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Correlation between heart rate variability and cerebral autoregulation in septic patients
Heart rate variability (HRV) may provide an estimation of the autonomous nervous system (ANS) integrity in critically ill patients. Disturbances of cerebral autoregulation (CAR) may share common pathways of ANS dysfunction. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - November 17, 2022 Category: Neuroscience Authors: Armin Alvaro Quispe-Cornejo, Ilaria Alice Crippa, P éter Bakos, Andrea Dominguez-Faure, Jacques Creteur, Fabio Silvio Taccone Tags: Review Source Type: research

Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies
Postural Orthostatic Tachycardia Syndrome (POTS) is a chronic health condition affecting mostly women of childbearing age, and significantly impacting their health and quality of life. It is currently poorly understood with no approved licensed treatments. The aim of this systematic review was to contextualize the symptom burden of POTS, and review factors associated with this burden that may guide future treatments. The specific questions were (1) How does symptom burden in POTS compare to the burden in other long term conditions (LTCs), (2) Which factors are associated with POTS symptom burden, and (3) Which intervention...
Source: Autonomic Neuroscience: Basic and Clinical - November 17, 2022 Category: Neuroscience Authors: Iris Knoop, Federica Picariello, Emma Jenkinson, Nicholas Gall, Claudia Chisari, Rona Moss-Morris Tags: Review Source Type: research

Exploring mechanisms of blood pressure regulation in response to device-guided and non-device-guided slow breathing: A mini review
Hypertension is a widespread disease that, if persistent, increases the risks of coronary heart disease mortality and morbidity. Slow breathing is a recommended blood pressure-lowering strategy though the mechanisms mediating its effects are unknown. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - November 14, 2022 Category: Neuroscience Authors: Harika Pingali, Stacy D. Hunter Source Type: research

Editorial Board
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - November 12, 2022 Category: Neuroscience Source Type: research

The multiple roles of dopamine receptor activation in the modulation of gastrointestinal motility and mucosal function
Dopamine (DA) is a catecholamine regulatory molecule with potential role in physiology and physiopathology of the intestinal tract. Various cellular sources of DA have been indicated as enteric neurons, immune cells, intestinal flora and gastrointestinal epithelium. Moreover, DA is produced by nutritional tyrosine. All the five DA receptors, actually described, are present throughout the gut. Current knowledge of DA in this area is reviewed, focusing on gastrointestinal function in health and during inflammation. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - November 7, 2022 Category: Neuroscience Authors: Rosa Serio, Maria Grazia Zizzo Source Type: research

Distribution of proteins for synaptic release in nerve endings associated with the trachealis muscle of rats
The immunohistochemical localization of proteins for synaptic release was examined in smooth muscle-associated sensory nerve endings using whole-mount preparations of the rat trachea. Plant-like smooth muscle-associated nerve endings with immunoreactivity for Na+-K+-ATPase, α3-subunit were identified in the trachealis muscle. VGLUT1, synapsin1, t-SNARE proteins (SNAP25 and syntaxin1), v-SNARE proteins (VAMP1 and VAMP2), and a presynaptic active zone-related protein (piccolo) were detected in the terminal parts of these endings. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - November 7, 2022 Category: Neuroscience Authors: Hisae Moriai, Takuya Yokoyama, Sayed Scharif Abdali, Nobuaki Nakamuta, Yoshio Yamamoto Tags: Short Communication Source Type: research

5-HT3 receptors modulate changes in voiding pattern and bladder contractility in water avoidance stress-induced bladder overactivity in male mice
This study aimed to investigate the roles of 5-HT3 receptors in modulating voiding patterns and spontaneous bladder contractile properties in water avoidance stress-induced mice. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - October 3, 2022 Category: Neuroscience Authors: Sarunnuch Sattayachiti, Affan Waemong, Dania Cheaha, Nipaporn Konthapakdee Source Type: research

Transcutaneous vagus nerve stimulation and the realm of its therapeutic hopes and physiologic enigmas
Vagus nerve stimulation (VNS) is an established treatment option for patients with treatment resistant epilepsy and depression. However, the procedure is invasive and has side-effects. Transcutaneous vagus nerve stimulation (tVNS) is a non-invasive alternative. Particularly transcutaneous stimulation at the outer ear is gaining increasing interest. While the scope of therapeutic tVNS applications is expanding, there are still questions regarding the optimal stimulation parameters and site as well as the physiology and pathways of auricular tVNS. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - September 27, 2022 Category: Neuroscience Authors: Max J. Hilz, Armin Bolz Tags: Editorial Source Type: research

Transcutaneous vagus nerve stimulation - A brief introduction and overview
Invasive cervical vagus nerve stimulation (VNS) is approved for the treatment of epilepsies, depression, obesity, and for stroke-rehabilitation. The procedure requires surgery, has side-effects, is expensive and not readily available. Consequently, transcutaneous VNS (tVNS) has been developed 20  years ago as non-invasive, less expensive, and easily applicable alternative. Since the vagus nerve reaches the skin at the outer acoustic canal and ear, and reflex-responses such as the ear-cough-reflex or the auriculo-cardiac reflex have been observed upon auricular stimulation, the ear seems w ell suited for tVNS. (Source: Au...
Source: Autonomic Neuroscience: Basic and Clinical - September 27, 2022 Category: Neuroscience Authors: Max J. Hilz Tags: Review Source Type: research

Autonomic nervous system and arrhythmias in structural heart disease
The autonomic nervous system functions in a fine-tuned manner to dynamically modulate cardiac function during normal physiological state. Autonomic dysregulation in cardiac disease states such as myocardial infarction and heart failure alters this fine balance, which in turn promotes disease progression and arrhythmogenesis. Neuromodulatory interventions that aim to restore this balance at distinct levels thus have been shown to be effective in the treatment of arrhythmias. This review first describes the anatomy of the cardiac autonomic nervous system and the pathological changes that occur with neural remodeling in the s...
Source: Autonomic Neuroscience: Basic and Clinical - September 24, 2022 Category: Neuroscience Authors: Aadhavi Sridharan, Jason S. Bradfield, Kalyanam Shivkumar, Olujimi A. Ajijola Tags: Review Source Type: research

How does head position induced intracranial pressure changes impact sympathetic activity and cerebral blood flow?
Acute head-down-tilt (HDT) simulates short duration hemodynamic impact of microgravity. We sought to determine whether an increase in ICP caused by acute HDT affects sympathetic nervous system activity and cerebral blood flow velocities (CBFV) in healthy male volunteers. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - September 23, 2022 Category: Neuroscience Authors: Marc Kermorgant, Marc Labrun ée, Fabien Despas, Ophélie Hélissen, Thomas Geeraerts, Elisabeth Lambert, Eric Schmidt, Jean-Michel Senard, Dina N. Arvanitis, Nathalie Nasr, Anne Pavy-Le Traon Tags: Review Source Type: research

Vasovagal Syncope: Treat the patient, and not just the disease
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - September 21, 2022 Category: Neuroscience Authors: Satish R. Raj, Robert S. Sheldon Tags: Editorial Source Type: research

Preferential impairment of parasympathetic autonomic function in type 2 diabetes
Cardiovascular autonomic neuropathy is a known complication in type 2 diabetes (T2D). However, the extent of sympathetic dysfunction and its relation to blood pressure (BP) dysregulation is insufficiently studied. We therefore assessed the cardiovascular sympathetic function using a standardized autonomic test-battery. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - September 14, 2022 Category: Neuroscience Authors: Thorsten K. Rasmussen, Nanna B. Finnerup, Wolfgang Singer, Troels Staehelin Jensen, John Hansen, Astrid Juhl Terkelsen Source Type: research

Isolated ictal apnea in neonatal age: Clinical features and treatment options. A systematic review
Among autonomic seizures apnea still represent a challenge for physicians, and it might constitute the only isolated sign of neurological disorder. The aim of this review is to describe ictal apnea (IA) and its treatment options. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - September 13, 2022 Category: Neuroscience Authors: Raffaele Falsaperla, Maria Chiara Consentino, Giovanna Vitaliti, Silvia Marino, Martino Ruggieri Tags: Review Source Type: research

Editorial Board
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - September 11, 2022 Category: Neuroscience Source Type: research