An invasive infection caused by the thermophilic mold Talaromyces thermophilus
AbstractBackgroundIncreasing incidence of invasive infections caused by rare fungi was observed over the recent years.CaseHere, we describe the first reported case of an infection caused by the thermophilic moldTalaromyces thermophilus. Cultivation and, hence, identification of this fastidious organism is challenging since standard incubation conditions are not sufficient. Retrospective analysis of patient samples and in vitro experiments demonstrated that testing for fungal antigens, i.e., the cell wall components galactomannan and β-1,3-d-glucan, is a promising tool. (Source: Infection)
Source: Infection - November 26, 2021 Category: Infectious Diseases Source Type: research

Screening paracoccidioidomycosis by double immunodiffusion test in a referred diagnostic center in Brazilian southeastern: an accessible tool
ConclusionOur results indicate the importance of the DID test for the screening and monitoring of PCM and that the incidence ofP. lutzii might be greater than expected in areas where it is not the predominant PCM species. Therefore, this article may contribute to improving the knowledge and clinical management about this disease. (Source: Infection)
Source: Infection - November 26, 2021 Category: Infectious Diseases Source Type: research

Deciphering the epidemiology of invasive candidiasis in the intensive care unit: is it possible?
AbstractInvasive candidiasis (IC) has emerged in the last decades as an important cause of morbidity, mortality, and economic load in the intensive care unit (ICU). The epidemiology of IC is still a difficult and unsolved enigma for the literature. Accurate estimation of the true burden of IC is difficult due to variation in definitions and limitations inherent to available case-finding methodologies. Candidemia and intra-abdominal candidiasis (IAC) are the two predominant types of IC in ICU. During the last two decades, an increase in the incidence of candidemia has been constantly reported particularly in the expanding p...
Source: Infection - November 26, 2021 Category: Infectious Diseases Source Type: research

Use of monoclonal antibody therapy for nosocomial SARS-CoV-2 infection in patients at high risk for severe COVID-19: experience from a tertiary-care hospital in Germany
AbstractAdditional treatment options for coronavirus disease (COVID-19) are urgently needed, particularly for populations at high risk of severe disease. This cross-sectional, retrospective study characterized the outcomes of 43 patients with nosocomial severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection with and without treatment using monoclonal SARS-CoV-2 spike antibodies (bamlanivimab or casirivimab/imdevimab). Our results indicate that treatment with monoclonal antibodies results in a significant decrease in disease progression and mortality when used for asymptomatic patients with early SARS-CoV-2 ...
Source: Infection - November 26, 2021 Category: Infectious Diseases Source Type: research

The first familial cluster of the B.1.1.7 variant of SARS-CoV-2 in the northeast of Italy
ConclusionThis allow us to make clear the very high attack rate and the great infective capacity of this B.1.1.7 variant of SARS-CoV-2. (Source: Infection)
Source: Infection - November 26, 2021 Category: Infectious Diseases Source Type: research

Pulmonary aspergilloma on transthoracic ultrasound
ConclusionsThe sonographic findings corresponded to chest X-ray and computed tomography imaging in this patient and to previously reported sonographic characteristics of mycotic abscesses in other organs. Lung ultrasound may be a tool to identify pulmonary aspergilloma, especially as a point-of-care imaging tool and where other imaging modalities are inaccessible. (Source: Infection)
Source: Infection - November 26, 2021 Category: Infectious Diseases Source Type: research

Detection of SARS-CoV-2 variants in India from UK returnees
(Source: Infection)
Source: Infection - November 26, 2021 Category: Infectious Diseases Source Type: research

Burrowing bug pigmentation
AbstractCydnidae bug (also termed the burrowing bug) are arthropods of the order Hemiptera, that are recognized by their morphological adaptations for digging. They release an odorous substance from special glands that serve as self-defense, causing pigmented macules when in contact with human skin, especially during the rainy season. Knowledge of this rarely described condition can help avoid unnecessary investigation(s). (Source: Infection)
Source: Infection - November 26, 2021 Category: Infectious Diseases Source Type: research

Correction to: Detection of SARS ‑CoV‑2 variants in India from UK returnees
(Source: Infection)
Source: Infection - November 26, 2021 Category: Infectious Diseases Source Type: research

Screening paracoccidioidomycosis by double immunodiffusion test in a referred diagnostic center in Brazilian southeastern: an accessible tool
ConclusionOur results indicate the importance of the DID test for the screening and monitoring of PCM and that the incidence ofP. lutzii might be greater than expected in areas where it is not the predominant PCM species. Therefore, this article may contribute to improving the knowledge and clinical management about this disease. (Source: Infection)
Source: Infection - November 24, 2021 Category: Infectious Diseases Source Type: research

Correction to: Detection of SARS ‑CoV‑2 variants in India from UK returnees
(Source: Infection)
Source: Infection - November 24, 2021 Category: Infectious Diseases Source Type: research

Herpes zoster and COVID-19 infection: a coincidence or a causal relationship?
AbstractThe first cases of COVID-19 were reported in Wuhan, China, in December 2019. Skin manifestations of COVID-19 vary, among which herpes zoster has recently been found to be associated with the infection. We studied the available literature regarding COVID-19-associated herpes zoster (HZ). We searched the PubMed and Scopus databases for available literature till 20th of May 2021 using the following terms: ‘Herpes zoster’ or ‘Varicella zoster virus’ and “COVID‐19” or “coronavirus disease” or “SARS-CoV-2”. This search revealed 87 publications, of which 29 art...
Source: Infection - November 22, 2021 Category: Infectious Diseases Source Type: research

Call, chosen, HA2T2, ANDC: validation of four severity scores in COVID-19 patients
ConclusionIn this external validation  study, the four analysed scores had a lower performance compared to the original cohorts regarding prediction of mortality and disease progression. However, all scores were significantly associated with mortality and the NPV of the CALL and CHOSEN scores in particular allowed reliable identificat ion of patients at low risk, making them suitable for outpatient management. (Source: Infection)
Source: Infection - November 19, 2021 Category: Infectious Diseases Source Type: research

Sensitivity of SARS-CoV-2 variant Delta to serum neutralization in BNT162b2 vaccinees and unvaccinated COVID-19 recovered cases
(Source: Infection)
Source: Infection - November 18, 2021 Category: Infectious Diseases Source Type: research

Infected deep vein thrombophlebitis in people who inject drugs: missed opportunities and potential for alternative antimicrobial approaches
AbstractInfected deep vein thrombophlebitis (i-DVT) in people who inject drugs (PWID) is a clinically challenging but poorly characterised disease. We undertook a retrospective observational study of 70 PWID presenting acutely with i-DVT to improve the clinical and microbiological characterisation of this disease. i-DVT was frequently associated with bacteraemia (59.1% patients with blood cultures obtained), groin abscesses (in 34.3%; of which 54.2% required surgical drainage), and septic pulmonary emboli (38.6%) requiring anticoagulation. Network analysis identified a cluster of patients presenting with respiratory sympto...
Source: Infection - November 2, 2021 Category: Infectious Diseases Source Type: research

Dynamics of urinary and respiratory shedding of Severe acute respiratory syndrome virus 2 (SARS-CoV-2) RNA excludes urine as a relevant source of viral transmission
ConclusionsSARS-CoV-2 RNA in the urine of COVID-19 patients occurs infrequently. The viral RNA load and dynamics of SARS-CoV-2 RNA shedding suggest no relevant route of transmission through the urinary tract. (Source: Infection)
Source: Infection - October 30, 2021 Category: Infectious Diseases Source Type: research

Enterococcus faecalis bloodstream infection: does infectious disease specialist consultation make a difference?
ConclusionEnterococcus faecalis bacteremia is associated with a high mortality. IDC contributed to improved diagnostic and therapeutic management. (Source: Infection)
Source: Infection - October 29, 2021 Category: Infectious Diseases Source Type: research

Humoral response to SARS-CoV-2 vaccines in people living with HIV
AbstractPurposeTo describe the humoral immune response to COVID-19 vaccines in people living with HIV and identify factors associated with the magnitude of anti-SARS-CoV-2 antibody concentrations.MethodsRetrospective analysis of electronic patient files in a big single HIV center in Munich, Germany. Non-parametric methods were used for descriptive and comparative statistics. Generalized linear models were used to analyze associations of general and HIV-specific variables with anti-SARS-CoV-2 antibody concentrations after standard vaccination.ResultOverall, 665 people living with HIV were included into the analysis (median ...
Source: Infection - October 25, 2021 Category: Infectious Diseases Source Type: research

Analytical performance of the point-of-care BIOSYNEX COVID-19 Ag BSS for the detection of SARS ‐CoV‐2 nucleocapsid protein in nasopharyngeal swabs: a prospective field evaluation during the COVID-19 third wave in France
ConclusionsTheBIOSYNEX Ag-RDT is a promising, potentially simple diagnostic tool, especially in symptomatic COVID-19 patients with substantial viral excretion in the nasopharynx. (Source: Infection)
Source: Infection - October 24, 2021 Category: Infectious Diseases Source Type: research

Evaluation of a multiplex PCR screening approach to identify community-acquired bacterial co-infections in COVID-19: a multicenter prospective cohort study of the German competence network of community-acquired pneumonia (CAPNETZ)
ConclusionGeneral CABP screening using multiplex PCR with nasopharyngeal swabs may not facilitate prediction or identification of bacterial co-infections in the early phase of COVID-19-related hospitalization. Most patients with positive PCR results appear to be colonized rather than infected at that time, questioning the value of routine antibiotic treatment on admission in COVID-19 patients. (Source: Infection)
Source: Infection - October 23, 2021 Category: Infectious Diseases Source Type: research

Increased risk of death in COVID-19 hospital admissions during the second wave as compared to the first epidemic wave: a prospective, single-centre cohort study in London, UK
ConclusionsAlthough crude mortality rates dropped during the second wave, the multivariable analysis suggests a higher underlying risk of death for COVID-19 admissions in the second wave. These findings are ecologically correlated with an increased circulation of SARS-CoV-2 variant of concern 202012/1 (alpha). Availability of improved management, particularly dexamethasone, was important in reducing risk of death. (Source: Infection)
Source: Infection - October 21, 2021 Category: Infectious Diseases Source Type: research

Cardiac iron overload promotes cardiac injury in patients with severe COVID-19
(Source: Infection)
Source: Infection - October 20, 2021 Category: Infectious Diseases Source Type: research

Gut and airway microbiota and their role in COVID-19 infection and pathogenesis: a scoping review
ConclusionDuring infection with SARS-CoV-2, there are significant changes in the composition of the gut and airway microbiota. Furthermore, the gut microbiota may have a more important role than the airway microbiota in COVID-19 infection. In the future, studies should be more carefully designed to derive more conclusive evidence on the role of the gut and airway microbiota following infection with SARS-CoV-2 which will lead to the formulation of better management strategies in combating COVID-19. (Source: Infection)
Source: Infection - October 20, 2021 Category: Infectious Diseases Source Type: research

Mobile PCR-based surveillance for SARS-CoV-2 to reduce visiting restrictions in nursing homes during the COVID-19 pandemic: a pilot study
ConclusionIn a real-world setting without available rapid testing, voluntary RT-PCR SARS-CoV-2 testing of HCW and visitors does not prevent COVID-19 outbreaks in NH. Complete, non-selective testing for these groups should be instituted before visiting restrictions can be reduced.Trial registrationThe study has been registered at ClinicalTrials.gov with the identifier: NCT04933981. (Source: Infection)
Source: Infection - October 20, 2021 Category: Infectious Diseases Source Type: research

Effectiveness of extended shutdown measures during the ´Bundesnotbremse´ introduced in the third SARS-CoV-2 wave in Germany
AbstractA third SARS-CoV-2 infection wave has affected Germany from March 2021 until April 24th, until the ´Bundesnotbremse´ introduced nationwide shutdown measures. The ´Bundesnotbremse´ is the technical term which was used by the German government to describe nationwide shutdown measures to control the rising infection numbers. These measures included mainly contact restrictions on several level. T his study investigates which effects locally dispersed pre- and post-´Bundesnotbremse´ measures had on the infection dynamics. We analyzed the variability and strength of the rates of the ch...
Source: Infection - October 20, 2021 Category: Infectious Diseases Source Type: research

Gut and airway microbiota and their role in COVID-19 infection and pathogenesis: a scoping review
ConclusionDuring infection with SARS-CoV-2, there are significant changes in the composition of the gut and airway microbiota. Furthermore, the gut microbiota may have a more important role than the airway microbiota in COVID-19 infection. In the future, studies should be more carefully designed to derive more conclusive evidence on the role of the gut and airway microbiota following infection with SARS-CoV-2 which will lead to the formulation of better management strategies in combating COVID-19. (Source: Infection)
Source: Infection - October 20, 2021 Category: Infectious Diseases Source Type: research

Cardiac iron overload promotes cardiac injury in patients with severe COVID-19
(Source: Infection)
Source: Infection - October 20, 2021 Category: Infectious Diseases Source Type: research

Mobile PCR-based surveillance for SARS-CoV-2 to reduce visiting restrictions in nursing homes during the COVID-19 pandemic: a pilot study
ConclusionIn a real-world setting without available rapid testing, voluntary RT-PCR SARS-CoV-2 testing of HCW and visitors does not prevent COVID-19 outbreaks in NH. Complete, non-selective testing for these groups should be instituted before visiting restrictions can be reduced.Trial registrationThe study has been registered at ClinicalTrials.gov with the identifier: NCT04933981. (Source: Infection)
Source: Infection - October 20, 2021 Category: Infectious Diseases Source Type: research

Effectiveness of extended shutdown measures during the ´Bundesnotbremse´ introduced in the third SARS-CoV-2 wave in Germany
AbstractA third SARS-CoV-2 infection wave has affected Germany from March 2021 until April 24th, until the ´Bundesnotbremse´ introduced nationwide shutdown measures. The ´Bundesnotbremse´ is the technical term which was used by the German government to describe nationwide shutdown measures to control the rising infection numbers. These measures included mainly contact restrictions on several level. T his study investigates which effects locally dispersed pre- and post-´Bundesnotbremse´ measures had on the infection dynamics. We analyzed the variability and strength of the rates of the ch...
Source: Infection - October 20, 2021 Category: Infectious Diseases Source Type: research

Generation and persistence of S1  IgG and neutralizing antibodies in post-COVID-19 patients
ConclusionHumoral immunity to SARS-CoV-2 infection depends on the severity of the disease, gender and age. This immune response could be long-lasting as for other coronaviruses. (Source: Infection)
Source: Infection - October 19, 2021 Category: Infectious Diseases Source Type: research

Long-term changes in pulmonary function among patients surviving to COVID-19 pneumonia
AbstractPurposeThe aim of this study was to assess respiratory function at the time of clinical recovery, 6  weeks, 6 months, and 12 months after discharge in patients surviving to COVID-19 pneumonia.MethodsOur case series consisted of 13 hospitalized patients with COVID-19 pneumonia.ResultsBaseline pulmonary function tests were 55.7  ± 15.6 for FEV1%, 68.6 ± 16.0 for FVC%, and 1.2 ± 0.1 for FEV1/FVC%. Although pulmonary function showed a small improvement after 6 weeks, patients experienced a more significant improvement after 6 and 12 ...
Source: Infection - October 15, 2021 Category: Infectious Diseases Source Type: research

Long-term health sequelae and quality of life at least 6  months after infection with SARS-CoV-2: design and rationale of the COVIDOM-study as part of the NAPKON population-based cohort platform (POP)
ConclusionNAPKON-POP COVIDOM-study complements other Long COVID studies assessing the long-term consequences of an infection with SARS-CoV-2 by providing detailed health data of population-based samples, including individuals with various degrees of disease severity.Trial registrationRegistered at the German registry for clinical studies (DRKS00023742). (Source: Infection)
Source: Infection - October 12, 2021 Category: Infectious Diseases Source Type: research

Correction to: An emergent infectious disease: Clostridioides difficile infection hospitalizations, 10-year trend in Sicily
(Source: Infection)
Source: Infection - October 11, 2021 Category: Infectious Diseases Source Type: research

Correction to: Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century
(Source: Infection)
Source: Infection - October 11, 2021 Category: Infectious Diseases Source Type: research

Correction to: An emergent infectious disease: Clostridioides difficile infection hospitalizations, 10-year trend in Sicily
(Source: Infection)
Source: Infection - October 11, 2021 Category: Infectious Diseases Source Type: research

Correction to: Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century
(Source: Infection)
Source: Infection - October 11, 2021 Category: Infectious Diseases Source Type: research

Fatal vaccine-induced immune thrombotic thrombocytopenia (VITT) post Ad26.COV2.S: first documented case outside US
ConclusionEven though it is an extremely rare complication of vaccination  physicians should maintain a high index of suspicion of VITT in patients who received an adenovirus-vector-based SARS-CoV-2 vaccine within the last 30 days with persistent complains compatible with VITT or thromboembolic event associated with thrombocytopenia. The diagnosis should not be exclude d if the rapid anti-PF4 immunological nor chemiluminescence techniques yield negative results. An adapted functional assay should be performed to confirm the diagnosis. Early treatment with intravenous immunoglobulin and non-heparin antic...
Source: Infection - October 9, 2021 Category: Infectious Diseases Source Type: research