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Non-pharmacologic management of orthostatic hypotension
The non-pharmacologic management of orthostatic hypotension includes: 1) review medications that may exacerbate the symptoms such as α- blockers, antihypertensives, narcotics, vasodilators such as nitrates and hydralazine, monoamine oxidase inhibitors, levodopa, bromocriptine and phosphodiestarase inhibitors; 2) increase fluids and salt aiming at of 2-2.5 L of fluid per day with a diet rich in salt in the range of>10  g/day; 3) avoid large meals, encourage small and more frequent meals; 4) encourage mobilization, avoiding prolonged bedrest; encourage recumbent aerobic exercise and strength training to increase the mus...
Source: Autonomic Neuroscience: Basic and Clinical - September 15, 2020 Category: Neuroscience Authors: Gisela Chelimsky, Thomas Chelimsky Source Type: research

Editorial Board
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - September 15, 2020 Category: Neuroscience Source Type: research

Is there cardiac autonomic neuropathy in prediabetes?
Although there is considerably more data showing an association between type 2 diabetes mellitus (T2DM) and autonomic neuropathy, accumulating evidence indicates that cardiovascular autonomic neuropathy (CAN) is common in persons with impaired glucose tolerance (IGT). Furthermore, CAN may occur early after a metabolic insult and obesity, especially among men, seems to play an important role in the early pathogenesis of CAN. Autonomic symptoms are common in subjects with IGT. In addition to defects in CAN, in subjects with IGT, there is impaired sudomotor function and abnormalities of endothelial peripheral vasoreactivity. ...
Source: Autonomic Neuroscience: Basic and Clinical - September 10, 2020 Category: Neuroscience Authors: Lindsay A. Zilliox, James W. Russell Source Type: research

Delayed orthostatic hypotension
is a fall in blood pressure beyond 3  min of standing or upright tilt table testing. The prevalence, clinical features and pathophysiology are reviewed. To date, there is little data to support a standardized or recommended treatment. However, the 10-year mortality rates of individuals with delayed orthostatic hypotension are approxi mately 50%. Despite the fact that delayed orthostatic hypotension carries the same symptoms, risks and high mortality rate as classical orthostatic hypotension, but is under-recognized. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - September 7, 2020 Category: Neuroscience Authors: Christopher H. Gibbons, Roy Freeman Source Type: research

Autonomic and cardiac repolarization Lability in long QT syndrome patients
Long QT-Syndrome (LQTS) patients are at risk of arrhythmias and seizures. We investigated whether autonomic and cardiac repolarization measures differed based on LQTS genotypes, and in LQTS patients with vs. without arrhythmias and seizures. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - September 4, 2020 Category: Neuroscience Authors: Natalia DeMaria, Ahmed Selmi, Samuel Kashtan, Xiaojuan Xia, Matthew Wang, Wojciech Zareba, Jean-Phillippe Couderc, David S. Auerbach Source Type: research