Management of headache and chronic pain in POTS
Primary headache syndromes and chronic pain syndromes are common in patients with postural tachycardia syndrome (POTS). There is overlap in potential mechanisms for migraine, chronic pain, and POTS symptomatology. Management of chronic pain and headaches in POTS requires a judicious use of pharmacotherapies that takes into account patient comorbidities and co-existing symptoms. Patient-centric, non-pharmacologic modalities include physical exercise, cognitive behavioral therapies, and treatment of sleep disorders. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - June 12, 2018 Category: Neuroscience Authors: Glen A. Cook, Paola Sandroni Tags: Review Source Type: research

Role of microglia M1/M2 polarisation in the paraventricular nucleus: New insight into the development of stress-induced hypertension in rats
The lack of precise therapies for stress-induced hypertension highlights the need to explore the process of blood pressure changes. Studies have shown that neuroinflammation in the central nervous system is associated with hypertension, although the mechanisms remain elusive. Microglia, are known to play dualistic protective and destructive roles, representing logical but challenging targets for improving stress-induced hypertension. Here, as a model, we used rats with stress-induced hypertension, and found that a switch from an immunoregulatory (M2) to a pro-inflammatory (M1) dominant response occurred in microglia during...
Source: Autonomic Neuroscience: Basic and Clinical - June 11, 2018 Category: Neuroscience Authors: Yang Mi, Qin Wu, Wanru Yuan, Fuxue Chen, Dongshu Du Source Type: research

S. Typhimurium challenge in juvenile pigs modulates the expression and localization of enteric cholinergic proteins and correlates with mucosal injury and inflammation
The objective of this study was to determine the intrinsic expression of the enteric cholinergic system in pig ileum following an acute challenge with Salmonella enterica serovar Typhimurium DT104 (S. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - June 8, 2018 Category: Neuroscience Authors: Calvin S. Pohl, Elizabeth M. Lennon, Yihang Li, Morgan P. DeWilde, Adam J. Moeser Source Type: research

The patient perspective: What postural orthostatic tachycardia syndrome patients want physicians to know
Diagnosing and treating postural orthostatic tachycardia syndrome (POTS) can be a frustrating experience for patients and physicians alike. Experienced patient leaders solicited input from the large online POTS community to identify patient suggestions and concerns, with the goal of improving the patient-physician relationship and outcomes in POTS. This review article offers practical tips to improve POTS patient care and links to credible resources for your patients. The authors emphasize the urgent need for improved physician education, a tailored treatment approach, and expanded research efforts. (Source: Autonomic Neur...
Source: Autonomic Neuroscience: Basic and Clinical - June 7, 2018 Category: Neuroscience Authors: Lauren E. Stiles, Jaclyn Cinnamon, Irina Balan Tags: Review Source Type: research

Effects of caveolae depletion and urothelial denudation on purinergic and cholinergic signaling in healthy and cyclophosphamide-induced cystitis in the rat bladder
Cholesterol rich membrane invaginations, caveolae, have important roles in various cellular activities, one of them being signal transduction. This signaling pathway seems to be affected during various bladder disorders and the current study aimed to elucidate the plausible involvement of caveolae mediated signal transduction during cyclophosphamide induced cystitis. Furthermore, the urothelial cholinergic part of ATP-evoked contractions and its possible link to caveolae were investigated.Cholinergic, as well as purinergic, contractile responses in rat urinary bladders were examined using a classic organ bath set-up with f...
Source: Autonomic Neuroscience: Basic and Clinical - June 6, 2018 Category: Neuroscience Authors: Johanna Stenqvist, Thomas Carlsson, Michael Winder, Patrik Aronsson Source Type: research

Impaired pupillary control in “schizophrenia-like” WISKET rats
Patients with schizophrenia show impairments in autonomic regulation, including pupillomotor control. The aim of this study was to explore the changes of pupillary light reflex in a new substrain (WISKET) with several schizophrenia-like alterations.Male WISKET rats housed individually (for four weeks) and treated with ketamine (for 3  × 5 days) after weaning and naive group-housed Wistar rats (controls) were involved in the study. The pupillary light reflex was studied in two series after sedation (diazepam) or anesthesia (chloral hydrate). (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 18, 2018 Category: Neuroscience Authors: Alexandra B üki, György Kalmár, Gabriella Kekesi, Gyorgy Benedek, László G. Nyúl, Gyongyi Horvath Source Type: research

Metabolic syndrome impact on cardiac autonomic modulation and exercise capacity in obese adults
Obesity is often associated with increased risk of cardiometabolic morbidities and mortality. However, evidence shows that some obese individuals are more likely to develop such risk factors early in life, including those with Metabolic Syndrome (MetS). Whether the presence of MetS in obese people impairs cardiac autonomic modulation (CAM) remains to be investigated. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 18, 2018 Category: Neuroscience Authors: L ívia P. Carvalho, Luciana Di Thommazo-Luporini, Renata G. Mendes, Ramona Cabiddu, Paula A. Ricci, Renata P. Basso-Vanelli, Manoel C. Oliveira-Junior, Rodolfo P. Vieira, José C. Bonjorno-Junior, Cláudio R. Oliveira, Rafael L. Luporini, Audrey Borghi-S Source Type: research

Editorial Board
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 17, 2018 Category: Neuroscience Source Type: research

Postural orthostatic tachycardia syndrome in children and adolescents
Postural orthostatic tachycardia syndrome (POTS) affects up to 3,000,000 people in the United States, with at least one-third of them developing POTS before the age of 18. POTS as a disorder is similar in adult and pediatric populations, but there are factors specific to pediatric patients that affect how it presents and how it is experienced that make pediatric POTS different. This review discusses the both the similarities in this population to their adult counterparts and the unique challenges faced by pediatric POTS patients, including management of schooling and education as well as the complex interactions between th...
Source: Autonomic Neuroscience: Basic and Clinical - May 12, 2018 Category: Neuroscience Authors: Jeffrey R. Boris Tags: Review Source Type: research

Effect of electroacupuncture on porcine cardiac excitability induced by left stellate ganglion stimulation
Augmentation of cardiac sympathetic tone has been shown to induce ventricular arrhythmias. Acupuncture has been clinically used to treat hypertension, angina pectoris, and atrial arrhythmias. However, the effects of acupuncture on ventricular electrophysiology and autonomic tone remain unknown. We hypothesized that acupuncture attenuates cardiac excitability and corrects the imbalance of autonomic tone during sympathetic hyperactivity. Fourteen Yorkshire pigs were randomized to electroacupuncture (EA, 2  Hz, 0.3–0.5 mA, 0.5 ms duration) or control (without EA) groups. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 12, 2018 Category: Neuroscience Authors: Tatsuo Takamiya, Yukiko Kubo, Peyman Benharash, Wei Zhou Source Type: research

Heart rate variability in individuals with Down syndrome – A systematic review and meta-analysis
Down syndrome (DS) results in many changes, including dysfunction in cardiac autonomic modulation. Heart rate variability (HRV) analysis evaluates the autonomic function and it is a predictor of adverse cardiovascular events. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 12, 2018 Category: Neuroscience Authors: Tatiana Dias de Carvalho, Thais Massetti, Talita Dias da Silva, T ânia Brusque Crocetta, Regiani Guarnieri, Luiz Carlos Marques Vanderlei, Carlos Bandeira de Mello Monteiro, David M. Garner, Celso Ferreira Tags: Review Source Type: research

Postural orthostatic tachycardia syndrome during pregnancy: A systematic review of the literature
Postural Orthostatic Tachycardia Syndrome is most commonly seen in women of child bearing age, however little is known about its effects in pregnancy. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 9, 2018 Category: Neuroscience Authors: Kate Morgan, Catherine Chojenta, Meredith Tavener, Angela Smith, Deb Loxton Tags: Review Source Type: research

Sleep disorders in patients with postural tachycardia syndrome: A review of the literature and guide for clinicians
This article will review the current literature on the prevalence of sleep disorders in POTS, their association with the underlying pathophysiology of POTS, and current treatment paradigms. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 8, 2018 Category: Neuroscience Authors: Mitchell G. Miglis, Fiona Barwick Tags: Review Source Type: research

Postural orthostatic tachycardia syndrome and the potential role of mast cell activation
Though a sizeable amount of data connects mast cell activity to the neurologic system, less is known about the true clinical implications of this relationship. Even less is understood about treatment strategies in those with both allergic and neurologic complaints. This is particularly true in postural orthostatic tachycardia syndrome (POTS), a common type of dysautonomia, where patients are burdened by symptoms of orthostatic cerebral hypoperfusion and several other comorbidities that are likely influenced by autonomic tone. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 4, 2018 Category: Neuroscience Authors: Taylor A. Doherty, Andrew A. White Tags: Review Source Type: research

Pharmacotherapy for postural tachycardia syndrome
Postural tachycardia syndrome (POTS) is a disorder characterized by the presence of orthostatic symptoms (including lightheadedness, palpitations, nausea, dyspnea, and tremulousness) as well as excessive upright tachycardia. POTS predominantly affects women of childbearing age. Treating POTS involves a multi-faceted approach using non-pharmacological and pharmacological interventions. There are no pharmacological treatments that are currently United States Food and Drug Administration (FDA) approved for POTS due to lack of randomized controlled trials. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 4, 2018 Category: Neuroscience Authors: Amanda J. Miller, Satish R. Raj Tags: Review Source Type: research

Inconsistent relation of nonlinear heart rate variability indices to increasing vagal tone in healthy humans
Prior work has found that linear heart rate variability (HRV) indices do not accurately reflect cardiac vagal control, and nonlinear indices of HRV have been proposed as alternative tools that may better capture cardiac vagal effects. We used progressive low dose atropine to induce changes in cardiac vagal tone to test the hypotheses that nonlinear HRV indices accurately reflect cardiac vagal control, and that their changes in response to low dose atropine correlate with those in RR interval. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 1, 2018 Category: Neuroscience Authors: Felipe X. Cepeda, Matthew Lapointe, Can Ozan Tan, J. Andrew Taylor Source Type: research

Differential effects of lipophilic and hydrophilic statins on muscle sympathetic nerve activity in heart failure with preserved left ventricular ejection fraction
Augmented sympathetic nerve activity is associated with heart failure with preserved left ventricular ejection fraction (HFpEF). Lipophilic statins reduce sympathetic nerve activity in patients with heart failure with reduced left ventricular ejection fraction. However, little is known about whether all types of statins, regardless of solubility, reduce sympathetic nerve activity in HFpEF. We evaluated the effect of atorvastatin, a lipophilic statin, and rosuvastatin, a hydrophilic statin, on muscle sympathetic nerve activity (MSNA) in HFpEF patients. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 28, 2018 Category: Neuroscience Authors: Hideki Tokuhisa, Hisayoshi Murai, Yoshitaka Okabe, Takuto Hamaoka, Hiroyuki Sugimoto, Yusuke Mukai, Oto Inoue, Shin-ichiro Takashima, Takeshi Kato, Soichiro Usui, Hiroshi Furusho, Shuichi Kaneko, Masayuki Takamura Source Type: research

Editorial Board
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 26, 2018 Category: Neuroscience Source Type: research

Autoimmunity in postural orthostatic tachycardia syndrome: Current understanding
This article summarizes the current state of knowledge on the role of autoimmunity in POTS, the clinical implications of these findings, and prospects for future research. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 26, 2018 Category: Neuroscience Authors: Steven Vernino, Lauren Stiles Tags: Review Source Type: research

Evaluation of postural tachycardia syndrome (POTS)
This article outlines the importance of a thorough history in identifying mechanism of symptom onset, clinical features, associated clinical conditions or disorders, and factors that may result in symptom exacerbation. The clinical examination involves an assessment of pupillary responses, an evaluation for sudomotor and vasomotor signs, and an assessment for joint hypermobility. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 22, 2018 Category: Neuroscience Authors: Brent P. Goodman Tags: Review Source Type: research

Surgical and dental considerations in patients with postural tachycardia syndrome
Postural tachycardia syndrome (POTS) is a chronic condition characterized by symptoms of orthostatic intolerance associated with an increase in heart rate (HR) ≥30 beat per minute (bpm) in adults within 10 min of standing or upright tilt-table test, in the absence of orthostatic hypotension (Grubb, 2008; Raj, 2013). (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 12, 2018 Category: Neuroscience Authors: Mohammed Ruzieh, Mark Dziuba, James P. Hofmann, Blair P. Grubb Source Type: research

Surgical and dental considerations in patients with postural tachycardia syndrome
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 12, 2018 Category: Neuroscience Authors: Mohammed Ruzieh, Mark Dziuba, James P. Hofmann, Blair P. Grubb Tags: Review Source Type: research

Contextual modulation of autonomic pain reactivity
Although modulation of cardiac activity may be influenced by several factors, interaction between autonomic nociceptive responses and the high-level of cortical processes is not clearly understood. Here, we studied in 26 subjects whether empathetic or unempathetic contexts could interact with autonomic pain responses. RR intervals variability was used to approach parasympathetic and sympathetic responses to painful thermal stimulations, according to contexts evoked by experimenters' comments. We observed that unempathetic context increased sympathetic reactivity to comments and to painful stimulations without any parasympa...
Source: Autonomic Neuroscience: Basic and Clinical - April 10, 2018 Category: Neuroscience Authors: Camille Fauchon, Vincent Pichot, Isabelle Faillenot, Benjamin Pommier, Luis Garcia-Larrea, Roland Peyron, Florian Chouchou Tags: Short communication Source Type: research

Cardiovascular responses to isometric handgrip exercise in young patients with recurrent vasovagal syncope
Arterial blood pressure (BP) increased in healthy humans in response to isometric handgrip (IHG), but the pattern of the relative contribution of cardiac output (CO) and total peripheral resistance (TPR) changes to the pressor response is different among individuals. We investigated weather patients with recurrent vasovagal syncope (VVS) have a similar pattern of individual CO, TPR and pressor responses to IHG, as healthy subjects. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 4, 2018 Category: Neuroscience Authors: Juan Idiaquez, Juan Francisco Idiaquez, Rodrigo Iturriaga Source Type: research

The autonomic neural mechanism of right ventricular outflow tract tachycardia
Ventricular tachycardia (VT) and ventricular premature complexes (VPCs) originating from the right ventricular outflow tract (RVOT) are generally considered as benign arrhythmias, with ECG morphology showing LBBB pattern and inferior axis. Pathogenic mechanisms in the genesis of RVOT VT/VPC remain largely unknown. We aimed to investigate the neural mechanism in RVOT ventricular arrhythmias in canine model. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - March 28, 2018 Category: Neuroscience Authors: Hung-Yu Chang, Li-Wei Lo, Yu-Ruey Chen, Yu-Hui Chou, Wei-Lun Lin, Yenn-Jiang Lin, Wei-Hsian Yin, An-Ning Feng, Shih-Ann Chen Source Type: research

Dual autonomic inhibitory action of central Apelin on gastric motor functions in rats
Centrally administered apelin has been shown to inhibit gastric emptying (GE) in rodents, however, the relevant mechanism has been investigated incompletely. Using male Wistar rats, we investigated the efferent pathways involved in gastroinhibitory action of central apelin. Stereotaxic intracerebroventricular (icv) cannulation, subdiaphragmatic vagotomy (VGX) and/or celiac ganglionectomy (CGX) were performed 7  days prior to the experiments. Apelin-13 was administered (30 nmol, icv) 90 min prior to GE measurement. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - March 28, 2018 Category: Neuroscience Authors: Mehmet B ülbül, Osman Sinen Source Type: research

The autonomic neural mechanism of right ventricular outflow tract tachycardia
Ventricular tachycardia (VT) and ventricular premature complexes (VPCs) originating from the right ventricular outflow tract (RVOT) are generally considered as benign arrhythmias, with ECG morphology showing LBBB pattern and inferior axis. Pathogenic mechanisms in the genesis of RVOT VT/VPC remain largely unknown. We aimed to investigate the neural mechanism in RVOT ventricular arrhythmias in canine model. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - March 28, 2018 Category: Neuroscience Authors: Hung-Yu Chang, Li-Wei Lo, Yu-Ruey Chen, Yu-Hui Chou, Wei-Lun Lin, Yenn-Jiang Lin, Wei-Hsian Yin, An-Ning Feng, Shih-Ann Chen Source Type: research

Dual autonomic inhibitory action of central Apelin on gastric motor functions in rats
Centrally administered apelin has been shown to inhibit gastric emptying (GE) in rodents, however, the relevant mechanism has been investigated incompletely. Using male Wistar rats, we investigated the efferent pathways involved in gastroinhibitory action of central apelin. Stereotaxic intracerebroventricular (icv) cannulation, subdiaphragmatic vagotomy (VGX) and/or celiac ganglionectomy (CGX) were performed 7  days prior to the experiments. Apelin-13 was administered (30 nmol, icv) 90 min prior to GE measurement. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - March 28, 2018 Category: Neuroscience Authors: Mehmet B ülbül, Osman Sinen Source Type: research

Cognitive and psychological issues in postural tachycardia syndrome
Postural tachycardia syndrome (POTS) is one of the most common forms of chronic orthostatic intolerance. In addition to orthostatic symptoms, many POTS patients report incapacitating cognitive dysfunction or “brain fog” even while lying down or seated. Consistent with these subjective reports, there is accruing objective evidence of specific cognitive difficulties in POTS, with studies showing mild to moderate cognitive impairment using standardized neuropsychological assessment batteries. The preci se profile of cognitive dysfunction in POTS patients has been shown to vary among these studies potentially due t...
Source: Autonomic Neuroscience: Basic and Clinical - March 26, 2018 Category: Neuroscience Authors: Vidya Raj, Morwenna Opie, Amy C. Arnold Tags: Review Source Type: research

Editorial Board
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - March 22, 2018 Category: Neuroscience Source Type: research

Special issue for the silver anniversary of Postural Tachycardia Syndrome
Postural Tachycardia Syndrome (POTS) is a multi-system disorder that can be associated with significant functional disability. Likely due to the multi-system nature of the disorder, it can be difficult for physicians caring for these patients with POTS to know enough about the management of problems that fall within so many different specialties. This special issue was written for these clinicians and their patients. We have brought together experts on POTS with different backgrounds to share their approach to many of the medical issues that confront patients with POTS. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - March 15, 2018 Category: Neuroscience Authors: Satish R. Raj, Lauren E. Stiles Tags: Review Source Type: research

Time-dependent changes in cardiorespiratory functions of anesthetized rats exposed to sustained hypoxia
Although cardiovascular responses may be altered by respiratory changes under prolonged hypoxia, the relationship between respiratory and cardiovascular changes remains unknown. The aim of the present study is to clarify cardiorespiratory changes in anesthetized rats during and after hypoxic conditions using simultaneous recordings of cardiorespiratory variables with 20-sec recording intervals. After air breathing for 20  min (pre-exposure period), rats were subjected to 10% O2 for 2 h (hypoxic exposure period) and then air for 30 min (recovery period). (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - March 14, 2018 Category: Neuroscience Authors: Kouki Kato, Ryosuke Morinaga, Seigo Fushuku, Nobuaki Nakamuta, Yoshio Yamamoto Source Type: research

Postural Orthostatic Tachycardia Syndrome (POTS) in Denmark: Increasingly recognized or new epidemic?
The incidence of Postural Orthostatic Tachycardia Syndrome (POTS) has grown in recent years. Whether this is an emerging epidemic or increasing recognition is unclear. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - March 3, 2018 Category: Neuroscience Authors: Louise Brinth, Kirsten Pors, Jasmina Medic Spahic, Richard Sutton, Artur Fedorowski, Jesper Mehlsen Source Type: research

Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome
To review the association between orthostatic intolerance syndromes and both joint hypermobility and Ehlers-Danlos syndrome, and to propose reasons for identifying hereditary connective tissue disorders in those with orthostatic intolerance in the context of both clinical care and research. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - February 28, 2018 Category: Neuroscience Authors: Maria Roma, Colleen L. Marden, Inge De Wandele, Clair A. Francomano, Peter C. Rowe Tags: Review Source Type: research

Universal characteristics of evolution and development are inherent in fetal autonomic brain maturation
Adverse prenatal environmental influences to the developing fetus are associated with mental and cardiovascular disease in later life. Universal developmental characteristics such as self-organization, pattern formation, and adaptation in the growing information processing system have not yet been sufficiently analyzed with respect to description of normal fetal development and identification of developmental disturbances. Fetal heart rate patterns are the only non-invasive order parameter of the developing autonomic brain available with respect to the developing complex organ system. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - February 28, 2018 Category: Neuroscience Authors: Alexander Schmidt, Ernst G. Schukat-Talamazzini, Janine Z öllkau, Adelina Pytlik, Sophia Leibl, Kathrin Kumm, Franziska Bode, Isabelle Kynass, Otto W. Witte, Ekkehard Schleussner, Uwe Schneider, Dirk Hoyer Source Type: research

Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome
To review the association between orthostatic intolerance syndromes and both joint hypermobility and Ehlers-Danlos syndrome, and to propose reasons for identifying hereditary connective tissue disorders in those with orthostatic intolerance in the context of both clinical care and research. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - February 28, 2018 Category: Neuroscience Authors: Maria Roma, Colleen L. Marden, Inge De Wandele, Clair A. Francomano, Peter C. Rowe Tags: Review Source Type: research

Universal characteristics of evolution and development are inherent in fetal autonomic brain maturation
Adverse prenatal environmental influences to the developing fetus are associated with mental and cardiovascular disease in later life. Universal developmental characteristics such as self-organization, pattern formation, and adaptation in the growing information processing system have not yet been sufficiently analyzed with respect to description of normal fetal development and identification of developmental disturbances. Fetal heart rate patterns are the only non-invasive order parameter of the developing autonomic brain available with respect to the developing complex organ system. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - February 28, 2018 Category: Neuroscience Authors: Alexander Schmidt, Ernst G. Schukat-Talamazzini, Janine Z öllkau, Adelina Pytlik, Sophia Leibl, Kathrin Kumm, Franziska Bode, Isabelle Kynass, Otto W. Witte, Ekkehard Schleussner, Uwe Schneider, Dirk Hoyer Source Type: research

Postural tachycardia syndrome – Diagnosis, physiology, and prognosis
Postural tachycardia syndrome (POTS) is a heterogeneous clinical syndrome that has gained increasing interest over the past few decades due to its increasing prevalence and clinical impact on health-related quality of life. POTS is clinically characterized by sustained excessive tachycardia upon standing that occurs in the absence of significant orthostatic hypotension and other medical conditions and or medications, and with chronic symptoms of orthostatic intolerance. POTS represents one of the most common presentations of syncope and presyncope secondary to autonomic dysfunction in emergency rooms and in cardiology, neu...
Source: Autonomic Neuroscience: Basic and Clinical - February 27, 2018 Category: Neuroscience Authors: Amy C. Arnold, Jessica Ng, Satish R. Raj Tags: Review Source Type: research

Managing fatigue in postural tachycardia syndrome (PoTS): The Newcastle approach
Fatigue is a significant symptom that is frequently reported by those with postural tachycardia syndrome (PoTS). There are a variety of reasons why those with PoTS might experience fatigue and as a consequence an individualised approach to management is most appropriate.In this chapter we will examine the prevalence of fatigue in those with PoTS, its overlap with conditions such as chronic fatigue syndrome and describe a clinical approach to the management of fatigue in those with PoTS. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - February 22, 2018 Category: Neuroscience Authors: Victoria Strassheim, Jenny Welford, Rob Ballantine, Julia L. Newton Tags: Review Source Type: research

Overview of the management of postural tachycardia syndrome in pregnant patients
Postural tachycardia syndrome (POTS) is a chronic condition characterized by symptoms of orthostatic intolerance.Pregnancy can cause different physiological changes in cardiovascular parameters, that could have greater impact on POTS patients.In this review, we discuss the management of POTS in the pregnant and obstetric settings. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - February 17, 2018 Category: Neuroscience Authors: Mohammed Ruzieh, Blair P. Grubb Tags: Review Source Type: research