Proton Therapy in the Treatment of Men with Breast Cancer
CONCLUSION: In a small case series for a rare diagnosis, PT to the chest wall and regional lymphatics, including internal mammary nodes, resulted in low cardiac exposure, high local regional disease control rates, and minimal toxicity. Proton therapy should be considered for treating men with breast cancer to achieve cardiac sparing.PMID:38075485 | PMC:PMC10698632 | DOI:10.14338/IJPT-23-00007.1 (Source: Cancer Control)
Source: Cancer Control - December 11, 2023 Category: Cancer & Oncology Authors: Julie A Bradley Jayden Gracie Raymond B Mailhot Vega Eric D Brooks Tenna Burchianti Oluwadamilola T Oladeru Xiaoying Liang Nancy P Mendenhall Source Type: research
FLASH radiotherapy sparing effect on the circulating lymphocytes in pencil beam scanning proton therapy: impact of hypofractionation and dose rate
Conclusion: Our dosimetric blood flow model provides quantitative measures of the PBS FLASH sparing effect on the CL in radiotherapy for brain cancer. FLASH Single treatment fraction offers superior CL sparing when compared to hypofractionated FLASH and conventional IMPT, supporting assumptions about reducing risks of lymphopenia compared to proton therapy at conventional dose rates. The results also indicate that faster conformal FLASH delivery, such as passive patient-specific energy modulation, may further enhance the sparing of the immune system.
.PMID:38081067 | DOI:10.1088/1361-6560/ad144e (Source: Physics in ...
Source: Physics in Medicine and Biology - December 11, 2023 Category: Physics Authors: Antje Galts Abdelkhalek Hammi Source Type: research
Single energy CT-based mass density and relative stopping power estimation for proton therapy using deep learning method
CONCLUSION: The results show that deep learning neural networks have the potential to generate accurate voxel-specific material property information, which can be used to improve the accuracy of proton dose calculation.ADVANCES IN KNOWLEDGE: Deep learning-based frameworks are proposed to estimate material mass density and RSP from SECT with improved accuracy compared with conventional methods.PMID:38074686 | PMC:PMC10702508 | DOI:10.3389/fonc.2023.1278180 (Source: Ann Oncol)
Source: Ann Oncol - December 11, 2023 Category: Cancer & Oncology Authors: Yuan Gao Chih-Wei Chang Justin Roper Marian Axente Yang Lei Shaoyan Pan Jeffrey D Bradley Jun Zhou Tian Liu Xiaofeng Yang Source Type: research
FLASH radiotherapy sparing effect on the circulating lymphocytes in pencil beam scanning proton therapy: impact of hypofractionation and dose rate
Conclusion: Our dosimetric blood flow model provides quantitative measures of the PBS FLASH sparing effect on the CL in radiotherapy for brain cancer. FLASH Single treatment fraction offers superior CL sparing when compared to hypofractionated FLASH and conventional IMPT, supporting assumptions about reducing risks of lymphopenia compared to proton therapy at conventional dose rates. The results also indicate that faster conformal FLASH delivery, such as passive patient-specific energy modulation, may further enhance the sparing of the immune system.
.PMID:38081067 | DOI:10.1088/1361-6560/ad144e (Source: Physics in ...
Source: Physics in Medicine and Biology - December 11, 2023 Category: Physics Authors: Antje Galts Abdelkhalek Hammi Source Type: research
Dosimetric evaluation of dose shaping by adaptive aperture and its impact on plan quality
Mevion's single-room HYPERSCAN proton therapy system employs a proton multileaf collimator called the adaptive aperture (AA), which collimates individual spots in the proton delivery as determined by the Treatment Planning System (TPS). The purpose of this study is to assess the dosimetric benefits of the AA, specifically in the dynamic aperture (DA) mode, and evaluate its impact on proton treatment plan quality as compared to a traditional pencil beam scanning (PBS) system (Varian ProBeam). The spot dose distributions with dynamic collimation (DA), a unique AA shape for each energy layer, and with static collimation (SA),...
Source: Medical Dosimetry - December 11, 2023 Category: Radiology Authors: Aaron Silvus, Jonathan Haefner, Michael B. Altman, Tianyu Zhao, Stephanie Perkins, Tiezhi Zhang Source Type: research
Development of a standalone delivery sequence model for proton arc therapy
CONCLUSIONS: The first model of dynamic arc therapy is established in this study through an independent experimental approach using logfiles and measurements which allows clinical users and investigators to simulate the dynamic treatment delivery and assess the daily treatment throughput improvement.PMID:38064634 | DOI:10.1002/mp.16879 (Source: Health Physics)
Source: Health Physics - December 8, 2023 Category: Physics Authors: Gang Liu Lewei Zhao Peilin Liu Di Yan Rohan Deraniyagala Craig Stevens Xiaoqiang Li Xuanfeng Ding Source Type: research
Cancers, Vol. 15, Pages 5722: Proton Reirradiation for High-Risk Recurrent or New Primary Breast Cancer
Isabelle Choi
Radiotherapy is an integral component of multidisciplinary breast cancer care. Given how commonly radiotherapy is used in the treatment of breast cancer, many patients with recurrences have received previous radiotherapy. Patients with new primary breast cancer may also have received previous radiotherapy to the thoracic region. Curative doses and comprehensive field photon reirradiation (reRT) have often been avoided in these patients due to concerns for severe toxicities to organs-at-risk (OARs), such as the heart, lungs, brachial plexus, and soft tissue. However, many patients may benefit from definiti...
Source: Cancers - December 6, 2023 Category: Cancer & Oncology Authors: Molly A. Chakraborty Atif J. Khan Oren Cahlon Amy J. Xu Lior Z. Braunstein Simon N. Powell J. Isabelle Choi Tags: Review Source Type: research
Evaluation of Monte Carlo to support commissioning of the treatment planning system of new pencil beam scanning proton therapy facilities
Phys Med Biol. 2023 Dec 5. doi: 10.1088/1361-6560/ad1272. Online ahead of print.ABSTRACTTo demonstrate the potential of Monte Carlo (MC) to support the resource-intensive measurements that comprise the commissioning of the treatment planning system (TPS) of new proton therapy facilities.

Approach: Beam models of a pencil beam scanning system (Varian ProBeam) were developed in GATE (v8.2), Eclipse proton convolution superposition algorithm (v16.1, Varian Medical Systems) and RayStation MC (v12.0.100.0, RaySearch Laboratories), using the beam commissioning data. All models were first benchmarked against the ...
Source: Physics in Medicine and Biology - December 5, 2023 Category: Physics Authors: Daniela Botnariuc Steven Court Ana Louren ço Andrew Gosling Gary J Royle Mohammad Hussein Vasilis Rompokos Catarina Veiga Source Type: research
The Pediatric Proton and Photon Therapy Comparison Cohort: Study Design for a Multicenter Retrospective Cohort to Investigate Subsequent Cancers After Pediatric Radiation Therapy
CONCLUSIONS: Our findings will affect clinical practice for pediatric patients with cancer by providing the first large-scale systematic comparison of the risk of subsequent cancers from proton compared with photon therapy.PMID:38047226 | PMC:PMC10692298 | DOI:10.1016/j.adro.2023.101273 (Source: Adv Data)
Source: Adv Data - December 4, 2023 Category: Epidemiology Authors: Amy Berrington de Gonz ález Todd M Gibson Choonsik Lee Paul S Albert Keith T Griffin Cari Meinhold Kitahara Danping Liu Matthew M Mille Jungwook Shin Benjamin V M Bajaj Tristin E Flood Sara L Gallotto Harald Paganetti Safia K Ahmed Bree R Eaton Daniel J Source Type: research
Cancers, Vol. 15, Pages 5698: Comparison of the Effectiveness of Radiotherapy with 3D-CRT, IMRT, VMAT and PT for Newly Diagnosed Glioblastoma: A Bayesian Network Meta-Analysis
Conclusion: Our findings suggested PT as a standard RT regime with possibly superior survival outcomes for selected patients with GBM. (Source: Cancers)
Source: Cancers - December 3, 2023 Category: Cancer & Oncology Authors: Shan Xu Rezarta Frakulli Yilan Lin Tags: Article Source Type: research
Proton Therapy Mediates Dose Reductions to Brain Structures Associated with Cognition in Children with Medulloblastoma
CONCLUSIONS: Proton therapy reduces doses to normal brain structures as compared with photon treatment. This leads to reduced cognitive decline post-RT across multiple intellectual endpoints. Proton therapy should be offered to children receiving radiation for medulloblastoma.PMID:38040059 | DOI:10.1016/j.ijrobp.2023.11.035 (Source: Health Physics)
Source: Health Physics - December 1, 2023 Category: Physics Authors: Julianna Sienna Lisa S Kahalley Donald Mabbott David Grosshans Anna Theresa Santiago Arnold Dela Cruz Paulino Thomas E Merchant Gohar S Manzar Hitesh Dama David C Hodgson Murali Chintagumpala Mehmet Fatih Okcu William E Whitehead Normand Laperriere Vijay Source Type: research
Proton Therapy Mediates Dose Reductions to Brain Structures Associated with Cognition in Children with Medulloblastoma
CONCLUSIONS: Proton therapy reduces doses to normal brain structures as compared with photon treatment. This leads to reduced cognitive decline post-RT across multiple intellectual endpoints. Proton therapy should be offered to children receiving radiation for medulloblastoma.PMID:38040059 | DOI:10.1016/j.ijrobp.2023.11.035 (Source: Health Physics)
Source: Health Physics - December 1, 2023 Category: Physics Authors: Julianna Sienna Lisa S Kahalley Donald Mabbott David Grosshans Anna Theresa Santiago Arnold Dela Cruz Paulino Thomas E Merchant Gohar S Manzar Hitesh Dama David C Hodgson Murali Chintagumpala Mehmet Fatih Okcu William E Whitehead Normand Laperriere Vijay Source Type: research
A Systematic Review of the Economic Burden of Proton Therapy in Head and Neck Cancer
CONCLUSION: Our systematic review showed that appropriate patient selection can make PBT cost-effective. HPV-associated tumors can be cost-effectively treated with PBT. From the payer's perspective, PBT is a cost-effective treatment option. In younger patients, PBT can result in lesser incidence of adverse effects, and hence, can reduce the subsequent need for long-term supportive care. Lower fractionation schedules can also make PBT a cost-effective treatment.PMID:38019221 | DOI:10.31557/APJCP.2023.24.11.3643 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - November 29, 2023 Category: Cancer & Oncology Authors: Poovizhi Bharathi R Athiyamaan Ms Ashwin Kamath Source Type: research
