Is there cardiac autonomic neuropathy in prediabetes?

Although there is considerably more data showing an association between type 2 diabetes mellitus (T2DM) and autonomic neuropathy, accumulating evidence indicates that cardiovascular autonomic neuropathy (CAN) is common in persons with impaired glucose tolerance (IGT). Furthermore, CAN may occur early after a metabolic insult and obesity, especially among men, seems to play an important role in the early pathogenesis of CAN. Autonomic symptoms are common in subjects with IGT. In addition to defects in CAN, in subjects with IGT, there is impaired sudomotor function and abnormalities of endothelial peripheral vasoreactivity.

Source: Autonomic Neuroscience: Basic and Clinical - September 10, 2020 Category: Neuroscience Authors: Lindsay A. Zilliox, James W. Russell Source Type: research