Autonomic Neuroscience: Basic and Clinical This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The extraordinary partnership of Geoff Burnstock and Mollie Holman
Here, we recognise some of the extraordinary accomplishments of the partnership between Geoff Burnstock and Mollie Holman, and the everlasting impact they both made in autonomic neuroscience in Australia. Much of strength today in autonomic neuroscience can be traced back to a time when Geoff and Mollie commenced their seminal studies on autonomic neuroscience, initially at Oxford, then at The University of Melbourne in the mid 1960's. Mollie and Geoff published their first paper together, at Oxford, with their then mentor, and doyenne of smooth muscle, Professor Edith B ülbring. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 31, 2021 Category: Neuroscience Authors: Nick J. Spencer, Marcello Costa Source Type: research

Visualizing the “internet of the body”: Winners of the NIH SPARC Art Contest
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 28, 2021 Category: Neuroscience Authors: Eugene F. Civillico, Kalyanam Shivkumar Tags: Editorial Source Type: research

Postexercise hypotension due to resistance exercise is not mediated by autonomic control: A systematic review and meta-analysis
Changes in autonomic control have been suggested to mediate postexercise hypotension (PEH). We investigated through meta-analysis the after-effects of acute resistance exercise (RE) on blood pressure (BP) and autonomic activity in individuals with normal and elevated BP. Electronic databases were searched for trials including: adults; exclusive RE interventions; and BP and autonomic outcomes measured pre- and postintervention for at least 30  min. Analyses incorporated random-effects assumptions. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 26, 2021 Category: Neuroscience Authors: Paulo Farinatti, Marcos D. Polito, Renato Massaferri, Walace D. Monteiro, Denilson Vasconcelos, Blair T. Johnson, Linda S. Pescatello Tags: Review Source Type: research

Ten days of high dietary sodium does not impair cerebral blood flow regulation in healthy adults
High dietary sodium impairs cerebral blood flow regulation in rodents and is associated with increased stroke risk in humans. However, the effects of multiple days of high dietary sodium on cerebral blood flow regulation in humans is unknown. Therefore, the purpose of this study was to determine whether ten days of high dietary sodium impairs cerebral blood flow regulation. Ten participants (3F/7M; age: 30  ± 10 years; blood pressure (BP): 113 ± 8/62 ± 9 mmHg) participated in this randomized, cross-over design study. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 26, 2021 Category: Neuroscience Authors: Kamila U. Migdal, Austin T. Robinson, Joseph C. Watso, Matthew C. Babcock, Shannon L. Lennon, Christopher R. Martens, Jorge M. Serrador, William B. Farquhar Source Type: research

Editorial Board
(Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 22, 2021 Category: Neuroscience Source Type: research

Autonomic neuromuscular junctions
This review traces the history of the discovery and subsequent understanding of smooth muscle cells and their motor innervation. Smooth muscle tissue is made up of thousands of very small, individual, electrically connected, muscle cells. Each axon that enters a smooth muscle tissue branches extensively to form a terminal arbour that comes close to hundreds of smooth muscle cells. The branches of the terminal arbour are varicose, and each varicosity, of which there can be thousands, contains numerous transmitter storage vesicles. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 9, 2021 Category: Neuroscience Authors: Madeleine R. Di Natale, Martin J. Stebbing, John B. Furness Source Type: research

The inevitability of ATP as a transmitter in the carotid body
Atmospheric oxygen concentrations rose markedly at several points in evolutionary history. Each of these increases was followed by an evolutionary leap in organismal complexity, and thus the cellular adaptions we see today have been shaped by the levels of oxygen within our atmosphere. In eukaryotic cells, oxygen is essential for the production of adenosine 5 ′-triphosphate (ATP) which is the ‘Universal Energy Currency’ of life. Aerobic organisms survived by evolving precise mechanisms for converting oxygen within the environment into energy. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 6, 2021 Category: Neuroscience Authors: Emma N. Bardsley, Dylan K. Pen, Fiona D. McBryde, Anthony P. Ford, Julian F.R. Paton Source Type: research

Alpha 1 adrenoceptor expression in skin, nerves and blood vessels of patients with painful diabetic neuropathy
Diabetic neuropathy (dNP) patients often suffer from severe neuropathic pain. It was suggested that alpha-1 adrenoceptor ( α1-AR) hyperresponsiveness contributes to pain in dNP. The aim of our study was to quantify α1-AR expression using immunohistochemistry in skin biopsies of nine patients with painful diabetic neuropathy compared to 10 healthy controls. Additionally, the association between α1-AR expression and ac tivation with spontaneous and sympathetically maintained pain (SMP) induced by intradermal injection of the α1-agonist phenylephrine was investigated. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - May 3, 2021 Category: Neuroscience Authors: Tanja Schlereth, Natalie Morellini, No émie C.A.M. Lismont, Cassandra Lemper, Frank Birklein, Peter D. Drummond Source Type: research

The impacts of the ganglionated plexus ablation sequence on the vagal response, heart rate, and blood pressure during cardioneuroablation
Cardioneuroablation is an emerging and promising therapy to treat vasovagal syncope (VVS). The aim of this study was to assess the characteristics of vagal response (VR), heart rate (HR), and blood pressure (BP) during cardioneuroablation with different sequences of ganglionated plexus (GPs) catheter ablation and clarify the regulatory mechanism of cardiac GPs of the left atrium. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 19, 2021 Category: Neuroscience Authors: Feng Hu, Lihui Zheng, Shangyu Liu, Lishui Shen, Erpeng Liang, Limin Liu, Lingmin Wu, Ligang Ding, Yan Yao Source Type: research

The relationship between lower urinary tract function and 123ioflupane scintigraphy in drug-na ïve Parkinson's disease
Parkinson's disease (PD) is the most common degenerative cause of movement disorder, and autonomic dysfunction has been recognized in this disorder. PD patients' lower urinary tract (LUT) function is not established. We investigated LUT function in PD by single-photon emission computerized tomography (SPECT) imaging of the dopamine transporter with 123I-ioflupane and clinical-urodynamic observations. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 19, 2021 Category: Neuroscience Authors: Fuyuki Tateno, Ryuji Sakakibara, Tsuyoshi Ogata, Yousuke Aiba, Osamu Takahashi, Megumi Sugiyama Source Type: research

Neurotrophin-4 is essential for survival of the majority of vagal afferents to the mucosa of the small intestine, but not the stomach
Vagal afferents form the primary gut-to-brain neural axis, communicating signals that regulate gastrointestinal (GI) function and promote satiation, appetition and reward. Neurotrophin-4 (NT-4) is essential for the survival of vagal smooth muscle afferents of the small intestine, but not the stomach. Here we took advantage of near-complete labeling of GI vagal mucosal afferents in Nav1.8cre-Rosa26tdTomato transgenic mice to determine whether these afferents depend on NT-4 for survival. We quantified the density and distribution of vagal afferent terminals in the stomach and small intestine mucosa and their central terminal...
Source: Autonomic Neuroscience: Basic and Clinical - April 18, 2021 Category: Neuroscience Authors: Hannah K. Serlin, Edward A. Fox Source Type: research

Understanding the future research needs in Postural Orthostatic Tachycardia Syndrome (POTS): Evidence mapping the POTS adult literature
POTS is under diagnosed with an estimated prevalence of 0.2%. North American and Australian researchers, as well as patient groups have called for more research into POTS. However, there has been no comprehensive appraisal of the current POTS evidence base. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 17, 2021 Category: Neuroscience Authors: H. Eftekhari, H. Maddock, G. Pearce, S. Raza, L. Kavi, P.B. Lim, F. Osman, S.A. Hayat Tags: Review Source Type: research

Relevance of carotid bodies in COVID-19: A hypothetical viewpoint
We have considered some of the available evidence to account for the impact of SARS-CoV on the regulatory control of the autonomic nervous and respiratory systems. Apart from stimulating general interest in the subject, our hope was to provide putative explanations for some of the patients' symptoms based on described physiological and pathophysiological mechanisms seen in other diseases. Herein, we have focused on the carotid bodies. In this hypothetical viewpoint, we have discussed the plasticity of the carotid body chemoreflex and made a comparison between acute and chronic exposures to high altitude with COVID-19. (Sou...
Source: Autonomic Neuroscience: Basic and Clinical - April 16, 2021 Category: Neuroscience Authors: Benedito H. Machado, Julian F.R. Paton Tags: Review Source Type: research

Signal transduction pathways involved in dopamine D2 receptor-evoked emesis in the least shrew (Cryptotis parva)
This study investigated potential mechanisms involved in dopamine D2 receptor-mediated vomiting using least shrews. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - April 10, 2021 Category: Neuroscience Authors: Louiza Belkacemi, Weixia Zhong, Nissar A. Darmani Source Type: research

Effect of sensory blockade and rate of sensory stimulation on local heating induced axon reflex response in facial skin
Local neuronal circuits in non-glabrous skin drive the initial increase of the biphasic cutaneous vasodilation response to fast non-noxious heating. Voltage-sensitive Na+ (NaV) channel inhibition blocks the afferent limb of the non-glabrous forearm cutaneous axon reflex. Slow local heating does not engage this response. These mechanisms have not been adequately investigated or extended into areas associated with flushing pathology. We hypothesized that despite regional differences in sensory afferents, both sensory blockade and slowing the heating rate would abate the cutaneous axon reflex-mediated vasodilator responses in...
Source: Autonomic Neuroscience: Basic and Clinical - April 7, 2021 Category: Neuroscience Authors: Kristen Metzler-Wilson, Thad E. Wilson, Samantha M. Ausmus, Austin M. Sventeckis Source Type: research