Development of a log file analysis tool for proton patient QA, system performance tracking, and delivered dose reconstruction
CONCLUSION: A tool has been developed to extract crucial information about the performance of the proton delivery and monitor system and provide a dose reconstruction based on delivered spots for quality improvement. Each patient's plan was verified before treatment to ensure accurate and safe delivery within the delivery tolerance of the machine.PMID:36951089 | DOI:10.1002/acm2.13972 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - March 23, 2023 Category: Physics Authors: Ozgur Ates Fakhriddin Pirlepesov Li Zhao Chia-Ho Hua Thomas E Merchant Source Type: research
Investigating survival, quality of life and cognition in PROton versus photon therapy for IDH-mutated diffuse grade 2 and 3 GLIOmas (PRO-GLIO): a randomised controlled trial in Norway and Sweden
Introduction
The use of proton therapy increases globally despite a lack of randomised controlled trials demonstrating its efficacy and safety. Proton therapy enables sparing of non-neoplastic tissue from radiation. This is principally beneficial and holds promise of reduced long-term side effects. However, the sparing of seemingly non-cancerous tissue is not necessarily positive for isocitrate dehydrogenase (IDH)-mutated diffuse gliomas grade 2–3, which have a diffuse growth pattern. With their relatively good prognosis, yet incurable nature, therapy needs to be delicately balanced to achieve a maximal survival bene...
Source: BMJ Open - March 20, 2023 Category: General Medicine Authors: Heggebo, L. C., Borgen, I. M. H., Rylander, H., Kiserud, C., Nordenmark, T. H., Hellebust, T. P., Evensen, M. E., Gustavsson, M., Ramberg, C., Sprauten, M., Magelssen, H., Blakstad, H., Moorthy, J., Andersson, K., Raunert, I., Henry, T., Moe, C., Granlund Tags: Open access, Oncology Source Type: research
Cancers, Vol. 15, Pages 1864: Non-Surgical Definitive Treatment for Operable Breast Cancer: Current Status and Future Prospects
This article reviews the results of various non-surgical curative treatments for operable breast cancer. Radiotherapy is considered the most important among such treatments, but conventional radiotherapy alone and concurrent chemoradiotherapy do not achieve high cure rates. As a radiosensitization strategy, intratumoral injection of hydrogen peroxide before radiation has been investigated, and high local control rates (75–97%) were reported. The authors treated 45 patients with whole-breast radiotherapy, followed by stereotactic or intensity-modulated radiotherapy boost, with or without a radiosensitization s...
Source: Cancers - March 20, 2023 Category: Cancer & Oncology Authors: Yuta Shibamoto Seiya Takano Tags: Review Source Type: research
MRI-based quantification of carbon and oxygen concentrations in human soft tissues for range verification in proton therapy
CONCLUSIONS: This study is limited to a proof-of-concept scope but demonstrates the feasibility of the MRWC-based method for the generation of elemental images of human soft tissues from MRI-derived water-content images. This article is protected by copyright. All rights reserved.PMID:36916123 | DOI:10.1002/mp.16353 (Source: Health Physics)
Source: Health Physics - March 14, 2023 Category: Physics Authors: Masatoshi Saito Source Type: research
Intensity modulated proton arc therapy via geometry-based energy selection for ependymoma
CONCLUSIONS: The proposed method demonstrated potential as an efficient technique for IMPAT planning and may offer a dosimetric benefit for patients with ependymoma or tumors in close proximity to critical organs. IMPAT plans created using this method had elevated RBE enhancement associated with increased linear energy transfer (LET) in both targets and abutting critical organs.PMID:36913484 | DOI:10.1002/acm2.13954 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - March 13, 2023 Category: Physics Authors: Wenhua Cao Yupeng Li Xiaodong Zhang Falk Poenisch Pablo Yepes Narayan Sahoo David Grosshans Susan McGovern G Brandon Gunn Steven J Frank Xiaorong R Zhu Source Type: research
Dosimetric Effects of the Supine and Prone Positions in Proton Therapy for Prostate Cancer
CONCLUSIONS: We confirmed that the rectal doses were significantly lower in the prone compared with the supine position in PT. Although uncertain, the prone position could be an effective method to reduce the rectal dose in PT.PMID:36908499 | PMC:PMC9997540 | DOI:10.4103/jmp.jmp_85_22 (Source: Health Physics)
Source: Health Physics - March 13, 2023 Category: Physics Authors: Takahiro Kato Masato Kato Kimihiro Takemasa Masao Murakami Source Type: research
Intensity modulated proton arc therapy via geometry-based energy selection for ependymoma
CONCLUSIONS: The proposed method demonstrated potential as an efficient technique for IMPAT planning and may offer a dosimetric benefit for patients with ependymoma or tumors in close proximity to critical organs. IMPAT plans created using this method had elevated RBE enhancement associated with increased linear energy transfer (LET) in both targets and abutting critical organs.PMID:36913484 | DOI:10.1002/acm2.13954 (Source: Health Physics)
Source: Health Physics - March 13, 2023 Category: Physics Authors: Wenhua Cao Yupeng Li Xiaodong Zhang Falk Poenisch Pablo Yepes Narayan Sahoo David Grosshans Susan McGovern G Brandon Gunn Steven J Frank Xiaorong R Zhu Source Type: research
Intensity modulated proton arc therapy via geometry-based energy selection for ependymoma
CONCLUSIONS: The proposed method demonstrated potential as an efficient technique for IMPAT planning and may offer a dosimetric benefit for patients with ependymoma or tumors in close proximity to critical organs. IMPAT plans created using this method had elevated RBE enhancement associated with increased linear energy transfer (LET) in both targets and abutting critical organs.PMID:36913484 | DOI:10.1002/acm2.13954 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - March 13, 2023 Category: Physics Authors: Wenhua Cao Yupeng Li Xiaodong Zhang Falk Poenisch Pablo Yepes Narayan Sahoo David Grosshans Susan McGovern G Brandon Gunn Steven J Frank Xiaorong R Zhu Source Type: research
Dosimetric Effects of the Supine and Prone Positions in Proton Therapy for Prostate Cancer
CONCLUSIONS: We confirmed that the rectal doses were significantly lower in the prone compared with the supine position in PT. Although uncertain, the prone position could be an effective method to reduce the rectal dose in PT.PMID:36908499 | PMC:PMC9997540 | DOI:10.4103/jmp.jmp_85_22 (Source: Health Physics)
Source: Health Physics - March 13, 2023 Category: Physics Authors: Takahiro Kato Masato Kato Kimihiro Takemasa Masao Murakami Source Type: research
Intensity modulated proton arc therapy via geometry-based energy selection for ependymoma
CONCLUSIONS: The proposed method demonstrated potential as an efficient technique for IMPAT planning and may offer a dosimetric benefit for patients with ependymoma or tumors in close proximity to critical organs. IMPAT plans created using this method had elevated RBE enhancement associated with increased linear energy transfer (LET) in both targets and abutting critical organs.PMID:36913484 | DOI:10.1002/acm2.13954 (Source: Health Physics)
Source: Health Physics - March 13, 2023 Category: Physics Authors: Wenhua Cao Yupeng Li Xiaodong Zhang Falk Poenisch Pablo Yepes Narayan Sahoo David Grosshans Susan McGovern G Brandon Gunn Steven J Frank Xiaorong R Zhu Source Type: research
Dosimetric comparison of pencil beam scanning proton therapy with or without multi-leaf collimator versus volumetric-modulated arc therapy for treatment of malignant glioma
This study aimed to examine the dosimetric effect of intensity-modulated proton therapy (IMPT) with a multi-leaf collimator (MLC) in treating malignant glioma. We compared the dose distribution of IMPT with or without MLC (IMPTMLC+ or IMPTMLC-, respectively) using pencil beam scanning and volumetric-modulated arc therapy (VMAT) in simultaneous integrated boost (SIB) plans for 16 patients with malignant gliomas. High- and low-risk target volumes were assessed using D2%, V90%, V95%, homogeneity index (HI), and conformity index (CI). (Source: Medical Dosimetry)
Source: Medical Dosimetry - March 11, 2023 Category: Radiology Authors: Junya Miyata, Yuki Tominaga, Kazuto Kondo, Yasuaki Sonoda, Hideki Hanazawa, Mami Sakai, Satoshi Itasaka, Masataka Oita, Masahiro Kuroda Source Type: research
Normal Tissue Integral Dose as a Result of Prostate Radiation Therapy: A Quantitative Comparison Between High-Dose-Rate Brachytherapy and Modern External Beam Radiation Therapy Techniques
CONCLUSIONS: High-dose-rate brachytherapy is an effective technique for reducing dose to nontarget body tissues relative to volumetric modulated arc therapy, stereotactic body radiation therapy, and pencil-beam scanning proton therapy.PMID:36896212 | PMC:PMC9991537 | DOI:10.1016/j.adro.2022.101160 (Source: Ann Oncol)
Source: Ann Oncol - March 10, 2023 Category: Cancer & Oncology Authors: Vincent P Grzywacz Jessica D Arden Nikhil P Mankuzhy Gary S Gustafson Evelyn A Sebastian Veronica L Abbott Kailee J Walters Julie A Puzzonia Amy S Limbacher Jason M Hafron Daniel J Krauss Source Type: research
Normal Tissue Integral Dose as a Result of Prostate Radiation Therapy: A Quantitative Comparison Between High-Dose-Rate Brachytherapy and Modern External Beam Radiation Therapy Techniques
CONCLUSIONS: High-dose-rate brachytherapy is an effective technique for reducing dose to nontarget body tissues relative to volumetric modulated arc therapy, stereotactic body radiation therapy, and pencil-beam scanning proton therapy.PMID:36896212 | PMC:PMC9991537 | DOI:10.1016/j.adro.2022.101160 (Source: Ann Oncol)
Source: Ann Oncol - March 10, 2023 Category: Cancer & Oncology Authors: Vincent P Grzywacz Jessica D Arden Nikhil P Mankuzhy Gary S Gustafson Evelyn A Sebastian Veronica L Abbott Kailee J Walters Julie A Puzzonia Amy S Limbacher Jason M Hafron Daniel J Krauss Source Type: research
Prompt-gamma fall-off estimation with C-ion irradiation at clinical energies, using a knife-edge slit camera: A Monte Carlo study
Purpose: In-vivo range verification has been a hot topic in particle therapy since two decades. Many efforts have been done for proton therapy, while fewer studies were conducted considering a beam of carbon ions. In the present work, a simulation study was performed to show whether it is possible to measure the prompt-gamma fall-off inside the high neutron background typical of carbon-ion irradiation, using a knife-edge slit camera. In addition to this, we wanted to estimate the uncertainty in retrieving the particle range in the case of a pencil beam of C-ions at clinically relevant energy of 150 MeVu. (Source: Physica M...
Source: Physica Medica: European Journal of Medical Physics - March 10, 2023 Category: General Medicine Authors: Andrea Missaglia, Aicha Bourkadi-Idrissi, Francesco Casamichiela, Davide Mazzucconi, Marco Carminati, Stefano Agosteo, Carlo Fiorini Tags: Review paper Source Type: research
Insurance authorization and access to proton therapy for patients with head and neck cancers
CONCLUSIONS: BIPOC patients were significantly more likely to have insurance plans unfavorable to proton therapy coverage. These PU insurance plans were associated with a longer median time to determination, a lower approval rate for proton therapy, and a longer time to start radiation of any modality.PMID:36889515 | DOI:10.1016/j.ijrobp.2023.02.033 (Source: Health Physics)
Source: Health Physics - March 8, 2023 Category: Physics Authors: Mark W McDonald James E Bates Neal S McCall Subir Goyal Yuan Liu Soumon Rudra Jill S Remick Sibo Tian Mark W El-Deiry Nabil F Saba William A Stokes Erica Swinney Source Type: research
