A stopping criterion for iterative proton CT image reconstruction based on correlated noise properties
CONCLUSIONS: Iterative algorithms not using a specific metric or rationale for stopping iterations may produce images with an unknown and arbitrary level of convergence or smoothing. We resolve this issue by stopping iterations of a least-squares iterative algorithm when r reaches the range of 0.5-1. This defines a pCT image reconstruction method with consistent statistical properties optimal for clinical use, including for treatment planning with pCT images.PMID:37573575 | DOI:10.1002/acm2.14114 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - August 13, 2023 Category: Physics Authors: Ethan A DeJongh Alexander A Pryanichnikov Don F DeJongh Reinhard W Schulte Source Type: research
A stopping criterion for iterative proton CT image reconstruction based on correlated noise properties
CONCLUSIONS: Iterative algorithms not using a specific metric or rationale for stopping iterations may produce images with an unknown and arbitrary level of convergence or smoothing. We resolve this issue by stopping iterations of a least-squares iterative algorithm when r reaches the range of 0.5-1. This defines a pCT image reconstruction method with consistent statistical properties optimal for clinical use, including for treatment planning with pCT images.PMID:37573575 | DOI:10.1002/acm2.14114 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - August 13, 2023 Category: Physics Authors: Ethan A DeJongh Alexander A Pryanichnikov Don F DeJongh Reinhard W Schulte Source Type: research
Innate Immune System in the Context of Radiation Therapy for Cancer
Cancers (Basel). 2023 Aug 4;15(15):3972. doi: 10.3390/cancers15153972.ABSTRACTRadiation therapy (RT) remains an integral component of modern oncology care, with most cancer patients receiving radiation as a part of their treatment plan. The main goal of ionizing RT is to control the local tumor burden by inducing DNA damage and apoptosis within the tumor cells. The advancement in RT, including intensity-modulated RT (IMRT), stereotactic body RT (SBRT), image-guided RT, and proton therapy, have increased the efficacy of RT, equipping clinicians with techniques to ensure precise and safe administration of radiation doses to ...
Source: Cancer Control - August 12, 2023 Category: Cancer & Oncology Authors: Ettickan Boopathi Robert B Den Chellappagounder Thangavel Source Type: research
Boron Nanoparticle-Enhanced Proton Therapy for Cancer Treatment
Nanomaterials (Basel). 2023 Jul 26;13(15):2167. doi: 10.3390/nano13152167.ABSTRACTProton therapy is one of the promising radiotherapy modalities for the treatment of deep-seated and unresectable tumors, and its efficiency can further be enhanced by using boron-containing substances. Here, we explore the use of elemental boron (B) nanoparticles (NPs) as sensitizers for proton therapy enhancement. Prepared by methods of pulsed laser ablation in water, the used B NPs had a mean size of 50 nm, while a subsequent functionalization of the NPs by polyethylene glycol improved their colloidal stability in buffers. Laser-synthesized...
Source: Cancer Control - August 12, 2023 Category: Cancer & Oncology Authors: Irina N Zavestovskaya Anton L Popov Danil D Kolmanovich Gleb V Tikhonowski Andrei I Pastukhov Maxim S Savinov Pavel V Shakhov Julia S Babkova Anton A Popov Ivan V Zelepukin Maria S Grigoryeva Alexander E Shemyakov Sergey M Klimentov Vladimir A Ryabov Para Source Type: research
Boron Nanoparticle-Enhanced Proton Therapy for Cancer Treatment
Nanomaterials (Basel). 2023 Jul 26;13(15):2167. doi: 10.3390/nano13152167.ABSTRACTProton therapy is one of the promising radiotherapy modalities for the treatment of deep-seated and unresectable tumors, and its efficiency can further be enhanced by using boron-containing substances. Here, we explore the use of elemental boron (B) nanoparticles (NPs) as sensitizers for proton therapy enhancement. Prepared by methods of pulsed laser ablation in water, the used B NPs had a mean size of 50 nm, while a subsequent functionalization of the NPs by polyethylene glycol improved their colloidal stability in buffers. Laser-synthesized...
Source: Cancer Control - August 12, 2023 Category: Cancer & Oncology Authors: Irina N Zavestovskaya Anton L Popov Danil D Kolmanovich Gleb V Tikhonowski Andrei I Pastukhov Maxim S Savinov Pavel V Shakhov Julia S Babkova Anton A Popov Ivan V Zelepukin Maria S Grigoryeva Alexander E Shemyakov Sergey M Klimentov Vladimir A Ryabov Para Source Type: research
Cancers, Vol. 15, Pages 4072: Pediatric Experience and Outcomes from the First Single-Vault Compact Proton Therapy Center
anyu Zhao
The first single-vault compact proton therapy center opened in 2013, utilizing a gantry-mounted synchrocylotron. The center was placed within a large academic radiation oncology department with a high priority for pediatric cancer care. Here we performed a retrospective study of pediatric (≤21 years) patients treated with proton therapy at our institution between 2013–2022. Patient, tumor, and treatment characteristics were obtained including race, socioeconomic status, insurance type, distance travelled, need for anesthesia, and outside referrals for proton therapy. In total, 250 ped...
Source: Cancers - August 12, 2023 Category: Cancer & Oncology Authors: Stephanie M. Perkins Sabrina Prime Michael Watts Jiayi Huang Tianyu Zhao Tags: Article Source Type: research
Breaking barriers: Stereotactic ablative proton and photon radiation therapy for renal cell carcinoma with extensive metastases: A case report
Med Dosim. 2023 Aug 8:S0958-3947(23)00062-6. doi: 10.1016/j.meddos.2023.06.003. Online ahead of print.ABSTRACTPatients with advanced renal cancer (RCC) often have limited success with systemic therapy due to tumor heterogeneity. However, stereotactic ablative radiotherapy (SABR) has been shown to have a beneficial therapeutic effect for oligometastatic disease when used early. Despite this, current guidelines recommend the use of tyrosine kinase inhibitors (TKIs) as the first-line therapeutic agent for patients with recurrent or metastatic kidney cancer. Additionally, there is limited data on the combination of systemic tr...
Source: Cancer Control - August 10, 2023 Category: Cancer & Oncology Authors: Ming-Wei Ma Zi-Shen Wang Hong-Zhen Li Xian-Shu Gao Chao Liu Xue-Ying Ren Wei-Li Zhang Kai-Wei Yang Source Type: research
A torus source and its application for non-primary radiation evaluation
Phys Med Biol. 2023 Aug 7. doi: 10.1088/1361-6560/acede7. Online ahead of print.ABSTRACTNon-primary radiation doses to normal tissues from proton therapy may be associated with an increased risk of secondary malignancies, particularly in long-term survivors. Thus, a systematic method to evaluate if the dose level of non-primary radiation meets the IEC standard requirements is needed. 
Approach. Different from the traditional photon radiation therapy system, proton therapy systems are composed of several subsystems in a thick bunker. These subsystems are all possible sources of non-primary radiation threatening the ...
Source: Physics in Medicine and Biology - August 7, 2023 Category: Physics Authors: Han-Long Cheng Jing-Long Wang Xiao-Yun Wang Jie-Fang Xiao Yang Wang Xiao-Guang Wu Yun Zheng Xiao Jin Ying Xu Li-Juan He Congbo Li Tian-Xiao Li Min Zheng Zi-Hao Zhao Zi-Yang He Jin-Ze Li Yun-Qiu Li Rui Hong Source Type: research
A torus source and its application for non-primary radiation evaluation
Phys Med Biol. 2023 Aug 7. doi: 10.1088/1361-6560/acede7. Online ahead of print.ABSTRACTNon-primary radiation doses to normal tissues from proton therapy may be associated with an increased risk of secondary malignancies, particularly in long-term survivors. Thus, a systematic method to evaluate if the dose level of non-primary radiation meets the IEC standard requirements is needed. 
Approach. Different from the traditional photon radiation therapy system, proton therapy systems are composed of several subsystems in a thick bunker. These subsystems are all possible sources of non-primary radiation threatening the ...
Source: Physics in Medicine and Biology - August 7, 2023 Category: Physics Authors: Han-Long Cheng Jing-Long Wang Xiao-Yun Wang Jie-Fang Xiao Yang Wang Xiao-Guang Wu Yun Zheng Xiao Jin Ying Xu Li-Juan He Congbo Li Tian-Xiao Li Min Zheng Zi-Hao Zhao Zi-Yang He Jin-Ze Li Yun-Qiu Li Rui Hong Source Type: research
A torus source and its application for non-primary radiation evaluation
Phys Med Biol. 2023 Aug 7. doi: 10.1088/1361-6560/acede7. Online ahead of print.ABSTRACTNon-primary radiation doses to normal tissues from proton therapy may be associated with an increased risk of secondary malignancies, particularly in long-term survivors. Thus, a systematic method to evaluate if the dose level of non-primary radiation meets the IEC standard requirements is needed. 
Approach. Different from the traditional photon radiation therapy system, proton therapy systems are composed of several subsystems in a thick bunker. These subsystems are all possible sources of non-primary radiation threatening the ...
Source: Physics in Medicine and Biology - August 7, 2023 Category: Physics Authors: Han-Long Cheng Jing-Long Wang Xiao-Yun Wang Jie-Fang Xiao Yang Wang Xiao-Guang Wu Yun Zheng Xiao Jin Ying Xu Li-Juan He Congbo Li Tian-Xiao Li Min Zheng Zi-Hao Zhao Zi-Yang He Jin-Ze Li Yun-Qiu Li Rui Hong Source Type: research
Cancers, Vol. 15, Pages 3972: Innate Immune System in the Context of Radiation Therapy for Cancer
gavel
Radiation therapy (RT) remains an integral component of modern oncology care, with most cancer patients receiving radiation as a part of their treatment plan. The main goal of ionizing RT is to control the local tumor burden by inducing DNA damage and apoptosis within the tumor cells. The advancement in RT, including intensity-modulated RT (IMRT), stereotactic body RT (SBRT), image-guided RT, and proton therapy, have increased the efficacy of RT, equipping clinicians with techniques to ensure precise and safe administration of radiation doses to tumor cells. In this review, we present the technological advancemen...
Source: Cancers - August 4, 2023 Category: Cancer & Oncology Authors: Ettickan Boopathi Robert B. Den Chellappagounder Thangavel Tags: Review Source Type: research
Curative high-dose reirradiation for patients with recurrent head and neck adenoid cystic carcinomas: Outcomes and analysis of patterns of failure
CONCLUSION: Curative reRT for HNACC is possible for selected cases, but the LR rate in the irradiated field and the risk of severe toxicity remain high. Improved selection criteria and more carefully defined target volumes may improve outcome in these patients. A further study including larger cohort of patients would be useful to confirm these results.PMID:37526368 | DOI:10.1080/09553002.2023.2242934 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - August 1, 2023 Category: Radiology Authors: Mathilde Mah é Arnaud Beddok Farid Goudjil Catherine Ala Eddine St éphanie Bolle Laurence Champion Lo ïc Feuvret Philippe Herman Sofia Zefkili Olivier Choussy Christophe Le Tourneau Remi Dendale Irene Buvat Elisabeth Sauvaget Gilles Cr éhange Md PhD V Source Type: research
Inhalation anesthesia without any intravenous management for pediatric proton beam therapy
CONCLUSION: Inhalation anesthesia without any intravenous management for pediatric proton therapy is, in our experience, an effective technique with a complication rate similar to other anesthetic approaches.PMID:37526245 | DOI:10.1111/pan.14739 (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - August 1, 2023 Category: Anesthesiology Authors: Miguel A Garc ía-Aroca Jos é M Fernández-de Miguel Mar ía Aymerich-de Franceschi Miguel A Fern ández-Vaquero Diego A Mel éndez-Salinas Mar ía Piñero-Merino Jos é M Álvarez-Avello Source Type: research
Proton therapy re-irradiation provides promising clinical results in recurrent brain meningioma
Acta Oncol. 2023 Aug 1:1-6. doi: 10.1080/0284186X.2023.2241994. Online ahead of print.NO ABSTRACTPMID:37526998 | DOI:10.1080/0284186X.2023.2241994 (Source: Acta Oncologica)
Source: Acta Oncologica - August 1, 2023 Category: Cancer & Oncology Authors: Daniele Scartoni Irene Giacomelli Riccardo Pertile Sabina Vennarini Paola Feraco Lorena Picori Luciano Annicchiarico Silvio Sarubbo Dante Amelio Source Type: research
Proton therapy re-irradiation provides promising clinical results in recurrent brain meningioma
Acta Oncol. 2023 Aug 1:1-6. doi: 10.1080/0284186X.2023.2241994. Online ahead of print.NO ABSTRACTPMID:37526998 | DOI:10.1080/0284186X.2023.2241994 (Source: Acta Oncologica)
Source: Acta Oncologica - August 1, 2023 Category: Cancer & Oncology Authors: Daniele Scartoni Irene Giacomelli Riccardo Pertile Sabina Vennarini Paola Feraco Lorena Picori Luciano Annicchiarico Silvio Sarubbo Dante Amelio Source Type: research
