Revisiting a null hypothesis: exploring the parameters of oligometastasis treatment
In the treatment of patients with metastatic cancer, the current paradigm states that metastasis-directed therapy does not prolong life. This paradigm forms the basis of clinical trial null hypotheses, where trials are built to test the null hypothesis: patients garner no overall survival benefit from targeting metastatic lesions. However, with advancing imaging technology and increasingly precise techniques for targeting lesions, a much larger proportion of metastatic disease can be treated. As a result, the life-extending benefit of targeting metastatic disease is becoming increasingly clear. (Source: International Journ...
Source: International Journal of Radiation Oncology * Biology * Physics - January 20, 2021 Category: Radiology Authors: Jessica A. Scaborough, Martin C. Tom, Michael W. Kattan, Jacob G. Scott Source Type: research

The Effect of Bolus on Local Control for Patients Treated with Mastectomy and Radiotherapy
Bolus is often prescribed during postmastectomy radiotherapy for patients without skin involvement by breast cancer. Practice variations in prescribing bolus for patients treated with breast reconstruction at our institution allowed us to compare local recurrence and breast cancer mortality in patients treated with and without bolus. Bolus use did not reduce the cumulative incidence of either local recurrence or breast cancer mortality. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 20, 2021 Category: Radiology Authors: Alan Nichol, Dylan Narinesingh, Srinivas Raman, Francois Germain, Elisa K. Chan, Eric Tran, Lovedeep Gondara, Caroline Speers, Caroline A. Lohrisch, Pauline Truong Source Type: research

Cosmetic outcomes of a phase I dose escalation study of 5-fraction stereotactic partial breast irradiation for early stage breast cancer
To evaluate cosmetic changes following 5-fraction adjuvant stereotactic partial breast irradiation (S-PBI). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 17, 2021 Category: Radiology Authors: Asal Rahimi, Howard E. Morgan, Dong W. Kim, Yuanyuan Zhang, Marilyn Leitch, Rachel Wooldridge, Sally Goudreau, Barbara Haley, Roshni Rao, Aeisha Rivers, Ann E. Spangler, Ryan T. Jones, Stella Stevenson, Jason Staley, Kevin Albuquerque, Chul Ahn, Sarah Neu Tags: Clinical Investigation Source Type: research

Receipt of guideline-recommended surveillance in a population-based cohort of active surveillance prostate cancer patients
Prospective clinical trials have demonstrated the safety and efficacy of active surveillance for men with localized prostate cancer, but also suggested that inadequate surveillance may risk missing an opportunity for cure. We used data from a population-based cohort of active surveillance patients to examine the rigor of surveillance monitoring in the general population. Among 1,419 patients enrolled from 2011 –2013 throughout the State of XXXXX in collaboration with the state cancer registry and followed prospectively, 346 pursued active surveillance. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 13, 2021 Category: Radiology Authors: Ronald C. Chen, Sabrina G. Prime, Ramsankar Basak, Dominic Himchan Moon, Claire Liang, Deborah S. Usinger, Aaron J. Katz Tags: Clinical Investigation Source Type: research

Early prediction of acute esophagitis for adaptive radiotherapy
Acute esophagitis (AE) is a common dose-limiting toxicity in radiotherapy (RT) of locally advanced non-small cell lung cancer (LA-NSCLC). We developed an early AE prediction model from weekly accumulated esophagus dose and its associated local volumetric change. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 12, 2021 Category: Radiology Authors: Sadegh R. Alam, Pengpeng Zhang, Si-Yuan Zhang, Ishita Chen, Andreas Rimner, Neelam Tyagi, Yu-Chi Hu, Wei Lu, Ellen D. Yorke, Joseph O. Deasy, Maria Thor Tags: Physics Contribution Source Type: research

The Dutch –Belgian Registry of Stereotactic Body Radiation Therapy for Liver Metastases: Clinical Outcomes of 515 Patients and 668 Metastases
Although various studies have reported that stereotactic body radiation therapy (SBRT) for liver metastases has high local control rates and relatively low toxicity, most series included a small number of patients. We aimed to validate these outcomes in a large multi-institution patient cohort treated in accordance with a common protocol. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 12, 2021 Category: Radiology Authors: Alejandra M éndez Romero, Wilco Schillemans, Rob van Os, Friederike Koppe, Cornelis J. Haasbeek, Ellen M. Hendriksen, Karin Muller, Heleen M. Ceha, Pètra M. Braam, Onne Reerink, Martijn P.M. Intven, Ines Joye, Edwin P.M. Jansen, Henrike Westerveld, Mere Tags: Clinical Investigation Source Type: research

Electron FLASH Delivery at Treatment Room Isocenter for Efficient Reversible Conversion of a Clinical LINAC
In this study, procedures were developed to achieve efficient reversible conversion of a clinical linear accelerator (LINAC) and deliver ultra-high dose-rate (UHDR) electron or conventional beams to the treatment room isocenter for FLASH radiotherapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 11, 2021 Category: Radiology Authors: Mahbubur Rahman, M. Ramish Ashraf, Rongxiao Zhang, Petr Bruza, Chad A. Dexter, Lawrence Thompson, Xu Cao, Benjamin B. Williams, P. Jack Hoopes, Brian W. Pogue, David J. Gladstone Tags: Physics Contribution Source Type: research

Strategic Training in Transdisciplinary Radiation Science for the 21st Century (STARS21): 15-year Evaluation of an Innovative Research Training Program
To evaluate the 15-year impact of a transdisciplinary research training program for graduate students, post-doctoral fellows, and clinical trainees focused in radiation science entitled “Strategic Training in Transdisciplinary Radiation Science for the 21st Century” (STARS21), with a primary objective to build capacity in radiation research. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 10, 2021 Category: Radiology Authors: Parasvi S. Patel, Sobiga Vyravanathan, Emily Milne, Andrea Bezjak, Bradly G. Wouters, Kevin Bennewith, Jan Seuntjens, Zhihui A. Liu, Shane M. Harding, Fei-Fei Liu, Marianne Koritzinsky, C. Anne Koch Source Type: research

A genotype signature for predicting pathologic complete response in locally advanced rectal cancer
To construct and validate a predicting genotype signature for pathologic complete response (pCR) in locally advanced rectal cancer (PGS-LARC) after neoadjuvant chemoradiation. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 9, 2021 Category: Radiology Authors: Wei-Wei Xiao, Min Li, Zhi-Wei Guo, Rong Zhang, Shao-Yan Xi, Xiang-Guo Zhang, Yong Li, De-Qing Wu, Yu-Feng Ren, Xiao-Lin Pang, Xiang-Bo Wan, Kun Li, Chun-Lian Zhou, Xiang-Ming Zhai, Zhi-Kun Liang, Qiao-Xuan Wang, Zhi-Fan Zeng, Hui-Zhong Zhang, Xue-Xi Yang, Tags: Biology Contribution Source Type: research

Spinal Cord Reirradiation:Balancing Benefit Against Risks
A 58-year-old patient without comorbidities received a diagnosis of breast cancer 20 years previously (T2N0M0, ER positive, PR positive, HR negative). Five years later a bone metastasis of the first thoracic vertebral body was diagnosed. Prior irradiation included the right chest wall, including regional lymph nodes (45 Gy in 1.8 Gy fractions; field border = vertebral column, including currently involved right-sided nerve roots) 20 years ago and the seventh cervical to third thoracic vertebrae 5 years later (39.6 Gy in 1.8 Gy fractions). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 7, 2021 Category: Radiology Authors: Michael Pinkawa Tags: Gray Zone Source Type: research

Radiate Once More
The presented scenario of long-term oligo-(mono)metastatic disease from a biologically favorable subtype of breast cancer1 illustrates important lessons regarding effective local treatment. The safe and conservative reirradiation regimen (39.6 Gy) eventually failed to prevent symptomatic progression. Surgical intervention was required; however, this approach alone is unable to provide permanent local control. Therefore, we are facing the dilemma of thoracic spinal cord reirradiation (not included in the adjuvant, initial target volume) and nerve root re-reirradiation. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 7, 2021 Category: Radiology Authors: Carsten Nieder, Anca-Ligia Grosu Tags: Gray Zone Source Type: research

Cautious SBRT
Systemic treatment, to be decided depending on the results of pathology (hormonal treatment and/or chemotherapy). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 7, 2021 Category: Radiology Authors: Berardino De Bari Tags: Gray Zone Source Type: research

Postoperative Stereotactic Body Radiation Therapy, Then Observe
This patient presented with high-grade epidural disease (Bilsky grade 2 and 3) and underwent urgent surgical decompression with subsequent downgrading of epidural disease on imaging.1 Postoperative spine stereotactic body radiation therapy (SBRT) experience has shown that a postoperative epidural Bilsky grade of 0 or 1 is a significant predictor of local control.2 In the absence of biomarkers or next-generation molecular diagnostics we cannot determine with certainty which patients with oligometastatic disease will benefit from metastasis-directed treatment with SBRT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 7, 2021 Category: Radiology Authors: Emma M. Dunne, Mitchell Liu Tags: Gray Zone Source Type: research

I Need a Sign: The Growing Need for a Signaling Mechanism to Improve the Residency Match
Increased attention has been directed toward the radiation oncology interview application process, as the COVID19 crisis threatens to exacerbate its many longstanding inefficiencies.1-3 A signaling mechanism, by which applicants can send a signal indicating strong interest to a strictly limited number of programs, has been discussed in other specialties to remedy similar inefficiencies4-6 and will be implemented this application cycle by otolaryngology residency programs. We strongly believe our field should similarly take a leading role on this initiative this application cycle. (Source: International Journal of Radiation...
Source: International Journal of Radiation Oncology * Biology * Physics - January 7, 2021 Category: Radiology Authors: Wesley J. Talcott, Suzanne B. Evans Tags: Education and Training Source Type: research

In Regard to Datta et al.
The systematic review of Datta et al (2019)1 on the evaluation of various therapeutic options in locally advanced cervix cancer has, in my opinion, a hidden agenda of substantiating the use of hyperthermia in locally advanced cervix cancer. The review is not systematic (ie, selective) because it includes only 6 favorable randomized controlled trials (RCTs) from 11 available; 5 RCTs were not included, including 3 phase 3 RCTs, and showed no effect of hyperthermia. Three of them were excluded as not compliant to inclusion criteria, but 2 phase 3 RCTs were excluded unreasonably: the RCT of Zolciak-Siwinska2 used standard frac...
Source: International Journal of Radiation Oncology * Biology * Physics - January 7, 2021 Category: Radiology Authors: Sergey Roussakow Tags: Comments Source Type: research

In Reply to Roussakow
We thank Dr Roussakow1 for critically evaluating our study2 and have noted the serious concerns expressed on the possibility of "selective" selection and inclusion of the papers in our network meta-analysis (NMA) for locally advanced cancer cervix (LACC). In this regard, we would like to clarify the specific reasons for excluding certain studies as mentioned in the letter. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 7, 2021 Category: Radiology Authors: Niloy R. Datta, Emanuel Stutz, Silvia Gomez, Stephan Bodis Tags: Comments Source Type: research

In Regard to Bovi et  al.
I read with great interest the article titled “Pulsed reduced dose rate radiation therapy in conjunction with bevacizumab significantly extends survival over bevacizumab alone in recurrent high-grade glioma” by Bovi et al.1 This retrospective report concludes that pulsed reduced dose-rate radiation therapy (PRDR-RT) plus bevacizumab provid es significant progression free survival and overall survival advantages compared with bevacizumab alone. As a user of PRDR-RT, not only is this publication an important step forward in the evaluation of novel fractionation schemes in brain tumors, but also I agree with ...
Source: International Journal of Radiation Oncology * Biology * Physics - January 7, 2021 Category: Radiology Authors: Jos é A. Peñagarícano Tags: Comments Source Type: research

In Reply to Pe ñagarícano
Thank you for your comments1 regarding our manuscript “Pulsed reduced dose rate radiation therapy in conjunction with bevacizumab significantly extends survival over bevacizumab alone in recurrent high-grade glioma.”2 We agree there is mounting evidence supporting the notion that dose rate is an important variable that impacts radiosensitivity and normal tissue tolerance in the irradiation of primary brain tumors and potentially other tumor types. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 7, 2021 Category: Radiology Authors: Joseph A. Bovi, Christopher J. Schultz Tags: Comments Source Type: research

In Regard to Odei et  al.
We thank Odei et  al for highlighting the challenges of the upcoming residency match given coronavirus disease 2019 (COVID-19) restrictions on away rotations and in-person residency interviews.1 This is a timely issue for our specialty, given declining numbers of applicants in recent years.2 We have launched severa l initiatives for medical students to mitigate COVID-19’s detrimental impact to learning and recruitment to radiation oncology. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 7, 2021 Category: Radiology Authors: Jenna M. Kahn, Navjot Sandhu, Erqi L. Pollom Tags: Comments Source Type: research

Randomized Trials for Esophageal, Liver, Pancreas, and Rectal Cancers
In this edition of the Gastrointestinal Oncology Scan, we have a few announcements to share with you. First of all, both Dr Christopher Hallemeier and Dr Florence Huguet will be rotating off the editorial board after 3 years of serving as associate editors. Both Drs Hallemeier and Huguet have been diligent, bright, efficient, and conscientious members of the editorial team, providing thorough reviews and thoughtful decisions. We sincerely thank them for their service and dedication. Also, Dr Salma Jabbour will be stepping down from the senior editor position, and we are pleased to announce that Dr Jeffrey Olsen will serve ...
Source: International Journal of Radiation Oncology * Biology * Physics - January 7, 2021 Category: Radiology Authors: Christopher L. Hallemeier, Florence Huguet, Diana Tait, Michael H. Buckstein, Christopher J. Anker, Jordan Kharofa, Jeffrey R. Olsen, Salma K. Jabbour Tags: Oncology Scan Source Type: research

Revising a Research Paper
I was encouraged by a number of people to write a follow-up to “Writing a Research Paper,”1 which ended with, “may your next paper be accepted without revisions!” As you know by now, that did not happen, even with all of the good advice I tried to give you. It certainly does not happen for me. (Worse than that—it did happen once early in my career, bu t never again.) You have received your review. I have been on both the “giving” side (as an editor of several journals) and the “receiving” side (as an author) of the review process. (Source: International Journal of ...
Source: International Journal of Radiation Oncology * Biology * Physics - January 7, 2021 Category: Radiology Authors: Theodore S. Lawrence Tags: Education and Training Source Type: research

Issue Highlights
Hallemeier et al (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 7, 2021 Category: Radiology Source Type: research

Meetings
January 9, 2021 (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 7, 2021 Category: Radiology Source Type: research

Phase III Multi-Center, Prospective, Randomized Trial Comparing Single Dose 24 Gy Radiotherapy to a 3-Fraction SBRT Regimen in the Treatment of Oligometastatic Cancer
This prospective phase III randomized trial was designed to test whether ultra-high single-dose radiotherapy (24 Gy SDRT) improves local control of oligometastatic lesions over a standard hypofractionated stereotactic body radiotherapy regimen (3 x 9 Gy SBRT). The secondary endpoint was to assess the associated toxicity and the impact of ablation on clinical patterns of metastatic progression. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 7, 2021 Category: Radiology Authors: Michael J. Zelefsky, Yoshiya Yamada, Carlo Greco, Eric Lis, Heiko Sch öder, Stephanie Lobaugh, Zhigang Zhang, Richard Braunstein, Mark H. Bilsky, Simon N. Powell, Richard Kolesnick, Zvi Fuks Tags: Clinical Investigation Source Type: research

Phase I Trial of Atezolizumab plus Trimodal Therapy in Patients with localized Muscle-Invasive Bladder Cancer
Immune checkpoint programmed death-ligand 1 (PDL-1) inhibitor therapy has shown response in metastatic muscle invasive bladder cancer (MIBC). We evaluated the safety and tolerability of atezolizumab (anti-PDL-1) in combination with trimodal therapy (TMT) in patients with localized MIBC. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 6, 2021 Category: Radiology Authors: Gautier Marcq, Luis Souhami, Fabio L. Cury, Afsar Salimi, Armen Aprikian, Simon Tanguay, Marie Vanhuyse, Raghu Rajan, Fadi Brimo, Jos é João Mansure, Wassim Kassouf Tags: Clinical Investigation Source Type: research

Combining clinical and dosimetric features in a PBS proton therapy cohort to develop a NTCP model for radiation-induced optic neuropathy
Radiation-induced optic neuropathy (RION) is a rare, yet severe complication following radiation therapy for brain, head and neck or skull-base tumors. While several risk factors such as age, metabolic syndrome and delivered dose have been identified, we aimed at expanding the understanding of the mechanisms of interplay regarding dosimetry and patient variables leading to the onset of RION with a focus on proton therapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 5, 2021 Category: Radiology Authors: A. K öthe, P. van Luijk, S. Safai, M. Kountouri, A.J. Lomax, D.C. Weber, G. Fattori Tags: Physics Contribution Source Type: research

Risk of Cardiac Disease in Breast Cancer Patients: Impact of Patient-Specific Factors and Individual Heart Dose from Three-Dimensional Radiotherapy Planning
This retrospective cohort study aimed to determine whether adjuvant radiation therapy increases the risk of cardiac toxicity in Asian women with breast cancer, with a focus on patient-specific factors. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 5, 2021 Category: Radiology Authors: Seung Yeun Chung, Jaewon Oh, Jee Suk Chang, Jaeyong Shin, Kyung Hwan Kim, Kyeong-Hyeon Chun, Ki Chang Keum, Chang-Ok Suh, Seok-Min Kang, Yong Bae Kim Source Type: research

Estimates of Alpha/Beta ( α/β) Ratios for Individual Late Rectal Toxicity Endpoints: An Analysis of the CHHiP trial
Changes in fraction size of external beam radiotherapy (EBRT) exert non-linear impacts on subsequent toxicity. Commonly described by the linear-quadratic model, fraction size sensitivity of normal tissues is expressed by the α/β ratio. Here we study individual α/β ratios for different late rectal side effects after prostate EBRT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 4, 2021 Category: Radiology Authors: Douglas H. Brand, Sarah C. Br üningk, Anna Wilkins, Katie Fernandez, Olivia Naismith, Annie Gao, Isabel Syndikus, David P. Dearnaley, Alison C. Tree, Nicholas van As, Emma Hall, Sarah Gulliford, CHHiP Trial Management Group Tags: Physics Contribution Source Type: research

Microstructural injury to corpus callosum and intra-hemispheric white matter tracts correlate with attention and processing speed decline after brain radiation
The corpus callosum (CC) and intra-hemispheric white matter tracts (IHWM) subserve critical aspects of attention and processing speed. We analyzed imaging biomarkers of microstructural injury within these regions and association with attention/processing speed decline post-radiotherapy in primary brain tumor patients. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 4, 2021 Category: Radiology Authors: Minh-Phuong Huynh-Le, Michelle D. Tibbs, Roshan Karunamuni, Kathryn R. Tringale, Mia Salans, Anthony Yip, Michael Connor, Aaron B. Simon, Lucas K. Vitzthum, Anny Reyes, Anna Christina Macari, Vitali Moiseenko, Carrie R. McDonald, Jona A. Hattangadi-Gluth Tags: Clinical Investigation Source Type: research

Risk of Hypothyroidism in Women after Radiotherapy for Breast Cancer
To study the hypothyroidism risk following adjuvant radiotherapy (RT) and the association of different RT targets with hypothyroidism risk. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 4, 2021 Category: Radiology Authors: Seo Hee Choi, Jee Suk Chang, Nak-Hoon Son, Chae ‐Seon Hong, Hwa Kyung Byun, Namki Hong, Ye-In Park, Jihun Kim, Jin Sung Kim, Yong Bae Kim Tags: Clinical Investigation Source Type: research

Osteoradionecrosis: Exposing the Evidence Not the Bone
This study comprehensively reviews the literature, with a focus on the past 10 years, to guide evaluation and treatment. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 3, 2021 Category: Radiology Authors: Andrew J. Frankart, Michael J. Frankart, Brian Cervenka, Alice L. Tang, Deepak G. Krishnan, Vinita Takiar Tags: Critical Review Source Type: research

Long-term results of dose-intensified fractionated stereotactic body radiotherapy (sbrt) for painful spinal metastases
To report long-term outcome of fractionated stereotactic body radiotherapy (SBRT) for painful spinal metastases. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 3, 2021 Category: Radiology Authors: Matthias Guckenberger, Frederick Mantel, Reinhart A. Sweeney, Maria Hawkins, Jos é Belderbos, Merina Ahmed, Nicolaus Andratschke, Indira Madani, Michael Flentje Tags: Clinical Investigation Source Type: research

Deciphering time-dependent DNA damage complexity, repair and oxygen tension: a mechanistic model for FLASH-dose-rate radiotherapy
Irradiation with ultra-high dose-rates (FLASH) has reemerged as a promising radiotherapy approach to effectively lower potential damage burden on normal tissue without sacrificing tumor control; however, the large number of recent FLASH studies are conducted under vastly different experimental conditions and circumstances i.e. investigated biological endpoint, radiation quality and environmental oxygen level, with unverified biological mechanisms of action and unexplored interplay effect of the main dependencies. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 3, 2021 Category: Radiology Authors: Hans Liew, Stewart Mein, Ivana Dokic, Thomas Haberer, J ürgen Debus, Amir Abdollahi, Andrea Mairani Tags: Physics Contribution Source Type: research

Mentorship initiatives in radiation oncology: A scoping review of the literature
While mentorship is described extensively in academic medical literature, there are few descriptions of mentorship specific to radiation oncology. The goal of the current study is to investigate the state of mentorship in radiation oncology through a scoping review of the literature. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 3, 2021 Category: Radiology Authors: John A. Marsiglio, David M. Rosenberg, Michael K. Rooney, Chelain R. Goodman, Erin F. Gillespie, Ariel E. Hirsch, Emma B. Holliday, Randall J. Kimple, Charles R. Thomas, Daniel W. Golden Source Type: research

Fostering Radiation Oncology Physician Scientist Trainees within a Diverse Workforce: The Radiation Oncology Research Scholar Track
There is a need to foster future generations of Radiation Oncology Physician Scientists, but the number of radiation oncologists with sufficient education, training and funding to make transformative discoveries is relatively small. Despite a large number of MD/PhD graduates entering the field of radiation oncology over the past 2 decades, this has not led to a significant cohort of externally funded physician scientists. Because radiation oncologists leading independent research labs have the potential to make transformative discoveries that advance our field and positively impact cancer patients, we created the Duke Radi...
Source: International Journal of Radiation Oncology * Biology * Physics - January 3, 2021 Category: Radiology Authors: Joseph K. Salama, Scott R. Floyd, Christopher G. Willett, David G. Kirsch Source Type: research

Drivers of Medicare Spending: A 15 Year Review of Radiation Oncology Charges Allowed by the Medicare Physician/Supplier Fee-for-Service Program Compared to Other Specialties
We examined changes in aggregate physician Medicare charges allowed per specialty to provide contemporary context to proposed changes and hypothesize that radiation oncology charges remained stable through 2017. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 3, 2021 Category: Radiology Authors: Meriem Mokhtech, James H. Laird, Sean Maroongroge, Diana Zhu, Benjamin Falit, Peter A.S. Johnstone, Constantine A. Mantz, Ronald D. Ennis, Howard M. Sandler, Arie P. Dosoretz, James B. Yu Tags: Clinical Investigation Source Type: research

Tumor Control Probability of Radiosurgery and Fractionated Stereotactic Radiosurgery for Brain Metastases
As part of the American Association of Physicists in Medicine Working Group on Stereotactic Body Radiotherapy, tumor control probability (TCP) after stereotactic radiosurgery (SRS) and fractionated stereotactic radiosurgery (fSRS) for brain metastases was modeled based on pooled dosimetric and clinical data from published English-language literature. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - December 31, 2020 Category: Radiology Authors: Kristin J. Redmond, Chengcheng Gui, Stanley Benedict, Michael T. Milano, Jimm Grimm, J. Austin Vargo, Scott G. Soltys, Ellen Yorke, Andrew Jackson, Issam El Naqa, Lawrence B. Marks, Jinyu Xue, Dwight E. Heron, Lawrence R. Kleinberg Tags: HyTEC Special Issue Source Type: research

Comparative Effectiveness Research in Localized Prostate Cancer: a 10-Year follow-up Cohort Study
Long-term comparative effectiveness research of localized prostate cancer treatments is scarce, evidence lacking specially for brachytherapy. The aim of this study was to assess the long-term impact of the side effects of radical prostatectomy, brachytherapy, and external radiotherapy on patients with localized prostate cancer at 10 years, using propensity score analyses. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - December 31, 2020 Category: Radiology Authors: Olatz Garin, Jos é Francisco Suárez, Ferran Guedea, Àngels Pont, Yolanda Pardo, Alai Goñi, Alfonso Mariño, Asunción Hervás, Ismael Herruzo, Patricia Cabrera, Gemma Sancho, Javier Ponce de León, Víctor Macías, Cristina Gutierrez, Manel Castells, Tags: Clinical Investigation Source Type: research

Stereotactic body radiotherapy and high-dose rate brachytherapy boost in combination with intensity modulated radiotherapy for localized prostate cancer: a single-institution propensity score matched analysis
To perform a propensity-score matched analysis comparing SBRT boost and HDR boost for localized prostate cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - December 29, 2020 Category: Radiology Authors: William C. Chen, Yun Li, Ann Lazar, Aysu Altan, Martina Descovich, Tomi Nano, Benjamin Ziemer, Atchar Sudhyadhom, Adam Cunha, Horatio Thomas, Alexander Gottschalk, I-Chow Hsu, Mack Roach Tags: Clinical Investigation Source Type: research

IGF-1 receptor signaling regulates type II pneumocyte senescence and resulting macrophage polarization in lung fibrosis.
(Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - December 29, 2020 Category: Radiology Authors: Eun Joo Chung, Seokjoo Kwon, Jessica L. Reedy, Ayla O. White, Joon Seon Song, Ilseon Hwang, Joon Yong Chung, Kris Ylaya, Stephen M. Hewitt, Deborah E. Citrin Tags: Biology Contribution Source Type: research

Review of palliative radiotherapy patterns of practice for adrenal metastases in british columbia
The adrenal gland is a common site of metastasis in patients with advanced cancer, but it is rarely symptomatic. A subset of patients develop a complex pain syndrome with anorexia, nausea, and poorly localized visceral pain in the back, flank, or epigastric region. These symptoms can impact quality of life and are occasionally challenging to palliate. The role of palliative radiotherapy (PRT) in these patients is unclear. This population-based retrospective study evaluates PRT practices for patients with adrenal metastases and aims to describe treatment response and acute toxicity. (Source: International Journal of Radiati...
Source: International Journal of Radiation Oncology * Biology * Physics - December 29, 2020 Category: Radiology Authors: Ravi Parhar, Jonathan Livergant, Shilo Lefresne Tags: Clinical Investigation Source Type: research

Long-Term Outcomes of Patients with Early-Stage Non-Bulky Hodgkin Lymphoma Treated with Combined Modality Therapy on the Stanford V Trials (The G4 and G5 Studies)
Combined modality therapy (CMT) is standard therapy for early-stage Hodgkin lymphoma (ESHL). We previously reported excellent outcomes with the abbreviated Stanford V regimen. Herein we report updated results with median follow-up>10 years on survival, therapy-related late effects, and impact of disease risk factors on patient outcomes. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - December 29, 2020 Category: Radiology Authors: Eric Mou, Ranjana H. Advani, Rie von Eyben, Saul A. Rosenberg, Richard T. Hoppe Tags: Clinical Investigation Source Type: research

Salvage mastectomy versus second conservative treatment for second ipsilateral breast tumor event: A propensity score-matched cohort analysis of the XXXXXXXXXXXXXXXXXXXX database
Second conservative treatment has emerged as an option for patients with second ipsilateral breast tumour event after conserving surgery and breast irradiation. We aimed to address the lack of evidence regarding second breast event treatment by comparing oncological outcomes after conservative treatment or mastectomy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - December 28, 2020 Category: Radiology Authors: Jean-Michel Hannoun-Levi, Jocelyn Gal, Erik Van Limbergen, Marie-Eve Chand, Renaud Schiappa, Viktor Smanyko, Daniela Kauer-Domer, David Pasquier, Claire Lemanski, S éverine Racadot, Gilles Houvenaeghel, Benjamin Guix, Aurélie Belliere-Calandry, Kristina Tags: Clinical Investigation Source Type: research

A mouse model for microbeam radiotherapy of the lung
Radiotherapy is an important treatment component for patients with lung cancer. However, the survival time gained with clinical radiotherapy techniques is relatively short.Data from pre-clinical experiments suggest that synchrotron microbeam radiotherapy (MRT) could be much better suited to control malignant brain tumours than current clinical concepts of radiotherapy. Even at peak doses of several hundred Gy, the extent of functional deficits is amazingly low. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - December 28, 2020 Category: Radiology Authors: Elisabeth Sch ültke, Sam Bayat, Stefan Bartzsch, Elke Bräuer-Krisch, Valentin Djonov, Stefan Fiedler, Cristian Fernandez-Palomo, Felix Jaekel, Paolo Pellicioli, Verdiana Trappetti, Guido Hildebrandt Tags: Biology Contribution Source Type: research

Enlightening the immune mechanism of the abscopal effect in a murine HCC model and overcoming the late resistance with anti PD-L1
The establishment of a preclinical model of the abscopal effect on HCC and evaluation on whether the hypofractionated RT multi-tumor Hepa1-6 mouse HCC model could be used to suppress non-radiated tumor mass would be implemented in this study. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - December 28, 2020 Category: Radiology Authors: Jin Hee Park, Hee Yeon Kim, Anbok Lee, Young Kyeong Seo, Il-Hwan Kim, Eun-tae Park, Mi seon Kang, Sung Jae Park, SaeGwang Park Tags: Biology Contribution Source Type: research

Stereotactic Radiosurgery for Vestibular Schwannomas: Tumor Control Probability Analyses and Recommended Reporting Standards
We sought to investigate the tumor control probability (TCP) of vestibular schwannomas after single-fraction stereotactic radiosurgery (SRS) or hypofractionated SRS over 2 to 5 fractions (fSRS). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - December 26, 2020 Category: Radiology Authors: Scott G. Soltys, Michael T. Milano, Jinyu Xue, Wolfgang A. Tom é, Ellen Yorke, Jason Sheehan, George X. Ding, John P. Kirkpatrick, Lijun Ma, Arjun Sahgal, Timothy Solberg, John Adler, Jimm Grimm, Issam El Naqa Tags: Clinical Investigation Source Type: research

Radiotherapy alone for human papillomavirus-related squamous cell carcinoma of the oropharynx: a single-arm, phase 2 study
Human papillomavirus (HPV)-related squamous cell carcinoma of the oropharynx (OPSCC) is extremely radiosensitive. Radiotherapy plus high-dose cisplatin remains the standard of care but causes long-term toxicity. Treatment de-intensification approaches that reduce toxicity while maintaining survival are desirable for HPV-related OPSCC. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - December 26, 2020 Category: Radiology Authors: Norihiko Takemoto, Yuji Seo, Susumu Nakahara, Yasuo Yoshioka, Teruki Teshima, Takashi Fujii, Fumiaki Isohashi, Keisuke Otani, Tadashi Yoshii, Yukinori Takenaka, Motoyuki Suzuki, Takahito Fukusumi, Atsushi Hanamoto, Toshimichi Yasui, Takahiro Michiba, Yosh Tags: Clinical Investigation Source Type: research

The Radiation Oncology Education Collaborative Study Group 2020 Spring Symposium: Is Virtual the New Reality?
This report details the experience hosting a virtual meeting and presents attendee feedback on the platform. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - December 26, 2020 Category: Radiology Authors: Bailey A. Nelson, Kaitlyn Lapen, Olivia Schultz, Joseph Nangachiveettil, Steve E. Braunstein, Christian Fernandez, Emma C. Fields, Jillian R. Gunther, Elizabeth Jeans, Rachel B. Jimenez, Jordan R. Kharofa, Anna Laucis, Raphael L. Yechieli, Erin F. Gillesp Source Type: research

Evaluating Bias in Speaker Introductions at the American Society for Radiation Oncology Annual Meeting
/Objective(s):Introducing a physician without a professional title may reinforce bias in medicine by influencing perceived credibility. We evaluated differences in the use of professional titles in introductions of speakers at recent American Society for Radiation Oncology (ASTRO) Annual Meetings. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - December 26, 2020 Category: Radiology Authors: Christina C. Huang, Kaitlyn Lapen, Kanan Shah, Jolie Kantor, Chiaojung Jillian Tsai, Miriam A. Knoll, Narjust Duma, Erin F. Gillespie, Fumiko Chino Source Type: research

Small animal IMRT using 3D printed compensators
Preclinical radiation replicating clinical IMRT techniques can provide data translatable to clinical practice. For this work, treatment plans are created for oxygen-guided dose-painting in small animals utilizing inverse-planned IMRT. Spatially varying beam intensities were achieved using 3D-printed compensators. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - December 26, 2020 Category: Radiology Authors: Gage Redler, Erik Pearson, Xinmin Liu, Inna Gertsenshteyn, Boris Epel, Charles Pelizzari, Bulent Aydogan, Ralph Weichselbaum, Howard J. Halpern, Rodney D. Wiersma Tags: Physics Contribution Source Type: research