Insurance authorization and access to proton therapy for patients with head and neck cancers
We evaluated our institutional experience to assess potential racial inequities in insurance coverage for proton therapy in head and neck (HN) cancer patients. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 6, 2023 Category: Radiology Authors: Mark W. McDonald, James E. Bates, Neal S. McCall, Subir Goyal, Yuan Liu, Soumon Rudra, Jill S. Remick, Sibo Tian, Mark W. El-Deiry, Nabil F. Saba, William A. Stokes, Erica Swinney Tags: Clinical Investigation Source Type: research
Intrafraction tumor motion monitoring and dose reconstruction for liver pencil beam scanning proton therapy
ConclusionsA method to estimate internal tumor motion and reconstruct the motion-including fraction dose for PBS proton therapy of HCC was developed and demonstrated successfully clinically. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 2, 2023 Category: Cancer & Oncology Source Type: research
Improved lateral penumbra for proton ocular treatments on a general-purpose spot scanning beamline
As many new proton therapy centers are coming online, treatments with high-energy general-purpose beamlines are essential to providing this valuable therapy for many patients with eye tumors. In an earlier research publication [1], we presented the design of an ocular applicator along with the associated eye gaze fixation and monitoring system on a spot-scanning beamline. Sharp lateral and distal penumbras are desired to spare normal tissue around the ocular targets and are a characteristic of dedicated ocular beamlines. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - March 1, 2023 Category: General Medicine Authors: Jatinder Saini, Dominic Maes, Rajesh Regmi, Angela Fung, Charles Bloch, Marco Schwarz, Andrew Stacey, Jonathan Chen, Ramesh Rengan, Lia Halasz Tags: Technical note Source Type: research
The risk of radiation-induced neurocognitive impairment and the impact of sparing the hippocampus during pediatric proton cranial irradiation
CONCLUSIONS: We present estimates of potential clinical benefit in terms of neurocognitive impairment and demonstrate the possibility of considerably reducing neurocognitive adverse effects, minimally compromising target coverage locally using HS-IMPT.PMID:36847433 | DOI:10.1080/0284186X.2023.2176253 (Source: Acta Oncologica)
Source: Acta Oncologica - February 27, 2023 Category: Cancer & Oncology Authors: Daniel Gram N Patrik Brodin Thomas Bj örk-Eriksson Karsten Nysom Per Munck Af Rosensch öld Source Type: research
The risk of radiation-induced neurocognitive impairment and the impact of sparing the hippocampus during pediatric proton cranial irradiation
CONCLUSIONS: We present estimates of potential clinical benefit in terms of neurocognitive impairment and demonstrate the possibility of considerably reducing neurocognitive adverse effects, minimally compromising target coverage locally using HS-IMPT.PMID:36847433 | DOI:10.1080/0284186X.2023.2176253 (Source: Cancer Control)
Source: Cancer Control - February 27, 2023 Category: Cancer & Oncology Authors: Daniel Gram N Patrik Brodin Thomas Bj örk-Eriksson Karsten Nysom Per Munck Af Rosensch öld Source Type: research
A feasibility study of enhanced prompt gamma imaging for range verification in proton therapy using deep learning
In this study, we simulated proton pencil beams delivered at clinical dose rates and levels in a tissue-equivalent phantom using Monte-Carlo (MC). PG detection with a CC was simulated using the MC-Plus-Detector-Effects model. Images were reconstructed using kernel-weighted-back-projection algorithm, and were then enhanced by the proposed method. Results demonstrated that the method effectively restored the 3D shape of PGs with proton pencil beam range clearly visible in all testing cases. Range errors were within 2 pixels (4 mm) in all directions in most cases at a dose level of 10^9 protons/beam. The method is fully autom...
Source: Physics in Medicine and Biology - February 27, 2023 Category: Physics Authors: Zhuoran Jiang Jerimy C Polf Carlos A Barajas Matthias K Gobbert Lei Ren Source Type: research
The risk of radiation-induced neurocognitive impairment and the impact of sparing the hippocampus during pediatric proton cranial irradiation
CONCLUSIONS: We present estimates of potential clinical benefit in terms of neurocognitive impairment and demonstrate the possibility of considerably reducing neurocognitive adverse effects, minimally compromising target coverage locally using HS-IMPT.PMID:36847433 | DOI:10.1080/0284186X.2023.2176253 (Source: Acta Oncologica)
Source: Acta Oncologica - February 27, 2023 Category: Cancer & Oncology Authors: Daniel Gram N Patrik Brodin Thomas Bj örk-Eriksson Karsten Nysom Per Munck Af Rosensch öld Source Type: research
Reduced radiation exposure to circulating blood cells in proton therapy compared with X-ray therapy in locally advanced lung cancer: Computational simulation based on circulating blood cells
ConclusionThe results of this study demonstrate the significance of the dose distribution of CBCs in predicting SRIL. Furthermore, reducing the dose of CBCs after PBSPT minimized the risk of SRIL. Lymphocyte-sparing radiotherapy in PBSPT could improve outcomes, particularly in the setting of maintenance immunotherapy. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - February 27, 2023 Category: Cancer & Oncology Source Type: research
Gross tumor volume margin and local control in p16-positive oropharynx cancer patients treated with intensity modulated proton therapy
CONCLUSION: Excellent local control was achieved using IMPT for p16+ OPC independent of GTV expansion. IMPT with minimal target expansions represent a potential harm-minimization technique for p16-positive oropharynx cancer.PMID:36840723 | DOI:10.1002/hed.27308 (Source: Cancer Control)
Source: Cancer Control - February 25, 2023 Category: Cancer & Oncology Authors: Ariel E Pollock Danielle Arons Gregory S Alexander David Alicia Kayla M Birkman Jason K Molitoris Ranee Mehra Kevin J Cullen Kyle M Hatten Rodney J Taylor Jeffrey S Wolf William F Regine Matthew E Witek Source Type: research
Clinical 3D/4D cumulative proton dose assessment methods for thoracic tumours with large motion
CONCLUSION: Our results show that intra-thoracic tumours can be adequately treated with IMPT in free breathing for target motion amplitudes up to 17 mm employing any of the accumulation methods. Anatomical changes, setup and range errors demonstrated a more severe impact on target coverage than motion in these patients treated with fractionated proton radiotherapy.PMID:36822356 | DOI:10.1016/j.radonc.2023.109575 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 23, 2023 Category: Radiology Authors: Sabine Visser Erik W Korevaar Christina T Muijs Robin Wijsman Johannes A Langendijk Pietro Pisciotta Gabriel Gutteres Marmitt C ássia O Ribeiro Stefan Both Source Type: research
Biophysical characterization of collimated and uncollimated fields in pencil beam scanning proton therapy
Phys Med Biol. 2023 Feb 23. doi: 10.1088/1361-6560/acbe8d. Online ahead of print.ABSTRACTOBJECTIVE: The lateral dose fall-off in proton pencil beam scanning (PBS) technique remains the preferred choice for sparing adjacent organs at risk as opposed to the distal edge due to the proton range uncertainties and potentially high relative biological effectiveness. However, because of the substantial spot size along with the scattering in the air and in the patient, the lateral penumbra in PBS can be degraded. Combining PBS with an aperture can result in a sharper dose fall-off, particularly for shallow targets.APPROACH: The aim...
Source: Molecular Medicine - February 23, 2023 Category: Molecular Biology Authors: Racell Nabha Marijke De Saint-Hubert Joachim Marichal Johannes Esser Olivier Van Hoey Christian B äumer Nico Gerd Verbeek Lara Struelens Edmond Sterpin Kevin Tabury Lukas Marek Carlos Granja Beate Timmermann Filip Vanhavere Source Type: research
Biophysical characterization of collimated and uncollimated fields in pencil beam scanning proton therapy
Phys Med Biol. 2023 Feb 23. doi: 10.1088/1361-6560/acbe8d. Online ahead of print.ABSTRACTOBJECTIVE: The lateral dose fall-off in proton pencil beam scanning (PBS) technique remains the preferred choice for sparing adjacent organs at risk as opposed to the distal edge due to the proton range uncertainties and potentially high relative biological effectiveness. However, because of the substantial spot size along with the scattering in the air and in the patient, the lateral penumbra in PBS can be degraded. Combining PBS with an aperture can result in a sharper dose fall-off, particularly for shallow targets.APPROACH: The aim...
Source: Physics in Medicine and Biology - February 23, 2023 Category: Physics Authors: Racell Nabha Marijke De Saint-Hubert Joachim Marichal Johannes Esser Olivier Van Hoey Christian B äumer Nico Gerd Verbeek Lara Struelens Edmond Sterpin Kevin Tabury Lukas Marek Carlos Granja Beate Timmermann Filip Vanhavere Source Type: research
Clinical 3D/4D cumulative proton dose assessment methods for thoracic tumours with large motion
CONCLUSION: Our results show that intra-thoracic tumours can be adequately treated with IMPT in free breathing for target motion amplitudes up to 17 mm employing any of the accumulation methods. Anatomical changes, setup and range errors demonstrated a more severe impact on target coverage than motion in these patients treated with fractionated proton radiotherapy.PMID:36822356 | DOI:10.1016/j.radonc.2023.109575 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 23, 2023 Category: Radiology Authors: Sabine Visser Erik W Korevaar Christina T Muijs Robin Wijsman Johannes A Langendijk Pietro Pisciotta Gabriel Gutteres Marmitt C ássia O Ribeiro Stefan Both Source Type: research
Clinical outcomes and toxicities of 100 patients treated with proton therapy for chordoma on the Proton Collaborative Group Prospective Registry
CONCLUSIONS: In our series, PBT achieved excellent safety and efficacy outcomes with very low rates of treatment failure. CNS necrosis is exceedingly low (<1%) despite the high doses of PBT delivered. Further maturation of data and larger patient numbers are necessary to optimize therapy in chordoma.PMID:36813169 | DOI:10.1016/j.radonc.2023.109551 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 22, 2023 Category: Radiology Authors: Stephanie R Rice Arpit M Chhabra Adam Holtzman J Isabelle Choi Shaakir Hasan Robert H Press John Chang Lia Halasz Henry K Tsai Chiachien Jake Wang Peyman Kabolizadeh Vinai Gondi William F Hartsell Sujay A Vora Carlos E Vargas Charles B Simone Source Type: research
Unchanged perfusion in normal-appearing white and grey matter of glioma patients nine months after proton beam irradiation
Conclusion: The perfusion in normal-appearing brain tissue remained unaltered after proton beam therapy. In further studies, a direct comparison with changes after photon therapy is recommended to confirm the different effect of proton therapy on the normal-appearing tissue.PMID:36801809 | DOI:10.1080/0284186X.2023.2176254 (Source: Acta Oncologica)
Source: Acta Oncologica - February 21, 2023 Category: Cancer & Oncology Authors: Katharina Witzmann Felix Raschke Steffen L öck Tim Wesemann Mechthild Krause Jennifer Linn Esther G C Troost Source Type: research
