TOPAS simulations of the response of a mini-TEPC: benchmark with experimental data
This study aims at the comparison of microdosimetric spectra obtained from both experimental measurements and the microdosimetric extension of TOPAS in the same radiation field.PMID:36595254 | DOI:10.1088/1361-6560/acabfe (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - January 3, 2023 Category: Physics Authors: Anna Bianchi Anna Selva Brigitte Reniers Filip Vanhavere Valeria Conte Source Type: research
TOPAS simulations of the response of a mini-TEPC: benchmark with experimental data
This study aims at the comparison of microdosimetric spectra obtained from both experimental measurements and the microdosimetric extension of TOPAS in the same radiation field.PMID:36595254 | DOI:10.1088/1361-6560/acabfe (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - January 3, 2023 Category: Physics Authors: Anna Bianchi Anna Selva Brigitte Reniers Filip Vanhavere Valeria Conte Source Type: research
Evaluation of treatment planning system accuracy in estimating the stopping-power ratio of immobilization devices for proton therapy
CONCLUSIONS: The TPS tends to underestimate the SPR of selected proton immobilization devices by an average of about 20%, but this does not induce major WET errors because of the low density of the devices. The dosimetric effect of this SPR error was negligible for most treatment sites, although the maximum dose of a few OARs exhibited noticeable variations.PMID:36593751 | DOI:10.1002/acm2.13831 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - January 3, 2023 Category: Physics Authors: Kai Jiang Michael MacFarlane Sina Mossahebi Mark J Zakhary Source Type: research
TOPAS simulations of the response of a mini-TEPC: benchmark with experimental data
This study aims at the comparison of microdosimetric spectra obtained from both experimental measurements and the microdosimetric extension of TOPAS in the same radiation field.PMID:36595254 | DOI:10.1088/1361-6560/acabfe (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - January 3, 2023 Category: Physics Authors: Anna Bianchi Anna Selva Brigitte Reniers Filip Vanhavere Valeria Conte Source Type: research
TOPAS simulations of the response of a mini-TEPC: benchmark with experimental data
This study aims at the comparison of microdosimetric spectra obtained from both experimental measurements and the microdosimetric extension of TOPAS in the same radiation field.PMID:36595254 | DOI:10.1088/1361-6560/acabfe (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - January 3, 2023 Category: Physics Authors: Anna Bianchi Anna Selva Brigitte Reniers Filip Vanhavere Valeria Conte Source Type: research
TOPAS simulations of the response of a mini-TEPC: benchmark with experimental data
This study aims at the comparison of microdosimetric spectra obtained from both experimental measurements and the microdosimetric extension of TOPAS in the same radiation field.PMID:36595254 | DOI:10.1088/1361-6560/acabfe (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - January 3, 2023 Category: Physics Authors: Anna Bianchi Anna Selva Brigitte Reniers Filip Vanhavere Valeria Conte Source Type: research
Effects of lymphopenia on survival in proton therapy with chemotherapy for non-small cell lung cancer
J Radiat Res. 2023 Jan 2:rrac084. doi: 10.1093/jrr/rrac084. Online ahead of print.ABSTRACTLymphocytes play an important role in the cancer immune system. In the present study, we aimed to evaluate the associations of lymphopenia during proton beam therapy (PBT) and concurrent chemotherapy with clinical outcomes and to determine whether lung or bone is more influential on lymphopenia during PBT. Data from 41 patients with stage III non-small cell lung cancer (NSCLC) who received PBT of 74 GyE with concurrent chemotherapy between 2007 and 2017 were reviewed retrospectively. The correlation between dosimetry parameters obtain...
Source: Cell Research - January 2, 2023 Category: Cytology Authors: Masatoshi Nakamura Hitoshi Ishikawa Kayoko Ohnishi Yutarou Mori Keiichiro Baba Kensuke Nakazawa Toshihiro Shiozawa Ikuo Sekine Kazushi Maruo Toshiyuki Okumura Hideyuki Sakurai Source Type: research
Limitations of phase-sorting based pencil beam scanned 4D proton dose calculations under irregular motion
Phys Med Biol. 2022 Dec 26;68(1). doi: 10.1088/1361-6560/aca9b6.ABSTRACTObjective.4D dose calculation (4DDC) for pencil beam scanned (PBS) proton therapy is typically based on phase-sorting of individual pencil beams onto phases of a single breathing cycle 4DCT. Understanding the dosimetric limitations and uncertainties of this approach is essential, especially for the realistic treatment scenario with irregular free breathing motion.Approach.For three liver and three lung cancer patient CTs, the deformable multi-cycle motion from 4DMRIs was used to generate six synthetic 4DCT(MRI)s, providing irregular motion (11/15 cycle...
Source: Physics in Medicine and Biology - December 26, 2022 Category: Physics Authors: A Duetschler J Prendi S Safai D C Weber A J Lomax Ye Zhang Source Type: research
Limitations of phase-sorting based pencil beam scanned 4D proton dose calculations under irregular motion
Phys Med Biol. 2022 Dec 26;68(1). doi: 10.1088/1361-6560/aca9b6.ABSTRACTObjective.4D dose calculation (4DDC) for pencil beam scanned (PBS) proton therapy is typically based on phase-sorting of individual pencil beams onto phases of a single breathing cycle 4DCT. Understanding the dosimetric limitations and uncertainties of this approach is essential, especially for the realistic treatment scenario with irregular free breathing motion.Approach.For three liver and three lung cancer patient CTs, the deformable multi-cycle motion from 4DMRIs was used to generate six synthetic 4DCT(MRI)s, providing irregular motion (11/15 cycle...
Source: Physics in Medicine and Biology - December 26, 2022 Category: Physics Authors: A Duetschler J Prendi S Safai D C Weber A J Lomax Ye Zhang Source Type: research
Neurocognitive considerations in the treatment of meningioma with radiation therapy: applications for quantitative neuroimaging and precision radiation medicine
This article focuses on the role of radiotherapy in the management of meningioma, in the definitive and adjuvant setting and across the spectrum of meningioma grade. Treatment paradigms, informed by clinical evidence, are discussed. Notably, we focus on the impact of radiotherapy on normal brain tissues and neurocognitive function, particularly the dose-dependent changes in white matter and cerebral cortex thickness. Novel imaging techniques have allowed the identification of microstructural changes to eloquent white matter, cortex, and subcortical regions as biomarkers for understanding RT-induced changes in cognitive fun...
Source: Journal of Neuro-Oncology - December 26, 2022 Category: Cancer & Oncology Source Type: research
The relation between prediction model performance measures and patient selection outcomes for proton therapy in head and neck cancer
CONCLUSIONS: Each measure independently impacts ΔNTCP and patient selection and should thus be assessed in a representative sufficiently large external sample. Our suggested practical model selection approach is considering the model with the highest AUC, and recalibrating it if needed.PMID:36566991 | DOI:10.1016/j.radonc.2022.109449 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 25, 2022 Category: Radiology Authors: A M Leeuwenberg J B Reitsma L V D Bosch Jeroen Hoogland A V D Schaaf Frank J P Hoebers Oda B Wijers J A Langendijk K G M Moons E Schuit Source Type: research
The relation between prediction model performance measures and patient selection outcomes for proton therapy in head and neck cancer
CONCLUSIONS: Each measure independently impacts ΔNTCP and patient selection and should thus be assessed in a representative sufficiently large external sample. Our suggested practical model selection approach is considering the model with the highest AUC, and recalibrating it if needed.PMID:36566991 | DOI:10.1016/j.radonc.2022.109449 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 25, 2022 Category: Radiology Authors: A M Leeuwenberg J B Reitsma L V D Bosch Jeroen Hoogland A V D Schaaf Frank J P Hoebers Oda B Wijers J A Langendijk K G M Moons E Schuit Source Type: research
Proton Therapy in Canada: Towards Universal Access and Health Equity with a Publicly-Funded Facility
This article outlines the current state of access to PBT across Canadian provinces, domains of health inequities among those receiving PBT, and strategies for addressing health inequity in PBT, in the context of ongoing planning for a Canadian publicly funded facility. The lessons learned from the Canadian experience may be applicable to other jurisdictions seeking to improve fair, equitable access to PBT.PMID:36565727 | DOI:10.1016/j.ijrobp.2022.12.021 (Source: Health Physics)
Source: Health Physics - December 24, 2022 Category: Physics Authors: Amir H Safavi Carolyn Freeman Sylvia Cheng Samir Patel Gunita Mitera Vijayanada Kundapur Rob Rutledge Derek S Tsang Source Type: research
Proton Therapy in Canada: Towards Universal Access and Health Equity with a Publicly-Funded Facility
This article outlines the current state of access to PBT across Canadian provinces, domains of health inequities among those receiving PBT, and strategies for addressing health inequity in PBT, in the context of ongoing planning for a Canadian publicly funded facility. The lessons learned from the Canadian experience may be applicable to other jurisdictions seeking to improve fair, equitable access to PBT.PMID:36565727 | DOI:10.1016/j.ijrobp.2022.12.021 (Source: Health Physics)
Source: Health Physics - December 24, 2022 Category: Physics Authors: Amir H Safavi Carolyn Freeman Sylvia Cheng Samir Patel Gunita Mitera Vijayanada Kundapur Rob Rutledge Derek S Tsang Source Type: research
Comparison of out-of-field normal tissue dose estimates for pencil beam scanning proton therapy: MCNP6, PHITS, and TOPAS
Biomed Phys Eng Express. 2022 Dec 23;9(1). doi: 10.1088/2057-1976/acaab1.ABSTRACTMonte Carlo (MC) methods are considered the gold-standard approach to dose estimation for normal tissues outside the treatment field (out-of-field) in proton therapy. However, the physics of secondary particle production from high-energy protons are uncertain, particularly for secondary neutrons, due to challenges in performing accurate measurements. Instead, various physics models have been developed over the years to reenact these high-energy interactions based on theory. It should thus be acknowledged that MC users must currently accept som...
Source: Health Physics - December 23, 2022 Category: Physics Authors: Keith T Griffin Yeon Soo Yeom Matthew M Mille Choonik Lee Jae Won Jung Nolan E Hertel Choonsik Lee Source Type: research
