Multimodal Imaging-based material mass density estimation for Proton therapy using supervised deep learning
CONCLUSIONS: The proposed PDMI framework can generate accurate mass density maps using MRI and DECT images. The supervised learning can further enhance model efficacy, making PRN-MR-DE outperform RN-MR-DE. The patient investigation also shows that the framework can potentially improve proton range uncertainty with accurate patient mass density maps.ADVANCES IN KNOWLEDGE: PDMI framework is proposed for the first time to inform DL models by physics insights and leverage the information from MRI to derive accurate mass density maps.PMID:37660372 | DOI:10.1259/bjr.20220907 (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 3, 2023 Category: Radiology Authors: Chih-Wei Chang Raanan Marants Yuan Gao Matthew Goette Jessica E Scholey Jeffrey D Bradley Tian Liu Jun Zhou Atchar Sudhyadhom Xiaofeng Yang Source Type: research
Modelling the influence of radiosensitivity on development of second primary cancer in out-of-field organs following proton therapy for paediatric cranial cancer
CONCLUSION: Breast tissue exhibited the highest susceptibility in calculated LAR risk, demonstrating the importance for accurate data input when estimating LAR of SPC.ADVANCES IN KNOWLEDGE: The findings of this study demonstrated younger female patients undergoing cranial proton therapy have a higher risk of developing second primary cancer of the breast tissue. Long-term multicenter registries are important to improve predictive radiobiological modelling studies of side effects.PMID:37660473 | DOI:10.1259/bjr.20230161 (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - September 3, 2023 Category: Radiology Authors: Mikaela Dell'Oro Puthenparampil Wilson Michala Short Dylan Peukert Eva Bezak Source Type: research
From protons to Picasso: recreating famous paintings using proton beams as a “Paintbrush”
In pencil-beam-scanning proton therapy, the dose is painted spot-by-spot, layer-by-layer, allowing for significantly more control compared to conventional radiation. This work intends to showcase the impressive ability of intensity-modulated proton therapy (IMPT) to shape complex dose distributions by recreating some of history's most renowned artworks as treatment plans. Five (5) well-recognized paintings were recreated in our clinical treatment planning system using a water phantom as a “canvas” and radiation dose as “paint.” For each “painting,” colors were assigned to various isodose levels, and the treatme...
Source: Medical Dosimetry - September 2, 2023 Category: Radiology Authors: Lee Xu Source Type: research
Risk of second primary cancer from proton arc therapy of pediatric brain tumors
This study therefore aimed at evaluating the risk of radiation-induced second primary cancer (SPC) for PAT in pediatric brain tumor patients. Two brain-specific models for SPC induction were applied in five cases to compare volumetric modulated arc therapy (VMAT), intensity modulated proton therapy (IMPT) and PAT surrogate plans. The PAT integral dose was reduced by a median of 29% compared to VMAT, and 17% compared to IMPT. For both models, the estimated SPC risks were consistently the lowest for PAT.PMID:37655121 | PMC:PMC10465935 | DOI:10.1016/j.phro.2023.100480 (Source: Health Physics)
Source: Health Physics - September 1, 2023 Category: Physics Authors: Laura Toussaint Daniel J Indelicato Ludvig P Muren Camilla H Stokkev åg Source Type: research
Risk of second primary cancer from proton arc therapy of pediatric brain tumors
This study therefore aimed at evaluating the risk of radiation-induced second primary cancer (SPC) for PAT in pediatric brain tumor patients. Two brain-specific models for SPC induction were applied in five cases to compare volumetric modulated arc therapy (VMAT), intensity modulated proton therapy (IMPT) and PAT surrogate plans. The PAT integral dose was reduced by a median of 29% compared to VMAT, and 17% compared to IMPT. For both models, the estimated SPC risks were consistently the lowest for PAT.PMID:37655121 | PMC:PMC10465935 | DOI:10.1016/j.phro.2023.100480 (Source: Health Physics)
Source: Health Physics - September 1, 2023 Category: Physics Authors: Laura Toussaint Daniel J Indelicato Ludvig P Muren Camilla H Stokkev åg Source Type: research
Uncertainty-aware spot rejection rate as quality metric for proton therapy using a digital tracking calorimeter
This study introduces a novel metric for proton therapy quality control based on uncertainties in range verification of individual spots.
Approach.We employ uncertainty-aware deep neural networks to predict the Bragg peak depth in an anthropomorphic phantom based on secondary charged particle detection in a silicon pixel telescope designed for proton computed tomography. The subsequently predicted Bragg peak positions, along with their uncertainties, are compared to the treatment plan, rejecting spots which are predicted to be outside the 95% confidence interval. The such-produced spot rejection rate presents a met...
Source: Physics in Medicine and Biology - August 31, 2023 Category: Physics Authors: Alexander Schilling Max Aehle Johan Alme Gergely G ábor Barnaföldi Tea Bodova Viatcheslav Borshchov Anthony van den Brink Viljar Nilsen Eikeland Grigori Feofilov Christoph Garth Nicolas R Gauger Ola Slettevoll Gr øttvik Haavard Helstrup Sergey Igolkin Source Type: research
Exploring beamline momentum acceptance for tracking respiratory variability in lung cancer proton therapy: a simulation study
Phys Med Biol. 2023 Aug 31. doi: 10.1088/1361-6560/acf5c4. Online ahead of print.ABSTRACTObjective
Investigating the aspects of proton beam delivery to track organ motion with pencil beam scanning therapy. Considering current systems as a reference, specify requirements for next-generation units aiming at real-time image-guided treatments. 
Approach
Proton treatments for six non-small cell lung cancer (NSCLC) patients were simulated using repeated 4DCTs to model respiratory motion variability. Energy corrections required for this treatment site were evaluated for different approaches to tumour track...
Source: Physics in Medicine and Biology - August 31, 2023 Category: Physics Authors: Anna Chiara Giovannelli Andreas K öthe Sairos Safai David Meer Ye Zhang Damien Charles Weber Antony John Lomax Giovanni Fattori Source Type: research
Exploring beamline momentum acceptance for tracking respiratory variability in lung cancer proton therapy: a simulation study
Phys Med Biol. 2023 Aug 31. doi: 10.1088/1361-6560/acf5c4. Online ahead of print.ABSTRACTObjective
Investigating the aspects of proton beam delivery to track organ motion with pencil beam scanning therapy. Considering current systems as a reference, specify requirements for next-generation units aiming at real-time image-guided treatments. 
Approach
Proton treatments for six non-small cell lung cancer (NSCLC) patients were simulated using repeated 4DCTs to model respiratory motion variability. Energy corrections required for this treatment site were evaluated for different approaches to tumour track...
Source: Physics in Medicine and Biology - August 31, 2023 Category: Physics Authors: Anna Chiara Giovannelli Andreas K öthe Sairos Safai David Meer Ye Zhang Damien Charles Weber Antony John Lomax Giovanni Fattori Source Type: research
Uncertainty-aware spot rejection rate as quality metric for proton therapy using a digital tracking calorimeter
This study introduces a novel metric for proton therapy quality control based on uncertainties in range verification of individual spots.
Approach.We employ uncertainty-aware deep neural networks to predict the Bragg peak depth in an anthropomorphic phantom based on secondary charged particle detection in a silicon pixel telescope designed for proton computed tomography. The subsequently predicted Bragg peak positions, along with their uncertainties, are compared to the treatment plan, rejecting spots which are predicted to be outside the 95% confidence interval. The such-produced spot rejection rate presents a met...
Source: Physics in Medicine and Biology - August 31, 2023 Category: Physics Authors: Alexander Schilling Max Aehle Johan Alme Gergely G ábor Barnaföldi Tea Bodova Viatcheslav Borshchov Anthony van den Brink Viljar Nilsen Eikeland Grigori Feofilov Christoph Garth Nicolas R Gauger Ola Slettevoll Gr øttvik Haavard Helstrup Sergey Igolkin Source Type: research
Uncertainty-aware spot rejection rate as quality metric for proton therapy using a digital tracking calorimeter
This study introduces a novel metric for proton therapy quality control based on uncertainties in range verification of individual spots.
Approach.We employ uncertainty-aware deep neural networks to predict the Bragg peak depth in an anthropomorphic phantom based on secondary charged particle detection in a silicon pixel telescope designed for proton computed tomography. The subsequently predicted Bragg peak positions, along with their uncertainties, are compared to the treatment plan, rejecting spots which are predicted to be outside the 95% confidence interval. The such-produced spot rejection rate presents a met...
Source: Physics in Medicine and Biology - August 31, 2023 Category: Physics Authors: Alexander Schilling Max Aehle Johan Alme Gergely G ábor Barnaföldi Tea Bodova Viatcheslav Borshchov Anthony van den Brink Viljar Nilsen Eikeland Grigori Feofilov Christoph Garth Nicolas R Gauger Ola Slettevoll Gr øttvik Haavard Helstrup Sergey Igolkin Source Type: research
Exploring beamline momentum acceptance for tracking respiratory variability in lung cancer proton therapy: a simulation study
Phys Med Biol. 2023 Aug 31. doi: 10.1088/1361-6560/acf5c4. Online ahead of print.ABSTRACTObjective
Investigating the aspects of proton beam delivery to track organ motion with pencil beam scanning therapy. Considering current systems as a reference, specify requirements for next-generation units aiming at real-time image-guided treatments. 
Approach
Proton treatments for six non-small cell lung cancer (NSCLC) patients were simulated using repeated 4DCTs to model respiratory motion variability. Energy corrections required for this treatment site were evaluated for different approaches to tumour track...
Source: Physics in Medicine and Biology - August 31, 2023 Category: Physics Authors: Anna Chiara Giovannelli Andreas K öthe Sairos Safai David Meer Ye Zhang Damien Charles Weber Antony John Lomax Giovanni Fattori Source Type: research
High energy proton therapy for extraocular tumors, neurotrophic keratitis and functional consequence: A series of 3 cases
CONCLUSION: Further studies to establish the impact of proton therapy on corneal sensitivity are necessary. However, this feedback and the multidisciplinary management of tumors can help to limit the risk of some complications of radiation therapy. Early diagnosis allows for appropriate management and could possibly minimize the anatomical and functional ocular complications of neurotrophic keratitis.PMID:37625997 | DOI:10.1016/j.jfo.2023.02.023 (Source: Journal Francais d Ophtalmologie)
Source: Journal Francais d Ophtalmologie - August 25, 2023 Category: Opthalmology Authors: F Lebrun P-A Marty J-C Quintyn J Thariat H Bailleul Source Type: research
Cancers, Vol. 15, Pages 4268: A Systematic Review of LET-Guided Treatment Plan Optimisation in Proton Therapy: Identifying the Current State and Future Needs
a Bezak
The well-known clinical benefits of proton therapy are achieved through higher target-conformality and normal tissue sparing than conventional radiotherapy. However, there is an increased sensitivity to uncertainties in patient motion/setup, proton range and radiobiological effect. Although recent efforts have mitigated some uncertainties, radiobiological effect remains unresolved due to a lack of clinical data for relevant endpoints. Therefore, RBE optimisations may be currently unsuitable for clinical treatment planning. LET optimisation is a novel method that substitutes RBE with LET, shifting LET hotspots o...
Source: Cancers - August 25, 2023 Category: Cancer & Oncology Authors: Melissa McIntyre Puthenparampil Wilson Peter Gorayski Eva Bezak Tags: Systematic Review Source Type: research
Cancers, Vol. 15, Pages 4269: Proton Therapy in the Adolescent and Young Adult Population
Conclusion: This report highlights the potential utility of proton beam radiation for certain adolescent young adult cancers, especially with reducing radiation doses to organs at risk and thereby potentially lowering risks of certain treatment-associated toxicities. (Source: Cancers)
Source: Cancers - August 25, 2023 Category: Cancer & Oncology Authors: Safia K. Ahmed Sameer R. Keole Tags: Review Source Type: research
