Variation in Inter-institutional Plan Quality When Adopting A Hypofractionated Protocol for Prostate Cancer External Beam Radiation Therapy
This study quantified plan quality differences across the four cancer centers in XXX(blinded for review) for plans that followed the PROstate Fractionated Irradiation Trial (PROFIT) protocol. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 26, 2020 Category: Radiology Authors: Lingyue Sun, Wendy Smith, Charles Kirkby Source Type: research

“Second cancers in patients with locally advanced prostate cancer randomized to lifelong endocrine treatment with or without radical radiotherapy. Long term follow- up of the Scandinavian Prostate Cancer Group-7 trial.”
(Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 26, 2020 Category: Radiology Authors: Bj ørg Y. Aksnessæther, Tor Åge Myklebust, Arne Solberg, Olbjørn H. Klepp, Eva Skovlund, Solveig Roth Hoff, Sophie D. Fosså, Anders Widmark, Jo-Åsmund Lund Tags: Letter to the Editor Source Type: research

In regard to aksness Æther et al.
(Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 26, 2020 Category: Radiology Authors: Sezin Yuce Sari, Aysenur Elmali, Serkan Arslan, Gokhan Ozyigit Tags: Letter to the Editor Source Type: research

Choosing Wisely: the Korean Perspective The Launch of the Nationwide ‘Right Decision in Cancer Care’ Initiative
(Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 26, 2020 Category: Radiology Authors: Joo-Young Kim Source Type: research

Watch the mass, save the gland (radiotherapy perhaps later)
(Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 24, 2020 Category: Radiology Authors: Giuseppe Minniti, Paolo Tini Source Type: research

Clinical outcomes of stereotactic MR-guided adaptive radiation therapy for high-risk lung tumors
Magnetic resonance (MR-)guided stereotactic ablative radiotherapy (SABR) was performed for patients with lung tumors in whom treatment delivery was challenging due to tumor location, motion or pulmonary comorbidity. As stereotactic MR-guided adaptive radiation therapy (or SMART) is a novel approach, we studied clinical outcomes in these high-risk lung tumors. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 24, 2020 Category: Radiology Authors: Tobias Finazzi, Cornelis J.A. Haasbeek, Femke O.B. Spoelstra, Miguel A. Palacios, Marjan A. Admiraal, Anna M.E. Bruynzeel, Berend J. Slotman, Frank J. Lagerwaard, Suresh Senan Source Type: research

Management of High-Risk Node-Negative Disease with Comprehensive Nodal Radiation
(Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 24, 2020 Category: Radiology Authors: Oluwadamilola T. Oladeru, Alice Y. Ho Source Type: research

Radiation Therapy in Gabon: Multi-Institutional Collaboration as a Paradigm for Growth in the African Radiation Oncology Sector
In Africa, there were over 846,000 new cancer cases and 591,000 deaths in 2012. These figures are projected to rise to 1.27 million cases and 0.97 million deaths annually by 20301 as a result of population growth and aging alone. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 22, 2020 Category: Radiology Authors: Onyinye Balogun, Laurianne James, Luiza Chepkemoi, Harmar Brereton, Silvia Formenti, Ernest Belembaogo Tags: Feature Source Type: research

Clear cCR, Then Observe
(Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 22, 2020 Category: Radiology Authors: Laura Melina Fernandez, Rodrigo Oliva Perez Tags: Gray Zone Source Type: research

Achieve cCR, Then Local Excision
(Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 22, 2020 Category: Radiology Authors: Eric Rullier, Quentin Denost Tags: Gray Zone Source Type: research

Optimizing Rectal Cancer Neoadjuvant Therapy —How to Manage a cCR?
A 58-year-old female presents with a 1-year history of hematochezia, 20-pound weight loss, and increased straining with bowel movements. She denies increased bowel frequency or change in stool caliber. Her medical history is notable for irritable bowel syndrome, but otherwise unremarkable. She has no family history of malignancy and does not take any prescribed medications or supplements. She denies abdominal pain, bone pain, or any symptoms concerning for metastatic disease. Her initial physical examination was notable for an Eastern Cooperative Oncology Group performance status of 0, and presence on digital rectal examin...
Source: International Journal of Radiation Oncology * Biology * Physics - February 22, 2020 Category: Radiology Authors: Adam Avant, Jeffrey R. Olsen Tags: Gray Zone Source Type: research

Gender Diversity in Radiation Oncology Board Certification
In this report, we describe the gender makeup of the American Board of Radiology (ABR) volunteer RO leadership to clarify the current gender diversity within its ranks. We also provide information on how individuals are selected to serve in positions. Such transparency is important because barriers to participation in influential roles may be related to lack of understanding of selection processes. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 22, 2020 Category: Radiology Authors: Miriam A. Knoll, Reshma Jagsi, Paul Wallner Tags: The Profession Source Type: research

Nonclinical Time in U.S. Radiation Oncology Residency Programs: Number of Months and Resident Opinion of Value
Data regarding the amount and use of nonclinical time (NCT) in radiation oncology residency programs are scarce. We surveyed every U.S. radiation oncology residency program to obtain benchmark data to inform decisions about optimal program structure. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 22, 2020 Category: Radiology Authors: Akash D. Parekh, Matthew M. Culbert, Jeffrey V. Brower, George Q. Yang, Daniel W. Golden, Robert J. Amdur Tags: The Profession Source Type: research

In Regard to Qi et al
We read with great interest the article by Qi et  al.1 In this paper, the authors reported the biochemical progression-free survival (bPFS) and toxicity results of a randomized phase 3 trial comparing in the postoperative setting (adjuvant or salvage) a dose-escalated radiation therapy (RT) protocol of 72 Gy versus a standard dose of 66 Gy to the prostate bed (PB) using modern image guided techniques. Patients were treated to the whole pelvis (whole pelvis RT) in the majority of the cases (87% of the whole cohort) without androgen deprivation. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 22, 2020 Category: Radiology Authors: V érane Achard, Thomas Zilli Tags: Comment Source Type: research

Writing a Research Paper
Although the papers I have written with residents and faculty are not always accepted, most reviewers begin their comments with “This is a clearly written paper.” I think this must be why several people have asked me if I have a formula for writing research papers. The answer is yes, I do, so I decided to write this brief essay to describe it. I do this because I have learned the hard way that good data can be sunk by ba d writing and have seen the pain in some colleagues’ faces when they have a good project but can only stare at a blank computer screen, not knowing how to start. (Source: International Jo...
Source: International Journal of Radiation Oncology * Biology * Physics - February 22, 2020 Category: Radiology Authors: Theodore S. Lawrence Tags: Education Source Type: research

In Regard to Albuquerque et  al
We applaud the University of Texas Southwestern Department of Radiation Oncology for conducting “A phase II trial of stereotactic ablative radiotherapy as a boost for locally advanced cervical cancer,” a necessary prospective study on definitive dose delivery for patients unable to undergo brachytherapy.1 The involved trialists were undoubtedly deliberate and meticulous in its design and e xecution, akin to their groundbreaking work with lung stereotactic body radiation therapy (SBRT). Although these results unfortunately showed high rates of rectal toxicity, the data does not indicate a failure of SBRT, but ra...
Source: International Journal of Radiation Oncology * Biology * Physics - February 22, 2020 Category: Radiology Authors: Shraddha M. Dalwadi, Mark D. Bonnen, Michelle S. Ludwig Tags: Comment Source Type: research

In Reply to Dalwadi et  al
We thank the authors1 for their letter highlighting the critical issues facing the feasibility and efficacy of stereotactic ablative radiation (SAbR) as a boost for patients with cervical cancer unable to receive standard brachytherapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 22, 2020 Category: Radiology Authors: Kevin Albuquerque, Robert Timmerman Tags: Comment Source Type: research

Radiation Dose Escalation or Longer Androgen Suppression to Prevent Distant Progression in Men With Locally Advanced Prostate Cancer: 10-Year Data From the TROG 03.04 RADAR Trial
To clarify the relative effects of duration of androgen suppression (AS) and radiation dose escalation (RDE) on distant progression (DP) in men with locally advanced prostate cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 22, 2020 Category: Radiology Authors: David Joseph, James W. Denham, Allison Steigler, David S. Lamb, Nigel A. Spry, John Stanley, Tom Shannon, Gillian Duchesne, Chris Atkinson, John H.L. Matthews, Sandra Turner, Lizbeth Kenny, David Christie, Keen-Hun Tai, Nirdosh Kumar Gogna, Rachel Kearvel Tags: Clinical Investigation Source Type: research

Gastrointestinal Cancers: Moving the Needle for Rectal, Gastroesophageal, Pancreaticobiliary, and Liver Cancers
We welcome 3 new associate editors: Drs Christopher Anker (University of Vermont Larner College of Medicine), Michael Buckstein (Icahn School of Medicine at Mount Sinai), and Jordan Kharofa (University of Cincinnati College of Medicine), whom were selected for their timely and thoughtful critiques as Red Journal reviewers. Although all 3 reviewers are experts in gastrointestinal (GI) radiation oncology, Dr Anker provides expertise in esophageal and rectal cancers, Dr Buckstein in liver cancers and translational science, and Dr Kharofa in pancreatic and anal cancers. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 22, 2020 Category: Radiology Authors: Jordan Kharofa, Christopher L. Hallemeier, Florence Huguet, Christopher J. Anker, Michael H. Buckstein, Diana Tait, Jeffrey R. Olsen, Salma K. Jabbour Tags: Feature Source Type: research

Erratum to: Zhongjie Chen, Yinshan Fang, Si Zhang, et  al. Haplodeletion of Follistatin-Like 1 Attenuates Radiation-Induced Pulmonary Fibrosis in Mice. Int J Radiat Oncol Biol Phys 2019;103:208-216.
Please add second corresponding author. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 22, 2020 Category: Radiology Tags: Erratum Source Type: research

Treatment Intensification in High-Risk Prostate Cancer: Lessons From the TROG 03.04 RADAR Trial
Thousands of men across the world have participated in randomized clinical trials testing the role of hormone therapy in the curative treatment of localized, high-risk prostate cancer. Over several decades, we have established that long-term hormone therapy improves survival, even in the setting of dose-escalated external beam radiation therapy (EBRT).1 Recently reported clinical trials suggest that for some men 18 months of hormone therapy may be a suitable duration that balances treatment efficacy with quality-of-life preservation. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 22, 2020 Category: Radiology Authors: Robert T. Dess Tags: Editorial Source Type: research

Issue Highlights
Kharofa et al (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 22, 2020 Category: Radiology Source Type: research

Meetings
February 27-29, 2020 (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 22, 2020 Category: Radiology Source Type: research

Synchrotron X-ray boost delivered by Microbeam Radiation Therapy after conventional X-ray therapy fractionated in time improves F98 glioma control
Synchrotron microbeam radiation therapy (MRT) is based on the spatial fractionation of the incident, highly collimated synchrotron beam into arrays of parallel microbeams depositing several hundred grays. It appears relevant to combine MRT with a conventional treatment course, preparing a treatment scheme for future patients in clinical trials. The efficiency of MRT delivered after several broad beam (BB) fractions to palliate of F98 brain tumors in rats in comparison with BB fractions alone was evaluated in this study. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 20, 2020 Category: Radiology Authors: Marine Potez, Audrey Bouchet, M élanie Flaender, Claire Rome, Nora Collomb, Michael Grotzer, Michael Krisch, Valentin Djonov, Jacques Balosso, Emmanuel Brun, Jean A. Laissue, Raphaël Serduc Source Type: research

Efficacy and safety of liver-directed concurrent chemoradiotherapy and sequential sorafenib for advanced hepatocellular carcinoma; a prospective phase 2 trial
Although sorafenib as a standard of care for advanced hepatocellular carcinoma (HCC) prolongs overall survival (OS), its efficacy is limited due to its unsatisfactory objective response and marginal survival benefit. To counter these limitations, we designed a single-arm, phase II trial with liver-directed concurrent chemoradiotherapy (LD-CCRT) and sequential sorafenib treatment in patients with advanced HCC. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 18, 2020 Category: Radiology Authors: Beom Kyung Kim, Do Young Kim, Hwa Kyung Byun, Hye Jin Choi, Seung-Hoon Beom, Hye Won Lee, Seung Up Kim, Jun Yong Park, Sang Hoon Ahn, Jinsil Seong, Kwang-Hyub Han Source Type: research

Beyond an Updated Graded Prognostic Assessment (Breast GPA): A Prognostic Index and Trends in Treatment and Survival in Breast Cancer Brain Metastases from 1985 to Today
For patients with breast cancer brain metastases, new prognostic factors are identified and incorporated into an updated Graded Prognostic Assessment (Breast GPA). Over decades, treatment patterns have changed and survival has improved. Median survival for patients in the best prognostic group now exceeds 3 years. Furthermore, these data suggest HER2-targeted therapies improve outcomes for these patients. The Breast GPA facilitates clinical decision-making, end-of-life care and appropriate stratification of future clinical trials. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 18, 2020 Category: Radiology Authors: Paul W. Sperduto, Shane Mesko, Jing Li, Daniel Cagney, Ayal Aizer, Nancy U. Lin, Eric Nesbit, Tim J. Kruser, Jason Chan, Steve Braunstein, Jessica Lee, John P. Kirkpatrick, Will Breen, Paul D. Brown, Diana Shi, Helen A. Shih, Hany Soliman, Arjun Sahgal, R Source Type: research

PHASE i TRIAL OF MRI-GUIDED Prostate Cancer Lattice Extreme Ablative Dose (LEAD) BOOST Radiotherapy
A phase I clinical trial was designed to test the feasibility and toxicity of administering high-dose spatially-fractionated radiotherapy to MRI-defined prostate tumor volumes, in addition to standard treatment. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 18, 2020 Category: Radiology Authors: Alan Pollack, Felix M. Chinea, Elizabeth Bossart, Deukwoo Kwon, Matthew Abramowitz, Charles Lynne, Merce Jorda, Brian Marples, Vivek N. Patel, Xiaodong Wu, Isildinha Reis, Matthew T. Studenski, Javier Casillas, Radka Stoyanova Source Type: research

Radiation Associated Secondary Malignancies in BRCA Mutation Carriers Treated for Breast Cancer
Radiation therapy (RT), a standard Breast Cancer (BC) treatment modality, is associated with a small increased risk of in-field second primary malignancy (SPM). SPM rates following RT in BRCA mutation carriers, have rarely been reported. An elevated risk of SPM would impact the safety of breast conservation for early BC or prophylactic radiation as a method of prevention. We analyzed a population of BRCA carriers irradiated for BC to determine if there is an elevated rate of SPM. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 18, 2020 Category: Radiology Authors: S. Schlosser, R. Rabinovitch, Z. Shatz, S. Galper, I. Shahadi-Dromi, S. Finkel, G. Jacobson, A. Rasco, E. Friedman, Y. Laitman, E. Evron, R. Bernstein, I. Weiss, M. Sklair- Levy, M.A. Ben-David Source Type: research

Single Institution Phase I/II Prospective Clinical Trial of Single Fraction High Gradient Adjuvant Partial Breast Irradiation for Hormone Sensitive Stage 0-I Breast Cancer
We sought to evaluate the feasibility and tolerability of a novel APBI regimen delivered in a single fraction postoperatively. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 18, 2020 Category: Radiology Authors: William R. Kennedy, Maria A. Thomas, Jennifer A. Stanley, Jingqin Luo, Laura L. Ochoa, Katherine K. Clifton, Amy E. Cyr, Julie A. Margenthaler, Todd A. DeWees, Alex Price, Rojano Kashani, Olga Green, Imran Zoberi Source Type: research

Impact of 18F-fluciclovine positron emission tomography on the management of patients with recurrence of prostate cancer: results from the FALCON trial
Early and accurate localisation of lesions in patients with biochemical recurrence (BCR) of prostate cancer may guide salvage therapy decisions. The present study, XXX, aimed to evaluate the impact of 18F-fluciclovine on management of men with BCR of prostate cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 14, 2020 Category: Radiology Authors: Andrew F. Scarsbrook, David Bottomley, Eugene J. Teoh, Kevin M. Bradley, Heather Payne, Asim Afaq, Jamshed Bomanji, Nicholas van As, Sue Chua, Peter Hoskin, Anthony Chambers, Gary J. Cook, Victoria S. Warbey, Sai Han, Hing Y. Leung, Albert Chau, Matthew P Source Type: research

Combining radiotherapy with interferons; back to the future
Radiotherapy has been linked to the induction of an intratumoral type I interferon (IFN) response which positively impacts response to treatment. This has linked the immunomodulatory effects of interferons to an increased radiotherapy efficacy which has spiked the interest to combine radiotherapy with IFN-based treatment. Interestingly, this combination treatment has been considered previously, based on preclinical studies demonstrating a radiosensitizing effects of interferons. As a result, multiple clinical trials have been performed combining radiotherapy with interferons in different tumor types. (Source: International...
Source: International Journal of Radiation Oncology * Biology * Physics - February 14, 2020 Category: Radiology Authors: R.S.A. Goedegebuure, C. Vonk, L. Kooij, S. Derks, V.L.J.L. Thijssen Source Type: research

Impact of Sequencing Radiation Therapy and Immune Checkpoint Inhibitors in the Treatment of Melanoma Brain Metastases
Melanoma brain metastases (MBM) occur in ∼50% of melanoma patients. While both Radiation Therapy (RT) and immune checkpoint inhibitor (ICI) are used alone or in combination for MBM treatment, the role of combination and how these treatments could best be sequenced, remains unclear. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 11, 2020 Category: Radiology Authors: Daniel A. Pomeranz Krummel, Tahseen H. Nasti, Benjamin Izar, Robert H. Press, Maxwell Xu, Lindsey Lowder, Laura Kallay, Manali Rupji, Havi Rosen, Jing Su, Walter Curran, Jeffrey Olson, Brent Weinberg, Matthew Schniederjan, Stewart Neill, David Lawson, Jea Source Type: research

Integrin αvβ6 positron emission tomography imaging in lung cancer patients treated with pulmonary radiotherapy
In this study, we observed PET uptake of the αvβ6 radio-ligand is up regulated after RT and is related to radiation dose per fraction and biological effective dose for fibrosis. αvβ6-PET imaging could therefore potentially be used as a tool in t herapy development and management for RT induced lung fibrosis. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 11, 2020 Category: Radiology Authors: Azeem Saleem, Yusuf Helo, Zarni Win, Roger Dale, Jo Cook, Graham E. Searle, Paula Wells Source Type: research

The Impact of an Introductory Radiation Oncology Curriculum (IROC) for Radiation Oncology Trainees Across the US and Canada
Despite interest from both radiation oncology residents and program directors, many residency training programs lack a formalized introductory curriculum to orient incoming radiation oncology residents to the specialty. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 11, 2020 Category: Radiology Authors: Rachel B. Jimenez, Andrew Johnson, Laura Padilla, Raphael Yechieli, Rachel Forman, Nora Horick, Horatio Thomas, Jillian R. Gunther, Kenneth Olivier, Daniel W. Golden, Emma Fields, Radiation Oncology Education Collaborative Study Group Source Type: research

Patterns of Failure in Parameningeal Alveolar Rhabdomyosarcoma
To determine patterns of failure, clinical outcomes, and prognostic factors among pediatric patients treated with radiotherapy for parameningeal alveolar rhabdomyosarcoma (ARMS). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 7, 2020 Category: Radiology Authors: Julie A. Bradley, Daniel J. Indelicato, Haruka Uezono, Christopher G. Morris, Eric Sandler, Hernando de Soto, Raymond B. Mailhot Vega, Ronny Rotondo Source Type: research

Definitive Management of Presumed Synchronous Early-Stage Non-Small Cell Lung Cancers: Outcomes and Utility of Stereotactic Ablative Radiotherapy
This study evaluates efficacy and patterns of failure following stereotactic ablative radiotherapy (SABR) for synchronous early-stage NSCLC. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 7, 2020 Category: Radiology Authors: Zeina Ayoub, Matthew S. Ning, Eric D. Brooks, Jingjing Kang, James W. Welsh, Aileen Chen, Saumil Gandhi, John V. Heymach, Ara A. Vaporciyan, Joe Y. Chang Source Type: research

Combination therapy with radiation and PARP inhibition enhances responsiveness to anti-PD-1 therapy in colorectal tumor models
The majority of colorectal cancers are resistant to cancer immune-checkpoint inhibitors. Ionizing radiation (IR) and several radiosensitizers, including PARP inhibitors, can enhance responsiveness to immune checkpoint inhibitors by potentially complementary mechanisms of action. We assessed the ability of radiation and PARP-inhibition to induce pro-immunogenic changes in tumor cells and enhance their in vivo responsiveness to anti-PD-1 antibodies. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 6, 2020 Category: Radiology Authors: Steven N. Seyedin, M.M. Hasibuzzaman, Vivan Pham, Michael S. Petronek, Cameron Callaghan, Amanda L. Kalen, Kranti A. Mapuskar, Sarah L. Mott, Douglas R. Spitz, Bryan G. Allen, Joseph M. Caster Source Type: research

Protons show greater relative biological effectiveness for mammary tumorigenesis with higher ER α and HER2 positive tumors relative to γ-rays in APCMin/+ mice
Exposure to ionizing radiation increases risk of breast cancer. Although proton radiation is encountered in outer space and in medicine, we do not fully understand breast cancer risks from protons due to limited in vivo data. The purpose of this study was to comparatively assess the effects of γ-rays and protons on mammary tumorigenesis in APCMin/+ mice. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 6, 2020 Category: Radiology Authors: Shubhankar Suman, Igor Shuryak, Bhaskar Kallakury, David J. Brenner, Albert J. Fornace, Michael D. Johnson, Kamal Datta Source Type: research

Absolute Lymphocyte Count Predicts Abscopal Responses and Outcomes in Patients Receiving Combined Immunotherapy and Radiotherapy: A prospective-retrospective analysis of 3 phase I/II Trials
This study, utilizing data from three institutional phase I/II trials, examined the predictive capacity of recorded parameters in patients undergoing combined radiotherapy (RT) and immunotherapy and explored outcomes based on those predictive factors. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 6, 2020 Category: Radiology Authors: Dawei Chen, Vivek Verma, Roshal R. Patel, Hampartsoum B. Barsoumian, Maria Angelica Cortez, James W. Welsh Source Type: research

Rectal Hydrogel Spacer Improves Late Gastrointestinal Toxicity Compared To Rectal Balloon Immobilization After Proton Beam Radiotherapy For Localized Prostate Cancer: A Retrospective Observational Study
To compare dosimetric parameters and late gastrointestinal (GI) outcomes between patients treated with proton beam therapy (PBT) for localized prostate cancer with rectal balloon immobilization versus hydrogel rectal spacer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 5, 2020 Category: Radiology Authors: Tru-Khang T. Dinh, Howard J. Lee, Meghan W. Macomber, Smith Apisarnthanarax, Jing Zeng, George E. Laramore, Ramesh Rengan, Kenneth J. Russell, Jonathen J. Chen, William J. Ellis, George R. Schade, Jay J. Liao Source Type: research

Translational aspects of Nuclear Factor - kappa B and its modulation by thalidomide on early and late radiation sequelae in urinary bladder dysfunction
This preclinical study aimed to investigate the role of NF- κB in early and late radiogenic sequelae of urinary bladder dysfunction in mice. Thalidomide was applied either during the early or late response phase to determine potential effects of NF-κB inhibition on functional bladder impairment. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 5, 2020 Category: Radiology Authors: Jakob Kowaliuk, Sina Sarsarshahi, Johanna Hlawatsch, Alexandra Kastsova, Maria Kowaliuk, Alexander Krischak, Peter Kuess, Lisa Duong, Wolfgang D örr Source Type: research

Phase I Trial of Weekly Cabazitaxel with Concurrent Intensity Modulated Radiation and Androgen Deprivation Therapy for the Treatment of High-Risk Prostate Cancer
Cabazitaxel has been demonstrated to improve the overall survival for men with metastatic castrate-resistant prostate cancer. The purpose of this study was to determine the maximum tolerated dose for concurrent cabazitaxel with androgen deprivation and intensity modulated radiation therapy in men with high-risk prostate cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 3, 2020 Category: Radiology Authors: Jianqing Lin, Robert B. Den, Jacob Greenspan, Timothy N. Showalter, Jean H. Hoffman-Censits, Costas D. Lallas, Edouard J. Trabulsi, Leonard G. Gomella, Mark D. Hurwitz, Benjamin Leiby, Adam P. Dicker, W. Kevin Kelly Tags: Clinical Investigation Source Type: research

Modeling Complex Deformations of the Sigmoid Colon Between External Beam Radiation Therapy and Brachytherapy Images of Cervical Cancer
In this study, we investigated registration methods for estimating the large interfractional sigmoid deformations that occur between external beam radiation therapy (EBRT) and brachytherapy (BT) for cervical cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 3, 2020 Category: Radiology Authors: Bastien Rigaud, Guillaume Cazoulat, Sastry Vedam, Aradhana M. Venkatesan, Christine B. Peterson, Nicolette Taku, Ann H. Klopp, Kristy K. Brock Tags: Physics Contribution Source Type: research

Shape of the Heart: A 68-Year-Old Man With a Primary Cardiac Non-Hodgkin Lymphoma
A previously healthy 68-year-old man presented to his primary care physician with a 6-month history of dyspnea on exertion, 50 pounds of body weight loss, and low QRS voltage on electrocardiogram, prompting computed tomography (CT). CT chest scan demonstrated a right ventricular intracardiac mass (2.9  × 2.6 cm; Fig. 1A), massive pericardial effusion, and multiple conglomerated lymphadenopathies in both high and low paratracheal, prevascular, and subcarinal regions. Cytology of 1000 mL of pericardiocentesis revealed a diffuse large B-cell lymphoma. (Source: International Journal of Radiation ...
Source: International Journal of Radiation Oncology * Biology * Physics - February 1, 2020 Category: Radiology Authors: Whoon Jong Kil Tags: Gray Zone Source Type: research

Excessive Exposure
The patient presents with stage IV diffuse large B-cell lymphoma (DLBCL) with a right ventricular mass and a malignant pericardial effusion with pericardial implants based on positron emission tomography-computed tomography (PET-CT).1 He does not appear to have bulky disease (>7.5  cm). His International Prognostic Index score puts him in a high-risk cohort. The patient is in remission after 6 cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). Consolidation radiation therapy (RT) is not routinely used in advanced DLBCL but may play a ro le in select patients. (Source: Internat...
Source: International Journal of Radiation Oncology * Biology * Physics - February 1, 2020 Category: Radiology Authors: Chris R. Kelsey Tags: Gray Zone Source Type: research

Oligoreview of Non-Small Cell Lung Cancer Oligometastases
In this Oncology Scan, we summarize 3 recent, prospective, randomized studies that have explored the role of local consolidative therapy (LCT), and in some more specifically, stereotactic ablative radiation therapy (SABR), in the setting of oligometastatic non-small cell lung cancer and its impact on cancer outcomes and survival. The oligometastatic state generally refers to a situation with a limited number of metastases and where the possibility to extend survival may materialize from metastases-directed treatments. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 1, 2020 Category: Radiology Authors: Meredith E. Giuliani, Clifford G. Robinson, Joseph K. Salama, Megan E. Daly Source Type: research

Shifting the Curtain —Can We Make Sense of the Whole Pelvis Controversy?
It is one of the classic debates in our field —the role of elective whole pelvis irradiation for high-risk localized prostate cancer. Fed by conflicting data and strong opinions, we await a resolution with the publication of Radiation Therapy Oncology Group (RTOG) 0924, comparing whole pelvis (WP) versus prostate only (PO) radiation therapy ( RT) in unfavorable intermediate and favorable high-risk prostate cancer, anticipated for 2021. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 1, 2020 Category: Radiology Authors: Bridget F. Koontz, Alan Dal Pra Tags: Clinical Investigation Source Type: research

SAbR as an Alternative Boost Modality for Cervical Cancer: A Cautionary Exercise
Mrs. LS is a 42-year-old Hispanic woman who works as a housekeeper for a hotel. The money she makes goes to help support her family in Guatemala, and she lives with 3 other female housekeepers in a 1-bedroom apartment downtown. She does not receive regular medical care and presented to the emergency department due to pelvic pain and vaginal bleeding. She received a diagnosis of stage IIIB cervical cancer and can receive treatment because she is eligible for insurance coverage through the California Breast and Cervical treatment program. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 1, 2020 Category: Radiology Authors: Mitchell Kamrava, Junzo P. Chino, Sushil Beriwal Tags: Clinical Investigation Source Type: research

In Reply to Nguyen et al.
We would like to thank Belkacemi1 for his interest in our study about DNA damage response (DDR) in induced pluripotent stem cell (iPSC) –derived keratinocytes and 3-dimensional (3D) skin keratinocyte organoid.1 As mentioned in his letter, ionizing radiation (IR) induced persistent activation of DDR causes cellular senescence and chronic inflammation leading to tumor progression. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 1, 2020 Category: Radiology Authors: Mikio Shimada, Tomoko Miyake Tags: Comment Source Type: research

In Regard to Miyake et al.
Ionizing radiation (IR)-induced skin toxicity prediction has emerged as a challenge for radiation oncologist treating patients who need loco-regional radiotherapy for non-metastatic cancer. The skin late sequela mechanisms after IR are not fully known. The recent article by Miyake et  al provided original data showing that cell fate of skin keratinocytes derived from human induced pluripotent stem cells after IR-induced DNA damage response (DDR) can promote senescence.1 Indeed, the senescent cell fate plays important roles in IR-induced healthy tissue damage of various cellular types and organs. (Source: International...
Source: International Journal of Radiation Oncology * Biology * Physics - February 1, 2020 Category: Radiology Authors: Hoang Quy Nguyen, Nhu Hanh To, Yazid Belkacemi Tags: Comment Source Type: research