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Adrenal gland response to adrenocorticotropic hormone is intact in patients with postural orthostatic tachycardia syndrome
Many patients with postural orthostatic tachycardia syndrome (POTS) are hypovolemic with plasma volume deficits of 10 –30 %. Some also have low levels of aldosterone and diminished aldosterone-renin ratios despite elevations in angiotensin II, pointing to potential adrenal dysfunction. To assess adrenal gland responsiveness in POTS, we measured circulating levels of aldosterone and cortisol following adrenocort icotropin hormone (ACTH) stimulation. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - June 23, 2023 Category: Neuroscience Authors: Jill K.H. Laurin, Oyebimbola A. Oyewunmi, Emily M. Garland, Alfredo Gamboa, Victor C. Nwazue, Sachin Y. Paranjape, Bonnie K. Black, Luis E. Okamoto, Cyndya A. Shibao, Italo Biaggioni, David Robertson, Andr é Diedrich, William D. Dupont, Robert S. Sheldon Source Type: research

The clinical utility of the Breathing Pattern Assessment Tool (BPAT) to identify dysfunctional breathing (DB) in individuals living with postural orthostatic tachycardia syndrome (POTS)
Dysfunctional breathing (DB) resulting in inappropriate breathlessness is common in individuals living with postural orthostatic tachycardia syndrome (POTS). DB in POTS is complex, multifactorial, and not routinely assessed clinically outside of specialist centres. To date DB in POTS has been identified and diagnosed predominately via cardiopulmonary exercise testing (CPEX), hyperventilation provocation testing and/or specialist respiratory physiotherapy assessment. The Breathing Pattern Assessment Tool (BPAT) is a clinically validated diagnostic tool for DB in Asthma. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - June 17, 2023 Category: Neuroscience Authors: Charles C. Reilly, Sarah V. Floyd, Shehnaz Raniwalla, Nicholas Gall, Gerrard F. Rafferty Source Type: research

Editorial Board
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - June 6, 2023 Category: Neuroscience Source Type: research

Stress and the autonomic nervous system
This Special Issue of Autonomic Neuroscience: Basic and Clinical presents expert reviews on major current topics in the area of stress and the autonomic nervous system (ANS). (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 10, 2023 Category: Neuroscience Authors: David S. Goldstein Tags: Editorial Source Type: research

Stress and the ANS: Editorial
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 10, 2023 Category: Neuroscience Authors: David S. Goldstein Tags: Editorial Source Type: research

Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons
Transient receptor potential melastatin 3 (TRPM3) channels contribute to nodose afferent and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained hypoxia (SH) and chronic intermittent hypoxia (CIH) enhances nTS activity, although the mechanisms are unknown. We hypothesized TRPM3 may contribute to increased neuronal activity in nTS-projecting nodose ganglia viscerosensory neurons, and its influence is elevated following hypoxia. Rats were exposed to either room air (normoxia), 24-h of 10  % O2 (SH), or CIH (episodic 6 % O2 for 10d). (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 28, 2023 Category: Neuroscience Authors: Katherine R. Langen, Heather A. Dantzler, Procopio Gama de Barcellos-Filho, David D. Kline Source Type: research

The effects of sex and menstrual cycle phase on sympathetic action potential recruitment patterns during hypercapnic-hypoxic apnea
Previously, we demonstrated that integrated muscle sympathetic nerve activity (MSNA) responses to acute chemoreflex stress were augmented during the early follicular (EF) phase of the menstrual cycle relative to both the midluteal (ML) phase and males. These differences were most pronounced in the amplitude component of MSNA, suggesting EF-driven increases in action potential (AP) recruitment in females. Therefore, we tested the hypothesis that neural recruitment, quantified as MSNA AP discharge patterns during acute chemoreflex stress, is potentiated during EF. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 23, 2023 Category: Neuroscience Authors: Yasmine Coovadia, J. Kevin Shoemaker, Charlotte W. Usselman Source Type: research

Exaggerated blood pressure elevation in response to orthostatic challenge, a post-acute sequelae of SARS-CoV-2 infection (PASC) after hospitalization
This study investigated the effect of COVID-19 after recovery on blood pressure (BP) during the orthostatic challenge. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 20, 2023 Category: Neuroscience Authors: J. Antonio Gonz ález-Hermosillo G, Esteban Jorge Galarza, Onasis Vicente Fermín, José Manuel Núñez González, Lucia Mariel Félix Álvarez Tostado, Marco Antonio Estrada Lozano, Claudia Ruíz Rabasa, María del Rocio Martinez Alvarado Source Type: research

Editorial Board
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 11, 2023 Category: Neuroscience Source Type: research

Editorial of the Special Issue on Autonomic Nervous System and Cerebral Blood Flow Autoregulation
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 10, 2023 Category: Neuroscience Authors: Alberto Porta, Ronney B. Panerai Tags: Editorial Source Type: research

Gamma secretase activity modulates BMP-7-induced dendritic growth in primary rat sympathetic neurons
In this study, we examined whether the γ-secretase pathway also influences dendritic growth in primary sympathetic neurons. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 5, 2023 Category: Neuroscience Authors: Krystal Karunungan, Rachel H. Garza, Ana Cristina Grodzki, Megan Holt, Pamela J. Lein, Vidya Chandrasekaran Source Type: research

The sensory and affective components of pain differentially shape pupillary dilatation during cold pressor tests
Nociceptive and affective stimuli increase reflex sympathetic outflow to the pupils. To investigate effects of stimulus intensity, unpleasantness and distress on these pupillary reflexes, and to assess their stability, healthy participants immersed their hand in ice-water three times (for 20, 40 and 60  s; or 60, 40 and 20 s; or three times for 60 s) (N = 21 in each condition). Each ice-water immersion was preceded by a 90 s warm water immersion. To evaluate phasic sympathetic influences on pupil diameter, pupillary re-dilatation after 1 s of bright light was assessed during the last 10 s of each immersion....
Source: Autonomic Neuroscience: Basic and Clinical - March 15, 2023 Category: Neuroscience Authors: Peter D. Drummond, Katie J.R. Clark Source Type: research

Role of circadian rhythms and melatonin in bladder function in heath and diseases
The circadian system modulates all visceral organ physiological processes including urine storage and voiding. The “master clock” of the circadian system lies within suprachiasmatic nucleus of the hypothalamus while “peripheral clocks” are found in most peripheral tissue and organs, including the urinary bladder. Disruptions of circadian rhythms can cause organ malfunction and disorder or exacerbate pre- existing ones. It has been suggested that nocturia, which develops mostly in the elderly, could be a circadian-related disorder of the bladder. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - March 1, 2023 Category: Neuroscience Authors: Stewart Ramsay, Vladimir Zagorodnyuk Tags: Review Source Type: research

The role of the autonomic nervous system in cerebral blood flow regulation in stroke: A review
Stroke is a pathophysiological condition which results in alterations in cerebral blood flow (CBF). The mechanism by which the brain maintains adequate CBF in presence of fluctuating cerebral perfusion pressure (CPP) is known as cerebral autoregulation (CA). Disturbances in CA may be influenced by a number of physiological pathways including the autonomic nervous system (ANS). The cerebrovascular system is innervated by adrenergic and cholinergic nerve fibers. The role of the ANS in regulating CBF is widely disputed owing to several factors including the complexity of the ANS and cerebrovascular interactions, limitations t...
Source: Autonomic Neuroscience: Basic and Clinical - February 27, 2023 Category: Neuroscience Authors: Alex Mankoo, Sankanika Roy, Aaron Davies, Ronney B. Panerai, Thompson G. Robinson, Patrice Brassard, Lucy C. Beishon, Jatinder S. Minhas Tags: Review Source Type: research

Editorial Board
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - February 3, 2023 Category: Neuroscience Source Type: research