Spread-out Bragg peak measurements using a compact quality assurance range calorimeter at the Clatterbridge Cancer Centre
Phys Med Biol. 2024 Apr 24. doi: 10.1088/1361-6560/ad42fd. Online ahead of print.ABSTRACTOBJECTIVE: The superior dose conformity provided by proton therapy relative to conventional X-ray radiotherapy necessitates more rigorous Quality Assurance (QA) procedures to ensure optimal patient safety. Practically however, time-constraints prevent comprehensive measurements to be made of the proton range in water: a key parameter in ensuring accurate treatment delivery.APPROACH: A novel scintillator-based device for fast, accurate water-equivalent proton range QA measurements for ocular proton therapy is presented. Experiments were...
Source: Physics in Medicine and Biology - April 24, 2024 Category: Physics Authors: Saad Shaikh Sonia Escribano-Rodriguez Raffaella Radogna Laurent Kelleter Connor Godden Matthew Warren Derek Attree Ruben Saakyan Linda Mortimer Peter Corlett Alison Warry Andrew Gosling Colin Baker Andrew Poynter Andrzej Kacperek Simon Jolly Source Type: research
Dosimetric comparison of advanced radiation techniques for scalp-sparing in low-grade gliomas
ConclusionOur study provides evidence that the SO approach is a feasible technique for reducing scalp radiation dose. However, it is imperative to conduct prospective trials to assess the benefits associated with this approach. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 22, 2024 Category: Cancer & Oncology Source Type: research
Balancing robustness and adaptation rate for proton therapy of lung cancer patients
CONCLUSION: The lowered risk of post treatment toxicities at lower robustness levels is clinically relevant but comes at the expense of more treatment adaptations, particularly in cases where meeting our clinical goals is not compromised by having a dose that is more conformal to the target. The trade-off between workload and reduced NTCP needs to be individually assessed.PMID:38643807 | DOI:10.1016/j.radonc.2024.110290 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 21, 2024 Category: Radiology Authors: Vlad Badiu Vicki Trier Taasti Gilles Defraene Wouter van Elmpt Edmond Sterpin Source Type: research
Uncertainties in ocular proton planning and their impact on required margins
Ocular proton therapy (OPT) for uveal melanoma dates back to 1975 at the Harvard Cylcotron Laboratory and up to date more than 45,000 patients have been treated worldwide with exceptional success rates [1]. Although technical improvements occurred mainly with respect to treatment planning and imaging, the general concept has stayed more or less the same: a geometric eye model is constructed and the positioning of the target relative to the beam isocenter is achieved by means of orthogonal X-rays, which show the radio-opaque tantalum markers sutured to the outer eyeball. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - April 21, 2024 Category: General Medicine Authors: J örg Wulff, Benjamin Koska, Dalia Ahmad Khalil, Ronald Richter, Claus Maximilian Bäcker, Christian Bäumer, Andreas Foerster, Nikolaos E. Bechrakis, Beate Timmermann Source Type: research
Balancing robustness and adaptation rate for proton therapy of lung cancer patients
Proton therapy aims at accurately delivering high radiation doses to tumors while reducing exposure to surrounding healthy tissue when compared to classical photon-based radiotherapy. The steep dose fall-off at the distal edge of the protons ’ range (the so-called “Bragg Peak”) results in a sharply localized dose peak [1]. This improved conformity when compared to photons comes at the expense of an increased susceptibility to treatment errors such as patient positioning or setup errors, range errors (resulting from the conversion of the CT numbers to proton stopping power ratios (SPRs), and inter- and intra- fraction...
Source: Radiotherapy and Oncology - April 19, 2024 Category: Radiology Authors: Vlad Badiu, Vicki Trier Taasti, Gilles Defraene, Wouter van Elmpt, Edmond Sterpin Tags: Original Article Source Type: research
In Regard to Dupere et al.
We present several key points that could affect neutron dose and risk assessments in pregnant patients receiving PBS-PT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Haibo Lin, Hang Qi, Minglei Kang, Charles B. Simone Tags: Letters to the Editor Source Type: research
In Reply to Lin et al.
We thank Lin et al1 for their comments and thank the editor for the opportunity to provide a response. We appreciate the concerns raised and agree it is crucial to exercise caution when treating pregnant patients whether using pencil beam scanning proton therapy (PBS-PRT) or x-ray therapy (XRT). Regardless of modality, fetal dose is influenced by prescription, target volume size, beam modifiers, beam angles, patient size, fetus-to-target distance, and so on. Gestational age is similarly an important consideration for either modality. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Justine M. Dupere, John J. Lucido, William G. Breen, Anita Mahajan, Nicholas B. Remmes Tags: Letter to the Editor Source Type: research
Thoracic Proton Minibeam Radiation Therapy: Tissue Preservation and Survival Advantage over Conventional Proton Therapy
CONCLUSION: pMBRT appears suitable to treat moving targets, holding a significant ability to preserve healthy lung tissue, even without respiratory control or precise targeting.PMID:38621606 | DOI:10.1016/j.ijrobp.2024.04.011 (Source: Cancer Control)
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Anna ïg Bertho Ramon Ortiz Mathieu Maurin Marjorie Juchaux Crist èle Gilbert Julie Espenon Gabriel Ramasamy Annalisa Patriarca Ludovic De Marzi Fr édéric Pouzoulet Yolanda Prezado Source Type: research
Comparing the effects of irradiation with protons or photons on neonatal mouse brain: Apoptosis, oncogenesis and hippocampal alterations
CONCLUSION: In-vivo experiments with radiosensitive mouse models improve our mechanistic understanding of the dependence of brain damage on radiation quality, thus having important implications in translational research.PMID:38614282 | DOI:10.1016/j.radonc.2024.110267 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 13, 2024 Category: Radiology Authors: Daniela Giovannini Francesca Antonelli Arianna Casciati Cinzia De Angelis Maria Denise Astorino Giulia Bazzano Emiliano Fratini Alessandro Ampollini Monia Vadrucci Evaristo Cisbani Paolo Nenzi Luigi Picardi Anna Saran Carmela Marino Mariateresa Mancuso Co Source Type: research
Long-term survival outcomes and quality of life of image-guided proton therapy for operable stage I non-small cell lung cancer: A phase 2 study
CONCLUSION: Our findings suggest that IGPT provides effective disease control and survival in operable stage I NSCLC, particularly for peripheral lesions. Moreover, toxicity associated with IGPT was minimal, and patients reported favorable QOL.PMID:38614284 | DOI:10.1016/j.radonc.2024.110276 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 13, 2024 Category: Radiology Authors: Koichiro Nakajima Masanosuke Oguri Hiromitsu Iwata Yukiko Hattori Shingo Hashimoto Kento Nomura Kensuke Hayashi Toshiyuki Toshito Kenji Akita Fumiya Baba Hiroyuki Ogino Akio Hiwatashi Source Type: research
Long-term survival outcomes and quality of life of image-guided proton therapy for operable stage I non-small cell lung cancer: A phase 2 study
CONCLUSION: Our findings suggest that IGPT provides effective disease control and survival in operable stage I NSCLC, particularly for peripheral lesions. Moreover, toxicity associated with IGPT was minimal, and patients reported favorable QOL.PMID:38614284 | DOI:10.1016/j.radonc.2024.110276 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 13, 2024 Category: Radiology Authors: Koichiro Nakajima Masanosuke Oguri Hiromitsu Iwata Yukiko Hattori Shingo Hashimoto Kento Nomura Kensuke Hayashi Toshiyuki Toshito Kenji Akita Fumiya Baba Hiroyuki Ogino Akio Hiwatashi Source Type: research
Comparing the effects of irradiation with protons or photons on neonatal mouse brain: Apoptosis, oncogenesis and hippocampal alterations
CONCLUSION: In-vivo experiments with radiosensitive mouse models improve our mechanistic understanding of the dependence of brain damage on radiation quality, thus having important implications in translational research.PMID:38614282 | DOI:10.1016/j.radonc.2024.110267 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 13, 2024 Category: Radiology Authors: Daniela Giovannini Francesca Antonelli Arianna Casciati Cinzia De Angelis Maria Denise Astorino Giulia Bazzano Emiliano Fratini Alessandro Ampollini Monia Vadrucci Evaristo Cisbani Paolo Nenzi Luigi Picardi Anna Saran Carmela Marino Mariateresa Mancuso Co Source Type: research
Comparing the effects of irradiation with protons or photons on neonatal mouse brain: Apoptosis, oncogenesis and hippocampal alterations
CONCLUSION: In-vivo experiments with radiosensitive mouse models improve our mechanistic understanding of the dependence of brain damage on radiation quality, thus having important implications in translational research.PMID:38614282 | DOI:10.1016/j.radonc.2024.110267 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 13, 2024 Category: Radiology Authors: Daniela Giovannini Francesca Antonelli Arianna Casciati Cinzia De Angelis Maria Denise Astorino Giulia Bazzano Emiliano Fratini Alessandro Ampollini Monia Vadrucci Evaristo Cisbani Paolo Nenzi Luigi Picardi Anna Saran Carmela Marino Mariateresa Mancuso Co Source Type: research
Long-term survival outcomes and quality of life of image-guided proton therapy for operable stage I non-small cell lung cancer: A phase 2 study
CONCLUSION: Our findings suggest that IGPT provides effective disease control and survival in operable stage I NSCLC, particularly for peripheral lesions. Moreover, toxicity associated with IGPT was minimal, and patients reported favorable QOL.PMID:38614284 | DOI:10.1016/j.radonc.2024.110276 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 13, 2024 Category: Radiology Authors: Koichiro Nakajima Masanosuke Oguri Hiromitsu Iwata Yukiko Hattori Shingo Hashimoto Kento Nomura Kensuke Hayashi Toshiyuki Toshito Kenji Akita Fumiya Baba Hiroyuki Ogino Akio Hiwatashi Source Type: research
Thoracic Proton Minibeam Radiation Therapy: Tissue Preservation and Survival Advantage over Conventional Proton Therapy.
This study assesses the potential advantages of pMBRT for thoracic irradiations compared to conventional radiotherapy in terms of normal tissue toxicity. The challenge here was the influence of respiratory motion on the typical peak and valley dose patterns of pMBRT and its potential biological impact. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 13, 2024 Category: Radiology Authors: Anna ïg Bertho, Ramon Ortiz, Mathieu Maurin, Marjorie Juchaux, Cristèle Gilbert, Julie Espenon, Gabriel Ramasamy, Annalisa Patriarca, Ludovic De Marzi, Frédéric Pouzoulet, Yolanda Prezado Tags: Biology Contribution Source Type: research
