Gender differences and influenza-associated mortality in hospitalized influenza A patients during the 2018/19 season
ConclusionsGender is associated with differences in clinical presentation and complications of influenza A virus infection. Women with acute heart failure or aged  >  75 years have an increased risk of influenza associated in-hospital mortality, while ICU admission and any malignancy are predictors for male patients. Mortality rates in patients >  75 years are 5–10 times higher compared to their non-hospitalized influenza-negative Austrian counterparts. (Source: Infection)
Source: Infection - October 22, 2020 Category: Infectious Diseases Source Type: research

Ceftazidime/avibactam and ceftolozane/tazobactam for the treatment of extensively drug-resistant Pseudomonas aeruginosa post-neurosurgical infections: three cases and a review of the literature
ConclusionThese recently developed antibiotics, C/T and CZA are promising and complementary therapy options against post-neurosurgical hard-to-treat P. aeruginosa infections. Further prospective real-life studies are required to validate these findings in this special setting. (Source: Infection)
Source: Infection - October 19, 2020 Category: Infectious Diseases Source Type: research

DGI recommendations for COVID-19 pharmacotherapy
(Source: Infection)
Source: Infection - October 19, 2020 Category: Infectious Diseases Source Type: research

Surgical Site Infections after glioblastoma surgery: results of a multicentric retrospective study
AbstractBackgroundThe effects of surgical site infections (SSI) after glioblastoma surgery on patient outcomes are understudied. The aim of this retrospective multicenter study was to evaluate the impact of SSI on the survival of glioblastoma patients.MethodsData from SSI cases after glioblastoma surgeries between 2009 and 2016 were collected from 14 French neurosurgical centers. Collected data included patient demographics, previous medical history, risk factors, details of the surgical procedure, radiotherapy/chemotherapy, infection characteristics, and infection management. Similar data were collected from gender- and a...
Source: Infection - October 9, 2020 Category: Infectious Diseases Source Type: research

Report on a lactating patient with COVID-19
We report the first confirmed case of the novel coronavirus disease (COVID-19) in a lactating patient in Chizhou, Anhui Province, China. The lactating patient presented with intermittent fever for 16  days and cough for 10 days. Given her travel history to the epidemic area and the chest CT scan results, the patient was immediately admitted to the isolation ward of the Infectious Disease Department and breastfeeding was discontinued. Pharyngeal swab specimens tested positive for severe acute r espiratory syndrome coronavirus 2 (SARS-CoV-2, previously known as 2019-nCoV) in nucleic acid testing. During hospitaliza...
Source: Infection - October 9, 2020 Category: Infectious Diseases Source Type: research

Epidemiology of SARS-CoV-2
ConclusionsDespite a rapid worldwide spread, attack rates have been low in most regions, demonstrating the efficacy of control measures. (Source: Infection)
Source: Infection - October 8, 2020 Category: Infectious Diseases Source Type: research

An approach to lifting self-isolation for health care workers with prolonged shedding of SARS-CoV-2 RNA
ConclusionWe recommend lifting isolation if the RT-PCR Ct-value of a naso- or oropharyngeal swab sample is over 30. Positive results obtained from genes targeted with Ct-values> 30 correspond to non-viable/noninfectious particles that are still detected by RT-PCR. In case of Ct-values lower than 30, a blood sample from the patient should be tested for the presence of neutralizing antibodies. If positive, non-infectiousness can also be assumed. (Source: Infection)
Source: Infection - October 5, 2020 Category: Infectious Diseases Source Type: research

First results of the “Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)”
AbstractPurposeKnowledge regarding patients ’ clinical condition at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is sparse. Data in the international, multicenter Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort study may enhance the understanding of COVID-19.MethodsSociodemographic and clinical characteristics of SARS-CoV-2-infected patients, enrolled in the LEOSS cohort study between March 16, 2020, and May 14, 2020, were analyzed. Associations between baseline characteristics and clinical stages at diagnosis (uncomplicated vs. complicated) were assessed using logis...
Source: Infection - September 30, 2020 Category: Infectious Diseases Source Type: research

Abiotrophia defectiva as a cause of infective endocarditis with embolic complications in children
This study reports four cases ofA. defectiva IE in children and reviews previously reported five pediatric cases ofA. defectiva IE. Most of the patients presented with a subacute course, with prolonged fever or atypical symptoms. Eight patients had embolic complications at presentation. All nine children were treated with combination antimicrobial therapy and six of them received surgical intervention. All patients recovered well without relapse.A. defectiva should be considered in children with infective endocarditis, especially in those with atypical presentations. As complications are frequent and more than half of the ...
Source: Infection - September 25, 2020 Category: Infectious Diseases Source Type: research

Staphylococcus capitis causing infective endocarditis: not so uncommon
(Source: Infection)
Source: Infection - September 23, 2020 Category: Infectious Diseases Source Type: research

Dalbavancin as long-term suppressive therapy for patients with Gram-positive bacteremia due to an intravascular source —a series of four cases
We present four cases with Gram-positive bacteremia (pathogens: MRSAn = 1, Enterococcus spp.n = 3) due to an intravascular source (left ventricular assist device:n = 2, transfemoral aortic valve implantationn = 1, prosthetic aortic valve:n = 1) where no curative treatment was available. These patients received indefinite, chronic suppressive (palliative) therapy with dalbavancin (500 mg weekly or 1000 mg biweekly regimens). Outcomes and clinical characteristics are described; treatment was effective in suppression of bacteremia in all patients ...
Source: Infection - September 22, 2020 Category: Infectious Diseases Source Type: research

First case of Candida auris isolated from the bloodstream of a Mexican patient with serious gastrointestinal complications from severe endometriosis
AbstractA 58-year-old woman was diagnosed with severe endometriosis and had multiple gastrointestinal tract complications for many years.Candida auris andC. parapsilosis were isolated from the bloodstream. Identification ofC. auris was confirmed by amplification and sequencing of the internal transcriber spacer and the D1/D2 domain of the large rRNA gene subunit. Antifungal susceptibility was tested in both isolates using the Clinical Laboratory Standards Institute protocol M27-A3/S4. The patient evolved favorably with systemic antifungal therapy consisting of caspofungin and liposomal amphotericin B. (Source: Infection)
Source: Infection - September 21, 2020 Category: Infectious Diseases Source Type: research

Detection of SARS-CoV-2 in conjunctival secretions from patients without ocular symptoms
ConclusionConjunctival secretions of a minority of COVID-19 patients without ocular symptoms may contain relatively low levels of SARS-CoV-2 RNA, but their infectiousness remains undetermined. Appropriate infection control measures should be implemented during ophthalmological assessment of COVID-19 patients to prevent potential nosocomial transmission of SARS-CoV-2. (Source: Infection)
Source: Infection - September 16, 2020 Category: Infectious Diseases Source Type: research

Comparison of four commercial SARS-CoV-2 IgG immuno-assays in RT-PCR negative patients with suspect CT findings
AbstractA subset of patients with Covid-19 presents with negative RT-PCR screening but suspect CT findings. Using four commercially available anti-SARS-CoV-2 IgG immuno-assays, we found this subset constituted 9.2% of all consecutively admitted outpatients with Covid-19 in our hospital. Clinical specificity for Covid-19 of some N protein-based immuno-assays was suboptimal, as positive results were observed in control patients with recent common human coronavirus, influenza B and adenovirus infections. (Source: Infection)
Source: Infection - September 9, 2020 Category: Infectious Diseases Source Type: research

Strongyloides infection manifested during immunosuppressive therapy for SARS-CoV-2 pneumonia
We report a case of a 59-year-old Italian patient treated with high dose intravenous dexamethasone and two intravenous doses of Tocilizumab for interstitial bilateral pneumonia associated with SARS-CoV-2 infection who developed itching, abdominal pain, and an increased eosinophil count. Stool examination confirmed the presence ofS. stercoralis larvae. The patient was treated with a 4-day course of Ivermectin with full recovery.DiscussionWe report the first case ofS. stercoralis infection following an 11-day treatment with high-dose steroids and Tocilizumab for severe COVID-19. Clinicians should be aware of the risk of stro...
Source: Infection - September 9, 2020 Category: Infectious Diseases Source Type: research

Confronting hidden COVID-19 burden: a telemedical solution for elective urological outpatient clinics
AbstractMaintaining high-quality care for urological patients is a challenge during and after the Coronavirus disease 2019 (COVID-19) pandemic. We observe an increasing volume of postponed elective visits at our tertiary care hospital, holding the risk for deterioration of non-emergency disease conditions. As it is unclear for how long the pandemic will last, we propose to implement telehealth as a solution to provide regular symptom monitoring compatible with social distancing guidelines during the pandemic and beyond. Telemedical assessment and prioritizing of high-risk patients for individual consults at outpatient serv...
Source: Infection - September 5, 2020 Category: Infectious Diseases Source Type: research

COVID-19 outbreak: history, mechanism, transmission, structural studies and therapeutics
AbstractPurposeThe coronavirus outbreak emerged as a severe pandemic, claiming more than 0.8 million lives across the world and raised a major global health concern. We survey the history and mechanism of coronaviruses, and the structural characteristics of the spike protein and its key residues responsible for human transmissions.MethodsWe have carried out a systematic review to summarize the origin, transmission and etiology of COVID-19. The structural analysis of the spike protein and its disordered residues explains the mechanism of the viral transmission. A meta-data analysis of the therapeutic compounds targeting the...
Source: Infection - September 3, 2020 Category: Infectious Diseases Source Type: research

Digestive enzymes of fungal origin as a relevant cause of false positive Aspergillus antigen testing in intensive care unit patients
AbstractBackgroundGalactomannan antigen (GM) testing is widely used in the diagnosis of invasive aspergillosis (IA). Digestive enzymes play an important role in enzyme substitution therapy in exocrine pancreatic insufficiency. As digestive enzymes of fungal origin like Nortase contain enzymes fromAspergillus, a false-positive result of the test might be possible because of cross-reacting antigens of the cell wall of the producing fungi. We, therefore, asked whether the administration of fungal enzymes is a relevant cause of false-positive GM antigen test results.MethodsPatients with a positive GM antigen test between Janua...
Source: Infection - September 2, 2020 Category: Infectious Diseases Source Type: research

Bloodstream infection due to Enterobacter ludwigii , correlating with massive aggregation on the surface of a central venous catheter
We report a case of catheter associated bloodstream infection due toEnterobacter ludwigii with a massive aggregation on the outside surface of a central venous catheter (CVC). The 57  years old patient with a history of spondylodiscitis andStaphylococcus aureus-associated endocarditis was admitted to the intensive care unit for acute cerebral infarction. The patient developed signs of infections and the CVC was removed 11  days after placement. The infectious agent was identified by standard diagnostics to the genus level as belonging to theEnterobacter cloacae complex, and additional molecular testing determined...
Source: Infection - September 2, 2020 Category: Infectious Diseases Source Type: research

Cats and kids: how a feline disease may help us unravel COVID-19 associated paediatric hyperinflammatory syndrome
(Source: Infection)
Source: Infection - September 1, 2020 Category: Infectious Diseases Source Type: research

A case report of cutaneous leishmaniasis: a misleading clinical presentation
We report the case of an otherwise healthy 67-year-old man who presented with inflammatory skin lesions on the scalp and face for the past 7  years. The lesions were first mistaken as cutaneous sarcoidosis, mycobacterial infection, and cutaneous lymphoma. Finally, the diagnosis was made by RT-PCR analysis on a punch-biopsy specimen, which was positive forLeishmania infantum.Discussion and  conclusionTo date, the choice of treatment for complex cutaneous leishmaniases is based on theLeishmania species. Our patient successfully responded to liposomal amphotericin B. (Source: Infection)
Source: Infection - September 1, 2020 Category: Infectious Diseases Source Type: research

Pneumothorax in 2019 novel coronavirus pneumonia needs to be recognized
(Source: Infection)
Source: Infection - September 1, 2020 Category: Infectious Diseases Source Type: research

Treatment options for K. pneumoniae , P. aeruginosa and A. baumannii co-resistant to carbapenems, aminoglycosides, polymyxins and tigecycline: an approach based on the mechanisms of resistance to carbapenems
AbstractThe management of carbapenem-resistant infections is often based on polymyxins, tigecycline, aminoglycosides and their combinations. However, in a recent systematic review, we found that Gram-negative bacteria (GNB) co-resistant to carbapanems, aminoglycosides, polymyxins and tigecycline (CAPT-resistant) are increasingly being reported worldwide. Clinical data to guide the treatment of CAPT-resistant GNB are scarce and based exclusively on few case reports and small case series, but seem to indicate that appropriate (in vitro active) antimicrobial regimens, including newer antibiotics and synergistic combinations, ...
Source: Infection - August 31, 2020 Category: Infectious Diseases Source Type: research

Continuous infusion of ceftolozane-tazobactam resulted in high cerebrospinal fluid concentrations of ceftolozane in a patient with multidrug-resistant Pseudomonas aeruginosa meningitis
AbstractMultidrug-resistantPseudomonas aeruginosa has limited treatment options. Treatment of healthcare-associated meningitis requires agents active against the organism in vitro and able to penetrate the cerebrospinal fluid adequately. Ceftolozane-tazobactam has been recently approved to treat various Gram-negative organisms, includingPseudomonas aeruginosa; however, ceftolozane ’s penetration into human cerebrospinal fluid is unknown. Here, we present a case of a patient with multidrug-resistantPseudomonas aeruginosa meningitis treated with a continuous infusion of ceftolozane-tazobactam. Samples of both serum and...
Source: Infection - August 28, 2020 Category: Infectious Diseases Source Type: research

Microbiology testing and antibiotic treatment for urinary tract infections in general practice: a nationwide observational study
This study aims to examine whether the proportion of UTI encounters where antibiotics are prescribed that have accompanying urine testing differs by patient groups.MethodsA retrospective analysis was conducted using records of general practice encounters for UTIs occurring between January 2013 and July 2018 in an Australian national database. We calculated the proportion of UTI encounters with antibiotics prescribed that had accompanying urine microbiology testing and the odds ratios for the likelihood of testing by patient groups using generalised estimating equations.ResultsOf 132,688 UTI encounters with antibiotics pres...
Source: Infection - August 28, 2020 Category: Infectious Diseases Source Type: research

Aspergillus fumigatus cholangitis in a patient with cholangiocarcinoma: case report and review of the literature
We report a 72-year-old man with primary diagnosis of cholangiocarcinoma and stent implantation by endoscopic retrograde cholangiopancreatography (ERCP) for biliary decompression who developed severe cholangitis with invasive aspergillosis. The patient had no history of prior hospitalisation, no immunosuppressive therapy and no preceding biliary surgery. Furthermore, in this exceptional case of extrapulmonary aspergillosis, there were no signs of pulmonary involvement. From the literature review, only three cases of Aspergillus cholangitis could be identified. Clinical manifestations of invasive aspergillosis can be variab...
Source: Infection - August 28, 2020 Category: Infectious Diseases Source Type: research

Risk factors for Covid-19 severity and fatality: a structured literature review
ConclusionFactors associated with increased risk of severe or fatal disease courses were identified, which include conditions connected with a poor state of health as well as organ damages and coagulation dysfunctions. The results may facilitate upcoming Covid-19 research. (Source: Infection)
Source: Infection - August 27, 2020 Category: Infectious Diseases Source Type: research

Detection of HIV-1 viral load in tears of HIV/AIDS patients
AbstractObjectivesThe tear, as an important bodily secretion, plays a crucial role in preventing infection and maintaining homeostasis of ocular surfaces. Although accumulating studies have reported on the HIV-1 viral load profile among varying bodily fluids and secretions, little was known concerning HIV-1 dynamics in tears. Therefore, the objectives of this study were to investigate the HIV-1 viral load in tears of HIV/AIDS patients and study factors influencing their tear viral load.MethodsA cross-sectional study was conducted. 67 patients with a confirmed HIV-1 infection or AIDS were recruited from the Beijing You &rsq...
Source: Infection - August 25, 2020 Category: Infectious Diseases Source Type: research

Risk for infective endocarditis in bacteremia with Gram positive cocci
ConclusionThese findings strongly support routine echocardiography in patients with high risk bacteremia and non-performance of echocardiography in patients with low risk bacteremia. (Source: Infection)
Source: Infection - August 24, 2020 Category: Infectious Diseases Source Type: research

Cardiac manifestations of  COVID-19 infection: the role of echocardiography in patient management
(Source: Infection)
Source: Infection - August 23, 2020 Category: Infectious Diseases Source Type: research

A highly specific and sensitive serological assay detects SARS-CoV-2 antibody levels in COVID-19 patients that correlate with neutralization
ConclusionsWith the described RBD-based ELISA protocol, we provide a reliable test for seroepidemiological surveys. Due to high specificity and strong correlation with virus neutralization, the RBD ELISA holds great potential to become a preferred tool to assess thresholds of protective immunity after infection and vaccination. (Source: Infection)
Source: Infection - August 20, 2020 Category: Infectious Diseases Source Type: research

Renal profile of chronic hepatitis C patients with sofosbuvir-based therapy
ConclusionSOF-based therapies seem to be safe in CHC patients with baseline normal or slightly impaired renal function. (Source: Infection)
Source: Infection - August 19, 2020 Category: Infectious Diseases Source Type: research

The epidemiological burden and overall distribution of chronic comorbidities in coronavirus disease-2019 among  202,005 infected patients: evidence from a systematic review and meta-analysis
ConclusionsThe chronic comorbid conditions were identified as dominating risk factors, which should be considered in an emergency disease management and treatment choices. There is urgent need to further enhance systematic and real-time sharing of epidemiologic data, clinical results, and experience to inform the global response to COVID-19. (Source: Infection)
Source: Infection - August 18, 2020 Category: Infectious Diseases Source Type: research

The epidemiological burden of and overall distribution of chronic comorbidities in coronavirus disease-2019 among  202,005 infected patients: evidence from a systematic review and meta-analysis
ConclusionsThe chronic comorbid conditions were identified as dominating risk factors, which should be considered in an emergency disease management and treatment choices. There is urgent need to further enhance systematic and real-time sharing of epidemiologic data, clinical results, and experience to inform the global response to COVID-19. (Source: Infection)
Source: Infection - August 18, 2020 Category: Infectious Diseases Source Type: research

Correction to: Time ‑trend population analysis of the clinical and epidemiologic effect on pediatric infective endocarditis after change of antibiotic prophylaxis guidelines
The original version of this article unfortunately contained a mistake. In the author list, the first and last names were tagged incorrectly. The corrected author list is given above. (Source: Infection)
Source: Infection - August 13, 2020 Category: Infectious Diseases Source Type: research

Diagnosis of COVID-19 using multiple antibody assays in two cases with negative PCR results from nasopharyngeal swabs
We report of two cases of progressed COVID-19 with negative PCR tests from nasopharyngeal swabs, in whom diagnosis was made by different antibody assays, including a lateral flow rapid test and multiple commercial ELISAs, finally confirmed by comprehensive serological assays. These cases highlight that commercial ELISAs and even rapid tests might significantly aid the diagnosis of COVID-19, particularly, if a combination of serological assays is used with a specific clinical question, in severely ill patients after seroconversion and when comprehensive serological methods are used for confirmation. (Source: Infection)
Source: Infection - August 11, 2020 Category: Infectious Diseases Source Type: research

Myocarditis in admitted patients with dengue fever
AbstractPurposeCardiac involvement in dengue fever is underdiagnosed due to low index of clinical suspicion and its contribution to hemodynamic instability in severe dengue is not well known.MethodsA prospective observational study was conducted among admitted patients  ≥ 14 years of age having confirmed dengue fever. Patients on medications affecting heart rhythm/rate, pre-existing heart disease and electrolyte abnormalities were excluded. A baseline electrocardiography (ECG), Trop-I and NT-proBNP were done for all patients. The biomarkers were measured us ing enzyme-linked fluorescent assay and reco...
Source: Infection - August 10, 2020 Category: Infectious Diseases Source Type: research

Pericarditis as a cardiac manifestation of acute leptospirosis
AbstractLeptospirosis is an infectious disease with an increasing incidence worldwide. The clinical presentation is unspecific and ranges from an asymptomatic clinical course to an acute fulminant disease. The current case report describes a 32-year-old male patient who presented with ST segment elevation in the electrocardiogram about 14  days after cross-country running. Pericarditis was diagnosed and linked to an acute leptospirosis that was serologically confirmed. (Source: Infection)
Source: Infection - August 9, 2020 Category: Infectious Diseases Source Type: research

Intrinsic resistance to terbinafine among human and animal isolates of Trichophyton mentagrophytes related to amino acid substitution in the squalene epoxidase
ConclusionFinally, our study revealed that the terbinafine resistance phenomenon might not be acquired by exposure to the drug but can be intrinsic. This is evidenced by the description of the terbinafine-resistant strains isolated from the asymptomatic animals. (Source: Infection)
Source: Infection - August 7, 2020 Category: Infectious Diseases Source Type: research

SOFA and qSOFA usefulness for in-hospital death prediction of elderly patients admitted for suspected infection in internal medicine
AbstractPurposeTo reduce intensive care unit overcrowding and optimize resources, elderly patients affected by suspected infection with declining clinical conditions could be managed in internal medicine departments with stepdown beds. However, commonly used prognostic scores, as Sequential Organ Failure Assessment (SOFA) or quick SOFA (qSOFA) have never been studied in this specific setting. The aim of this study was to evaluate the role and the accuracy of SOFA and qSOFA as prognostic scores in a population of elderly patients with suspected infection admitted to stepdown beds of two internal medicine departments.Methods...
Source: Infection - August 5, 2020 Category: Infectious Diseases Source Type: research

Mycobacterium bovis infection of an aortobifemoral bypass graft with Streptococcus intermedius superinfection after intravesical bacillus Calmette-Gu érin immunotherapy for bladder cancer
ConclusionsAmong 35 cases of mycotic aneurysm reported after BCG therapy in the last 10  years, only one involved a vascular prosthesis. Surgical repair of such aneurysms using prosthetic grafts is commonly performed, associated with anti-mycobacterial treatment. Prognosis is poor with mortality of 14% (4/35) and a 26% rate of aneurysm recurrence under treatment (9/35). (Source: Infection)
Source: Infection - August 3, 2020 Category: Infectious Diseases Source Type: research

COVID-19 in patients with HIV-1 infection: a single-centre experience in northern Italy
ConclusionsIn our experience, COVID-19 associated with HIV infection had a clinical presentation comparable to the general population and was frequently associated with chronic comorbidities. (Source: Infection)
Source: Infection - August 2, 2020 Category: Infectious Diseases Source Type: research

Early-onset symptomatic neonatal COVID-19 infection with high probability of vertical transmission
ConclusionThis report highlights a very strong possibility of vertical transmission of COVID-19 from a mildly symptomatic, RT-PCR negative but antibody-positive mother with significant symptomatic, early —onset neonatal infection. (Source: Infection)
Source: Infection - August 1, 2020 Category: Infectious Diseases Source Type: research

Personalized machine learning approach to predict candidemia in medical wards
AbstractPurposeCandidemia is a highly lethal infection; several scores have been developed to assist the diagnosis process and recently different models have been proposed. Aim of this work was to assess predictive performance of a Random Forest (RF) algorithm for early detection of candidemia in the internal medical wards (IMWs).MethodsA set of 42 potential predictors was acquired in a sample of 295 patients (male: 142, age: 72  ± 15 years; candidemia: 157/295; bacteremia: 138/295). Using tenfold cross-validation, a RF algorithm was compared with a classic stepwise multivariable logistic regressi...
Source: Infection - July 31, 2020 Category: Infectious Diseases Source Type: research

Changes in T-lymphocyte subsets and risk factors in human immunodeficiency virus-negative patients with active tuberculosis
AbstractPurposeImmune function imbalance is closely associated with the occurrence and development of infectious diseases. We studied the characteristics of changes in T-lymphocyte subsets and their risk factors in HIV-negative patients with active tuberculosis (ATB).MethodsT-lymphocyte subsets in 275 HIV-negative ATB patients were quantitatively analyzed and compared with anMycobacteriumtuberculosis-free control group. Single-factor and multifactor analyses of clinical and laboratory characteristics of patients were also conducted.ResultsIn ATB patients, CD4 and CD8 T-cell counts decreased, and the levels were positively ...
Source: Infection - July 31, 2020 Category: Infectious Diseases Source Type: research

Staphylococcus aureus bacteremia and the skip phenomenon
(Source: Infection)
Source: Infection - July 31, 2020 Category: Infectious Diseases Source Type: research

Prognostic value of serum amyloid A in patients with COVID-19
ConclusionSAA can be used as a predictor of the prognosis in patients with COVID-19. (Source: Infection)
Source: Infection - July 29, 2020 Category: Infectious Diseases Source Type: research

Pulmonary function in patients surviving to COVID-19 pneumonia
AbstractPurposeThe aim of our study was to assess respiratory function at the time of clinical recovery and 6 weeks after discharge in patients surviving to COVID-19 pneumonia.MethodsOur case series consisted of 13 patients with COVID-19 pneumonia.ResultsAt the time of clinical recovery, FEV1 (2.07 ± 0.72 L) and FVC (2.25 ± 0.86 L) were lower compared to lower limit of normality (LLN) values (2.56 ± 0.53 L,p = 0.004, and 3.31 ± 0.65 L,p
Source: Infection - July 27, 2020 Category: Infectious Diseases Source Type: research

Co-infection of SARS-CoV-2 with Chlamydia or Mycoplasma pneumoniae : a case series and review of the literature
AbstractIntroductionThe novel coronavirus SARS-CoV-2 has spread all over the world causing a global pandemic and representing a great medical challenge. Nowadays, there is limited knowledge on the rate of co-infections with other respiratory pathogens, with viral co-infection being the most representative agents. Co-infection withMycoplasma pneumoniae has been described both in adults and pediatrics whereas only two cases ofChlamydia pneumoniae have been reported in a large US study so far.MethodsIn the present report, we describe a series of seven patients where co-infection withC. pneumoniae (n = 5) orM. pn...
Source: Infection - July 27, 2020 Category: Infectious Diseases Source Type: research

Absent immune response to SARS-CoV-2 in a 3-month recurrence of coronavirus disease 2019 (COVID-19) case
ConclusionsThe patient displayed declining immune responses in spite of the viral shedding for 3  months. We inferred the declining immune responses might result from the segregation of the virus from the immune system. (Source: Infection)
Source: Infection - July 27, 2020 Category: Infectious Diseases Source Type: research