Role of multimodality therapy in cIIIA-N2 non–small cell lung cancer: perspective §
AbstractA number of promising new approaches for both local and systemic control of locally advanced non–small cell lung cancer have been examined in clinical trials, aimed at improving the patient survival. Development of better systemic therapies by adopting newer agents (such as epidermal growth factor receptor-tyrosine kinase inhibitors and immune checkpoint inhibitors) from advanced non–small cell lung cancer is mandatory. As for radiotherapy, adaptive radiotherapy and proton therapy are under investigation after the RTOG 0617 trial unexpectedly failed to show the efficacy of high-dose radiotherapy for Sta...
Source: Japanese Journal of Clinical Oncology - December 8, 2016 Category: Cancer & Oncology Source Type: research

Local dose enhancement of proton therapy by ceramic oxide nanoparticles investigated with Geant4 simulations
Proton therapy is a highly conformal radiation therapy technique, widely used for the treatment of eye, prostate, lung and brain tumours. With respect to conventional photon or electron beam therapy, proton therapy has the advantage of higher treatment conformity due to the proton Bragg peak as well as higher radiobiological effectiveness (on average 1.1 as accepted currently in clinical practice) [1,2]. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - December 2, 2016 Category: Journals (General) Authors: Sally McKinnon, Susanna Guatelli, Sebastien Incerti, Vladimir Ivanchenko, Konstantin Konstantinov, St éphanie Corde, Michael Lerch, Moeava Tehei, Anatoly Rosenfeld Tags: Original paper Source Type: research

Volumetric response of intracranial meningioma after photon or particle irradiation.
CONCLUSION: Significant volumetric shrinkage of meningiomas could be observed independently of the applied radiation modality. Long-term follow-up is recommended to evaluate further dynamic of size reduction and its correlation with outcome data. PMID: 27911139 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 2, 2016 Category: Cancer & Oncology Authors: Mozes P, Dittmar JO, Habermehl D, Tonndorf-Martini E, Hideghety K, Dittmar A, Debus J, Combs SE Tags: Acta Oncol Source Type: research

Proton therapy - Present and future.
Abstract In principle, proton therapy offers a substantial clinical advantage over the conventional photon therapy. This is because of the unique depth-dose characteristics of protons, which can be exploited to achieve significant reductions in normal tissue doses proximal and distal to the target volume. These may, in turn, allow escalation of tumor doses, greater sparing of normal tissues, thus potentially improving local control and survival while at the same time reducing toxicity and improving quality of life. Protons, accelerated to therapeutic energies ranging from 70 to 250MeV, typically with a cyclotron o...
Source: Advanced Drug Delivery Reviews - December 2, 2016 Category: Drugs & Pharmacology Authors: Mohan R, Grosshans D Tags: Adv Drug Deliv Rev Source Type: research

Local dose enhancement of proton therapy by ceramic oxide nanoparticles investigated with Geant4 simulations.
Abstract Nanoparticles (NPs) have been shown to enhance X-ray radiotherapy and proton therapy of cancer. The effectiveness of radiation damage is enhanced in the presence of high atomic number (high-Z) NPs due to increased production of low energy, higher linear energy transfer (LET) secondary electrons when NPs are selectively internalized by tumour cells. This work quantifies the local dose enhancement produced by the high-Z ceramic oxide NPs Ta2O5 and CeO2, in the target tumour, for the first time in proton therapy, by means of Geant4 simulations. The dose enhancement produced by the ceramic oxides is compared ...
Source: Physica Medica - December 1, 2016 Category: Physics Authors: McKinnon S, Guatelli S, Incerti S, Ivanchenko V, Konstantinov K, Corde S, Lerch M, Tehei M, Rosenfeld A Tags: Phys Med Source Type: research

Neutron shielding for a new projected proton therapy facility: A Geant4 simulation study
Since it was first theoretically proposed in 1946 by R. Wilson [1,2] and the development of the first hospital-based centers in the early nineties, proton therapy has become an increasingly popular technique for treating tumors, due to its capability of uniformly delivering high doses to the tumor volumes, while, at the same time, sparing the surrounding healthy tissue from undesired radiation damage. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - December 1, 2016 Category: Journals (General) Authors: Francesco Cadini, David Bolst, Susanna Guatelli, Chris Beltran, Michael Jackson, Anatoly B. Rosenfeld Tags: Original paper Source Type: research

4B. Management of a proton therapy facility installation: needs, constraints, prerequisites
The market of particle therapy is still rapidly growing worldwide and this modality is now being considered as one modality of radiation therapy, in complementarity with other types of RT treatments.However, the number of facilities and patient treated remains negligible compared to photon RT (less than 1 mainly due to the complexity and therefore overall costs of the particle (proton and moreover ion) facility. Due to the current technology employed and the size/costs, a particle therapy project cannot be managed like a standard radiation therapy project. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - December 1, 2016 Category: Journals (General) Authors: R. Ferrand Source Type: research

3. A dynamic collimation system improving target conformity of spot scanning proton therapy: comparison of dose calculations for two nozzles
Spot scanning proton therapy (SSPT) treatments suffer from poor conformity, especially at low energy, due to increased lateral spot size, which is further increased with the patient scattering. The University of Iowa Hospitals and Clinics recently proposed a dynamic collimation system (DCS) for SSPT, which is capable of providing spot-by-spot collimation. The purpose of this study is to quantify by simulations improvement in target conformity from the use of the DCS, in brain and head and neck tumor treatments. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - December 1, 2016 Category: Journals (General) Authors: A. Moignier, E. Gelover, B.R. Smith, D. Wang, R.T. Flynn, M.L. Kirk, L. Lin, T.D. Solberg, A. Lin, D.E. Hyer Source Type: research

2. Current and future indications of proton therapy, the clinician ’s point of view
Proton Therapy (PT) has gained interest recently. Indeed, protons have the advantage of depositing minimal dose until the end of its path, where a peak of energy deposition occurs (Bragg Peak). As a consequence of the reduced entrance dose and no exit dose, PT is expected to better spare normal tissues from radiation exposure, and should therefore facilitate the delivery of high radiation dose to the targets that are close to critical dose-limiting organs, or when severe late effects are foreseen. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - December 1, 2016 Category: Journals (General) Authors: X. Geets Source Type: research

P9. Haptic multimodal assessment of robot manual guidance for patient pre-positioning in proton therapy
Reducing treatment duration in proton therapy is one of the key factor to increase the number of patient treated per day. To overcome this issue, we have developed novels haptic manual guidance control implemented on the patient positioning robot (Orion PT) to be used during the pre-positioning phase by the paramedical assistant. These manual control modes allow the paramedical assistant to be close to the patient while reducing the time for the pre-positioning setup. The four manual control modes of the robot are compared with a generic reach-and-point trajectory. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - December 1, 2016 Category: Journals (General) Authors: J. Baumeyer, S. Miossec, C. Novales, G. Poisson, P. Vieyres, S. Pinault Source Type: research

Spot-Scanning Proton Arc (SPArc) Therapy: The First Robust and Delivery-Efficient Spot-Scanning Proton Arc Therapy.
CONCLUSION: The SPArc plan is the first robust and delivery-efficient proton spot-scanning arc therapy technique, which could potentially be implemented into routine clinical practice. PMID: 27869083 [PubMed - in process] (Source: Health Physics)
Source: Health Physics - November 23, 2016 Category: Physics Authors: Ding X, Li X, Zhang JM, Kabolizadeh P, Stevens C, Yan D Tags: Int J Radiat Oncol Biol Phys Source Type: research

Gated carbon-ion scanning treatment for pancreatic tumour with field specific target volume and organs at risk
Pancreatic cancer has been one of the ten most common cancers worldwide for more than ten years [1]. Compared to photon beam therapy, particle beam delivers a higher dose to the target lesion with greater sparing of organs at risk (OARs). Bouchard et al. investigated dose distribution dependency on tumour location using three-dimensional conformal photon-radiation therapy (3DCRT), intensity-modulated radiation therapy (IMRT), and passive-scattering proton therapy in pancreatic tumour treatment [2]. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - November 21, 2016 Category: Journals (General) Authors: Kentaro Miki, Shinichiro Mori, Miho Shiomi, Shigeru Yamada Tags: Original paper Source Type: research

Progress on the Therapeutic Approaches for Malignant Tumor 
with Superior Vena Cava Syndrome
Patients with thoracic malignant tumors often suffered from superior vena cava syndrome (SVCS), featured by high morbidity and mortality. Traditionally treated with palliative approaches, SVCS has been widely studied and novel therapeutic approaches have been investigated, focusing on drug therapy, interventional therapy, radiation therapy, surgery and proton therapy. In this manuscript, the progress of therapeutic approaches for SVCS is summarized. DOI: 10.3779/j.issn.1009-3419.2016.11.11 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 20, 2016 Category: Cancer & Oncology Source Type: research

The effect of anatomical changes on pencil beam scanned proton dose distributions for cranial and extra cranial tumors
A retrospective analysis of the PSI adaptive planning strategy has been performed. Out of a cohort of 730 patients treated with PBS proton therapy, 244 (33.5%) had control CT ’s to monitor anatomical changes. Of these, 40 patients (5.5%) required re-planning. Retrospective re-calculation of the nominal plan on re-planning CT’s indicated that 88% of analyzed OARs were within 5% of the nominal planned dose and 87%/90% of analyzed PTV/CTV’s within 5%. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 16, 2016 Category: Radiology Authors: Lorenzo Placidi, Alessandra Bolsi, Antony J. Lomax, Ralf A. Schneider, Robert Malyapa, Damien C. Weber, Francesca Albertini Tags: Clinical Investigation Source Type: research

Clinical evidence of variable proton biological effectiveness in pediatric patients treated for ependymoma
A constant relative biological effectiveness (RBE) is used for clinical proton therapy; however, experimental evidence indicates that RBE can vary. We analyzed pediatric ependymoma patients who received proton therapy to determine if areas of normal tissue damage indicated by post-treatment image changes were associated with increased biological dose effectiveness. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - November 16, 2016 Category: Radiology Authors: Christopher R. Peeler, Dragan Mirkovic, Uwe Titt, Pierre Blanchard, Jillian R. Gunther, Anita Mahajan, Radhe Mohan, David R. Grosshans Tags: Original article Source Type: research

Clinical evidence of variable proton biological effectiveness in pediatric patients treated for ependymoma.
CONCLUSIONS: Our correlation of changes on MR images after proton therapy with increased LET constitutes the first clinical evidence of variable proton biological effectiveness. PMID: 27863964 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 16, 2016 Category: Radiology Authors: Peeler CR, Mirkovic D, Titt U, Blanchard P, Gunther JR, Mahajan A, Mohan R, Grosshans DR Tags: Radiother Oncol Source Type: research

Effect of Anatomic Changes on Pencil Beam Scanned Proton Dose Distributions for Cranial and Extracranial Tumors
To  estimate the frequency and impact of anatomic changes on the delivered dose in pencil beam scanning proton therapy, to assess the need for repeat CT scanning and adaptive replanning. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 16, 2016 Category: Radiology Authors: Lorenzo Placidi, Alessandra Bolsi, Antony J. Lomax, Ralf A. Schneider, Robert Malyapa, Damien C. Weber, Francesca Albertini Tags: Clinical Investigation Source Type: research

PRONTOX – proton therapy to reduce acute normal tissue toxicity in locally advanced non-small-cell lung carcinomas (NSCLC): study protocol for a randomised controlled trial
Primary radiochemotherapy with photons is the standard treatment for locally advanced-stage non-small cell lung cancer (NSCLC) patients. Acute radiation-induced side effects such as oesophagitis and radiation ... (Source: Trials)
Source: Trials - November 15, 2016 Category: Journals (General) Authors: Sebastian Zschaeck, Monique Simon, Steffen L öck, Esther G. C. Troost, Kristin Stützer, Patrick Wohlfahrt, Steffen Appold, Sebastian Makocki, Rebecca Bütof, Christian Richter, Michael Baumann and Mechthild Krause Source Type: research

Establishing evidence-based indications for proton therapy: An overview of current clinical trials
There has been a public mandate for the development of evidenced-based guidelines to define appropriate use of proton beam therapy. The current study provides an overview of active proton therapy clinical trials. Although the majority of ongoing studies are interventional, the majority of patients will be accrued to observational studies. There are multiple ongoing randomized studies, but future efforts should focus on strategies to encourage optimal patient enrollment and retention. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 8, 2016 Category: Radiology Authors: Mark V. Mishra, Sameer Aggarwal, Soren M. Bentzen, Nancy Knight, Minesh P. Mehta, William F. Regine Tags: Clinical Investigation Source Type: research

Pencil beam scanning proton therapy vs rotational arc radiation therapy: A treatment planning comparison for postoperative oropharyngeal cancer
Patients diagnosed with head and neck cancer are traditionally treated with photon radiotherapy. Proton therapy is currently being used clinically and may potentially reduce treatment-related toxicities by minimizing the dose to normal organs in the treatment of postoperative oropharyngeal cancer. The finite range of protons has the potential to significantly reduce normal tissue toxicity compared to photon radiotherapy. Seven patients were planned with both proton and photon modalities. The planning goal for both modalities was achieving the prescribed dose to 95% of the planning target volume (PTV). (Source: Medical Dosimetry)
Source: Medical Dosimetry - November 8, 2016 Category: Radiology Authors: Ontida Apinorasethkul, Maura Kirk, Kevin Teo, Samuel Swisher-McClure, John N. Lukens, Alexander Lin Tags: Original article Source Type: research

Rthp-24. pseudoprogression after proton vs. photon therapy in patients with oligodendroglioma
Proton therapy is increasingly used for treatment of primary brain tumors. Recent concern has emerged regarding potentially higher rates of pseudoprogression, the development of new enhancement within the radiation field, after proton therapy compared to photon therapy. Pseudoprogression can be difficult to distinguish from true progression and is poorly described for patients with oligodendroglioma. We retrospectively reviewed 68 patients with grade 2 or 3 oligodendroglioma treated with proton (n = 27) or photon (n = 41) therapy. All patients were treated between 2004 and 2015 and had a minimum of 6&nb...
Source: Neuro-Oncology - November 7, 2016 Category: Cancer & Oncology Authors: Bronk, J. K., Guha-Thakurta, N., Mahajan, A., Grosshans, D. R., McGovern, S. L. Tags: RADIATION THERAPY Source Type: research

Rthp-35. impact of tumor treatment field array on proton beam dose distribution and image guidance in the treatment of cns malignancies
CONCLUSIONS:Use of the TTF system concurrently with proton beam therapy may be possible with alterations in treatment planning and array placement on radiotherapy treatment days. Further clinical study is warranted to determine feasibility and whether an additional clinical effect is possible. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 7, 2016 Category: Cancer & Oncology Authors: Morgan, H., Wilkinson, J. B., Maynard, M., Dugas, J., Wu, H., Bonnette, D., Rosen, L., Chen, K. Tags: RADIATION THERAPY Source Type: research

Simulation of positron emitters for monitoring of dose distribution in proton therapy
Conclusions There is a good relationship between the positions of positron annihilation profile and positron emitters radioactive decay. Also, GEANT4 is a powerful and suitable tool for simulation of nuclear interactions and positron emitters in tissues. (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - November 1, 2016 Category: Cancer & Oncology Source Type: research

Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for Linear Energy Transfer and Dose-Volume Parameters for the Brainstem and Organs at Risk
In proton therapy of posterior fossa tumors, at least partial inclusion of the brainstem in the target is necessary because of its proximity to the tumor and required margins. Additionally, the preferred beam geometry results in directing the field distal edge toward this critical structure, raising concerns for brainstem toxicity. Some treatment techniques place the beam's distal edge within the brainstem (dose-sparing techniques), and others avoid elevated linear energy transfer (LET) of the proton field by placing the distal edge beyond it (LET-sparing techniques). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 1, 2016 Category: Radiology Authors: Drosoula Giantsoudi, Judith Adams, Shannon M. MacDonald, Harald Paganetti Tags: Physics Contribution Source Type: research

Spot scanning proton therapy minimizes neutron dose in the setting of radiation therapy administered during pregnancy.
Abstract This is a real case study to minimize the neutron dose equivalent (H) to a fetus using spot scanning proton beams with favorable beam energies and angles. Minimum neutron dose exposure to the fetus was achieved with iterative planning under the guidance of neutron H measurement. Two highly conformal treatment plans, each with three spot scanning beams, were planned to treat a 25-year-old pregnant female with aggressive recurrent chordoma of the base of skull who elected not to proceed with termination. Each plan was scheduled for delivery every other day for robust target coverage. Neutron H to the fetus ...
Source: Journal of Applied Clinical Medical Physics - September 30, 2016 Category: Physics Authors: Wang X, Poenisch F, Sahoo N, Zhu RX, Lii M, Gillin MT, Li J, Grosshans D Tags: J Appl Clin Med Phys Source Type: research

Whole-pelvic radiotherapy with spot-scanning proton beams for uterine cervical cancer: a planning study
The aim of this study was to compare the dosimetric parameters of whole-pelvic radiotherapy (WPRT) for cervical cancer among plans involving 3D conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), or spot-scanning proton therapy (SSPT). The dose distributions of 3D-CRT-, IMRT-, and SSPT-based WPRT plans were compared in 10 patients with cervical cancer. All of the patients were treated with a prescribed dose of 50.4 Gy in 1.8-Gy daily fractions, and all of the plans involved the same planning target volume (PTV) constrictions. A 3D-CRT plan involving a four-field box, an IMRT plan involving seven copla...
Source: Journal of Radiation Research - September 30, 2016 Category: Physics Authors: Hashimoto, S., Shibamoto, Y., Iwata, H., Ogino, H., Shibata, H., Toshito, T., Sugie, C., Mizoe, J.-e. Tags: Regular paper Source Type: research

A treatment planning study comparing tomotherapy, volumetric modulated arc therapy, Sliding Window and proton therapy for low-risk prostate carcinoma
Comparing radiation treatment plans to ascertain the optimal intensity-modulated radiation technique for low-risk prostate cancer. (Source: Radiation Oncology)
Source: Radiation Oncology - September 27, 2016 Category: Cancer & Oncology Authors: Sergiu Scobioala, Christopher Kittel, Nicolas Wissmann, Uwe Haverkamp, Mohammed Channaoui, Omar Habibeh, Khaled Elsayad and Hans Theodor Eich Source Type: research

Impact of Real-Time-Image Gating on Spot Scanning Proton Therapy for Lung Tumors: A Simulation Study
This study investigated the impact of beam gating for lung treatment and demonstrated that a gating window of ±2 mm is appropriate in a trade-off between dose distribution and treatment time. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 27, 2016 Category: Radiology Authors: Takahiro Kanehira, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Yusuke Fujii, Takaaki Fujii, Yoichi M. Ito, Naoki Miyamoto, Tetsuya Inoue, Norio Katoh, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato Source Type: research

Impact of Real-Time Image Gating on Spot Scanning Proton Therapy for Lung Tumors: A  Simulation Study
To investigate the effectiveness of real-time-image gated proton beam therapy for lung tumors and to establish a suitable size for the gating window (GW). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 27, 2016 Category: Radiology Authors: Takahiro Kanehira, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Yusuke Fujii, Takaaki Fujii, Yoichi M. Ito, Naoki Miyamoto, Tetsuya Inoue, Norio Katoh, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato Tags: Physics Contribution Source Type: research

Proton therapy for pediatric cancer: are we ready for prime time?
Future Oncology Ahead of Print. (Source: Future Oncology)
Source: Future Oncology - September 22, 2016 Category: Cancer & Oncology Authors: Tobias R Chapman Ralph P Ermoian Source Type: research

P08.52 Proton therapy re-Irradiation in large-volume recurrent glioblastoma.
Conclusion:PT re-irradiation of large-volume rGBM showed to be feasible and safe even with concomitant chemotherapy administration. Despite the small number of patients and the retrospective nature of the study PFS and OS rates were promising and deserve further evaluation in a larger pts sample. (Source: Neuro-Oncology)
Source: Neuro-Oncology - September 21, 2016 Category: Cancer & Oncology Authors: Amelio, D., Widesott, L., Vennarini, S., Fellin, F., Maines, F., Righetto, R., Lorentini, S., Farace, P., Schwarz, M., Amichetti, M. Tags: P08 Glioblastom and Anaplastic gliomas Source Type: research

Radiotherapy-related outcomes in pediatric patients with atypical teratoid thabdoid tumor of the central nervous system
ConclusionModern treatment for ATRT with intensive multimodality therapy including radiotherapy results in a significant portion of subjects with long-term disease control. Initial evidence demonstrates that focal proton therapy in very young subjects is feasible with limited toxicities. Prognosis appears to be improved in localized, completely resected disease. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - September 19, 2016 Category: Cancer & Oncology Source Type: research

Toward a model-based patient selection strategy for proton therapy: External validation of photon-derived normal tissue complication probability models in a head and neck proton therapy cohort
To externally validate head and neck cancer (HNC) photon-derived normal tissue complication probability (NTCP) models in patients treated with proton beam therapy (PBT). (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 15, 2016 Category: Radiology Authors: Pierre Blanchard, Andrew J. Wong, G. Brandon Gunn, Adam S. Garden, Abdallah S.R. Mohamed, David I. Rosenthal, Joseph Crutison, Richard Wu, Xiaodong Zhang, X. Ronald Zhu, Radhe Mohan, Mayankkumar V. Amin, C. David Fuller, Steven J. Frank Tags: Original article Source Type: research

Toward a model-based patient selection strategy for proton therapy: External validation of photon-derived normal tissue complication probability models in a head and neck proton therapy cohort.
CONCLUSION: Although a drop in NTCP model performance was expected for PBT patients, the models showed robustness and remained valid. Further work is warranted, but these results support the validity of the model-based approach for selecting treatment for patients with HNC. PMID: 27641784 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 15, 2016 Category: Radiology Authors: Blanchard P, Wong AJ, Gunn GB, Garden AS, Mohamed AS, Rosenthal DI, Crutison J, Wu R, Zhang X, Zhu XR, Mohan R, Amin MV, Fuller CD, Frank SJ Tags: Radiother Oncol Source Type: research

Dry eye syndrome following proton therapy of ocular melanomas
PurposeSome institutions contra‐indicate proton therapy (PT) for ocular melanomas of temporal superior location (TS) owing to lacrimal gland irradiation and the risk of dry eye syndrome (DES) and advocate brachytherapy. We investigated whether PT can be safely performed in TS melanomas. MethodsLocation, DES grade and dose to the lacrimal gland estimated from Eyeplan blindly by two operators were correlated in consecutive patients treated from 1999 to 2014 with 52 Gy ResultsOf 1473 patients, 13.6% had DES, including 5.4% with severe DES (sDES). Temporal superior and temporal melanoma patients had a higher risk of DES...
Source: Acta Ophthalmologica - September 14, 2016 Category: Opthalmology Authors: C. Maschi, L. Sara, M.L. Peyrichon, S. Baillif, J. Herault, J. Thariat, J.P. Caujolle Tags: Abstracts from the 2016 European Association for Vision and Eye Research Conference Source Type: research

Long ‐term visual acuity preservation after proton therapy for peri‐ and parapapillary melanoma patients treated at the Paul Scherrer Institute
ConclusionsPreservation of visual function in some of these cases could be consequential to reduced radiation exposure to the macula and optic nerve behind the disk. We speculate on a possible role of the posterior ciliary artery (PCA) and their capillary anastomoses, protecting the papillo‐macular area from ischemia. (Source: Acta Ophthalmologica)
Source: Acta Ophthalmologica - September 14, 2016 Category: Opthalmology Authors: A. Pica, J. Hrbacek, L. Zografos, A. Schalenbourg, H. Wagner, L. Vallat, M. Walser, R. Schneider, D.C. Weber Tags: Abstracts from the 2016 European Association for Vision and Eye Research Conference Source Type: research

A case of very elderly patient with multiple cervical metastases of salivary duct carcinoma successfully treated by anti-androgen and proton beam therapies
Conclusions ADT should be considered as a therapeutic option for unresectable advanced SDC. (Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology)
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - September 14, 2016 Category: ENT & OMF Source Type: research

Benefit of particle therapy in re-irradiation of head and neck patients. Results of a multicentric in silico ROCOCO trial.
CONCLUSIONS: In this ROCOCO in silico trial, a reduction in mean dose to OARs was achieved using particle therapy compared to photons in the re-irradiation of HNSCC. There was a dosimetric benefit favouring carbon-ions above proton therapy. These dose reductions may potentially translate into lower severe complication rates related to the re-irradiation. PMID: 27639891 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 14, 2016 Category: Radiology Authors: Eekers DB, Roelofs E, Jelen U, Kirk M, Granzier M, Ammazzalorso F, Ahn PH, Janssens GO, Hoebers FJ, Friedmann T, Solberg T, Walsh S, Troost EG, Kaanders JH, Lambin P Tags: Radiother Oncol Source Type: research

Proton therapy for early stage prostate cancer: is there a case?
(Source: OncoTargets and Therapy)
Source: OncoTargets and Therapy - September 9, 2016 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research

Spot scanning proton therapy minimizes neutron dose in the setting of radiation therapy administered during pregnancy
This is a real case study to minimize the neutron dose equivalent (H) to a fetus using spot scanning proton beams with favorable beam energies and angles. Minimum neutron dose exposure to the fetus was achieved with iterative planning under the guidance of neutron H measurement. Two highly conformal treatment plans, each with three spot scanning beams, were planned to treat a 25-year-old pregnant female with aggressive recurrent chordoma of the base of skull who elected not to proceed with termination. Each plan was scheduled for delivery every other day for robust target coverage. Neutron H to the fetus was measured using...
Source: Journal of Applied Clinical Medical Physics - September 8, 2016 Category: Physics Source Type: research

Secondary neutron doses in a proton therapy centre
The formation of secondary high-energy neutrons in proton therapy can be a concern for radiation protection of staff. In this joint intercomparative study (CERN, SCK•CEN and IBA/IRISIB/ULB), secondary neutron doses were assessed with different detectors in several positions in the Proton Therapy Centre, Essen (Germany). The ambient dose equivalent H*(10) was assessed with Berthold LB 6411, WENDI-2, tissue-equivalent proportional counter (TEPC) and Bonner spheres (BS). The personal dose equivalent Hp(10) was measured with two types of active detectors and with bubble detectors. Using spectral and basic angular informat...
Source: Radiation Protection Dosimetry - September 8, 2016 Category: Radiology Authors: De Saint-Hubert, M., Saldarriaga Vargas, C., Van Hoey, O., Schoonjans, W., De Smet, V., Mathot, G., Stichelbaut, F., Manessi, G., Dinar, N., Aza, E., Cassell, C., Silari, M., Vanhavere, F. Tags: Paper Source Type: research

[Robust treatment planning in proton therapy].
The objective of this paper is to present a vision for the management of uncertainties in proton therapy in the continuity of formalisms established for X-rays. The latter are first summarized before discussing the necessary developments in order to consistently apply them to protons. PMID: 27614528 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 7, 2016 Category: Cancer & Oncology Authors: Sterpin E, Barragan A, Souris K, Lee JA Tags: Cancer Radiother Source Type: research

[Indications and results for protontherapy in cancer treatments].
un-Lévi JM Abstract Purpose was to summarize results for proton therapy in cancer treatment. A systematic review has been done by selecting studies on the website www.pubmed.com (Medline) and using the following keywords: proton therapy, radiation therapy, cancer, chordoma, chondrosarcoma, uveal melanoma, retinoblastoma, meningioma, glioma, neurinoma, pituitary adenoma, medulloblastoma, ependymoma, craniopharyngioma and nasal cavity. There are several retrospective studies reporting results for proton therapy in cancer treatments in the following indications: ocular tumors, nasal tumors, skull-based tumors,...
Source: Cancer Radiotherapie - September 7, 2016 Category: Cancer & Oncology Authors: Doyen J, Bondiau PY, Benezery K, Thariat J, Vidal M, Gérard A, Hérault J, Carrie C, Hannoun-Lévi JM Tags: Cancer Radiother Source Type: research

[Intensity-modulated radiotherapy of head and neck cancers: Dose effects on the ocular, orbital and eyelid structures].
Abstract Radiation-induced damage of ocular, orbital and eyelid structures are mainly reported for the optic nerve, retina, lens and lacrimal gland. Dose-volume relationships are, however, inaccurate due to the small volume of most of the organs at risk involved and limited ability of irradiation techniques to spare these structures in the pre-IMRT (intensity-modulated radiation therapy) era. The ability of newest radiation techniques including IMRT and proton therapy to generate steep dose gradients may yield more accurate models in the future. Some toxicities are severe and irreversible, leading to vision loss, ...
Source: Cancer Radiotherapie - September 7, 2016 Category: Cancer & Oncology Authors: Thariat J, Racadot S, Pointreau Y, Boisselier P, Grange JD, Graff P, Weber DC Tags: Cancer Radiother Source Type: research

Proton therapy posterior beam approach with pencil beam scanning for esophageal cancer
AbstractPurposeThe aim of this study is to present the dosimetry, feasibility, and preliminary clinical results of a  novel pencil beam scanning (PBS) posterior beam technique of proton treatment for esophageal cancer in the setting of trimodality therapy.MethodsFrom February 2014 to June 2015, 13  patients with locally advanced esophageal cancer (T3-4N0-2M0; 11 adenocarcinoma, 2 squamous cell carcinoma) were treated with trimodality therapy (neoadjuvant chemoradiation followed by esophagectomy). Eight patients were treated with uniform scanning (US) and 5 patients were treated with a si ngle ...
Source: Strahlentherapie und Onkologie - September 5, 2016 Category: Cancer & Oncology Source Type: research

Reoptimization of intensity-modulated proton therapy plans based on linear energy transfer
We present a treatment planning method for intensity-modulated proton therapy based on prioritized optimization, which avoids elevated LET in critical organs. The approach is demonstrated for meningiomas, base-of-skull chordomas and ependymomas where the brainstem, chiasm or optic nerve overlay the target volume. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 1, 2016 Category: Radiology Authors: Jan Unkelbach, Pablo Botas, Drosoula Giantsoudi, Bram Gorissen, Harald Paganetti Source Type: research

Reoptimization of Intensity Modulated Proton Therapy Plans Based on Linear Energy Transfer
We describe a treatment plan optimization method for intensity modulated proton therapy (IMPT) that avoids high values of linear energy transfer (LET) in critical structures located within or near the target volume while limiting degradation of the best possible physical dose distribution. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 1, 2016 Category: Radiology Authors: Jan Unkelbach, Pablo Botas, Drosoula Giantsoudi, Bram L. Gorissen, Harald Paganetti Tags: Physics Contribution Source Type: research

Proton therapy patterns-of-care and early outcomes for Hodgkin lymphoma: results from the Proton Collaborative Group Registry.
PMID: 27579554 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 31, 2016 Category: Cancer & Oncology Authors: Hoppe BS, Tsai H, Larson G, Laramore GE, Vargas C, Tseng YD, Dunn M, McGee L, Cahlon O, Hartsell W Tags: Acta Oncol Source Type: research

Patterns of Failure in Pediatric Rhabdomyosarcoma Following Proton Therapy
This study examines patterns of failure in children who received proton therapy for rhabdomyosarcoma. Routine use of a small CTV margin in the setting of highly conformal proton therapy does not compromise local control in children diagnosed with rhabdomyosarcoma with unfavorable risk features. The patterns of failure suggest improvements in local control will come through dose escalation of select high-risk tumors rather than larger CTV margins. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - August 29, 2016 Category: Radiology Authors: Tamara Z. Vern-Gross, Daniel J. Indelicato, Julie A. Bradley, Ronny L. Rotondo Source Type: research

Nowadays proton therapy: Double scattering versus pencil beam scanning mode
Pencil beam scanning mode is becoming widely used in proton therapy. The biological consequences of the use of pencil beam scanning instead of double scattering mode have not been studied in detail yet. Most of the biological studies of relative biological effectiveness of protons were carried out using double scattering mode. The dose rates in pencil beam scanning are locally essentially higher than those in double scattering mode, which could affect the cell response. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - August 27, 2016 Category: Journals (General) Authors: Anna Michaelidesov á, Jana Konířová, Jana Vachelová, Vladimír Vondráček, Marie Davídková Source Type: research