Sparing Cardiac Substructures With Optimized Volumetric Modulated Arc Therapy and Intensity Modulated Proton Therapy in Thoracic Radiation for Locally Advanced Non-small Cell Lung Cancer
ConclusionsVMAT is now widely available, and high-quality VMAT plans that incorporate cardiac substructures into the optimization process can provide overall improvements in dose to OARs and, in particular, substantial sparing of critical cardiac structures. IMPT provides some incremental dosimetric improvements beyond cardiac-optimized VMAT, the clinical significance of which remains uncertain. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - June 22, 2019 Category: Cancer & Oncology Source Type: research

Experimental comparison of proton CT and dual energy X-ray CT for relative stopping power estimation in proton therapy.
This study aimed at directly comparing the RSP accuracy of both modalities using phantoms scanned at an advanced prototype pCT scanner and a state-of-the-art DECT scanner.
 
 Two phantoms containing 13 tissue-mimicking inserts of known RSP were scanned at the pCT phase II prototype and a latest generation dual-source DECT scanner (Siemens SOMATOM Definition FORCE). RSP accuracy was compared by mean absolute percent error (MAPE) over all inserts. A highly realistic Monte Carlo (MC) simulation was used to gain insight on pCT image artifacts which degraded MAPE.
 
 MAPE was 0.55...
Source: Physics in Medicine and Biology - June 20, 2019 Category: Physics Authors: Dedes G, Dickmann J, Niepel KB, Wesp P, Johnson RP, Pankuch M, Bashkirov VA, Rit S, Volz L, Schulte RW, Landry G, Parodi K Tags: Phys Med Biol Source Type: research

Stereotactical fields applied in proton spot scanning mode with range shifter and collimating aperture.
f J Abstract Some clinical indications require small fields with sharp lateral dose gradients, which is technically challenging in proton beam therapy. This holds especially true for low-range fields applied with the spot scanning technique, where large beam profiles entering from the beam-line or the insertion of range shifting blocks lead to large lateral gradients. We regard the latter case and solve it by shifting the range shifting block far upstream in conjunction with a collimating aperture close to the patient. The experiments of the current work are based on a commercial proton therapy treatment head desi...
Source: Physics in Medicine and Biology - June 19, 2019 Category: Physics Authors: Bäumer C, Fuentes C, Janson M, Matic A, Timmermann B, Wulff J Tags: Phys Med Biol Source Type: research

It's the Team, Not the Beam
At the conclusion of a recent office visit, one of our patients summarized his feelings and stated, with a sense of absolute conviction, “The only type of radiation therapy I am willing to undergo is proton therapy.” In contrast, another recent patient facing a similar situation stated, “I don't care which I get [proton or photon therapy]; to me, it sounds like it's the team, not the beam.” The former patient put his hope in a technology; the latter patient prioritized the experience of his care team over any particular technology. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - June 15, 2019 Category: Radiology Authors: Samuel Swisher-McClure, Justin E. Bekelman Tags: Payment Policy Source Type: research

Four-year outcomes from a prospective phase II clinical trial of moderately hypofractionated proton therapy for localized prostate cancer
This study was performed to determine the clinical and patient-reported outcomes for patients with PC treated with HFPT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - June 11, 2019 Category: Radiology Authors: Amardeep S. Grewal, Caitlin Schonewolf, Eun Jeong Min, Hann-Hsiang Chao, Stefan Both, Sarah Lam, Susan Mazzoni, Justin Bekelman, John Christodouleas, Neha Vapiwala Source Type: research

Post-mastectomy intensity modulated proton therapy after immediate breast reconstruction: Initial report of reconstruction outcomes and predictors of complications.
CONCLUSIONS: IMPT following IBR spared underlying organs and had low rates of acute toxicity. Reconstruction complications are more common in irradiated breasts, and reconstructive outcomes appear comparable with photon literature. Hypofractionation was associated with higher reconstruction failure rates. Further investigation of optimal dose-fractionation after IBR is needed. PMID: 31185327 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 8, 2019 Category: Radiology Authors: Smith NL, Jethwa KR, Viehman JK, Harmsen WS, Gonuguntla K, Elswick SM, Grauberger JN, Amundson AC, Whitaker TJ, Remmes NB, Harless CA, Boughey JC, Nguyen MT, Park SS, Corbin KS, Mutter RW Tags: Radiother Oncol Source Type: research

Design optimization of a pixel-based range telescope for proton computed tomography
Proton Computed Tomography (proton CT) is an imaging modality able to measure the proton stopping power of the patient prior to treatment planning and treatment in proton therapy [1]. The goal of proton CT is to increase the accuracy of the proton range estimation, compared to conversion from the X-ray mass attenuation using X-ray CT [2]. Several design approaches for proton CT have been proposed. Usually, tracker planes in front of and behind the patient measure each proton ’s position and direction so that their path through the patient can be estimated [3,4]. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - June 6, 2019 Category: General Medicine Authors: Helge Egil Seime Pettersen, Johan Alme, Gergely G ábor Barnaföldi, Rene Barthel, Anthony van den Brink, Mamdouh Chaar, Viljar Eikeland, Alba García-Santos, Georgi Genov, Silje Grimstad, Ola Grøttvik, Håvard Helstrup, Kristin Fanebust Hetland, Shruti Tags: Original paper Source Type: research

Pencil Beam Proton Therapy Spares Cognition in Craniopharyngioma
No abstract available (Source: Oncology Times)
Source: Oncology Times - June 5, 2019 Category: Cancer & Oncology Tags: News Source Type: research

Three Discipline Collaborative Radiation Therapy (3DCRT) Special Debate: I would treat prostate cancer with proton therapy.
PMID: 31166085 [PubMed - as supplied by publisher] (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - June 5, 2019 Category: Physics Authors: Carrier F, Liao Y, Mendenhall N, Guerrieri P, Todor D, Ahmad A, Dominello M, Joiner MC, Burmeister J Tags: J Appl Clin Med Phys Source Type: research

Clinical results of proton therapy reirradiation for recurrent nasopharyngeal carcinoma.
Conclusions: Our initial results with the use of modern PT for reirradiation of recurrent NPC patients are encouraging. Favorable LC and OS rates were obtained at the cost of acceptable severe late toxicity. PMID: 31155998 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 3, 2019 Category: Cancer & Oncology Authors: Dionisi F, Croci S, Giacomelli I, Cianchetti M, Caldara A, Bertolin M, Vanoni V, Pertile R, Widesott L, Farace P, Schwarz M, Amichetti M Tags: Acta Oncol Source Type: research

Consensus Report From the Miami Liver Proton Therapy Conference
An international group of 22 liver cancer experts from 18 institutions met in Miami, Florida to discuss the optimal utilization of proton beam therapy (PBT) for primary and metastatic liver cancer. There was consensus that PBT may be preferred for liver cancer patients expected to have a suboptimal therapeutic ratio from XRT, but that PBT should not be preferred for all patients. Various clinical scenarios demonstrating appropriateness of PBT versus XRT were reviewed. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - May 31, 2019 Category: Cancer & Oncology Source Type: research

Quantification of the dependencies of the Bragg peak degradation due to lung tissue in proton therapy on a CT-based lung tumor phantom.
Abstract The fine, sub-millimeter sized structure of lung tissue causes a degradation of the Bragg peak curve in particle therapy. The Bragg peak is degraded because particles of the same energy traverse lung tissue of different compositions of high and low density materials. Hence, they experience different energy losses resulting in variable ranges and a broadened Bragg peak. 
 Since this fine structure of lung tissue is not resolved in standard treatment-planning CTs, current state-of-the-art dose calculation procedures used in the clinical routine are unable to account for this degradation. Neglect...
Source: Physics in Medicine and Biology - May 31, 2019 Category: Physics Authors: Flatten V, Baumann KS, Weber U, Engenhart-Cabillic R, Zink K Tags: Phys Med Biol Source Type: research

Modeling the Potential Benefits of Proton Therapy for Patients With Oropharyngeal Head and Neck Cancer
It is critical that rigorous evaluation of technology in radiation oncology be undertaken during the early stages of implementation or when there is a marked cost differential. Prospective clinical data proving the clinical effectiveness of emerging technology may not be available to guide proper investment and development. In these scenarios, models can be used to simulate expected clinical outcomes and predict comparative effectiveness and cost-effectiveness.1 In this edition of the Red Journal, 2 studies use model-based approaches to compare photon intensity modulated radiation therapy (IMRT) to proton beam therapy (PBT...
Source: International Journal of Radiation Oncology * Biology * Physics - May 30, 2019 Category: Radiology Authors: Nataniel H. Lester-Coll, Danielle N. Margalit Tags: Clinical Investigation Source Type: research

[Boost in proton for locally advanced nasopharyngeal carcinoma: A Curie Institute experience].
CONCLUSION: This study showed that a complementary dose with proton seems to be a good option for the treatment of locally advanced nasopharyngeal carcinoma, particularly for T4N0M0. PMID: 31138519 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 25, 2019 Category: Cancer & Oncology Authors: Beddok A, Feuvret L, Noël G, Bolle S, Deberne M, Mammar H, Chaze A, Le Tourneau C, Goudjil F, Zefkili S, Herman P, Dendale R, Calugaru V Tags: Cancer Radiother Source Type: research

Comparison of Techniques for Involved-Site Radiation Therapy in Patients with Lower Mediastinal Lymphoma
Publication date: Available online 22 May 2019Source: Practical Radiation OncologyAuthor(s): Ashlyn S. Everett, Bradford S. Hoppe, Debbie Louis, Andrew M. McDonald, Christopher M. Morris, Nancy P. Mendenhall, Zuofeng Li, Stella FlampouriAbstractIntroductionPatients with lower mediastinal lymphoma (LML) benefit dosimetrically from proton therapy (PT) compared with intensity-modulated radiotherapy (IMRT). The added dosimetric benefit of deep-inspiration breath-hold (DIBH) is unknown; therefore, we evaluated IMRT versus PT and free-breathing (FB) versus DIBH among patients with LML.Materials and MethodsTwenty-one patients wit...
Source: Practical Radiation Oncology - May 23, 2019 Category: Cancer & Oncology Source Type: research

Quantification of global lung inflammation using volumetric 18F-FDG PET/CT parameters in locally advanced non-small-cell lung cancer patients treated with concurrent chemoradiotherapy: a comparison of photon and proton radiation therapy
Conclusion We observed a significant increase in global lung inflammation bilaterally as measured by quantification of PG. However, no significant change in global lung inflammation was noted after proton therapy. Future larger studies are needed to determine whether this difference correlates with lower risks of radiation pneumonitis in NSCLC patients treated with proton therapy. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 21, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Dosimetric comparison of distal esophageal carcinoma plans for patients treated with small-spot intensity-modulated proton versus volumetric-modulated arc therapies.
CONCLUSIONS: Small-spot IMPT decreases doses to heart, liver, and total lung compared to VMAT as well as achieves clinically acceptable plan robustness. Our study supports the use of small-spot IMPT for the treatment of distal esophageal carcinoma. PMID: 31112371 [PubMed - as supplied by publisher] (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - May 21, 2019 Category: Physics Authors: Liu C, Bhangoo RS, Sio TT, Yu NY, Shan J, Chiang JS, Ding JX, Rule WG, Korte S, Lara P, Ding X, Bues M, Hu Y, DeWees T, Ashman JB, Liu W Tags: J Appl Clin Med Phys Source Type: research

Development of a prompt gamma imaging system with multi-slit collimator and BGO + SiPM detector for proton therapy monitoring
Conclusions: The developed detector, collimator and reconstruction technology are feasible for imaging prompt gamma photons. Simulation and initial experimental test show satisfactory system performance. System assembling, imaging system optimization and full performance tests are under way. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 21, 2019 Category: Nuclear Medicine Authors: Ma, T., Fan, P., Lu, W., Zhang, H., Zhang, D., Xia, Y., Wang, S., Liu, Y. Tags: Instrumentation: New System Design and Emerging Technology II Source Type: research

Applications of PET in Radiation Oncology
1139Introduction: Thoracic malignancies are among the most common malignancies diagnosed both in the United States and worldwide. Radiation therapy (RT) plays an important role in the treatment of thoracic malignancies. Depending on the primary disease site and tumor stage, RT can be used as monotherapy, or as part of multimodality therapy for curative intent, or for palliative reduction of advanced disease. In fact, more than 50% of all patients with thoracic malignancies will receive RT as part of their multidisciplinary care. 18F-Fluorodeoxyglucose positron emission tomography (PET) is commonly used for initial cancer d...
Source: Journal of Nuclear Medicine - May 21, 2019 Category: Nuclear Medicine Authors: Jahangiri, P., Pournazari, K., Mehdizadeh Seraj, S., Khosravi, M., Alavi, A., Torigian, D. Tags: Educational Exhibit Posters Source Type: research

Pediatric S-Values for a Mulitregional Brain Model
Conclusions: The phantoms created in this study allow more detailed dosimetry to be performed for a variety of radionuclides that may have differential uptake in brain substructures. Additionally, the updated eye model allows for dose assessment to the radiosensitive tissues of the eye lens that might be relevant in the CT portion of hybrid SPECT/CT or PET/CT imaging systems. Acknowledgments: This work was support by NIH Grant R01 EB013558 from the National Institute for Biomedical Imaging and Bioengineering. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 21, 2019 Category: Nuclear Medicine Authors: Brown, J., Li, Y., Frey, E., Plyku, D., Sgouros, G., Fahey, F., Sexton-Stallone, B., Cao, X., Treves, S. T., Bolch, W. Tags: Dosimetry Posters Source Type: research

GEANT4 simulation of exit energy in proton medical imaging
Publication date: Available online 16 May 2019Source: Radiation Physics and ChemistryAuthor(s): R.C.L. Silva, V. Denyak, H.R. Schelin, G. Hoff, S.A. Paschuk, J.A.P. SettiAbstractImaging techniques using protons as incident particles are currently being actively developed as a substitute for X-ray computed tomography and nuclear magnetic resonance methods in proton therapy. In proton imaging, density resolution depends on the position of the maximum of the exit energy distribution and the width of this distribution which influences uncertainty in the definition of the exit energy. In recent years, many research groups have ...
Source: Radiation Physics and Chemistry - May 17, 2019 Category: Physics Source Type: research

The first prototype of spot-scanning proton arc treatment delivery.
CONCLUSION: The first prototype of dynamic proton arc delivery on a clinical proton therapy system was successfully performed. The measurements and simulations demonstrated the feasibility of SPArc treatment within the clinical requirements. PMID: 31100606 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 14, 2019 Category: Radiology Authors: Li X, Liu G, Janssens G, De Wilde O, Bossier V, Lerot X, Pouppez A, Yan D, Stevens C, Kabolizadeh P, Ding X Tags: Radiother Oncol Source Type: research

Applying a variable relative biological effectiveness (RBE) might affect the analysis of clinical trials comparing photon and proton therapy for prostate cancer.
Abstract The purpose of this study was the evaluation of the impact of a variable relative biological effectiveness (RBE) compared to a constant RBE value of 1.1 in proton therapy prostate trials due to uncertainties in α/β ratio.
 
 Twenty patients receiving passive scattered proton therapy (PSPT) and fifteen patients receiving intensity modulated proton therapy (IMPT) were compared to twenty patients treated with 7-field intensity modulated photon therapy (IMRT). For proton beam therapy (PBT), the RBE was estimated using two different RBE models. Tumor control probabilities (TC...
Source: Physics in Medicine and Biology - May 13, 2019 Category: Physics Authors: Marteinsdottir M, Paganetti H Tags: Phys Med Biol Source Type: research

Sparing Cardiac Substructures with Optimized Volumetric Modulated Arc Therapy and Intensity-Modulated Proton Therapy in Thoracic Radiation for Locally Advanced Non-Small Cell Lung Cancer
ConclusionsVMAT is now widely available, and high-quality VMAT plans that incorporate the cardiac substructures into the optimization process can provide overall improvements in doses to OARs and in particular substantial sparing of critical cardiac structures. IMPT provides some incremental dosimetric improvements beyond cardiac-optimized VMAT, the clinical significance of which remains uncertain. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - May 11, 2019 Category: Cancer & Oncology Source Type: research

Effect of irradiation time on biological effectiveness and tumor control probability in proton therapy
An effect of the irradiation time on the biological effectiveness was systematically evaluated in proton therapy for various target sizes, depths and prescribed doses per fraction. Spread-out Bragg peak plans were created using a constant relative biological effectiveness of 1.1 and the biological doses were then calculated based on the microdosimetric kinetic model. The biological dose large decreased with longer irradiation time or higher prescribed dose. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - May 11, 2019 Category: Radiology Authors: Hideyuki Takei, Taku Inaniwa Source Type: research

In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field.
Abstract To optimize beam delivery and conformality of proton therapy, MRI integration has been proposed. Therefore, we investigated if proton irradiation in a magnetic field would change biological responses. Our data in cancer cell lines and stem cell-derived organoid models suggest that a magnetic field does not modify the biological response. PMID: 31085392 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 11, 2019 Category: Radiology Authors: Nagle PW, van Goethem MJ, Kempers M, Kiewit H, Knopf A, Langendijk JA, Brandenburg S, van Luijk P, Coppes RP Tags: Radiother Oncol Source Type: research

Long-term outcomes and late adverse effects of a prospective study on proton radiotherapy for patients with low-grade glioma.
CONCLUSIONS: The majority of patients with LGG who received proton therapy retained stable cognitive and neuroendocrine function. The IDH1-R132H mutation was present in the majority, while 1p/19q loss was present in a minority. A subset of patients developed neuroendocrine deficiencies and was more common in those with higher dose to the HPA. PMID: 31082632 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 10, 2019 Category: Radiology Authors: Tabrizi S, Yeap BY, Sherman JC, Nachtigall LB, Colvin MK, Dworkin M, Fullerton BC, Daartz J, Royce TJ, Oh KS, Batchelor TT, Curry WT, Loeffler JS, Shih HA Tags: Radiother Oncol Source Type: research

TOPAS Monte Carlo simulation for double scattering proton therapy and dosimetric evaluation
Proton therapy has become increasingly accepted around the world. According to the latest PTCOG statistics, there are currently 77 proton therapy centers in operation worldwide, with 44 new facilities under construction and 20 facilities in plan stage [1]. By the end of 2017, more than 170,000 patients have been treated with proton therapy [2]. Based on how 3D dose distributions are produced, proton therapy delivery methods can be divided as passive scattering, uniform scanning, and pencil beam scanning techniques [3 –5]. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - May 9, 2019 Category: General Medicine Authors: Hongdong Liu, Zuofeng Li, Roelf Slopsema, Liu Hong, Xi Pei, Xie George Xu Tags: Original paper Source Type: research

Proton therapy for brain tumours in the area of evidence-based medicine.
Abstract ADVANCES IN KNOWLEDGE: This review details the indication of brain tumors for proton therapy and give a list of the open prospective trials for these challenging tumors. PMID: 31067074 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - May 8, 2019 Category: Radiology Authors: Weber DC, Weber DC, Lim PS, Tran S, Walser M, Bolsi A, Kliebsch U, Beer J, Bachtiary B, Lomax T, Pica A Tags: Br J Radiol Source Type: research

Influence of intravenous contrast agent on dose calculation in proton therapy using dual energy CT.
Abstract The purpose of this study is to evaluate the effect of an intravenous (IV) contrast agent on proton therapy dose calculation using dual-energy computed tomography (DECT). Two DECT methods are considered. The first one, ρ<sub>e</sub>- Z<sub>med</sub>, attempts to accurately predict the proton stopping powers relative to water (SPR) of contrast enhanced (CE) DECT images, while the second generates a virtual non-contrast (VNC) volume that can be processed as a native non-contrast (NC) one. Both methods are compared ag...
Source: Physics in Medicine and Biology - May 2, 2019 Category: Physics Authors: Lalonde A, Xie Y, Burgdorf B, O'Reilly S, Ingram WS, Yin L, Zou W, Dong L, Bouchard H, Teo K Tags: Phys Med Biol Source Type: research

Dosimetric uncertainties as a result of temporal resolution in 4D dose calculations for PBS proton therapy.
Abstract This work investigates the dosimetric impact on 4D dose distribution estimation for pencil beam scanned (PBS) proton therapy as function of the temporal resolution used for the time resolved dose calculation. For three liver patients (CTV volume: 403/122/264cc), 10-phase 4DCT-MRI datasets with ~15mm tumour motion were simulated for seven different motion periods (2-8s). 4D dose distributions were calculated and compared by considering both coarser and finer temporal resolutions (200-800ms and 20ms). Single scanned 4D plans for seven fraction doses (0.7/2/4/6/8/10/12Gy) were investigated, whose dose delive...
Source: Physics in Medicine and Biology - April 29, 2019 Category: Physics Authors: Zhang Y, Huth I, Weber DC, Lomax AJ Tags: Phys Med Biol Source Type: research

Surgery and proton beam therapy for mediastinal extraskeletal osteosarcoma
We present the case of a 73-year-old man with a hoarseness. Imaging studies revealed a large calcified tumor of the median mediastinum. Surgery was performed, but complete resection was impossible and about two-thirds of the tumor was excised. The tumor was pathologically diagnosed as ESOS. Proton beam therapy has been performed on the remaining lesion, and the patient is alive without tumor regrowth for 29 months. This is the first case of mediastinum ESOS successfully treated with surgery and postoperative proton therapy. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - April 27, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

The impact of dose algorithms on tumor control probability in intensity-modulated proton therapy for breast cancer
Current proton therapy clinical practices primarily use the pencil-beam (PB) algorithm for dose calculations, as it has been the mainstay of commercially-available proton dose calculation algorithms and offers efficient treatment planning workflow. On the other hand, PB algorithms are known to be inaccurate in heterogeneous tissue environment or when a range shifter is used. To this end, Monte Carlo (MC) algorithm have recently been introduced into proton treatment planning systems that provide much more accurate dose modeling. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - April 27, 2019 Category: General Medicine Authors: Xiaoying Liang, Julie A. Bradley, Dandan Zheng, Michael Rutenberg, Raymond Mailhot Vega, Nancy Mendenhall, Zuofeng Li Tags: Original paper Source Type: research

Optical imaging for the characterization of radioactive carbon and oxygen ion beams.
In conclusion, optical imaging using luminescence and Cerenkov light could be used for the precise range estimation of radioactive ion beams. PMID: 31026851 [PubMed - as supplied by publisher] (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - April 26, 2019 Category: Physics Authors: Kang HG, Yamamoto S, Takyu S, Nishikido F, Mohammadi A, Horita R, Sato S, Yamaya T Tags: Phys Med Biol Source Type: research

Surgery and proton beam therapy for mediastinal extraskeletal osteosarcoma.
We present the case of a 73-year-old man with a hoarseness. Imaging studies revealed a large calcified tumor of the median mediastinum. Surgery was performed, but complete resection was impossible and about two-thirds of the tumor was excised. The tumor was pathologically diagnosed as ESOS. Proton beam therapy has been performed on the remaining lesion, and the patient is alive without tumor regrowth for 29 months. This is the first case of mediastinum ESOS successfully treated with surgery and postoperative proton therapy. PMID: 31034825 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - April 26, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Shimizu N, Tanaka Y, Demizu Y, Okimoto T, Maniwa Y Tags: Ann Thorac Surg Source Type: research

Dependence of LET on material and its impact on current RBE model.
Abstract Biological uncertainty remains one of the main sources of uncertainties
 in Proton Therapy, and is encapsulated in a scalar quantity known as Relative
 Biological Eective (RBE). It is currently recognized that a constant RBE of 1.1 is
 not consistent with radiobiological experiment and will lead to sub-optimal clinical
 outcome during treatment planning. To overcome this problem, several RBE models
 have been developed, and in most of these models, there is a dependence of RBE on
 dose-averaged Linear Energy Transfer (LET), LETd. In t...
Source: Physics in Medicine and Biology - April 25, 2019 Category: Physics Authors: Tan HQ, Koh WYC, Tan LKR, Phua JH, Ang KW, Park SY, Lew WS, Lee JCL Tags: Phys Med Biol Source Type: research

Enteral Nutrition in Pediatric High-risk Head and Neck Cancer Patients Receiving Proton Therapy: Identifying Risk Factors and Quality of Life Concerns to Optimize Care
Conclusions: Pediatric patients with head and neck cancer can be risk-stratified based on clinical and dosimetric factors. This data, combined with parent and patient perceptions, is key to the development of rational guidelines. (Source: Journal of Pediatric Hematology Oncology)
Source: Journal of Pediatric Hematology Oncology - April 24, 2019 Category: Hematology Tags: Online Articles: Original Articles Source Type: research

Increased distance from a treating proton center is associated with diminished ability to follow patients enrolled on a multicenter radiation oncology registry.
Abstract PURPOSE: Consistent follow-up and data collection are necessary to identify long-term benefits/detriments of proton radiotherapy. Obtaining comprehensive clinical follow-up can be difficult and time-intensive for proton centers. Here we evaluate what factors affect maximum follow-up time among MGH Pediatric Proton Consortium Registry (PPCR) participants. PATIENTS AND METHODS: Enrollment in the PPCR was offered to any patient
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Lawell MP, Bajaj BVM, Gallotto SL, Hess CB, Patteson BE, Nartowicz JA, Giblin MJ, Kleinerman RA, Berrington de Gonzalez A, Ebb DH, Tarbell NJ, MacDonald SM, Weyman EA, Yock TI Tags: Radiother Oncol Source Type: research

Patient-Reported Sexual Survivorship Following High-Dose Image-Guided Proton Therapy for Prostate Cancer.
CONCLUSIONS: Patient-reported pretreatment sexual function and comorbidities enables stratification and prediction of erectile function. EPIC subset questions with baseline comorbidities may potentially serve as a quick and practical clinical tool for predicting sexual survivorship. PMID: 31005217 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Holtzman AL, Bryant CM, Mendenhall NP, Mendenhall WM, Nichols RC, Henderson RH, Figura N, Morris CG, Williams CR, Li Z, Hoppe BS Tags: Radiother Oncol Source Type: research

The dosimetric effect of residual breath-hold motion in pencil beam scanned proton therapy - An experimental study.
CONCLUSIONS: The breath-hold technique is robust to residual intra-breath-hold motion for SFUD treatment plans, based on our experimental study. IMPT was less robust with larger detected dose deviations. PMID: 31005207 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Gorgisyan J, Lomax AJ, Rosenschold PMA, Persson GF, Krieger M, Colvill E, Scherman J, Gagnon-Moisan F, Egloff M, Fattori G, Engelholm SA, Weber DC, Perrin R Tags: Radiother Oncol Source Type: research

Effect of setup and inter-fraction anatomical changes on the accumulated dose in CT-guided breath-hold intensity modulated proton therapy of liver malignancies.
CONCLUSIONS: IMPT with FGBH and CT-on-rail guidance is a robust treatment approach for liver tumor cases. PMID: 31005203 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Yang Z, Chang Y, Brock KK, Cazoulat G, Koay EJ, Koong AC, Herman JM, Park PC, Poenisch F, Li Q, Yang K, Wu G, Anderson B, Ohrt AN, Li Y, Zhu XR, Zhang X, Li H Tags: Radiother Oncol Source Type: research

Selection of lymph node target volumes for definitive head and neck radiation therapy: a 2019 Update.
CONCLUSIONS: The selection of lymph node target volumes for head and neck cancers treated with IMRT/VMAT or other highly conformal techniques (e.g. proton therapy) requires a rigorous approach. This updated proposal of selection should help clinicians for the selection of lymph nodes target volumes and contribute to increase consistency. PMID: 31005201 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Biau J, Lapeyre M, Troussier I, Budach W, Giralt J, Grau C, Kazmierska J, Langendijk JA, Ozsahin M, O'Sullivan B, Bourhis J, Grégoire V Tags: Radiother Oncol Source Type: research

Distant Subconjunctival Recurrences following Proton Therapy for a Choroidal Melanoma with Extrascleral Extension.
Authors: Mouvet V, Moulin A, Pica A, Schalenbourg A PMID: 30999338 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)
Source: Klinische Monatsblatter fur Augenheilkunde - April 20, 2019 Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research

Comprehensive 4D robustness evaluation for pencil beam scanned proton plans
Due to anticipated clinical benefits, moving targets are potential future indications for pencil beam scanned proton therapy (PBS-PT). However, currently they are not widely treated at PBS-PT facilities due to dosimetric uncertainties caused by motion. We developed a method, the 4D robustness evaluation method (4DREM), to realistically and efficiently assess all possible events impacting PBS-PT treatments in the thorax. Using the 4DREM in large cohorts of lung and oesophageal cancer patients, it will become possible to illustrate, in clinical practice, how to trigger robustness settings for plan optimisation and to select ...
Source: Radiotherapy and Oncology - April 20, 2019 Category: Radiology Authors: C ássia O. Ribeiro, Arturs Meijers, Erik W. Korevaar, Christina T. Muijs, Stefan Both, Johannes A. Langendijk, Antje Knopf Tags: Technical Note Source Type: research

Effects of modulation materials for lung dose distribution in proton therapy
This study created an easier approach and successfully created the spread–out Bragg peak (SOBP) in lung heterogeneous media, using statistically fitted matrix with uniformity of SOBP better than 2%. The weighting factors matrix for creating SOBP may theoretically be applied to any multiple range modulation systems. The methodology for the 150 MeV proton beams' range modulation in the lung heterogeneous media can be similarly applied to other energy of proton as well as for heavy ion therapy. (Source: Radiation Physics and Chemistry)
Source: Radiation Physics and Chemistry - April 19, 2019 Category: Physics Source Type: research

Clinical outcomes after intensity-modulated proton therapy with concurrent chemotherapy for inoperable non-small cell lung cancer
Radiation therapy with concurrent chemotherapy is the recommended treatment for patients with locally advanced inoperable non-small cell lung cancer (NSCLC). Unfortunately, local and distant relapses are common, and the median survival time is only about 20 –30 months [1]. Moreover, cardiopulmonary disease is common in such patients, which can make concurrent chemoradiotherapy difficult to tolerate [2]. More effective modalities that allow systemic and local therapies to be combined can improve outcomes. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 17, 2019 Category: Radiology Authors: Adnan Elhammali, Pierre Blanchard, Alison Yoder, Zhongxing Liao, Xiadong Zhang, X. Ronald Zhu, Pamela K. Allen, Melenda Jeter, James Welsh, Quynh-Nhu Nguyen Tags: Original Article Source Type: research

Prediction of positron emitter distributions for range monitoring in carbon ion therapy: an analytical approach.
Abstract Range verification is one of the most relevant tasks in ion beam therapy. In the case of carbon ion therapy, positron emission tomography (PET) is the most widely used method for this purpose, which images the β<sup>+</sup>-activation following nuclear interactions of the ions with the tissue nuclei. Since the positron emitter activity profile is not directly proportional to the dose distribution, until today only its comparison to a prediction of the PET profile allows for treatment verification. Usually, this prediction is obtained from time-consuming Monte Carlo simulat...
Source: Physics in Medicine and Biology - April 10, 2019 Category: Physics Authors: Hofmann T, Fochi A, Parodi K, Pinto M Tags: Phys Med Biol Source Type: research

Clinical implementation of respiratory-gated spot-scanning proton therapy: An efficiency analysis of active motion management.
Abstract PURPOSE: The aim of this work is to describe the clinical implementation of respiratory-gated spot-scanning proton therapy (SSPT) for the treatment of thoracic and abdominal moving targets. The experience of our institution is summarized, from initial acceptance and commissioning tests to the development of standard clinical operating procedures for simulation, motion assessment, motion mitigation, treatment planning, and gated SSPT treatment delivery. MATERIALS AND METHODS: A custom respiratory gating interface incorporating the Real-Time Position Management System (RPM, Varian Medical Systems, Inc....
Source: Journal of Applied Clinical Medical Physics - April 10, 2019 Category: Physics Authors: Gelover E, Deisher AJ, Herman MG, Johnson JE, Kruse JJ, Tryggestad EJ Tags: J Appl Clin Med Phys Source Type: research

Processing of prompt gamma-ray timing data for proton range measurements at a clinical beam delivery.
Pausch G Abstract In proton therapy, patients benefit from the precise deposition of the dose in the tumor volume due to the interaction of charged particles with matter. Currently, the determination of the beam range in the patient's body during the treatment is not a clinical standard. This lack causes broad safety margins, which limits the potential of proton therapy. To overcome this obstacle, different methods are under investigation aiming at the verification of the proton range in real time. One approach is the Prompt Gamma-ray Timing (PGT) method, where the range of the primary protons is derived from the...
Source: Physics in Medicine and Biology - April 9, 2019 Category: Physics Authors: Werner T, Berthold J, Hueso-González F, Kögler T, Petzoldt J, Roemer KE, Richter C, Rinscheid A, Straessner A, Enghardt W, Pausch G Tags: Phys Med Biol Source Type: research

An advanced junction concept in pediatric craniospinal irradiation by proton pencil beam scanning
Medulloblastoma survivors have often significant adverse late effects involving heart, lungs, thyroid, growth of vertebral bodies, reproductive organs and risk of second neoplasm after irradiation of the spine as part of craniospinal irradiation (CSI). Proton therapy is emerging as the preferred treatment modality for CSI in pediatric patients [1,2], due to its physical characteristic and limited exit dose allowing to spare normal tissue. Since proton pencil beam scanning (PBS) is becoming more widely available, increasing precision of dose delivery and reducing contamination from secondary particles, with a low out-of-fie...
Source: Physica Medica: European Journal of Medical Physics - April 9, 2019 Category: General Medicine Authors: Francesco Fellin, Francesco Fracchiolla, Barbara Rombi, Mirko Lipparini, Sabina Vennarini, Paolo Farace Tags: Technical note Source Type: research