The current therapeutical strategies in human brucellosis
AbstractPrompt and adequate treatment of human brucellosis continues to be the most important strategy in its management, as eradication of animal brucellosis is not possible so far, and there is no adequate vaccine for humans. The goal of antibrucellar treatment is to alleviate and shorten the symptomatic period and reduce complications, relapses, and chronicity. Contemporary trends in the treatment of human brucellosis are postulated on the ability ofBrucellae to persist in host macrophages through the inhibition of phagolysosome fusion and to survive for prolonged periods intracellularly without restricting basic cellul...
Source: Infection - March 1, 2021 Category: Infectious Diseases Source Type: research

COVID-19 anosmia and gustatory symptoms as a prognosis factor: a subanalysis of the HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID-19) registry
AbstractOlfactory and gustatory dysfunctions (OGD) are a frequent symptom of coronavirus disease 2019 (COVID-19). It has been proposed that the neuroinvasive potential of the novel SARS-CoV-2 could be due to olfactory bulb invasion, conversely studies suggest it could be a good prognostic factor. The aim of the current study was to investigate the prognosis value of OGD in COVID-19. These symptoms were recorded on admission from a cohort study of 5868 patients with confirmed or highly suspected COVID-19 infection included in the multicenter international HOPE Registry (NCT04334291). There was statistical relation in multiv...
Source: Infection - March 1, 2021 Category: Infectious Diseases Source Type: research

Evidence-based uncertainty: do implant-related properties of titanium reduce the susceptibility to perioperative infections in clinical fracture management? A systematic review
ConclusionOur results show that currently, no proven advantage for titanium implants in respect to IAI can be seen in contemporary literature. Implants preserving periosteal blood-flow and minimising soft-tissue trauma show statistically significant benefits in reducing the incidence of IAI. Clinical studies providing reliable evidence regarding the influence of titanium implants on IAI and investigating the susceptibility of titanium to infection are necessary (Source: Infection)
Source: Infection - February 13, 2021 Category: Infectious Diseases Source Type: research

Antigen testing and non-infectious shedding of SARS-COV-2
(Source: Infection)
Source: Infection - February 10, 2021 Category: Infectious Diseases Source Type: research

Clinical performance of Xpert MTB/RIF on contrast-enhanced ultrasound-guided core biopsy specimens for rapid diagnosis of superficial tuberculous lymphadenitis in high TB burden settings
ConclusionsCurrent examinations on specimens by CEUS-guided core biopsy can achieve a high diagnostic efficacy for TBLN. Pathological differentiation of CEUS-guided biopsy tissue, then followed by Xpert, may be the best pattern for the diagnosis of TBLN in high TB burden areas. (Source: Infection)
Source: Infection - February 4, 2021 Category: Infectious Diseases Source Type: research

Torque Teno Virus plasma level as novel biomarker of retained immunocompetence in HIV-infected patients
ConclusionWithin the cohort, the significantly elevated TTV plasma concentration in patients with diminished CD4+ cell recovery indicates a more profound immune defect. Baseline TTV plasma concentrations and CD4+ cell count are predictive for the course of immune recovery in HIV-1-infected patients with severe immunodeficiency. (Source: Infection)
Source: Infection - February 3, 2021 Category: Infectious Diseases Source Type: research

Fungal infections of the feet in patients with erysipelas of the lower limb: is it a significant clinical problem?
ConclusionsFungal infections of the feet are important risk factors for the first episode as well as recurrent erysipelas. Prevention and early treatment of fungal infections, especially in elderly people, can significantly reduce the incidence of erysipelas. (Source: Infection)
Source: Infection - February 3, 2021 Category: Infectious Diseases Source Type: research

Mono vs. combo regimens with novel beta-lactam/beta-lactamase inhibitor combinations for the treatment of infections due to carbapenemase-producing Enterobacterales : insights from the literature
AbstractCeftazidime –avibactam (CZA), meropenem–vaborbactam (MVB) and imipenem–relebactam (I–R) are combinations of old ß-lactams with novel non-ß-lactam ß-lactamase inhibitors (BLBLIs) able to inhibit some carbapenemases, such as the KPC-type, thus are becoming the standard for difficult-to-treat carbapenem ase-producingEnterobacterales (CPE); a practical question is whether these novel BLBLIs should be used as monotherapy or as part of a combination regimen with other antibiotics, and if so, with which ones, to reduce the emergence of resistant strains and to optimize their effic...
Source: Infection - February 3, 2021 Category: Infectious Diseases Source Type: research

Impact of an Antimicrobial Stewardship Program-bundled initiative utilizing Accelerate Pheno ™ system in the management of patients with aerobic Gram-negative bacilli bacteremia
AbstractPurposeGram-negative bacteria (GNB) are a leading cause of bloodstream infections (BSI) and management is complicated by antibiotic resistance. The Accelerate Pheno ™ system (ACC) can provide rapid organism identification and antimicrobial susceptibility testing (AST).MethodsA retrospective, pre-intervention/post-intervention study was conducted to compare management of non-critically ill patients with GNB BSI before and after implementation of a bundled initiative. This bundled initiative included dissemination of a clinical decision algorithm, ACC testing on all GNB isolated from blood cultures, real-time c...
Source: Infection - February 2, 2021 Category: Infectious Diseases Source Type: research

Life expectancy of HIV-infected patients followed at the largest hospital in Guinea-Bissau is one-fourth of life expectancy of the background population
ConclusionsLE was shown to be markedly lower among HIV-infected patients compared with the background population. While other settings have shown marked improvements in prognosis of HIV-infected patients in recent years, no improvement in Bissau was observed over time (9.8  years (95% CI 7.6–12.2) and 9.9 years (95% CI 7.6–12.1) for the periods 2005–2010 and 2014–2016, respectively). (Source: Infection)
Source: Infection - February 2, 2021 Category: Infectious Diseases Source Type: research

Serum citrullinated histone H3 concentrations differentiate patients with septic verses non-septic shock and correlate with disease severity
AbstractPurposeMicrobial infection stimulates neutrophil/macrophage/monocyte extracellular trap formation, which leads to the release of citrullinated histone H3 (CitH3) catalyzed by peptidylarginine deiminase (PAD) 2 and 4. Understanding these molecular mechanisms in the pathogenesis of septic shock will be an important next step for developing novel diagnostic and treatment modalities. We sought to determine the expression of CitH3 in patients with septic shock, and to correlate CitH3 levels with PAD2/PAD4 and clinically relevant outcomes.MethodsLevels of CitH3 were measured in serum samples of 160 critically ill patient...
Source: Infection - February 1, 2021 Category: Infectious Diseases Source Type: research

Higher viral loads in asymptomatic COVID-19 patients might be the invisible part of the iceberg
ConclusionIn conclusion, this study demonstrates that asymptomatic patients have higher SARSCoV-2 viral loads than symptomatic patients and unlike in the few study in the literature, a significant decrease in viral load of nasopharyngeal/oropharyngeal samples was observed with increasing disease severity. Factors associated with poor prognosis are found to be significantly correlated with low viral load. (Source: Infection)
Source: Infection - February 1, 2021 Category: Infectious Diseases Source Type: research

Influenza-associated in-hospital mortality during the 2017/2018 influenza season: a retrospective multicentre cohort study in central Germany
AbstractThe aim of this retrospective cohort study at eight hospitals in Germany was to specify influenza-associated in-hospital mortality during the 2017/2018 flu season, which was the strongest in Germany in the past 30  years. A total of 1560 patients were included in the study. Overall, in-hospital mortality was 6.7% (n = 103), in patients treated in the intensive care unit (n = 161) mortality was 22.4%. The proportion of deceased patients per hospital was between 0% and 7.0%. Influenza was the immediate cause of death in 82.8% (n = 82) of the decedents. (Source: Infection)
Source: Infection - February 1, 2021 Category: Infectious Diseases Source Type: research

Correction to: 2019 Novel coronavirus: where we are and what we know
The original version of this article unfortunately contained a mistake. (Source: Infection)
Source: Infection - February 1, 2021 Category: Infectious Diseases Source Type: research

Left and right ventricular dysfunction in patients with COVID-19-associated myocardial injury
ConclusionIn patients with COVID-19-associated myocardial injury, comprehensive 3D and strain echocardiography revealed LV dysfunction by GLS and RV dysfunction, which partially resolved at 2-month follow-up.Trial registrationCOVID-19 Registry of the LMU University Hospital Munich (CORKUM), WHO trial ID DRKS00021225. (Source: Infection)
Source: Infection - January 30, 2021 Category: Infectious Diseases Source Type: research

Worldwide inverse correlation between Bacille Calmette –Guérin (BCG) immunization and COVID-19 mortality
ConclusionThis study contributes to a growing body of evidence supporting the notion that BCG vaccination may be protective against COVID-19 mortality. (Source: Infection)
Source: Infection - January 25, 2021 Category: Infectious Diseases Source Type: research

Haematological changes in Schistosoma haematobium infections in school children in Gabon
ConclusionsSchistosomiasis is associated with a characteristic FBC profile of schoolchildren living in Lambar éné, indicating the necessity to consider schistosomiasis as a single cause of disease, or a co-morbidity, when interpreting FBC in endemic areas. (Source: Infection)
Source: Infection - January 24, 2021 Category: Infectious Diseases Source Type: research

Concurrent cavitary pulmonary tuberculosis and COVID-19 pneumonia with in vitro immune cell anergy
AbstractTuberculosis (TB) is top infectious disease killer caused by a single organism responsible for 1.5 million deaths in 2018. Both COVID-19 and the pandemic response are risking to affect control measures for TB and continuity of essential services for people affected by this infection in western countries and even more in developing countries. Knowledge about concomitant pulmonary TB and COVID-19 is extremely limited. The double burden of these two diseases can have devastating effects. Here, we describe from both the clinical and the immunological point of view a case of a patient with in vitro immune cell anergy af...
Source: Infection - January 17, 2021 Category: Infectious Diseases Source Type: research

Real-life experience with fidaxomicin in Clostridioides difficile infection: a multicentre cohort study on 244 episodes
AbstractThe high cost of fidaxomicin has restricted its use despite the benefit of a lowerClostridioides difficile infection (CDI) recurrence rate at 4  weeks of follow-up. This short follow-up represents the main limitation of pivotal clinical trials of fidaxomicin, and some recent studies question its benefits over vancomycin. Moreover, the main risk factors of recurrence after treatment with fidaxomicin remain unknown. We designed a multicentre retrospective cohort study among four Spanish hospitals to assess the efficacy of fidaxomicin in real life and to investigate risk factors of fidaxomicin failure at weeks 8 ...
Source: Infection - January 8, 2021 Category: Infectious Diseases Source Type: research

Association between high vancomycin minimum inhibitory concentration and clinical outcomes in patients with methicillin-resistant Staphylococcus aureus bacteremia: a meta-analysis
ConclusionOverall mortality and complicated bacteremia were not significantly associated with high vancomycin MICs in a patient with MRSAB. Randomized controlled trials to assess the utility of vancomycin MIC values in predicting mortality and other adverse clinical outcomes are warranted. (Source: Infection)
Source: Infection - January 4, 2021 Category: Infectious Diseases Source Type: research

Comparative virulence of seasonal viruses responsible for lower respiratory tract infections: a southern European multi-centre cohort study of hospital admissions
AbstractObjectivesOur study aimed to compare the clinical severity of lower respiratory tract infections (LRTI ’s) caused by Influenza and Respiratory Syncytial Virus (RSV).MethodsWe conducted a retrospective cohort study of LRTI admissions with positive PCR results for Influenza or RSV from 2017 to 2019 in three teaching hospitals in southern Europe. Data on clinical characteristics, viral agents and disease outcome were collected. Nosocomial infection was excluded. Main outcomes were invasive mechanical ventilation and in-hospital death.ResultsA total of 984 patients were included. Median age was 75  years. In...
Source: Infection - January 3, 2021 Category: Infectious Diseases Source Type: research

CRISPR-based strategies in infectious disease diagnosis and therapy
ConclusionsCRISPR systems have broad applicability in the field of infectious diseases and may offer solutions to many of the most challenging human  infections. (Source: Infection)
Source: Infection - January 3, 2021 Category: Infectious Diseases Source Type: research

Bacterial coinfection in critically ill COVID-19 patients with severe pneumonia
AbstractSevere 2019 novel coronavirus infectious disease (COVID-19) with pneumonia is associated with high rates of admission to the intensive care unit (ICU). Bacterial coinfection has been reported to be rare. We aimed at describing the rate of bacterial coinfection in critically ill adult patients with severe COVID-19 pneumonia. All the patients with laboratory-confirmed severe COVID-19 pneumonia admitted to the ICU of Tenon University-teaching hospital, from February 22 to May 7th, 2020 were included. Respiratory tract specimens were obtained within the first 48  h of ICU admission. During the study period, 101 pa...
Source: Infection - January 3, 2021 Category: Infectious Diseases Source Type: research

Invasive pulmonary aspergillosis caused by Aspergillus terreus diagnosed using virtual bronchoscopic navigation and endobronchial ultrasonography with guide sheath and successfully treated with liposomal amphotericin B
AbstractInvasive aspergillosis is a significant cause of mortality in patients with hematological malignancy. Early diagnosis of invasive pulmonary aspergillosis (IPA) by bronchoscopy is recommended but is often difficult to perform because of small lesion size and bleeding risk due to thrombocytopenia. A 71-year-old woman had received initial induction therapy for acute myeloid leukemia. On day 22 of chemotherapy, she had a high fever, and the chest computed tomography scan revealed a 20-mm-sized nodule with a halo sign. Bronchoscopy assisted by virtual bronchoscopic navigation (VBN) and endobronchial ultrasonography with...
Source: Infection - January 3, 2021 Category: Infectious Diseases Source Type: research

Different types of bullae of limbs with necrotizing fasciitis predict different outcome: a prospective study
ConclusionsIn southern Taiwan, patients with NF accompanied by hemorrhagic bullae appear to have more bacteremia,Vibrio infection, septic shock, and risk for amputation. If the physicians at the emergency department can detect for the early signs of NF as soon as possible, and more patient ’s life and limbs may be saved. (Source: Infection)
Source: Infection - January 3, 2021 Category: Infectious Diseases Source Type: research

Characterization and outcomes of acute myocardial injury in COVID-19 intensive care patients
(Source: Infection)
Source: Infection - January 3, 2021 Category: Infectious Diseases Source Type: research

Remdesivir in Coronavirus Disease 2019 (COVID-19) treatment: a review of evidence
AbstractCOVID-19 is an infectious disease caused by a novel β-coronavirus, belonging to the same subgenus as the Severe Acute Respiratory Syndrome (SARS) virus. Remdesivir, an investigational broad-spectrum antiviral agent has previously demonstrated in vitro activity against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), and in vivo efficacy against other related coronaviruses in animal models. Its safety profile has been tested in a compassionate use setting for patients with COVID-19. The current therapeutic studies demonstrate clinical effectiveness of remdesivir in COVID-19 patients by shortening t...
Source: Infection - January 2, 2021 Category: Infectious Diseases Source Type: research

Use of rifampicin and graft removal are associated with better outcomes in prosthetic vascular graft infection
ConclusionsTreatment failure occurred in 27.5% of patients with PVGI. Total removal of the infected graft and rifampicin administration were associated with better outcomes. (Source: Infection)
Source: Infection - January 2, 2021 Category: Infectious Diseases Source Type: research

COVID-19 reinforces the need to improve sepsis care resources in Africa
(Source: Infection)
Source: Infection - January 2, 2021 Category: Infectious Diseases Source Type: research

HIV and SARS-CoV-2 co-infection: cross-sectional findings from a German ‘hotspot’
ConclusionThe seroprevalence of SARS-CoV-2 co-infection in people living with HIV as found in our study does not seem to exceed previous reports from general populations of ‘hot-sport’ areas; comparative data from the Munich population can be expected to be published soon. Our data also highlight, once more, the need to do confirmatory testing on positive samples to minimize the impact of false-positive results. (Source: Infection)
Source: Infection - January 2, 2021 Category: Infectious Diseases Source Type: research

Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain
We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes.CaseOne patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers.Discussion and conclusionThus, host individual factors may be the main drivers of the immune response varying with age and clinical severity. (Source: Infection)
Source: Infection - January 2, 2021 Category: Infectious Diseases Source Type: research

Rapid antigen testing and non-infectious shedding of SARS-Cov2
(Source: Infection)
Source: Infection - January 2, 2021 Category: Infectious Diseases Source Type: research

Macrophage migration inhibitory factor − 794 CATT 5−8 microsatellite polymorphism and susceptibility of tuberculosis
ConclusionsThe genotype 5/5 and the allele 5 of MIF − 794 CATT 5 −8 were more frequent among TB patients than in controls. (Source: Infection)
Source: Infection - January 1, 2021 Category: Infectious Diseases Source Type: research

Selective toxicity of antibacterial agents —still a valid concept or do we miss chances and ignore risks?
ConclusionThe effects of antibiotics on eukaryotes are due to identical mechanisms as their antibacterial activities because of structural and functional homologies of pro- and eukaryotic targets, so that the effects of antibiotics on mammals are integral parts of their overall mechanisms of action. (Source: Infection)
Source: Infection - December 23, 2020 Category: Infectious Diseases Source Type: research

A challenging complication following SARS-CoV-2 infection: a case of pulmonary mucormycosis
AbstractSevere acute respiratory syndrome coronavirus 2 infection might induce a significant and sustained lymphopenia, increasing the risk of developing opportunistic infections. Mucormycosis is a rare but severe invasive fungal infection, mainly described in immunocompromised patients. The first case of a patient diagnosed with coronavirus disease (COVID-19) who developed a pulmonary mucormycosis with extensive cavitary lesions is here reported. This case highlights how this new coronavirus might impair the immune response, exposing patients to higher risk of developing opportunistic infections and leading to worse outco...
Source: Infection - December 17, 2020 Category: Infectious Diseases Source Type: research

Are antibacterial effects of non-antibiotic drugs random or purposeful because of a common evolutionary origin of bacterial and mammalian targets?
ConclusionsData summarized in this review support the theory that prokaryotic proteins represent targets for non-antibiotics because of a common evolutionary origin of bacterial- and mammalian targets resulting in highly conserved active centres of both, pro- and eukaryotic proteins with which the non-antibiotics interact and exert antibacterial actions. (Source: Infection)
Source: Infection - December 15, 2020 Category: Infectious Diseases Source Type: research

Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore
ConclusionThe effect of decreasing salivary load with CPC and PI mouth-rinsing was observed to be sustained at 6  h time point. Within the limitation of the current study, as number of the samples analyzed, the use of CPC and PI formulated that commercial mouth-rinses may be useful as a pre-procedural rinse to help reduce the transmission of COVID-19.ISRCTN (ISRCTN95933274), 09/09/20, retrospectively registered (Source: Infection)
Source: Infection - December 14, 2020 Category: Infectious Diseases Source Type: research

Predictors of intensive care unit admission in patients with Legionella pneumonia: role of the time to appropriate antibiotic therapy
The objective of this study is to identify predictors of ICU admission in patients with LP.MethodsA single-center, retrospective, observational study conducted in an academic tertiary-care hospital in Pisa, Italy. Adult patients with LP consecutively admitted to study center from October 2012 to October 2019.ResultsDuring the study period, 116 cases of LP were observed. The rate of ICU admission was 20.7% and the overall 30-day mortality rate was 12.1%. Mortality was 4.3% in patients hospitalized in medical wards versus 41.7% in patients transferred to ICU (p   24 h from admission) underwent urinary anti...
Source: Infection - December 14, 2020 Category: Infectious Diseases Source Type: research

The importance of SHBG and calculated free testosterone for the diagnosis of symptomatic hypogonadism in HIV-infected men: a single-centre real-life experience
ConclusionOnly a complete hormonal profile can properly diagnose and classify hypogonadism in HIV-infected men complaining about sexual symptoms. TT alone reliance may lead to half of diagnoses missing, while lack of gonadotropin prevents the identification of compensated hypogonadism. This largely comes from high SHBG, which seems to play a central role in the pathogenesis of hypogonadism in this population. (Source: Infection)
Source: Infection - December 8, 2020 Category: Infectious Diseases Source Type: research

Increasing influenza vaccination coverage in healthcare workers: a review on campaign strategies and their effect
ConclusionMandatory vaccination policies are effective measures to achieve high overall vaccination coverage. In clinics where policies are infeasible, multifaceted campaigns comprising on-site vaccination, vaccination stands and educational and promotional campaigns as well as incentives should be implemented. Lessons learned from influenza campaigns could be implemented in future SARS-CoV-2 vaccination campaigns. (Source: Infection)
Source: Infection - December 7, 2020 Category: Infectious Diseases Source Type: research

Reply to the correspondence “ Staphylococcus capitis causing infective endocarditis: not so uncommon” by Tchana-Sato & amp; Defraigne
(Source: Infection)
Source: Infection - November 19, 2020 Category: Infectious Diseases Source Type: research

Evaluating the clinical utility and sensitivity of SARS-CoV-2 antigen testing in relation to RT-PCR Ct values
(Source: Infection)
Source: Infection - November 13, 2020 Category: Infectious Diseases Source Type: research

Hypertrophic pachymeningitis caused by Schizophyllum sp.: a novel case report
ConclusionOur study suggests that when symptoms of central nervous system infection due toSchizophyllum sp. do not improve with liposomal amphotericin B, voriconazole can be administered at high trough levels to improve the symptoms. (Source: Infection)
Source: Infection - November 6, 2020 Category: Infectious Diseases Source Type: research

Preoperative synovial fluid culture poorly predicts the pathogen causing periprosthetic joint infection
AbstractPurposeWe investigated the value of preoperative pathogen detection and evaluated its concordance with intraoperative cultures in patients with culture-positive periprosthetic joint infection (PJI).MethodsCulture-positive PJI episodes with available preoperative (synovial fluid) and intraoperative cultures (periprosthetic tissue, synovial or sonication fluid) were analyzed. The pathogen detection rate in preoperative and intraoperative cultures was compared using Fisher ’s exact test and their concordance was calculated.ResultsAmong 167 included PJI episodes, 150 were monomicrobial with  coagulase-negati...
Source: Infection - November 3, 2020 Category: Infectious Diseases Source Type: research

Plasma interferon- γ-inducible protein 10 (IP-10) levels correlate with disease severity and paradoxical reactions in extrapulmonary tuberculosis
In this study, we prospectively evaluated clinical data and treatment response which were correlated with different biomarkers.MethodsThe study was conducted at the University Hospital of Cologne. 20 patients with EPTB were enrolled. We analyzed plasma interferon- γ-inducible protein 10 (IP-10) levels in plasma by ELISA for up to 12 months of treatment. In addition, the QuantiFERON®-TB Gold Plus (QFT® Plus) test was performed during the course of treatment. Clinical data were assessed prospectively and correlated with QFT® Plus and IP-10 levels.ResultsPlasma IP-10 levels were found to be significantl...
Source: Infection - November 2, 2020 Category: Infectious Diseases Source Type: research

Older age groups and country-specific case fatality rates of COVID-19 in Europe, USA and Canada
ConclusionData from 20 European countries and the USA and Canada showed that the variance of crude CFR of COVID-19 is predominantly (80 –96%) determined by the proportion of older individuals who are diagnosed with SARS-CoV-2. The age distribution of SARS-CoV-2 infections is still far from being homogeneous. Detailed demographic data have to be taken into account in all the analyses on COVID-19-associated mortality. We urgently ca ll for standardized data collection by national health authorities. (Source: Infection)
Source: Infection - October 24, 2020 Category: Infectious Diseases Source Type: research

Clinical characteristics, management and outcome of patients with invasive candidiasis hospitalized in Internal Medicine Units: findings from a registry by the Italian Scientific Society FADOI
ConclusionsThe incidence of IC is not negligible, and our registry confirmed that these patients have a relevant mortality rate at 90  days. Concomitant bacteremia, featuring polymicrobial sepsis, and starting antifungal treatment with fluconazole instead of echinocandins independently increase the risk of death. Efforts are needed to improve the awareness and management of IC in IMUs. (Source: Infection)
Source: Infection - October 23, 2020 Category: Infectious Diseases Source Type: research

Gender differences and influenza-associated mortality in hospitalized influenza A patients during the 2018/19 season
ConclusionsGender is associated with differences in clinical presentation and complications of influenza A virus infection. Women with acute heart failure or aged  >  75 years have an increased risk of influenza associated in-hospital mortality, while ICU admission and any malignancy are predictors for male patients. Mortality rates in patients >  75 years are 5–10 times higher compared to their non-hospitalized influenza-negative Austrian counterparts. (Source: Infection)
Source: Infection - October 22, 2020 Category: Infectious Diseases Source Type: research

Ceftazidime/avibactam and ceftolozane/tazobactam for the treatment of extensively drug-resistant Pseudomonas aeruginosa post-neurosurgical infections: three cases and a review of the literature
ConclusionThese recently developed antibiotics, C/T and CZA are promising and complementary therapy options against post-neurosurgical hard-to-treat P. aeruginosa infections. Further prospective real-life studies are required to validate these findings in this special setting. (Source: Infection)
Source: Infection - October 19, 2020 Category: Infectious Diseases Source Type: research

DGI recommendations for COVID-19 pharmacotherapy
(Source: Infection)
Source: Infection - October 19, 2020 Category: Infectious Diseases Source Type: research