasion in 2019, COVID-19 has affected several aspects of patients ’ lives and posed a significant impact on the health care system. Several patient populations were identified to be at high risk of contracting SARS-CoV-2 infection and/or developing severe COVID-19-related sequelae. Conversely, anyone who has contracted SARS-CoV-2 is at risk to experience symptom s and signs consistent with post-COVID manifestations. Patients with asthma were initially thought to be at increased risk and severity for SARS-CoV-2 infection. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 9, 2023 Category: Respiratory Medicine Authors: Sara Assaf, Henning Stenberg, Milos Jesenak, Svitlana P. Tarasevych, Nicola A. Hanania, Zuzana Diamant Tags: Original Research Source Type: research
Mortality in individuals with COPD on long-term home non-invasive ventilation
Obesity is associated with improved survival in COPD patients highly adherent to NIV. Other factors associated with mortality reflect disease severity and ventilator parameters, with differences between obese and non-obese patients. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 9, 2023 Category: Respiratory Medicine Authors: Mathew Cherian, Veronique Adam, Bryan Ross, Jean Bourbeau, Marta Kaminska Tags: Original Research Source Type: research
Evolving to a single inhaler extrafine LABA/LAMA/ICS – Inhalation technique and adherence at the heart of COPD patient care (TRIVOLVE)
Incorrect inhaler use and poor treatment adherence have a negative impact on COPD outcomes. This multi-centre, single arm, non-interventional, phase IV study investigated whether inhalation technique, treatment adherence and patient outcomes change in patients who evolve from dual therapy or multiple inhaler triple therapy to single inhaler extrafine triple therapy (beclomethasone dipropionate (BDP, 87 μg), formoterol fumarate (FF, 5 μg) and glycopyrronium (G, 9 μg)) in combination with inhalation technique training. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 8, 2023 Category: Respiratory Medicine Authors: G. Brusselle, U. Himpe, P. Fievez, M. Leys, S. Perez Bogerd, R. Pech é, E. Vanderhelst, M. Lins, P. Capiau, TRIVOLVE investigators Tags: Original Research Source Type: research
Electronic monitoring with a digital smart spacer to support personalized inhaler use education in patients with asthma: The randomized controlled OUTERSPACE trial
Poor adherence to inhaled medication has been associated with poor outcomes. Smart spacers can monitor inhaler use and technique, yet their feasibility in adults with asthma and their potential benefits are unknown. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 4, 2023 Category: Respiratory Medicine Authors: Boudewijn J.H. Dierick, Maria Achterbosch, Amber A. Eikholt, Sandra Been-Buck, Titia Klemmeier-Boekhout, Susanne J. van de Hei, Paul Hagedoorn, Huib A.M. Kerstjens, Janwillem W.H. Kocks, Job F.M. van Boven Tags: Original Research Source Type: research
Bronchodilator response does not associate with asthma control or symptom burden among patients with poorly controlled asthma
The purpose of this study was to determine how four different definitions of bronchodilator response (BDR) relate to asthma control and asthma symptom burden in a large population of participants with poorly controlled asthma. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 1, 2023 Category: Respiratory Medicine Authors: David A. Kaminsky, Jiaxian He, Robert Henderson, Anne E. Dixon, Charles G. Irvin, John Mastronarde, Lewis J. Smith, Elizabeth A. Sugar, Robert A. Wise, Janet T. Holbrook Tags: Original Research Source Type: research
Parenteral treprostinil induction for rapid attainment of therapeutic doses of oral treprostinil
Oral treprostinil slows disease progression and improves exercise capacity in pulmonary arterial hypertension, however titration can be prolonged. Published data suggests prostacyclin-na ïve patients achieve daily oral treprostinil doses around 6 mg by Week 16, while those on prior parenteral treprostinil reach higher doses at the same timepoint. (Source: Respiratory Medicine)
Source: Respiratory Medicine - July 31, 2023 Category: Respiratory Medicine Authors: Chad E. Miller, Veronica Franco, Jimmy S. Smith, Vijay Balasubramanian, John Kingrey, Ronald Zolty, Lana Melendres-Groves, Jessica Huston, Jean M. Elwing, Ashwin Ravichandran, Dana Cella, Eric Shen, Scott Seaman, Claire M. Thrasher, Meredith Broderick, Ro Tags: Original Research Source Type: research
A network meta-analysis of the association between patient traits and response to regular dosing with ICS/long-acting β2-agonist plus short-acting β2 agonist reliever or maintenance and reliever therapy for asthma
Current treatment for moderate –severe asthma with inhaled corticosteroid (ICS)-based therapy can follow two strategies: a single inhaler maintenance and reliever therapy (MART) regimen, or regular dosing with ICS/long-acting β2-agonist used as maintenance therapy plus a separate short acting β2-agonist reliever inhaler. It w ould be clinically useful to understand the potential of patient traits to influence regular dosing or MART treatment outcomes. (Source: Respiratory Medicine)
Source: Respiratory Medicine - July 29, 2023 Category: Respiratory Medicine Authors: Arzu Yorganc ıoğlu, Alvaro A. Cruz, Gabriel Garcia, Kim L. Lavoie, Nicolas Roche, P.G. Abhijith, Manish Verma, Anurita Majumdar, Swarnendu Chatterjee Tags: Original Research Source Type: research
EUFOREA pocket guide on the diagnosis and management of asthma: An educational and practical tool for general practitioners, non-respiratory physicians, paramedics and patients
International and national initiatives on asthma management provide extensive information on asthma pathophysiology, offering expert guidance on diagnosis and recommendations on treatment, highlighting contemporary therapeutic options [1 –3]. Likewise, there are several high-impact task force articles and expert reviews on related topics, including asthma exacerbations, treatable traits, comorbid conditions, biomarkers, biologics and corticosteroids [4–12]. However, the majority of these articles are very comprehensive and requi re profound background knowledge, and hence, are mainly suitable for experts in the field o...
Source: Respiratory Medicine - July 27, 2023 Category: Respiratory Medicine Authors: Zuzana Diamant, Milos Jesenak, Nicola A. Hanania, Liam G. Heaney, Ratko Djukanovic, Dermot Ryan, Santiago Quirce, Vibeke Backer, Mina Gaga, Ian Pavord, Dar ío Antolín-Amérigo, Sara Assaf, Petros Bakakos, Anna Bobcakova, William Busse, Jasper Kappen, St Tags: Original Research Source Type: research
Dysfunctional mucociliary clearance in asthma and airway remodeling – New insights into an old topic
Bronchial asthma is a heterogeneous respiratory condition characterized by chronic airway inflammation, airway hyperresponsiveness and airway structural changes (known as remodeling). The clinical symptoms can be evoked by (non)specific triggers, and their intensity varies over time. In the past, treatment was mainly focusing on symptoms ’ alleviation; in contrast modern treatment strategies target the underlying inflammation, even during asymptomatic periods. Components of airway remodeling include epithelial cell shedding and dysfunction, goblet cell hyperplasia, subepithelial matrix protein deposition, fibrosis, neoan...
Source: Respiratory Medicine - July 27, 2023 Category: Respiratory Medicine Authors: Milos Jesenak, Peter Durdik, Dasa Oppova, Sona Franova, Zuzana Diamant, Kornel Golebski, Peter Banovcin, Jarmila Vojtkova, Elena Novakova Tags: Original Research Source Type: research
