A multicenter high-quality data registry for advanced proton therapy approaches: the POWER registry
Paucity and low evidence-level data on proton therapy (PT) represent one of the main issues for the establishment of solid indications in the PT setting. Aim of the present registry, the POWER registry, is to pro... (Source: BMC Cancer)
Source: BMC Cancer - March 12, 2024 Category: Cancer & Oncology Authors: Daniela Alterio, Maria Giulia Vincini, Stefania Volpe, Luca Bergamaschi, Mattia Zaffaroni, Sara Gandini, Giulia Peruzzotti, Federica Cattani, Cristina Garibaldi, Barbara Alicja Jereczek-Fossa and Roberto Orecchia Tags: Study Protocol Source Type: research
Early effects of different brain radiotherapy modalities on circulating leucocyte subpopulations in rodents
CONCLUSIONS: Leucocyte subpopulations reacted differently to X-ray or proton brain irradiation. This difference could be partly explained by LN exposure to radiation dose. Further researches and analyses on other biological processes and interactions between leucocyte subpopulations are ongoing. The various mechanisms underlying leucocyte subpopulation changes under different irradiation modalities may have implications for the choice of radiotherapy modalities and their combination with immunotherapy in brain cancer treatment.PMID:38466699 | DOI:10.1080/09553002.2024.2324471 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 11, 2024 Category: Radiology Authors: Thao-Nguyen Pham Julie Coupey J érôme Toutain Serge M Cand éias Ga ël Simonin Marc Rousseau Omar Touzani Juliette Thariat Samuel Valable Source Type: research
Comparing interplay effects in scanned proton therapy of lung cancer: Free breathing with various layer and volume rescanning versus respiratory gating with different gate widths
CONCLUSIONS: FB (L4V1) is the most efficient treatment, but not necessarily the optimal choice due to interplay effects. To satisfy both TT extensions and interplay, RG with a gate width as large as possible within safety limits is desirable.PMID:38461635 | DOI:10.1016/j.ejmp.2024.103323 (Source: Health Physics)
Source: Health Physics - March 10, 2024 Category: Physics Authors: Yuki Tominaga Masaki Suga Mikuni Takeda Yuki Yamamoto Takashi Akagi Takahiro Kato Sunao Tokumaru Michinori Yamamoto Masataka Oita Source Type: research
Comparing interplay effects in scanned proton therapy of lung cancer: Free breathing with various layer and volume rescanning versus respiratory gating with different gate widths
Pencil beam scanning (PBS) proton therapy significantly reduces the dose to normal tissue while maintaining uniform target coverage compared with passive scattering and intensity-modulated radiotherapy [1,2]. However, an active scanning beam for a moving tumor suffers from interplay effects [3]. A previous report showed that PBS plans with a commercial treatment planning system (TPS) do not consider interplay effects and may result in reduced target coverage and overdose to organs-at-risk (OARs) during actual irradiation [4]. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - March 9, 2024 Category: General Medicine Authors: Yuki Tominaga, Masaki Suga, Mikuni Takeda, Yuki Yamamoto, Takashi Akagi, Takahiro Kato, Sunao Tokumaru, Michinori Yamamoto, Masataka Oita Source Type: research
Proton therapy induces a local microglial neuroimmune response
CONCLUSION: Overall, our data indicate that the brain responds in a similar manner to photons and plateau protons with a shared local upregulation of microglial priming-associated genes, potentially enhancing the immune response to subsequent inflammatory challenges.PMID:38453539 | DOI:10.1016/j.radonc.2024.110117 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 7, 2024 Category: Radiology Authors: Dani ëlle C Voshart Myrthe Klaver Yuting Jiang Hilmar R J van Weering Fleur van Buuren-Broek Gideon P van der Linden Davide Cinat Harry H Kiewiet Justin Malimban Daniel A Vazquez-Matias Luiza Reali Nazario Ayla C Scholma Jeffrey Sewdihal Marc-Jan van Goe Source Type: research
Proton therapy induces a local microglial neuroimmune response
CONCLUSION: Overall, our data indicate that the brain responds in a similar manner to photons and plateau protons with a shared local upregulation of microglial priming-associated genes, potentially enhancing the immune response to subsequent inflammatory challenges.PMID:38453539 | DOI:10.1016/j.radonc.2024.110117 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 7, 2024 Category: Radiology Authors: Dani ëlle C Voshart Myrthe Klaver Yuting Jiang Hilmar R J van Weering Fleur van Buuren-Broek Gideon P van der Linden Davide Cinat Harry H Kiewiet Justin Malimban Daniel A Vazquez-Matias Luiza Reali Nazario Ayla C Scholma Jeffrey Sewdihal Marc-Jan van Goe Source Type: research
Proton therapy induces a local microglial neuroimmune response
Neurocognitive sequelae are the leading cause of a reduced quality of life in paediatric and adult primary brain and central nervous system tumour patients [1]. In addition, patients with brain metastases also experience debilitating neurocognitive impairment [2]. Although radiotherapy is an integral part of the treatment of brain tumours, it is associated with the development of neurocognitive side effects due to the co-irradiation of normal brain tissue [3]. Despite the introduction of 3D conformal radiotherapy and intensity-modulated radiotherapy, preventing or minimising radiotherapy-induced neurocognitive sequelae rem...
Source: Radiotherapy and Oncology - March 6, 2024 Category: Radiology Authors: Dani ëlle C. Voshart, Myrthe Klaver, Yuting Jiang, Hilmar R.J. van Weering, Fleur van Buuren-Broek, Gideon P. van der Linden, Davide Cinat, Harry H. Kiewiet, Justin Malimban, Daniel A. Vazquez-Matias, Luiza Reali Nazario, Ayla C. Scholma, Jeffrey Sewdiha Tags: Original Article Source Type: research
