Vagus nerve stimulation alleviates cardiac dysfunction and inflammatory markers during heart failure in rats

This study aimed to investigate its therapeutic effects on three main components of heart failure: cardiac function, cardiac remodeling and central neuroinflammation using a pressure overload (PO) rat model. Male Sprague-Dawley rats were divided into four groups: PO, PO  + VNS, PO + VNS sham, and controls. All rats, except controls, underwent a PO surgery to constrict the thoracic aorta (~50 %) to induce HFrEF.

Source: Autonomic Neuroscience: Basic and Clinical - March 4, 2024 Category: Neuroscience Authors: Misty M. Owens, Suman Dalal, Aleksandra Radovic, Luciano Fernandes, Hassan Syed, Mary-Katherine Herndon, Coty Cooper, Krishna Singh, Eric Beaumont Source Type: research