National Early Warning Score 2 (NEWS2) better predicts critical Coronavirus Disease 2019 (COVID-19) illness than COVID-GRAM, a multi-centre study
AbstractPurposeClinical scores to rapidly assess the severity illness of Coronavirus Disease 2019 (COVID-19) could be considered of help for clinicians. Recently, a specific score (named COVID-GRAM) for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, based on a nationwide Chinese cohort, has been proposed. We routinely applied the National Early Warning Score 2 (NEWS2) to predict critical COVID-19. Aim of this study is to compare NEWS2 and COVID-GRAM score.MethodsWe retrospectively analysed data of 121 COVID-19 patients admitted in two Clinics of Infectious Diseases in the Umbria region, Italy. The ...
Source: Infection - May 10, 2021 Category: Infectious Diseases Source Type: research

Self-sampling versus health care professional-guided swab collection for SARS-CoV-2 testing
ConclusionOropharyngeal self-sampling is an applicable testing approach for SARS-CoV-2 diagnostics. Self-sampling tends to be more effective in early versus late infection and symptom onset, and the collection of two distinct samples is recommended to maintain high test sensitivity. (Source: Infection)
Source: Infection - May 10, 2021 Category: Infectious Diseases Source Type: research

Strongyloidiasis in the COVID era: a warning for an implementation of the screening protocol
(Source: Infection)
Source: Infection - May 10, 2021 Category: Infectious Diseases Source Type: research

CD4/CD8 ratio in pregnant women with HIV and its association with pregnancy outcome: data from a national study in Italy
AbstractPurposeTo evaluate associations between CD4/CD8 ratio and pregnancy outcomes in women with HIV.MethodsWe evaluated, in a national study of pregnant women with HIV receiving antiretroviral treatment (ART), values of CD4/CD8 ratio at entry in pregnancy, changes between first and third trimester, and possible associations with preterm delivery, low birthweight, and HIV-RNA  
Source: Infection - May 8, 2021 Category: Infectious Diseases Source Type: research

Coincidental SARS-CoV-2 infection and mRNA vaccination: a case report addressing the most important clinical questions
AbstractThe case describes the coincidental mRNA vaccination and SARS-CoV-2 infection of a 31-year-old physician addressing the theoretical considerations and recommendations for further actions in such a particular constellation that we will expect more often in the near future. (Source: Infection)
Source: Infection - May 7, 2021 Category: Infectious Diseases Source Type: research

From blanket quarantine in Wuhan to distant centralized quarantine in Shijiazhuang: the evolution of China's COVID-19 quarantine approach
AbstractWith COVID-19 spreading globally, the World Health Organization (WHO) declared a pandemic on March 11, 2020. COVID-19 swept many countries and regions worldwide. An effective response to COVID-19 requires newer and more creative tools. In this paper, we discussed the evolution of China ’s COVID-19 quarantine approach, compared the blanket quarantine in Wuhan and the distant centralized quarantine in rural areas of Shijiazhuang, and analyzed the important issues which authorities will have to pay attention to ensure success from the moment they begin to take close contacts to the single room isolation in a dis...
Source: Infection - May 7, 2021 Category: Infectious Diseases Source Type: research

Usefulness of ultrasound in sub-Saharan patients with a serological diagnosis of schistosomiasis
ConclusionFor those patients with a diagnosis of schistosomiasis based solely in a positive serology, the ultrasound examination could safely be spared due to the low prevalence of pathological findings and its response to treatment anyway. (Source: Infection)
Source: Infection - May 4, 2021 Category: Infectious Diseases Source Type: research

Multicentric Castleman ’s disease in HIV patients: a single-center cohort diagnosed from 2008 to 2018
ConclusionThe most effective first-line therapy and retreatment option remains rituximab. The effectiveness of other treatment options like splenectomy or different immunotherapeutic approaches requires confirmation in larger-scale studies. (Source: Infection)
Source: Infection - May 4, 2021 Category: Infectious Diseases Source Type: research

Virological COVID-19 surveillance in Bavaria, Germany suggests no SARS-CoV-2 spread prior to the first German case in January 2020
AbstractThe Bavarian Influenza Sentinel (BIS) monitors the annual influenza season by combining virological and epidemiological data. The 2019/2020 influenza season overlapped with the beginning COVID-19 pandemic thus allowing to investigate whether there was an unnoticed spread of SARS-CoV-2 among outpatients with acute respiratory infections in the community prior to the first COVID-19 cluster in Bavaria. Therefore, we retrospectively analysed oropharyngeal swabs obtained in BIS between calendar week (CW) 39 in 2019 and CW 14 in 2020 for the presence of SARS-CoV-2 RNA by RT-PCR. 610 of all 1376 BIS swabs-contained suffic...
Source: Infection - April 23, 2021 Category: Infectious Diseases Source Type: research

Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational study
AbstractPurposeAdequate patient allocation is pivotal for optimal resource management in strained healthcare systems, and requires detailed knowledge of clinical and virological disease trajectories. The purpose of this work was to identify risk factors associated with need for invasive mechanical ventilation (IMV), to analyse viral kinetics in patients with and without IMV and to provide a comprehensive description of clinical course.MethodsA cohort of 168 hospitalised adult COVID-19 patients enrolled in a prospective observational study at a large European tertiary care centre was analysed.ResultsForty-four per cent (71/...
Source: Infection - April 22, 2021 Category: Infectious Diseases Source Type: research

Penetration of echinocandins into wound secretion of critically ill patients
AbstractPurposeWound infections caused byCandida are life-threatening and difficult to treat. Echinocandins are highly effective againstCandida species and recommended for treatment of invasive candidiasis. As penetration of echinocandins into wounds is largely unknown, we measured the concentrations of the echinocandins anidulafungin (AFG), micafungin (MFG), and caspofungin (CAS) in wound secretion (WS) and in plasma of critically ill patients.MethodsWe included critically ill adults with an indwelling wound drainage or undergoing vacuum-assisted closure therapy, who were treated with an echinocandin for suspected or prov...
Source: Infection - April 20, 2021 Category: Infectious Diseases Source Type: research

Skin and sepsis: contribution of dermatology to a rapid diagnosis
AbstractIn patients who develop sepsis, whether due to primary, secondary or metastatic lesions, the skin is frequently affected. However, there are unresolved aspects regarding the general clinical manifestations in the skin or the prognosis and/or therapeutic implications. The main challenge in the approach to sepsis is its early diagnosis and management. In this review, we address the sepsis –skin relationship and the potential impact of early dermatological intervention on the septic patient through ten basic questions. We found little evidence of the participation of the dermatologist in sepsis alert programs. T...
Source: Infection - April 15, 2021 Category: Infectious Diseases Source Type: research

Clinical course and predictive risk factors for fatal outcome of SARS-CoV-2 infection in patients with chronic kidney disease
AbstractPurposeThe ongoing pandemic caused by the novel severe acute respiratory coronavirus 2 (SARS-CoV-2) has stressed health systems worldwide. Patients with chronic kidney disease (CKD) seem to be more prone to a severe course of coronavirus disease (COVID-19) due to comorbidities and an altered immune system. The study ’s aim was to identify factors predicting mortality among SARS-CoV-2-infected patients with CKD.MethodsWe analyzed 2817 SARS-CoV-2-infected patients enrolled in the Lean European Open Survey on SARS-CoV-2-infected patients and identified 426 patients with pre-existing CKD. Group comparisons were p...
Source: Infection - April 13, 2021 Category: Infectious Diseases Source Type: research

The first familial cluster of the B.1.1.7 variant of SARS-CoV-2 in the northeast of Italy
ConclusionThis allow us to make clear the very high attack rate and the great infective capacity of this B.1.1.7 variant of SARS-CoV-2. (Source: Infection)
Source: Infection - April 10, 2021 Category: Infectious Diseases Source Type: research

CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity
AbstractCoronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I interferons are important in the defense of viral infections. Recently, neutralizing IgG auto-antibodies against type I interferons were found in patients with severe COVID-19 infection. Here, we analyzed expression of CD169/SIGLEC1, a well described downstream molecule in interferon signaling, and found increased monocytic CD169/SIGLEC1 expression levels in patients with mild, acute COVID-19, compared to patients with severe disease. We recommend further clinical studies to evaluate ...
Source: Infection - April 6, 2021 Category: Infectious Diseases Source Type: research

Hospital at home for the management of COVID-19: preliminary experience with 63 patients
AbstractAlternatives to conventional hospitalization are needed to increase health systems resilience in the face of COVID-19 pandemic. Herein, we describe the characteristics and outcomes of 63 patients admitted to a single HaH during the peak of COVID-19 in Barcelona. Our results suggest that HaH seems to be a safe and efficacious alternative to conventional hospitalization for accurately selected patients with COVID-19. (Source: Infection)
Source: Infection - March 24, 2021 Category: Infectious Diseases Source Type: research

Renin –angiotensin system inhibitors and mortality in patients with COVID-19
AbstractAssociation of renin –angiotensin system inhibitors with risk of death in patients with hypertension (HTN) and coronavirus disease 2019 (COVID-19) is not well characterized. The aim of this study was to evaluate the outcomes of patients with HTN and COVID-19 with respect to different chronic antihypertensive drug inta ke. We performed a retrospective, observational study from a large cohort of patients with HTN and with a laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection admitted to the Emergency Rooms (ER) of the Piacenza Hospital network from February 21, 2020 to March 20, 2020....
Source: Infection - March 24, 2021 Category: Infectious Diseases Source Type: research

Correction to: Mono vs. combo regimens with novel beta-lactam/beta-lactamase inhibitor combinations for the treatment of infections due to carbapenemase-producing Enterobacterales : insights from the literature
A correction to this paper has been published: https://doi.org/10.1007/s15010-021-01596-8 (Source: Infection)
Source: Infection - March 19, 2021 Category: Infectious Diseases Source Type: research

A combined oro-nasopharyngeal swab is more sensitive than mouthwash in detecting SARS-CoV-2 by a high-throughput PCR assay
ConclusionMouthwash is not as sensitive as combined oro-nasopharyngeal swab in detecting upper respiratory tract infection. (Source: Infection)
Source: Infection - March 18, 2021 Category: Infectious Diseases Source Type: research

Correction to: Impact of an Antimicrobial Stewardship Program-bundled initiative utilizing Accelerate Pheno ™ system in the management of patients with aerobic Gram-negative bacilli bacteremia
A correction to this paper has been published: https://doi.org/10.1007/s15010-021-01601-0 (Source: Infection)
Source: Infection - March 17, 2021 Category: Infectious Diseases Source Type: research

Abstracts of the 10th German/Austrian AIDS Conference
(Source: Infection)
Source: Infection - March 16, 2021 Category: Infectious Diseases Source Type: research

Antibiotic-resistant microorganisms in patients with bloodstream infection of intraabdominal origin: risk factors and impact on mortality
ConclusionBiliary manipulation and septic shock are predictors of ARM. The presence of an ARM from a non-biliary focus is a poor-prognosis indicator. Source control continues to be of paramount importance. (Source: Infection)
Source: Infection - March 16, 2021 Category: Infectious Diseases Source Type: research

State-of-the-art review of secondary pulmonary infections in patients with COVID-19 pneumonia
ConclusionThe widespread use of empirical antibiotics during the current pandemic may contribute to the development of multidrug-resistant microorganisms, and antimicrobial stewardship programs are required for minimizing and de-escalating antibiotics. Due to the variation in definition across most studies, a large, well-designed study is required to determine the incidence, risk factors, and outcomes of secondary pulmonary infections in hospitalized COVID-19 patients. (Source: Infection)
Source: Infection - March 11, 2021 Category: Infectious Diseases Source Type: research

Admission lysophosphatidylethanolamine acyltransferase level predicts the severity and prognosis of community-acquired pneumonia
ConclusionElevated LPEAT levels can reliably predict the severity of illness in patients with CAP at the time of admission. Adding LPEAT to clinical scoring methods could improve prognostic accuracy.Trial registrationClinicalTrials.gov, NCT03093220. Registered on March 28th, 2017. (Source: Infection)
Source: Infection - March 10, 2021 Category: Infectious Diseases Source Type: research

SARS-CoV-2-directed antibodies persist for more than six months in a cohort with mild to moderate COVID-19
ConclusionSerological immune responses after COVID-19 show considerable inter-individual variability, but show an association with increasing age and higher severity of disease. IgG-type anti-SARS-CoV-2 antibodies remain positive in 90% of the individuals 30  weeks after onset of symptoms. (Source: Infection)
Source: Infection - March 10, 2021 Category: Infectious Diseases Source Type: research

Pulmonary aspergilloma on transthoracic ultrasound
ConclusionsThe sonographic findings corresponded to chest X-ray and computed tomography imaging in this patient and to previously reported sonographic characteristics of mycotic abscesses in other organs. Lung ultrasound may be a tool to identify pulmonary aspergilloma, especially as a point-of-care imaging tool and where other imaging modalities are inaccessible. (Source: Infection)
Source: Infection - March 9, 2021 Category: Infectious Diseases Source Type: research

Presence of microorganisms in children with pharyngotonsillitis and healthy controls: a prospective study in primary healthcare
This study, however, analyses a broad spectrum of bacteria and viruses related to paediatric pharyngotonsillitis and evaluates their associated clinical symptoms and courses.MethodsThis observational prospective study in primary healthcare includes 77 children aged  
Source: Infection - March 8, 2021 Category: Infectious Diseases Source Type: research

The presenting characteristics of erythema migrans vary by age, sex, duration, and body location
ConclusionsGiven that EM remains a clinical diagnosis, it is essential that both physicians and the general public are aware of its varied manifestations. Our findings suggest possible patterns within this variability, with implications for prompt diagnosis and treatment initiation, as well as an understanding of the clinical spectrum of EM. (Source: Infection)
Source: Infection - March 7, 2021 Category: Infectious Diseases Source Type: research

Pooled saliva samples as an approach to reduce the spread of infections with SARS-CoV-2
(Source: Infection)
Source: Infection - March 6, 2021 Category: Infectious Diseases Source Type: research

Clinical and epidemiological data of COVID-19 from Regensburg, Germany: a retrospective analysis of 1084 consecutive cases
We report data on type and duration of symptoms, and clinical severity of nearly all (99.5%) patients with SARS-CoV-2 recorded from March 2020 to May 2020 in Regensburg. A broad range of symptoms and symptom duration was seen, some of them lasting several weeks in a considerable number of cases. The case-fatality ratio was 2.1%. Asymptomatic cases may be underrepresented due to the nature of the study. (Source: Infection)
Source: Infection - March 5, 2021 Category: Infectious Diseases Source Type: research

The current therapeutical strategies in human brucellosis
AbstractPrompt and adequate treatment of human brucellosis continues to be the most important strategy in its management, as eradication of animal brucellosis is not possible so far, and there is no adequate vaccine for humans. The goal of antibrucellar treatment is to alleviate and shorten the symptomatic period and reduce complications, relapses, and chronicity. Contemporary trends in the treatment of human brucellosis are postulated on the ability ofBrucellae to persist in host macrophages through the inhibition of phagolysosome fusion and to survive for prolonged periods intracellularly without restricting basic cellul...
Source: Infection - March 1, 2021 Category: Infectious Diseases Source Type: research

COVID-19 anosmia and gustatory symptoms as a prognosis factor: a subanalysis of the HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID-19) registry
AbstractOlfactory and gustatory dysfunctions (OGD) are a frequent symptom of coronavirus disease 2019 (COVID-19). It has been proposed that the neuroinvasive potential of the novel SARS-CoV-2 could be due to olfactory bulb invasion, conversely studies suggest it could be a good prognostic factor. The aim of the current study was to investigate the prognosis value of OGD in COVID-19. These symptoms were recorded on admission from a cohort study of 5868 patients with confirmed or highly suspected COVID-19 infection included in the multicenter international HOPE Registry (NCT04334291). There was statistical relation in multiv...
Source: Infection - March 1, 2021 Category: Infectious Diseases Source Type: research

Evidence-based uncertainty: do implant-related properties of titanium reduce the susceptibility to perioperative infections in clinical fracture management? A systematic review
ConclusionOur results show that currently, no proven advantage for titanium implants in respect to IAI can be seen in contemporary literature. Implants preserving periosteal blood-flow and minimising soft-tissue trauma show statistically significant benefits in reducing the incidence of IAI. Clinical studies providing reliable evidence regarding the influence of titanium implants on IAI and investigating the susceptibility of titanium to infection are necessary (Source: Infection)
Source: Infection - February 13, 2021 Category: Infectious Diseases Source Type: research

Antigen testing and non-infectious shedding of SARS-COV-2
(Source: Infection)
Source: Infection - February 10, 2021 Category: Infectious Diseases Source Type: research

Clinical performance of Xpert MTB/RIF on contrast-enhanced ultrasound-guided core biopsy specimens for rapid diagnosis of superficial tuberculous lymphadenitis in high TB burden settings
ConclusionsCurrent examinations on specimens by CEUS-guided core biopsy can achieve a high diagnostic efficacy for TBLN. Pathological differentiation of CEUS-guided biopsy tissue, then followed by Xpert, may be the best pattern for the diagnosis of TBLN in high TB burden areas. (Source: Infection)
Source: Infection - February 4, 2021 Category: Infectious Diseases Source Type: research

Torque Teno Virus plasma level as novel biomarker of retained immunocompetence in HIV-infected patients
ConclusionWithin the cohort, the significantly elevated TTV plasma concentration in patients with diminished CD4+ cell recovery indicates a more profound immune defect. Baseline TTV plasma concentrations and CD4+ cell count are predictive for the course of immune recovery in HIV-1-infected patients with severe immunodeficiency. (Source: Infection)
Source: Infection - February 3, 2021 Category: Infectious Diseases Source Type: research

Fungal infections of the feet in patients with erysipelas of the lower limb: is it a significant clinical problem?
ConclusionsFungal infections of the feet are important risk factors for the first episode as well as recurrent erysipelas. Prevention and early treatment of fungal infections, especially in elderly people, can significantly reduce the incidence of erysipelas. (Source: Infection)
Source: Infection - February 3, 2021 Category: Infectious Diseases Source Type: research

Mono vs. combo regimens with novel beta-lactam/beta-lactamase inhibitor combinations for the treatment of infections due to carbapenemase-producing Enterobacterales : insights from the literature
AbstractCeftazidime –avibactam (CZA), meropenem–vaborbactam (MVB) and imipenem–relebactam (I–R) are combinations of old ß-lactams with novel non-ß-lactam ß-lactamase inhibitors (BLBLIs) able to inhibit some carbapenemases, such as the KPC-type, thus are becoming the standard for difficult-to-treat carbapenem ase-producingEnterobacterales (CPE); a practical question is whether these novel BLBLIs should be used as monotherapy or as part of a combination regimen with other antibiotics, and if so, with which ones, to reduce the emergence of resistant strains and to optimize their effic...
Source: Infection - February 3, 2021 Category: Infectious Diseases Source Type: research

Impact of an Antimicrobial Stewardship Program-bundled initiative utilizing Accelerate Pheno ™ system in the management of patients with aerobic Gram-negative bacilli bacteremia
AbstractPurposeGram-negative bacteria (GNB) are a leading cause of bloodstream infections (BSI) and management is complicated by antibiotic resistance. The Accelerate Pheno ™ system (ACC) can provide rapid organism identification and antimicrobial susceptibility testing (AST).MethodsA retrospective, pre-intervention/post-intervention study was conducted to compare management of non-critically ill patients with GNB BSI before and after implementation of a bundled initiative. This bundled initiative included dissemination of a clinical decision algorithm, ACC testing on all GNB isolated from blood cultures, real-time c...
Source: Infection - February 2, 2021 Category: Infectious Diseases Source Type: research

Life expectancy of HIV-infected patients followed at the largest hospital in Guinea-Bissau is one-fourth of life expectancy of the background population
ConclusionsLE was shown to be markedly lower among HIV-infected patients compared with the background population. While other settings have shown marked improvements in prognosis of HIV-infected patients in recent years, no improvement in Bissau was observed over time (9.8  years (95% CI 7.6–12.2) and 9.9 years (95% CI 7.6–12.1) for the periods 2005–2010 and 2014–2016, respectively). (Source: Infection)
Source: Infection - February 2, 2021 Category: Infectious Diseases Source Type: research

Serum citrullinated histone H3 concentrations differentiate patients with septic verses non-septic shock and correlate with disease severity
AbstractPurposeMicrobial infection stimulates neutrophil/macrophage/monocyte extracellular trap formation, which leads to the release of citrullinated histone H3 (CitH3) catalyzed by peptidylarginine deiminase (PAD) 2 and 4. Understanding these molecular mechanisms in the pathogenesis of septic shock will be an important next step for developing novel diagnostic and treatment modalities. We sought to determine the expression of CitH3 in patients with septic shock, and to correlate CitH3 levels with PAD2/PAD4 and clinically relevant outcomes.MethodsLevels of CitH3 were measured in serum samples of 160 critically ill patient...
Source: Infection - February 1, 2021 Category: Infectious Diseases Source Type: research

Higher viral loads in asymptomatic COVID-19 patients might be the invisible part of the iceberg
ConclusionIn conclusion, this study demonstrates that asymptomatic patients have higher SARSCoV-2 viral loads than symptomatic patients and unlike in the few study in the literature, a significant decrease in viral load of nasopharyngeal/oropharyngeal samples was observed with increasing disease severity. Factors associated with poor prognosis are found to be significantly correlated with low viral load. (Source: Infection)
Source: Infection - February 1, 2021 Category: Infectious Diseases Source Type: research

Influenza-associated in-hospital mortality during the 2017/2018 influenza season: a retrospective multicentre cohort study in central Germany
AbstractThe aim of this retrospective cohort study at eight hospitals in Germany was to specify influenza-associated in-hospital mortality during the 2017/2018 flu season, which was the strongest in Germany in the past 30  years. A total of 1560 patients were included in the study. Overall, in-hospital mortality was 6.7% (n = 103), in patients treated in the intensive care unit (n = 161) mortality was 22.4%. The proportion of deceased patients per hospital was between 0% and 7.0%. Influenza was the immediate cause of death in 82.8% (n = 82) of the decedents. (Source: Infection)
Source: Infection - February 1, 2021 Category: Infectious Diseases Source Type: research

Correction to: 2019 Novel coronavirus: where we are and what we know
The original version of this article unfortunately contained a mistake. (Source: Infection)
Source: Infection - February 1, 2021 Category: Infectious Diseases Source Type: research

Left and right ventricular dysfunction in patients with COVID-19-associated myocardial injury
ConclusionIn patients with COVID-19-associated myocardial injury, comprehensive 3D and strain echocardiography revealed LV dysfunction by GLS and RV dysfunction, which partially resolved at 2-month follow-up.Trial registrationCOVID-19 Registry of the LMU University Hospital Munich (CORKUM), WHO trial ID DRKS00021225. (Source: Infection)
Source: Infection - January 30, 2021 Category: Infectious Diseases Source Type: research

Worldwide inverse correlation between Bacille Calmette –Guérin (BCG) immunization and COVID-19 mortality
ConclusionThis study contributes to a growing body of evidence supporting the notion that BCG vaccination may be protective against COVID-19 mortality. (Source: Infection)
Source: Infection - January 25, 2021 Category: Infectious Diseases Source Type: research

Haematological changes in Schistosoma haematobium infections in school children in Gabon
ConclusionsSchistosomiasis is associated with a characteristic FBC profile of schoolchildren living in Lambar éné, indicating the necessity to consider schistosomiasis as a single cause of disease, or a co-morbidity, when interpreting FBC in endemic areas. (Source: Infection)
Source: Infection - January 24, 2021 Category: Infectious Diseases Source Type: research

Concurrent cavitary pulmonary tuberculosis and COVID-19 pneumonia with in vitro immune cell anergy
AbstractTuberculosis (TB) is top infectious disease killer caused by a single organism responsible for 1.5 million deaths in 2018. Both COVID-19 and the pandemic response are risking to affect control measures for TB and continuity of essential services for people affected by this infection in western countries and even more in developing countries. Knowledge about concomitant pulmonary TB and COVID-19 is extremely limited. The double burden of these two diseases can have devastating effects. Here, we describe from both the clinical and the immunological point of view a case of a patient with in vitro immune cell anergy af...
Source: Infection - January 17, 2021 Category: Infectious Diseases Source Type: research

Real-life experience with fidaxomicin in Clostridioides difficile infection: a multicentre cohort study on 244 episodes
AbstractThe high cost of fidaxomicin has restricted its use despite the benefit of a lowerClostridioides difficile infection (CDI) recurrence rate at 4  weeks of follow-up. This short follow-up represents the main limitation of pivotal clinical trials of fidaxomicin, and some recent studies question its benefits over vancomycin. Moreover, the main risk factors of recurrence after treatment with fidaxomicin remain unknown. We designed a multicentre retrospective cohort study among four Spanish hospitals to assess the efficacy of fidaxomicin in real life and to investigate risk factors of fidaxomicin failure at weeks 8 ...
Source: Infection - January 8, 2021 Category: Infectious Diseases Source Type: research

Association between high vancomycin minimum inhibitory concentration and clinical outcomes in patients with methicillin-resistant Staphylococcus aureus bacteremia: a meta-analysis
ConclusionOverall mortality and complicated bacteremia were not significantly associated with high vancomycin MICs in a patient with MRSAB. Randomized controlled trials to assess the utility of vancomycin MIC values in predicting mortality and other adverse clinical outcomes are warranted. (Source: Infection)
Source: Infection - January 4, 2021 Category: Infectious Diseases Source Type: research