Alpha 1 adrenoceptor expression in skin, nerves and blood vessels of patients with painful diabetic neuropathy

Diabetic neuropathy (dNP) patients often suffer from severe neuropathic pain. It was suggested that alpha-1 adrenoceptor ( α1-AR) hyperresponsiveness contributes to pain in dNP. The aim of our study was to quantify α1-AR expression using immunohistochemistry in skin biopsies of nine patients with painful diabetic neuropathy compared to 10 healthy controls. Additionally, the association between α1-AR expression and ac tivation with spontaneous and sympathetically maintained pain (SMP) induced by intradermal injection of the α1-agonist phenylephrine was investigated.

Source: Autonomic Neuroscience: Basic and Clinical - May 3, 2021 Category: Neuroscience Authors: Tanja Schlereth, Natalie Morellini, No émie C.A.M. Lismont, Cassandra Lemper, Frank Birklein, Peter D. Drummond Source Type: research