Proton Therapy Mediates Dose Reductions to Brain Structures Associated with Cognition in Children with Medulloblastoma
Background: Emerging evidence suggests proton radiotherapy may offer cognitive sparing advantages over photon radiotherapy, yet dosimetry has not been compared previously. The purpose of this study is to examine dosimetric correlates of cognitive outcomes in children with medulloblastoma treated with proton vs. photon radiotherapy.Methods: In this retrospective, bi-institutional study, dosimetric and cognitive data from 75 patients (39 photon and 36 proton) were analyzed. Doses to brain structures were compared between treatment modalities. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 29, 2023 Category: Radiology Authors: Julianna Sienna, Lisa S. Kahalley, Donald Mabbott, David Grosshans, Anna Theresa Santiago, Arnold dela Cruz Paulino, Thomas E. Merchant, Gohar S. Manzar, Hitesh Dama, David C. Hodgson, Murali Chintagumpala, Mehmet Fatih Okcu, William E. Whitehead, Normand Tags: Clinical Investigation Source Type: research
The Effective Radiation Dose to Immune Cells Predicts Lymphopenia and Inferior Cancer Control in Locally Advanced NSCLC
CONCLUSIONS: EDIC is associated with inferior disease outcomes and the development of severe lymphopenia. Proton therapy is associated with lower EDIC. Further investigations to limit radiation dose to the immune system appear warranted.PMID:38008414 | DOI:10.1016/j.radonc.2023.110030 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 26, 2023 Category: Radiology Authors: Cole Friedes Michelle Iocolano Sang Ho Lee Lian Duan Bolin Li Abigail Doucette Roger B Cohen Charu Aggarwal Lova L Sun William P Levin Keith A Cengel Gary Kao Boon-Keng Kevin Teo Corey J Langer Ying Xiao Jeffrey Bradley Steven J Feigenberg Nikhil Yegya-Ra Source Type: research
The Effective Radiation Dose to Immune Cells Predicts Lymphopenia and Inferior Cancer Control in Locally Advanced NSCLC
CONCLUSIONS: EDIC is associated with inferior disease outcomes and the development of severe lymphopenia. Proton therapy is associated with lower EDIC. Further investigations to limit radiation dose to the immune system appear warranted.PMID:38008414 | DOI:10.1016/j.radonc.2023.110030 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 26, 2023 Category: Radiology Authors: Cole Friedes Michelle Iocolano Sang Ho Lee Lian Duan Bolin Li Abigail Doucette Roger B Cohen Charu Aggarwal Lova L Sun William P Levin Keith A Cengel Gary Kao Boon-Keng Kevin Teo Corey J Langer Ying Xiao Jeffrey Bradley Steven J Feigenberg Nikhil Yegya-Ra Source Type: research
The Effective Radiation Dose to Immune Cells Predicts Lymphopenia and Inferior Cancer Control in Locally Advanced NSCLC
CONCLUSIONS: EDIC is associated with inferior disease outcomes and the development of severe lymphopenia. Proton therapy is associated with lower EDIC. Further investigations to limit radiation dose to the immune system appear warranted.PMID:38008414 | DOI:10.1016/j.radonc.2023.110030 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 26, 2023 Category: Radiology Authors: Cole Friedes Michelle Iocolano Sang Ho Lee Lian Duan Bolin Li Abigail Doucette Roger B Cohen Charu Aggarwal Lova L Sun William P Levin Keith A Cengel Gary Kao Boon-Keng Kevin Teo Corey J Langer Ying Xiao Jeffrey Bradley Steven J Feigenberg Nikhil Yegya-Ra Source Type: research
Cancers, Vol. 15, Pages 5579: Five-Fraction Proton Therapy for the Treatment of Skull Base Chordomas and Chondrosarcomas: Early Results of a Prospective Series and Description of a Clinical Trial
Conclusions: Hypofractionated proton therapy is showing encouraging preliminary results. However, to fully assess the efficacy of this therapeutic approach, future trials with adequate sample sizes and extended follow-ups are necessary. (Source: Cancers)
Source: Cancers - November 25, 2023 Category: Cancer & Oncology Authors: Morena Sallabanda Juan Antonio Vera Juan Mar ía Pérez Ra úl Matute Marta Montero Ana de Pablo Fernando Cerr ón Mireia Valero Juan Castro Alejandro Mazal Raymond Miralbell Tags: Article Source Type: research
Predicting the impact of proton beam therapy technology on pulmonary toxicities for locally advanced lung cancer patients enrolled on the Proton Collaborative Group prospective clinical trial
CONCLUSION: In the largest analysis of prospectively enrolled patients with lung cancer assessing pulmonary toxicities from proton therapy to date, advanced machine learning methods have identified that PBS, abdominal compression, and lower normal lung doses can lead to significantly lower probability of developing grade ≥2 pneumonitis or dyspnea.PMID:38000701 | DOI:10.1016/j.ijrobp.2023.11.026 (Source: Health Physics)
Source: Health Physics - November 24, 2023 Category: Physics Authors: Gilmer Valdes Jessica Scholey Tomi Nano Efstathios D Gennatas Pranshu Mohindra Nasir Mohammed Jing Zeng Rupesh D Kotesha Lane R Rosen John Chang Henry K Tsai James J Urbanic Carlos E Vargas Nathan Y Yu Lyle H Ungar Eric Eaton Charles B Simone Source Type: research
Proton and photon radiotherapy in stage III NSCLC: effects on hematological toxicity and adjuvant immune therapy
CONCLUSION: IMPT was associated with a lower incidence of severe lymphopenia and anemia, better PS after CCRT and a higher probability of receiving adjuvant durvalumab.PMID:38000689 | DOI:10.1016/j.radonc.2023.110019 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 24, 2023 Category: Radiology Authors: Francesco Cortiula Lizza E L Hendriks Robin Wijsman Ruud Houben Michelle Steens Sarah Debakker Richard Canters Marco Trovo Nanna M Sijtsema Anne G H Niezink Mirko Unipan Susanna Urban Anna Michelotti Safiye Dursun Gerben Bootsma Djoya Hattu Joost J Nuytte Source Type: research
Predicting the impact of proton beam therapy technology on pulmonary toxicities for locally advanced lung cancer patients enrolled on the Proton Collaborative Group prospective clinical trial
CONCLUSION: In the largest analysis of prospectively enrolled patients with lung cancer assessing pulmonary toxicities from proton therapy to date, advanced machine learning methods have identified that PBS, abdominal compression, and lower normal lung doses can lead to significantly lower probability of developing grade ≥2 pneumonitis or dyspnea.PMID:38000701 | DOI:10.1016/j.ijrobp.2023.11.026 (Source: Health Physics)
Source: Health Physics - November 24, 2023 Category: Physics Authors: Gilmer Valdes Jessica Scholey Tomi Nano Efstathios D Gennatas Pranshu Mohindra Nasir Mohammed Jing Zeng Rupesh D Kotesha Lane R Rosen John Chang Henry K Tsai James J Urbanic Carlos E Vargas Nathan Y Yu Lyle H Ungar Eric Eaton Charles B Simone Source Type: research
Single energy CT-based mass density and relative stopping power estimation for proton therapy using deep learning method
ConclusionThe results show that deep learning neural networks have the potential to generate accurate voxel-specific material property information, which can be used to improve the accuracy of proton dose calculation.Advances in knowledgeDeep learning-based frameworks are proposed to estimate material mass density and RSP from SECT with improved accuracy compared with conventional methods. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - November 23, 2023 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 15, Pages 5545: More than Five Decades of Proton Therapy: A Bibliometric Overview of the Scientific Literature
Conclusions: The results of the present bibliometric analysis showed that PT is an active and rapidly increasing field of research. Themes of the published works encompass the main aspects of its application in clinical practice, such as the comparison with the actual photon-based standard of care technique and the continuing technological advances. This analysis gives an overview of past scientific production and, most importantly, provides a useful point of view on the future directions of the research activities. (Source: Cancers)
Source: Cancers - November 23, 2023 Category: Cancer & Oncology Authors: Maria Giulia Vincini Mattia Zaffaroni Marco Schwarz Giulia Marvaso Federico Mastroleo Stefania Volpe Luca Bergamaschi Giovanni Carlo Mazzola Giulia Corrao Roberto Orecchia Barbara Alicja Jereczek-Fossa Daniela Alterio Tags: Article Source Type: research
Dosimetric comparison of magnetic resonance-guided radiation therapy, intensity-modulated proton therapy and volumetric-modulated arc therapy for distal esophageal cancer
Advances in radiotherapy (RT) technologies permit significant decreases in the dose delivered to organs at risk (OARs) for patients with esophageal cancer (EC). Novel RT modalities such as proton beam therapy (PBT) and magnetic resonance-guided radiotherapy (MRgRT), as well as motion management techniques including breath hold (BH) are expected to further improve the therapeutic ratio. However, to our knowledge, the dosimetric benefits of PBT vs MRgRT vs volumetric-modulated arc therapy (VMAT) have not been directly compared for EC. (Source: Medical Dosimetry)
Source: Medical Dosimetry - November 23, 2023 Category: Radiology Authors: Andrew R. Barsky, Jerry George, Andrew J. Wroe, Kathryn E. Mittauer, Adeel Kaiser, Roberto Herrera, Jen Yu, Alonso N. Gutierrez, Diane Alvarez, James McCulloch, Michael E. Kasper, Minesh P. Mehta, Michael D. Chuong Tags: Research Article Source Type: research
Visual outcome and ocular complications in patients with lacrimal gland carcinoma after eye-sparing surgery and adjuvant radiation therapy
Conclusion
Eye-sparing surgery followed by adjuvant radiotherapy in patients with lacrimal gland carcinoma has a reasonable overall visual prognosis. Patients with tumours crossing the orbital midline and Hispanic patients have a higher risk of severe vision loss. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 22, 2023 Category: Opthalmology Authors: Zhao, Z., Frank, S. J., Ning, J., Zhao, J., Jiang, X., Wang, X. A., Schefler, A. C., Hanna, E., Moreno, A., Gunn, B., Ferrarotto, R., Esmaeli, B. Tags: Original articles - Clinical science Source Type: research
Incorporating variable RBE in IMPT optimization for ependymoma
CONCLUSION: We demonstrated the feasibility of directly incorporating variable RBE models in IMPT optimization. A hybrid RBE optimization strategy showed potential for clinical implementation by maintaining all current dose limits and reducing the incidence of high RBE in critical normal tissues in ependymoma patients.PMID:37985962 | DOI:10.1002/acm2.14207 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - November 21, 2023 Category: Physics Authors: Hadis Moazami Goudarzi Gino Lim David Grosshans Radhe Mohan Wenhua Cao Source Type: research
