Unusual dermatomycoses caused by Nannizzia nana : the geophilic origin of human infections
ConclusionsIn conclusion, the cases studied by us may indicate that the infrequency ofN. nana infections may not necessarily be related to the low infectivity of this fungal agent, but they are rather associated with misdiagnosis. Furthermore,N. nana reservoirs should also be sought in soil. (Source: Infection)
Source: Infection - May 28, 2020 Category: Infectious Diseases Source Type: research

Extended-spectrum beta-lactamase (ESBL) producing Enterobacterales in stool surveillance cultures of preterm infants are no risk factor for necrotizing enterocolitis: a retrospective case –control study over 12 years
AbstractPurposeMicrobial dysbiosis has been found preceding necrotizing enterocolitis (NEC) in preterm infants; thus, we aimed to investigate whether there is evidence that neonates with extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) positive stool cultures are at higher risk for NEC at the NICU.MethodsWe included very preterm inborn infants of ≤ 32 weeks of gestational age being fecal carriers of ESBL-E and compared them with 1:1 matched (gestational age, birth weight, gender and year) controls tested negative for ESBL-E in the stool between 2005 and 2016. An association with NEC was d...
Source: Infection - May 27, 2020 Category: Infectious Diseases Source Type: research

Chromoblastomycosis caused by Cladophialophora carrionii
(Source: Infection)
Source: Infection - May 25, 2020 Category: Infectious Diseases Source Type: research

Detailed hemodynamics of fulminant myocarditis caused by COVID-19
(Source: Infection)
Source: Infection - May 24, 2020 Category: Infectious Diseases Source Type: research

A simple algorithm helps early identification of SARS-CoV-2 infection patients with severe progression tendency
ConclusionsThe age-LDH-CD4 model is a simple algorithm for early identifying patients with severe progression tendency following SARS-CoV-2 infection, and warrants further validation. (Source: Infection)
Source: Infection - May 21, 2020 Category: Infectious Diseases Source Type: research

Correction to: Clinical and economic effects of an antimicrobial stewardship intervention in a surgical intensive care unit
The original version of this article unfortunately contained a mistake (Source: Infection)
Source: Infection - May 20, 2020 Category: Infectious Diseases Source Type: research

Voriconazole-induced periostitis in stem cell transplant patient
(Source: Infection)
Source: Infection - May 20, 2020 Category: Infectious Diseases Source Type: research

Blood culture sampling rate in hospitalised children as a quality indicator for diagnostic stewardship
ConclusionWe found different BCR values according the ward studied, being higher in patients with high risk of bloodstream infection such as haematology/oncology patients. (Source: Infection)
Source: Infection - May 19, 2020 Category: Infectious Diseases Source Type: research

HIV-1 recombinant forms in immigrants regularly residing in Milan, northern Italy
AbstractTo assess the HIV -1subtypes distribution in HIV-1 positive migrants living in Milan we studied 77 HIV-1 patients followed at the San Raffaele Hospital of Milan. Twenty subjects were born in Europe, 43 in the Americas, 10 in Africa and 4 in Asia. Unsafe heterosexual activity prevailed in migrants born in Africa and male homosexuality in those born in European, American and Asian countries (p = 0.05). The phylogeny showed that 38/77 (49.3%) subjects carried HIV-B subtype while the remaining strains were classified as not pure HIV-1 B subtypes 13/77 (16.9%) or recombinant forms 26/77 (33.8%). Female gen...
Source: Infection - May 19, 2020 Category: Infectious Diseases Source Type: research

Hospitalization for Chagas disease, dengue, filariasis, leishmaniasis, schistosomiasis, strongyloidiasis, and Taenia solium taeniasis/cysticercosis, Italy, 2011 –2016
ConclusionsNTDs have a not negligible burden in Italy. The most clinically relevant NTDs in Italy are leishmaniasis and schistosomiasis, followed by strongyloidiasis, Chagas disease, and dengue. Cystic echinococcosis, that was not included in the analysis since a similar study on this disease was recently published, should also be listed among the leading NTD in Italy. While schistosomiasis has its highest burden on population coming from highly endemic areas such as SSA, leishmaniasis is especially relevant in Italian-born residents of southern regions. Education at university and post-graduate levels, to increase the awa...
Source: Infection - May 16, 2020 Category: Infectious Diseases Source Type: research

Early experience with remdesivir in SARS-CoV-2 pneumonia
We describe our early experience with remdesivir in four critically ill COVID-19 patients. Patients received a 200  mg loading dose, followed by 100 mg daily intravenously for up to 10 days. All patients had been previously treated with other antivirals before remdesivir initiation. One patient experienced a torsade de pointes requiring cardiac resuscitation and one died due to multiple organ failure. Three p atients showed biochemical signs of liver injury. Lymphocyte count increased in all patients soon after remdesivir initiation. Nasal swab SARS-CoV-2 RNA became negative in three of four patients after 3...
Source: Infection - May 16, 2020 Category: Infectious Diseases Source Type: research

Recurrence of COVID-19 after recovery: a case report from Italy
(Source: Infection)
Source: Infection - May 16, 2020 Category: Infectious Diseases Source Type: research

Contribution of anosmia and dysgeusia for diagnostic of COVID-19 in outpatients
(Source: Infection)
Source: Infection - May 14, 2020 Category: Infectious Diseases Source Type: research

High effectiveness of recommended first-line antiretroviral therapies in Germany: a nationwide, prospective cohort study
The objective was to examine the outcomes of recommended first-line ART in Germany.MethodsThis nationwide observational study included treatment-na ïve chronically HIV-1 infected patients receiving one of the recommended first-line regimens. Patients were allocated to three arms (INSTI, NNRTI, PI) and were prospectively followed for 24 months. Delayed treatment initiation was defined by a baseline CD4 T-cell count of 
Source: Infection - May 11, 2020 Category: Infectious Diseases Source Type: research

COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients
ConclusionsThis preliminary case series does not support excess morbidity and mortality among symptomatic COVID-19 PLWH and with viral suppression on ART. SARS-CoV-2 infections may occur during boosted darunavir-based and/or on tenofovir-containing ART. (Source: Infection)
Source: Infection - May 11, 2020 Category: Infectious Diseases Source Type: research

Clinical characteristics of 194 cases of COVID-19 in Huanggang and Taian, China
ConclusionClinical symptoms, laboratory tests and CT imaging should be combined for comprehensive analysis to diagnose COVID-19. ACE2 may be the receptor of COVID-19. (Source: Infection)
Source: Infection - May 10, 2020 Category: Infectious Diseases Source Type: research

Glucocorticoid versus immunoglobulin in the treatment of COVID-19-associated fulminant myocarditis
(Source: Infection)
Source: Infection - May 10, 2020 Category: Infectious Diseases Source Type: research

Corona Virus Disease 2019 (COVID-19): the image tells the truth
(Source: Infection)
Source: Infection - May 8, 2020 Category: Infectious Diseases Source Type: research

Outcome of spinal implant-associated infections treated with or without biofilm-active antibiotics: results from a 10-year cohort study
ConclusionTreatment with biofilm-active antibiotics was associated with better treatment outcome and less postoperative pain intensity. (Source: Infection)
Source: Infection - May 5, 2020 Category: Infectious Diseases Source Type: research

On the death of 100  + Italian doctors from COVID-19
(Source: Infection)
Source: Infection - May 1, 2020 Category: Infectious Diseases Source Type: research

Time-trend population analysis of the clinical and epidemiologic effect on pediatric infective endocarditis after change of antibiotic prophylaxis guidelines
AbstractPurposeIn 2007, antibiotic prophylaxis (AP) guidelines for infective endocarditis (IE) changed, but the possible influence on the annual incidences of pediatric IE is unclear.MethodsWe studied the clinical and epidemiologic impact of AP change by comparing two time periods before and after change of AP guidelines in a tertiary care center as referral center for a total population of more than 4,500,000 inhabitants.ResultsAfter change of AP guidelines, twenty-five patients were diagnosed for IE at a median age of 6.9  years (range 0.1–19.4, female 48%). Modified Duke criteria were fulfilled for definite (...
Source: Infection - April 30, 2020 Category: Infectious Diseases Source Type: research

Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China
AbstractObjectiveThe aim of this study was to investigate the clinical characteristics of Corona Virus Disease 2019 in Taizhou, China.MethodsA single center retrospective observational study was performed between Jan 1, 2020 and Mar 11, 2020 at Taizhou Public Health Medical Center, Zhejiang, China. All patients with confirmed Corona Virus Disease 2019 were enrolled, and their clinical data were gathered by reviewing electronic medical records. Outcomes of severely ill patients and non-severely ill patients were compared.ResultsOf 145 hospitalized patients with COVID-19, the average age was 47.5  years old (standard de...
Source: Infection - April 28, 2020 Category: Infectious Diseases Source Type: research

Correction to: Respiratory tract infection-related healthcare utilisation in children with Down ’s syndrome
The original version of this article unfortunately contained an omission. (Source: Infection)
Source: Infection - April 27, 2020 Category: Infectious Diseases Source Type: research

Corticosteroid therapy for the management of paradoxical inflammatory reaction in patients with pulmonary tuberculosis
ConclusionsThe presented cases further highlight the need for immunological studies and randomized trials for corticosteroid therapy are needed to better understand this phenomenon as well as provide an evidence-base for anti-inflammatory treatment. Furthermore, by means of this case series, we are also able to highlight the potential variability in the symptomatology of the lesser known PR phenomenon, in which we observed a hypotensive shock-like syndrome not previously described in literature. (Source: Infection)
Source: Infection - April 24, 2020 Category: Infectious Diseases Source Type: research

Metagenomic next-generation sequencing in the diagnosis of severe pneumonias caused by Chlamydia psittaci
ConclusionsThe use of mNGS can improve accuracy and reduce the delay in diagnosis of psittacosis. Severe psittacosis pneumonia responds well to the timely use of appropriate antibiotics. (Source: Infection)
Source: Infection - April 20, 2020 Category: Infectious Diseases Source Type: research

Clinical characteristics of COVID-19 in children compared with adults in Shandong Province, China
ConclusionsThe clinical symptoms of children are mild, there is substantial lung injury even among children, but that there is less clinical disease, perhaps because of a less pronounced inflammatory response, and that the occurrence of this pattern appears to inversely correlate with age. (Source: Infection)
Source: Infection - April 16, 2020 Category: Infectious Diseases Source Type: research

Diabetes mellitus increases mortality in acute pyelonephritis patients: a population study based on the National Health Insurance Claim Data of South Korea for 2010 –2014
AbstractObjectiveDiabetes mellitus has been suspected to increase mortality in acute pyelonephritis (APN) patients and the goal of this study is to verify this suspicion with a large data set based on almost the entire population of South Korea.MethodsA nationwide cohort study was conducted using a South Korean Health Insurance Review and Assessment Service claim database. We collected demographic and clinical information including comorbidities of patients with APN as the primary discharge diagnosis during 2010 –2014. Then we compared the in-hospital mortality and recurrence of APN across the diabetes and non-diabet...
Source: Infection - April 16, 2020 Category: Infectious Diseases Source Type: research

A review of outbreaks of cryptosporidiosis due to unpasteurized milk
ConclusionCryptosporidiosis is generally considered a waterborne intestinal infection, but several reports on foodborne transmission (including through raw milk) have been reported in the literature. Calves are frequently infected withCryptosporidium spp., which does not multiply in milk. However,Cryptosporidium oocysts can survive if pasteurization fails. Thus, pasteurization is essential to inactivate oocysts. Although cryptosporidiosis cases acquired from raw milk are seldom reported, the risk should not be underestimated andCryptosporidium should be considered as a potential agent of contamination. GenotypingCryptospor...
Source: Infection - April 15, 2020 Category: Infectious Diseases Source Type: research

The Shapiro –Procalcitonin algorithm (SPA) as a decision tool for blood culture sampling: validation in a prospective cohort study
ConclusionsThis study validates the high predictive value of SPA for bacteremia, increasing true BC positivity from 15 to 26%. Restricting BC sampling to SPA would have reduced BC sampling by 48%, while still detecting 194/215 organisms (90%), which makes SPA a valuable diagnostic  stewardship tool. (Source: Infection)
Source: Infection - April 14, 2020 Category: Infectious Diseases Source Type: research

Clinical and economic effects of an antimicrobial stewardship intervention in a surgical intensive care unit
ConclusionsAMS programmes can both reduce the consumption of antimicrobials and modify their spectrum in intensive care without negatively affecting treatment outcomes. The resulting cost savings are negligible. The incentive to implement such programmes cannot, therefore, be immediate institutional cost savings, but should be rather the long-term goal of reducing antibiotic resistance, and its consequences, in terms of long-term health care costs. (Source: Infection)
Source: Infection - April 11, 2020 Category: Infectious Diseases Source Type: research

First case of COVID-19 complicated with fulminant myocarditis: a case report and insights
ConclusionCOVID-19 patients may develop severe cardiac complications such as myocarditis and heart failure. This is the first report of COVID-19 complicated with fulminant myocarditis. The mechanism of cardiac pathology caused by COVID-19 needs further study. (Source: Infection)
Source: Infection - April 10, 2020 Category: Infectious Diseases Source Type: research

SARS-CoV-2 and Europe: timing of containment measures for outbreak control
(Source: Infection)
Source: Infection - April 9, 2020 Category: Infectious Diseases Source Type: research

Scabies crustosa in a recipient of an allogeneic stem cell transplantation
(Source: Infection)
Source: Infection - April 8, 2020 Category: Infectious Diseases Source Type: research

Treatment of fracture-related infection of the lower extremity with antibiotic-eluting ceramic bone substitutes: case series of 35 patients and literature review
ConclusionThe results in the literature and in our case series are explicitly promising regarding the treatment of posttraumatic fracture-related infection. (Source: Infection)
Source: Infection - April 8, 2020 Category: Infectious Diseases Source Type: research

Complications of retained pacemaker hardware in heart transplant recipients: case series and review of the literature
AbstractHeart transplantation (HT) in patients with prior cardiovascular implantable electronic devices (CIEDs) is becoming more common, in parallel with the increased use of CIEDs for patients with advanced heart failure. Complete removal of CIED components during HT is not always feasible, and it is thus surprising that the literature addressing the implications of retained CIED components is limited. Indeed, there are neither guidelines nor consensus regarding the need for removal of these CIED fragments. This issue is nonetheless becoming important in light of the increase in the percentage of HT candidates having CIED...
Source: Infection - April 3, 2020 Category: Infectious Diseases Source Type: research

Infections causing stroke or stroke-like syndromes
ConclusionsStroke or stroke-like syndrome of infectious origin can be observed in an important proportion of case presenting with sensory-motor deficit of unknown origin; their accurate diagnosis has a considerable impact in terms of treatment choices and outcome. (Source: Infection)
Source: Infection - April 1, 2020 Category: Infectious Diseases Source Type: research

Dalbavancin as a second-line treatment in methicillin-resistant Staphylococcus aureus prosthetic vascular graft infection
(Source: Infection)
Source: Infection - March 28, 2020 Category: Infectious Diseases Source Type: research

Clostridioides difficile infections in the intensive care unit: a monocentric cohort study
ConclusionsCDI affects a high-risk population, in whom predictive scoring tools are not accurate, and outcomes are poor despite intensive treatment. Further research in this field is warranted to improve prediction scoring and patient outcomes. (Source: Infection)
Source: Infection - March 24, 2020 Category: Infectious Diseases Source Type: research

Large stomatitis in a young woman
(Source: Infection)
Source: Infection - March 21, 2020 Category: Infectious Diseases Source Type: research

Clinical management of ageing people living with HIV in Europe: the view of the care providers
ConclusionHowever, we identified some important gaps, such as the lack of standardisation or implementation of the assessment of frailty or menopause, which are emerging as important factors to optimise ageing PLWH clinical care. Further studies are warranted to confirm whether intensified screening translates into HIV morbidity advances. (Source: Infection)
Source: Infection - March 20, 2020 Category: Infectious Diseases Source Type: research

Clinical relevance and impact of Corynebacterium isolation in lower respiratory tract of critically ill patients requiring mechanical ventilation
ConclusionCorynebacteriumspp seems to be responsible for authentic pneumonia in mechanically ventilated patients. It should be considered as clinically relevant when predominantly present in respiratory specimen from patients suspected with pneumonia in ICU, and empirically treated. (Source: Infection)
Source: Infection - March 17, 2020 Category: Infectious Diseases Source Type: research

Successful containment of COVID-19: the WHO-Report on the COVID-19 outbreak in China
(Source: Infection)
Source: Infection - March 17, 2020 Category: Infectious Diseases Source Type: research

Respiratory tract infection-related healthcare utilisation in children with Down ’s syndrome
ConclusionsChildren with DS have higher rates of GP consultations, hospitalisations and antibiotic prescribing compared to controls. This poses a significant burden on families. Further research is recommended to characterise healthcare behaviours and clinical decision-making, to optimise care for this at risk group. (Source: Infection)
Source: Infection - March 14, 2020 Category: Infectious Diseases Source Type: research

Pre-engraftment infectious complications and patient outcomes after allogeneic hematopoietic cell transplantation: a single-center experience from Lebanon
ConclusionThe cumulative incidence of pre-engraftment bacteremia and pneumonia was 14.3% and 11.2% respectively in this cohort. Aplastic anemia predicted for the occurrence of bacteremia, increasing patient age contributed to the occurrence of pneumonia, and myelodysplastic syndrome increased the risk of death. (Source: Infection)
Source: Infection - March 13, 2020 Category: Infectious Diseases Source Type: research

Update on the “Choosing Wisely” initiative in infectious diseases in Germany
ConclusionApplying these new Choosing Wisely® recommendations will increase patient safety and the value of health care. (Source: Infection)
Source: Infection - March 10, 2020 Category: Infectious Diseases Source Type: research

Disseminated cytomegalovirus infection with bilateral adrenal pseudotumors masquerading as recurrent hematologic malignancy
ConclusionIn the settings of advanced cancer therapy and organ transplantation, a high index of suspicion for CMV should be maintained for mass-like disease. (Source: Infection)
Source: Infection - March 6, 2020 Category: Infectious Diseases Source Type: research

Disseminated Nocardia farcinica infection in immunocompromised patient
(Source: Infection)
Source: Infection - March 6, 2020 Category: Infectious Diseases Source Type: research

A horse and a zebra: an atypical clinical picture including Guillain-Barr é syndrome, recurrent fever and mesenteric lymphadenopathy caused by two concomitant infections
ConclusionBroad serology testing was crucial to discover that two concomitant infections were causing the symptoms. This case demonstrates that when a clinical picture is not fully explained by one known infection, another infection with the same underlying risk factor has to be considered, hence “a horse and a zebra”. (Source: Infection)
Source: Infection - March 3, 2020 Category: Infectious Diseases Source Type: research

Controversies in the therapeutic approach to congenital cytomegalovirus infection
AbstractTreatment of congenital cytomegalovirus infection is mandatory in cases with severe systemic and/or neurological involvement. However, some patients are paucisymptomatic, with very subtle systemic manifestations and/or minimal brain alterations. Current international guidelines do not clearly state whether these children should be treated, and this decision is not straightforward for clinicians. Of a small series of six infants with congenital cytomegalovirus infection admitted to our neonatal unit between 2015 and 2019, half showed paucisymptomatic neurological manifestations. In these cases, the determination of ...
Source: Infection - March 3, 2020 Category: Infectious Diseases Source Type: research

An unusual clinical presentation of necrotizing fasciitis
(Source: Infection)
Source: Infection - March 3, 2020 Category: Infectious Diseases Source Type: research