International Journal of Radiation Oncology * Biology * Physics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Risk of Subsequent Neoplasms in Childhood Cancer Survivors After Radiation Therapy: A Comprehensive PENTEC Review
A Pediatric Normal Tissue Effects in the Clinic (PENTEC) analysis of published investigations of central nervous system (CNS) subsequent neoplasms (SNs), subsequent sarcomas, and subsequent lung cancers in childhood cancer survivors who received radiation therapy (RT) was performed to estimate the effect of RT dose on the risk of SNs and the modification of this risk by host and treatment factors. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 29, 2023 Category: Radiology Authors: Dana L. Casey, Ivan R. Vogelius, N. Patrik Brodin, Kenneth B. Roberts, Michele Avanzo, Janaki Moni, Constance Owens, C écile M. Ronckers, Louis S. Constine, Soren M. Bentzen, Arthur Olch Tags: CLINICAL INVESTIGATION Source Type: research

A prospective study demonstrating early prediction of skin toxicity from radiotherapy using radiomic features from optical and infrared images
The objectives of this study were to evaluate the correlation between skin toxicity and radiomic features extracted from optical and infrared (thermal) images of skin, and to develop a model for predicting a patient's skin response to radiation. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 29, 2023 Category: Radiology Authors: Abby Yashayaeva, Hannah Dahn, Michelle Svatos, Kenny Zhan, Shaun Naugle, Karyn Sutherland, Britney Green, Cayleigh Martell, James Robar Tags: Physics Contribution Source Type: research

Integrated high-throughput screening and large-scale isobolographic analysis to accelerate the discovery of radiosensitizers with greater selectivity for cancer cells
Purpose: High-throughput screening (HTS) platforms have been widely used to identify candidate anticancer drugs and drug-drug combinations, however; HTS-based identification of new drug-ionizing radiation (IR) combinations has rarely been reported. Herein, we developed an integrated approach including cell based HTS and computational large-scale isobolographic analysis to accelerate the identification of radiosensitizing compounds acting strongly and more specifically on cancer cells.Methods: In a 384-well plate format, 160 compounds likely to interfere with the cell response to radiation were screened on human glioblastom...
Source: International Journal of Radiation Oncology * Biology * Physics - September 29, 2023 Category: Radiology Authors: Pierre Verrelle, Pierre Gestraud, Florent Poyer, Ad èle Soria, Sarah Tessier, Aurianne Lescure, Elodie Anthony, Maxime Corbé, Sophie Henrich, Claire Beauvineau, Ludovic Chaput, Anton Granzhan, Sandrine Piguel, Franck Perez, Marie-Paule Teulade-Fichou, F Tags: Biology Contribution Source Type: research

Clinical and Dosimetric Results of Proton or Photon Radiotherapy for Large ( > 5 cm) Hepatocellular Carcinoma: A Retrospective Analysis
: To report the clinical and dosimetric attributes of patients with large unresectable hepatocellular carcinoma (HCC) undergoing proton or photon radiotherapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 29, 2023 Category: Radiology Authors: Rodney Cheng-En Hsieh, Ching-Hsin Lee, Hsiao-Chieh Huang, Shu-Wei Wu, Chen-Yu Chou, Sheng-Ping Hung, Chao-Wei Lee, Sunil Krishnan, Bhanu Prasad Venkatesulu, Jin-Chiao Lee, Yung-Chih Chou, Kun-Ming Chan, Po-Ting Lin, Wei-Chen Lee, Chen-Chun Lin, Shen-Yen L Tags: Clinical Investigation Source Type: research

Proton beam therapy for hepatocellular carcinoma: Multicenter prospective registry study in Japan
A prospective multicenter registry study was started in May 2016 in Japan to evaluate the efficacy and safety of proton beam therapy (PBT) for hepatocellular carcinoma (HCC). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 29, 2023 Category: Radiology Authors: Masashi Mizumoto, Hiroyuki Ogino, Toshiyuki Okumura, Kazuki Terashima, Masao Murakami, Takashi Ogino, Hiroyasu Tamamura, Tetsuo Akimoto, Takahiro Waki, Norio Katoh, Masayuki Araya, Tsuyoshi Onoe, Masaru Takagi, Hiromitsu Iwata, Haruko Numajiri, Tomoaki Ok Tags: Clinical Investigation Source Type: research

Open RT Structures: A Solution for TG-263 Accessibility
Consistency of nomenclature within radiation oncology is increasingly important as big data efforts and data sharing become more feasible. Automation of radiation oncology workflows depends on standardized contour nomenclature which enables toxicity and outcomes research, while also reducing medical errors and facilitating quality improvement activities. Recommendations for standardized nomenclature have been published in the American Association of Physicists in Medicine (AAPM) report from Task Group 263. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 29, 2023 Category: Radiology Authors: Brian M. Anderson, Laura Padilla, Jeffrey M. Ryckman, Elizabeth Covington, David S. Hong, Kaley Woods, Matthew S Katz, Raed Zuhour, Chris Estes, Kevin L. Moore, Casey Bojechko Tags: Brief Report Source Type: research

Carbon –ion radiotherapy for unresectable locally recurrent colorectal cancer: A promising curative treatment for both radiotherapy–naïve cases and re–irradiation cases
It is difficult to effectively cure patients with unresectable locally recurrent colorectal cancers (LRCRCs) using conventional chemotherapy or chemoradiotherapy. Furthermore, treatment options vary depending on the patient's history of radiation therapy. Carbon –ion radiotherapy (CIRT) is a potentially curative treatment for these patients. Here, we compare the treatment outcomes of radiotherapy–naïve cases (nRT) and re–irradiation cases (reRT). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 28, 2023 Category: Radiology Authors: Takiyama Hirotoshi, Yamada Shigeru, Shinoto Makoto, Isozaki Tetsuro, Ikawa Hiroaki, Imai Reiko, Koto Masashi Tags: Clinical Investigation Source Type: research

Interim toxicity analysis from the randomised HERMES trial of 2- and 5-fraction MRI-guided adaptive prostate radiotherapy
At this interim analysis, the rate of genitourinary toxicity in the 2-fraction and 5-fraction treatment groups was found to be below the pre-specified threshold (5/10 grade 2 or higher) and continuation of the study to complete recruitment of 23 participants per group was recommended. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 28, 2023 Category: Radiology Authors: Dr Rosalyne Laura Westley, Katie Biscombe, Alex Dunlop, Adam Mitchell, Uwe Oelfke, Simeon Nil, Julia Murray, Angela Pathmanathan, Shaista Hafeez, Chris Parker, Ragu Ratnakumaran, Sophie Alexander, Trina Herbert, Emma Hall, Alison C Tree Tags: Brief Report Source Type: research

Evaluating a physician audit and feedback intervention to increase clinical trial enrollment in radiation oncology in a multi-site tertiary cancer center: A randomized study
Clinical trial participation continues to be low, slowing new cancer therapy development. Few strategies have been prospectively tested to address barriers to enrollment. We investigated the effectiveness of a physician audit and feedback report to improve clinical trial enrollment. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 26, 2023 Category: Radiology Authors: Nicholas P. Verdini, Daphna Y. Gelblum, Emily A. Vertosick, Jamie S. Ostroff, Andrew J. Vickers, Daniel R. Gomez, Erin F. Gillespie Tags: Clinical Investigation Source Type: research

Immunomodulatory effects of histone variant H2A.J in ionizing radiation dermatitis
Histone variant H2A.J is associated with premature senescence following ionizing radiation (IR) and modulates senescence-associated secretory phenotype (SASP). Using constitutive H2A.J knock-out mice, the role of H2A.J was investigated in radiation dermatitis. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 25, 2023 Category: Radiology Authors: Gargi Tewary, Benjamin Freyter, Mutaz Abd Al-razaq, Hendrik Auerbach, Matthias W. Laschke, Tanja K übelbeck, Antonia Kolb, Adèle Mangelinck, Carl Mann, Daniela Kramer, Claudia E. Rübe Tags: Biology Contribution Source Type: research

Racial and Ethnic Differences in Long-Term Adverse Radiotherapy Effects among Breast Cancer Survivors
Breast and skin changes are an underrecognized side effect of radiotherapy for breast cancer, which may have long-term implications for quality of life (QOL). Racial and ethnic disparities in breast cancer outcomes including long-term QOL differences following breast radiotherapy are poorly understood. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 24, 2023 Category: Radiology Authors: Kevin Diao, Xiudong Lei, Weiguo He, Reshma Jagsi, Sharon H. Giordano, Grace L. Smith, Abigail Caudle, Yu Shen, Susan K. Peterson, Benjamin D. Smith Tags: Brief Report Source Type: research

A Phase I Study of the DNA-PK Inhibitor Peposertib in Combination with Radiotherapy with or without Cisplatin in Patients with Advanced Head and Neck Tumors
DNA-dependent protein kinase (DNA-PK) plays a key role in the repair of DNA double-strand breaks (DSBs) via non-homologous end joining. Inhibition of DNA-PK can enhance the effect of DNA DSB-inducing anticancer therapies. Peposertib (formerly M3814) is an orally administered, potent, and selective small molecule DNA-PK inhibitor that has demonstrated radiosensitizing and antitumor activity in xenograft models and was well-tolerated in monotherapy. This Phase I trial (NCT02516813) investigated the maximum tolerated dose, recommended Phase II dose (RP2D), safety, and tolerability of peposertib in combination with palliative ...
Source: International Journal of Radiation Oncology * Biology * Physics - September 24, 2023 Category: Radiology Authors: Michael Samuels, Johan Falkenius, Voichita Bar-Ad, Juergen Dunst, Baukelien van Triest, Jeffrey Yachnin, Almudena Rodriguez-Gutierrez, Mirjam Kuipers, Xiaoli You, Barbara Sarholz, Giuseppe Locatelli, Andreas Becker, Esther G.C. Troost Tags: Clinical Investigation Source Type: research

Racecadotril versus Loperamide in acute radiation enteritis: a randomized, double-blind, phase 3, non-inferiority trial.
There is currently no gold standard available for the management of acute radiation enteritis. We compared the efficacy and safety of Racecadotril an antihypersecretory drug versus Loperamide an anti-motility agent in acute radiation enteritis. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 22, 2023 Category: Radiology Authors: Dr P.B. Abhijith, Dr Shyama Prem Sudha, Dr Pazhanivel Mohan, Dr Ninad Harish Patil, Dr K.A. Asif Rahman, Dr Bhargav Shreeram Gundapuneedi, Dr M. Harish Tags: Clinical Investigation Source Type: research

A Bear of an Aberrant Case: Bilateral Breast Malignancies in a Woman With Previous History of Breast Radiation
An 83-year-old woman with history of left-sided breast cancer treated with lumpectomy, axillary lymph node dissection, and adjuvant radiation therapy to the left breast alone 25 years ago presented for skin ulceration over the left breast. Shave biopsy returned breast carcinoma, Estrogen Receptor 90%, Progesterone Receptor 95%, Human Epidermal Growth Factor Receptor 2 nonamplified. Diagnostic mammography and ultrasound demonstrated a 2.0 cm right axillary lymph node and one mass in each breast. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 20, 2023 Category: Radiology Authors: Ji Hyae Lee, Karen Tye Tags: Gray Zone Source Type: research

Operational Ontology for Oncology: A Framework for Improved Communication and Understanding in Cancer Care
Although radiation oncologists and medical physicists regularly produce large amounts of clinical data deposited in various systems, substantial barriers impede the sharing of this information across practices and research repositories, or even with the medical oncologist down the hall. In this issue of the Red Journal, Mayo et al present the Operational Ontology for Oncology (O3), developed by the American Association of Physicists in Medicine's Big Data Science Committee (BDSC),1 a professional society-based, multidisciplinary, international, consensus-driven solution addressing the lack of data standardization in oncolo...
Source: International Journal of Radiation Oncology * Biology * Physics - September 20, 2023 Category: Radiology Authors: David S. Hong, Amanda Caissie, Coen W. Hurkmans, Andra V. Krauze, Randi Kudner, Thomas G. Purdie, Ying Xiao Tags: Editorial Source Type: research