Exploring the interplay between mechanisms of neuroplasticity and cardiovascular health in aging adults: A multiple linear regression analysis study
Neuroplasticity and cardiovascular health behavior are critically important factors for optimal brain health. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - September 6, 2022 Category: Neuroscience Authors: Danylo F. Cabral, Marcelo Bigliassi, Gabriele Cattaneo, Tatjana Rundek, Alvaro Pascual-Leone, Lawrence P. Cahalin, Joyce Gomes-Osman Source Type: research

Mild thermal stimulation of the buttock skin increases urinary voiding efficiency in anesthetized rats
In the present study, we examined the effects of mild thermal stimulation of the skin on voiding efficiency using urethane-anesthetized rats with reduced voiding efficiency. Spontaneous urination was induced by infusing saline. For each voiding, the voiding efficiency was calculated from the voided volume and the bladder capacity measured. A Peltier thermode was attached to the buttock skin to apply stimulation: cooling between to 25  °C and 35 °C, every 20 s throughout the saline infusion. The voiding efficiency was 29 ± 9 % (mean ± SD) before stimulation and increased significantly by 10–15 % duri...
Source: Autonomic Neuroscience: Basic and Clinical - August 31, 2022 Category: Neuroscience Authors: Kaori Iimura, Nobuhiro Watanabe, Harumi Hotta Source Type: research

Spectral decomposition of cerebrovascular and cardiovascular interactions in patients prone to postural syncope and healthy controls
We present a framework for the linear parametric analysis of pairwise interactions in bivariate time series in the time and frequency domains, which allows the evaluation of total, causal and instantaneous interactions and connects time- and frequency-domain measures. The framework is applied to physiological time series to investigate the cerebrovascular regulation from the variability of mean cerebral blood flow velocity (CBFV) and mean arterial pressure (MAP), and the cardiovascular regulation from the variability of heart period (HP) and systolic arterial pressure (SAP). (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - August 8, 2022 Category: Neuroscience Authors: Riccardo Pernice, Laura Sparacino, Vlasta Bari, Francesca Gelpi, Beatrice Cairo, Gorana Mijatovic, Yuri Antonacci, Davide Tonon, Gianluca Rossato, Michal Javorka, Alberto Porta, Luca Faes Tags: Review Source Type: research

Anatomical characterization of vagal nodose afferent innervation and ending morphologies at the murine heart using a transgenic approach
Heart is an extensively innervated organ and its function is strictly coordinated by autonomic neural circuits. After pathological events such as myocardial infarction (MI), cardiac nerves undergo a structural and functional remodeling contributing to cardiac dysfunction. Although the efferent component of the cardiac nerves has been well described, sensory innervation of the heart has not been defined in detail. Considering its importance, comprehensive charting of vagal afferent innervation on the whole heart would enable a better description of autonomic imbalances manifesting as sympathoexcitation and vagal withdrawal ...
Source: Autonomic Neuroscience: Basic and Clinical - July 11, 2022 Category: Neuroscience Authors: Yusuf Enes Kazc ı, Sevilay Şahoğlu Göktaş, Mehmet Şerif Aydın, Behnaz Karadoğan, Aylin Nebol, Mehmet Uğurcan Turhan, Gürkan Öztürk, Esra Çağavi Source Type: research

Cerebrovascular regulation in patients with vasovagal syncope and autonomic failure due to familial amyloidotic polyneuropathy
While there is strong evidence for autonomic involvement in cerebrovascular function acutely, long-term role of autonomic nervous system in cerebrovascular function has been controversial. We assessed autoregulation in 10 healthy individuals, nine patients with vasovagal syncope (VVS), and nine with Familial Amyloidotic Polyneuropathy (FAP), in response to head-up tilt test (HUTT). (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - July 11, 2022 Category: Neuroscience Authors: Pedro Castro, Jo ão Freitas, Elsa Azevedo, Can Ozan Tan Tags: Review Source Type: research

Editorial Board
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - July 8, 2022 Category: Neuroscience Source Type: research

Exploring metrics for the characterization of the cerebral autoregulation during head-up tilt and propofol general anesthesia
Techniques grounded on the simultaneous utilization of Tiecks' second order differential equations and spontaneous variability of mean arterial pressure (MAP) and mean cerebral blood flow velocity (MCBFV), recorded from middle cerebral arteries through a transcranial Doppler device, provide a characterization of cerebral autoregulation (CA) via the autoregulation index (ARI). These methods exploit two metrics for comparing the measured MCBFV series with the version predicted by Tiecks' model: normalized mean square prediction error (NMSPE) and normalized correlation ρ. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - July 8, 2022 Category: Neuroscience Authors: Vlasta Bari, Lorenzo Barbarossa, Francesca Gelpi, Beatrice Cairo, Beatrice De Maria, Davide Tonon, Gianluca Rossato, Luca Faes, Marco Ranucci, Riccardo Barbieri, Alberto Porta Tags: Review Source Type: research

Varicella-zoster virus infection and autonomic dysfunction
Autonomic dysfunction has been occasionally described in varicella-zoster virus (VZV) infection, while few systematic reviews are available. We systematically review autonomic dysfunction due to VZV infection. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - July 8, 2022 Category: Neuroscience Authors: Ryuji Sakakibara, Setsu Sawai, Tsuyoshi Ogata Tags: Review Source Type: research

Respiratory and heart rate dynamics during peripheral chemoreceptor deactivation compared to targeted sympathetic and sympathetic/parasympathetic co-activation
The importance of peripheral chemoreceptors for cardiorespiratory neural control is known for decades. Pure oxygen inhalation deactivates chemoreceptors and increases parasympathetic outflow. However, the relationship between autonomic nervous system (ANS) activation and resulting heart rate (HR) dynamics is still not fully understood. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - June 14, 2022 Category: Neuroscience Authors: Katharina Apelt-Glitz, Fares-Alexander Alken, Christiane Jungen, Katharina Scherschel, Nikolaj Kl öcker, Christian Meyer Source Type: research

Prefrontal cortex oxygenation and autonomic nervous system activity under transcutaneous auricular vagus nerve stimulation in adolescents
The Neurovisceral Integration Model (NIM) proposes a complex interplay of visceral and neural structures that are crucial for adaptive responses to environmental demands. The aim of the present study was to investigate this circuitry using experimental manipulation via transcutaneous auricular vagus nerve stimulation (tVNS), measures of peripheral autonomic nervous system (ANS) activity and prefrontal cortex (PFC) oxygenation, quantified using functional near infrared spectroscopy (fNIRS). (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - June 13, 2022 Category: Neuroscience Authors: Saskia H öper, Michael Kaess, Julian Koenig Tags: Review Source Type: research

The reciprocal relationship between cardiac baroreceptor sensitivity and cerebral autoregulation during simulated hemorrhage in humans
A reciprocal relationship between the baroreflex and cerebral autoregulation (CA) has been demonstrated at rest and in response to acute hypotension. We hypothesized that the reciprocal relationship between cardiac baroreflex sensitivity (BRS) and CA would be maintained during sustained central hypovolemia induced by lower body negative pressure (LBNP), and that the strength of this relationship would be greater in subjects with higher tolerance to this stress. Healthy young adults (n  = 51; 23F/28M) completed a LBNP protocol to presyncope. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - June 10, 2022 Category: Neuroscience Authors: Alexander J. Rosenberg, Victoria L. Kay, Garen K. Anderson, My-Loan Luu, Haley J. Barnes, Justin D. Sprick, Hannah B. Alvarado, Caroline A. Rickards Tags: Review Source Type: research

Autonomic function testing in long-COVID syndrome patients with orthostatic intolerance
This study retrospectively characterized the findings of autonomic reflex screen (ARS) in long-COVID patients presenting with orthostatic intolerance (OI). Fourteen patients were identified. All patients had normal cardiovagal function and 2 patients had abnormal sudomotor function. The head-up tilt table (HUTT) was significantly abnormal in 3 patients showing postural orthostatic tachycardia syndrome (POTS). (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - June 1, 2022 Category: Neuroscience Authors: Ahmed M. Eldokla, Sara T. Ali Tags: Short communication Source Type: research

Pacing for vasovagal syncope: Tips for use in practice
Vasovagal syncope (VVS) continues to be the most frequent cause of syncope in all age groups. Recent randomized double-blinded trials (RCTs) provide further support for pacing in selected cases of patients with recurrent refractory VVS with significant cardio-inhibitory response either documented spontaneously or induced during head-up tilt testing (HUTT). Cardiac pacing is the only therapy of proven efficacy for the predominant cardio-inhibitory phenotype of vasovagal (reflex) syncope; however, several questions regarding the best candidates remain. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - June 1, 2022 Category: Neuroscience Authors: Carlos A. Morillo, Michele Brignole Tags: Review Source Type: research

Editorial Board
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 14, 2022 Category: Neuroscience Source Type: research

Supine hypertension: A state of the art
Patients with cardiovascular autonomic failure (AF) may suffer from neurogenic supine hypertension (nSH), defined as systolic blood pressure (SBP) ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg, after 5 min of rest in the supine position, combined with neurogenic orthostatic hypotension (nOH) in approximately 50% of the cases.nSH may be the manifestation of central or peripheral autonomic lesions.Long-term risks are hypothesized with SH, including renal dysfunction, left ventricular hypertrophy, cerebrovascular disease and cognitive impairment. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 14, 2022 Category: Neuroscience Authors: G. Mantovani, I. Marozzi, M. Rafanelli, G. Rivasi, S. Volpato, A. Ungar Tags: Review Source Type: research