Combination of Olaparib and radiotherapy for triple negative breast cancer: preliminary results of the RADIOPARP phase I trial
Preclinical studies have evidenced that triple-negative breast cancer (TNBC) cell lines are more sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. This provides a strong rational for developing a new therapeutic approach for TNBC management based on PARP inhibition. The primary goal of the XXXXXXXXX phase-I trial was to evaluate the dose-limiting toxicities (DLT) and the maximum tolerated dose (MTD) of Olaparib (O) combined with loco-regional radiotherapy (RT). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 20, 2020 Category: Radiology Authors: Pierre Loap, Delphine Loirat, Frederique Berger, Francesco Ricci, Anne Vincent -Salomon, Cyrine Ezzili, Veronique Mosseri, Alain Fourquet, Monia Ezzalfani, Youlia Kirova Source Type: research

Simultaneous reduction of volume and dose in clinical target volume for nasopharyngeal cancer patients
To compare the treatment outcome and severe late adverse effects (AE) between conventional (CVD) and simultaneously reduced volume and dose of clinical target volumes (SRVD) treatments in nasopharyngeal carcinoma (NPC) patients. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 20, 2020 Category: Radiology Authors: Wen-Shan Liu, Kuo-Wang Tsai, Bor-Hwang Kang, Ching-Chieh Yang, Wei-Lun Huang, Ching-Chih Lee, Yu-Chang Hu, Kuo-Ping Chang, Hsiu-Min Chen, Yaoh-Shiang Lin Source Type: research

Behavioral determinants of Canadian radiation oncologists' use of single fraction palliative radiation therapy for uncomplicated bone metastases.
A mainstay therapy for pain relief from uncomplicated bone metastases is external beam radiation therapy. Single fraction radiation therapy (SFRT) is more convenient and cost-effective, causes fewer acute side effects, and is equivalent to multiple fraction radiation therapy for pain relief. Despite these advantages, radiation oncologists seldom prescribe SFRT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 19, 2020 Category: Radiology Authors: Janet E. Squires, Sarah Asad, Melissa Demery Varin, Kristin Dorrance, Edward Chow, Alysa Fairchild, Rebecca Wong, Ian D. Graham, Jeremy M. Grimshaw, Kristopher Dennis Source Type: research

US Radiation Oncologists (Re)Defined: An American Society for Radiation Oncology Scope of Practice Study
To assess United States radiation oncologists ’ views on practice scope and the ideal role of the radiation oncologist (RO), the American Society for Radiation Oncology (ASTRO) conducted a scope of practice survey. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 18, 2020 Category: Radiology Authors: Claire Y. Fung, Neha Vapiwala, Malcolm D. Mattes, Pranshu Mohindra, Chirag Shah, Raphael Yechieli, Minh-Tam Truong, Tim Sanders, Anna Arnone, Trevor J. Royce, Ronald D. Ennis Source Type: research

Proton Accelerated Partial Breast Irradiation: Clinical Outcomes at a Planned Interim Analysis of a Prospective Phase II Trial
Summary: Proton accelerated partial breast irradiation (APBI) is a maturing treatment option for patients with early stage breast cancer. At this planned interim analysis of a prospective single-arm trial, proton APBI demonstrates exceptional heart and lung sparing effects, high local control, favorable cosmetic outcomes, high patient satisfaction, minimal treatment time and time off work, and low patient out-of-pocket cost. Further investigation into treatment planning and patient selection parameters are required to improve outcomes. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 15, 2020 Category: Radiology Authors: Dario Pasalic, Eric A. Strom, Pamela K. Allen, Tyler D. Williamson, Falk Poenisch, Richard A. Amos, Wendy A. Woodward, Michael C. Stauder, Simona F. Shaitelman, Benjamin D. Smith, George H. Perkins, Welela Tereffe, Karen E. Hoffman Source Type: research

A novel anti-cancer therapeutic strategy to target autophagy accelerates radiation-associated atherosclerosis
Autophagy inhibition is a novel therapeutic strategy suggested for patients with advanced cancer, especially those who underwent radiation therapy. In the present study, we investigated whether autophagy inhibitors accelerate the progression of radiation-associated atherosclerosis (RAA). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 14, 2020 Category: Radiology Authors: Ruosen Yuan, Zhe Sun, Jiali Cai, Xiaoxiao Yang, Weifeng Zhang, Caizhe Wu, Yejiao Shen, Anwen yin, Xia Wang, Xuwei Cai, Xiaolong Fu, Linghong Shen, Ben He Source Type: research

Pharmacological inhibition of HIF-1 α attenuates radiation-induced pulmonary fibrosis in a preclinical image-guided radiation therapy
Radiation-induced pulmonary fibrosis (RIPF) is a long-term side effect of thoracic radiotherapy. Hypoxia-induced vascular endothelial mesenchymal transition (EndMT) can occur during the development of RIPF. Here, we examined the direct contribution of endothelial HIF-1 α (EC-HIF1α) on RIPF. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 14, 2020 Category: Radiology Authors: Jae-Kyung Nam, A-Ram Kim, Seo-Hyun Choi, Ji-Hee Kim, Su Chul Han, Seungwoo Park, Yong Jin Lee, Joon Kim, Jaeho Cho, Hae-June Lee, Yoon-Jin Lee Source Type: research

A Phase I Dose Escalation Study of Neoadjuvant SBRT plus Elective Nodal Radiation with Concurrent Capecitabine for Resectable Pancreatic Cancer.
and Purpose: The role of neoadjuvant radiation for resectable pancreatic adenocarcinoma is controversial. We performed a prospective dose-escalation study of neoadjuvant stereotactic body radiation therapy (SBRT) with concurrent capecitabine and elective nodal irradiation (ENI) followed by surgical resection to explore the toxicity and feasibility of this approach. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 14, 2020 Category: Radiology Authors: Jacob S. Witt, Aleksandra Kuczmarska-Haas, Meghan Lubner, Scott B. Reeder, Steve Y. Cho, Rebecca Minter, Sharon Weber, Sean Ronnekleiv-Kelly, Daniel Abbott, Noelle LoConte, Daniel L. Mulkerin, Sam J. Lubner, Nataliya V. Uboha, Dustin Deming, Mark A. Ritte Source Type: research

Current Status of Clinical Trials for Cervical and Uterine Cancer Using Immunotherapy Combined with Radiation
Novel therapies combined with radiation continue to be of significant interest in the developmental treatment paradigm of gynecologic cancers. Clinical implementation of immunotherapy in oncology has rapidly changed the treatment landscape, options, paradigm, and outcomes through clinical trials. Immunotherapy has emerged as a therapeutic pillar in the treatment of solid tumors with demonstrable synergistic activity when combined with radiotherapy and chemoradiotherapy by an alteration or enhancement of the immune system. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 14, 2020 Category: Radiology Authors: B.A. Dyer, C.H. Feng, R. Eskander, A.B. Sharabi, L.K. Mell, M. McHale, J.S. Mayadev Tags: Critical Review Source Type: research

Improving the Pediatric Patient Experience During Radiation Therapy – A Children’s Oncology Group Study
Treatment with radiation therapy (RT) can cause anxiety and distress for pediatric patients and their families. Radiation oncology teams have developed strategies to reduce the negative psychological impact. This survey study aimed to characterize these methods. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 12, 2020 Category: Radiology Authors: Douglas E. Holt, Susan M. Hiniker, John A. Kalapurakal, John C. Breneman, Jay C. Shiao, Nicole Boik, Benjamin T. Cooper, Paige L. Dorn, Matthew D. Hall, Natalie Logie, John T. Lucas, Iain J. MacEwan, Adam C. Olson, Joshua D. Palmer, Samir Patel, Luke E. P Source Type: research

Trends in Utilization of Hypofractionated Whole Breast Radiation in Breast Cancer: An Analysis of the National Cancer Database
Utilization of hypofractionated radiation (HR) as a component of breast conserving treatment (BCT) in breast cancer is relatively low in the U.S. despite studies demonstrating its efficacy and guidelines supporting its use from the American Society for Radiation Oncology (ASTRO) in 2011 and 2018. Little is known regarding national trends in uptake and factors associated with uptake of HR in the U.S. since the 2011 ASTRO guidelines. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 12, 2020 Category: Radiology Authors: Steven G. Woodward, Karan Varshney, Pramilla R. Anne, Brandon J. George, Alliric I. Willis Source Type: research

Simultaneous targeting of RSK and AKT efficiently inhibits YB-1-mediated repair of ionizing radiation-induced DNA double strand breaks in breast cancer cells
Y-box binding protein 1 (YB-1) overexpression is associated with chemotherapy- and radiotherapy resistance. Ionizing radiation (IR), receptor tyrosine kinase ligands and mutation in KRAS gene stimulate activation of YB-1. YB-1 accelerates the repair of IR-induced DNA double-strand breaks (DSBs). Ribosomal S6 kinase (RSK) is the main kinase inducing YB-1 phosphorylation. We investigated the impact of RSK targeting on DSB repair and radiosensitivity. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 12, 2020 Category: Radiology Authors: Konstanze Lettau, Daniel Zips, Mahmoud Toulany Source Type: research

Absolute versus Relative Benefit of Androgen Deprivation Therapy for Prostate Cancer: Moving Beyond the Hazard Ratio to Personalize Therapy
Multiple phase 3 randomized trials of men with localized prostate cancer have proven that androgen deprivation therapy (ADT) improves metastasis-free survival, prostate cancer –specific survival, and overall survival when added to conventionally fractionated radiation therapy (RT).1 Post hoc subset analyses of these trials demonstrate that these clinically meaningful endpoints are improved predominately in men with National Comprehensive Cancer Network (NCCN) intermedia te- and high-risk disease. This level 1 evidence forms the basis of the current guidelines, which recommend ADT with RT for intermediate- and high-ri...
Source: International Journal of Radiation Oncology * Biology * Physics - September 11, 2020 Category: Radiology Authors: Daniel E. Spratt, Jonathan D. Tward Tags: Editorial Source Type: research

Single- and Multifraction Stereotactic Radiosurgery Dose/Volume Tolerances of the Brain
As part of the American Association of Physicists in Medicine Working Group on Stereotactic Body Radiotherapy investigating normal tissue complication probability (NTCP) after hypofractionated radiation therapy, data from published reports (PubMed indexed 1995-2018) were pooled to identify dosimetric and clinical predictors of radiation-induced brain toxicity after single-fraction stereotactic radiosurgery (SRS) or fractionated stereotactic radiosurgery (fSRS). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 11, 2020 Category: Radiology Authors: Michael T. Milano, Jimm Grimm, Andrzej Niemierko, Scott G. Soltys, Vitali Moiseenko, Kristin J. Redmond, Ellen Yorke, Arjun Sahgal, Jinyu Xue, Anand Mahadevan, Alexander Muacevic, Lawrence B. Marks, Lawrence R. Kleinberg Source Type: research

Predicting Dental Dosimetry with Diagnostic Imaging Using a Machine Learning-Based Clinical Decision Support System
Dental evaluation is a necessary part of preparing for head and neck radiation treatment and is used to identify teeth that are at significant risk of infection and that could lead to invasive dental procedures in the future, including tooth extraction (Devi et al. National Journal of Maxillofacial Surgery 2014; Devi et al. NJMS 2014). Osteoradionecrosis (ORN) is the most severe long-term sequelae caused by radiation therapy to the head or neck and can severely affect a patient ’s quality of life (Koga et al., Oral Diseases 2008). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Nicole Hohenstein, Jason Chan, Benjamin Ziemer, Marc Nash, Colin Carpenter, Adam Pattison, Timothy Solberg, Sue Yom Source Type: research

Carbon Ion Radiation Therapy for Salvage Treatment of Locoregionally Recurrent Nasopharyngeal Carcinoma
Reirradiation for locally recurrent nasopharyngeal carcinoma (LR-NPC) after a definitive radiotherapy is challenging and usually associated with severe adverse-effects. The 2-year overall survival (OS) rates of LR-NPC patients treated with X-ray based intensity-modulated radiation (IMRT) ranged between 45% ∼60%, depends on the stage at local recurrence. Carbon-ion radiotherapy (CIRT) offers both physical and biological advantages over IMRT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Jiade Lu, Jiyi Hu, Jing Gao, Xiyin Guan, Weixu Hu, Jing Yang, Xianxin Qiu, Qingting Huang, Lin Kong Source Type: research

The Rise of HPV in the Elderly: A Changing Landscape of Oropharyngeal Carcinoma
As the human papillomavirus (HPV) epidemic continues to grow, the number of elderly patients with oropharynx squamous cell carcinoma (OPSCC) is rapidly increasing. Despite this observation, this cohort remains understudied as they are often excluded from clinical trials. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Daniel Dickstein, Marc Egerman, Anthony Bui, John Doucette, Jerry Liu, Sonam Sharma, Vishal Gupta, Marshall Posner, Brett Miles, William Westra, Krzysztof Misiukiewicz, Eric Genden, Richard Bakst Source Type: research

Does the Incorporation of Chemotherapy to Adjuvant Radiation Skew the Influence of Treatment Package Time in High-risk Oral Cavity Carcinoma? A Multi-institutional Collaborative Study
Treatment package time (TPT) defined as days elapsing from surgery to the end of adjuvant radiation therapy (RT) is known to impact outcomes in head and neck cancer patients receiving adjuvant RT alone. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Ahmed Ghanem, Neil Woody, Matthew Shymick, Jessica Geiger, C. Jillian Tsai, Neal Dunlap, Howard Liu, Brian Burkey, Eric Lamarre, Jimmy Caudell, Sandro Porceddu, Nahyun Lee, David Adelstein, Shlomo Koyfman, Farzan Siddiqui Source Type: research

Utilizing the Genomic Immune Profile to Predict Progression in Melanoma
The use of systemic immunotherapy has revolutionized the management of advanced melanoma. The CIBERSORT algorithm is a computational method that provides a gene expression profile of tumor infiltrating leukocytes (TILs). Previous studies have shown the presence of TILs have a varying significance amongst cancer histologies. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Russell Palm, Daniela Martir, G. Grass, Eric Welsh, Steven Eschrich, Javier Torres-Roca, Evan Wuthrick, Kamran Ahmed Source Type: research

Pharyngeal Sparing Radiation for Head and Neck Carcinoma of Unknown Primary Following TORS-Assisted Work-up
Patients with squamous cell carcinoma involving cervical lymph nodes without a known primary tumor (HNCUP) increasingly undergo transoral robotic surgery (TORS) to facilitate identification and treatment of occult primary tumors. Radiotherapy (RT) treatment targets for patients with HNCUP have historically been controversial and highly variable. In patients with persistent HNCUP (pT0) following TORS assisted workup, we have adopted a pharyngeal sparing RT (PSRT) approach targeting only the at-risk neck and omitting treatment of the pharynx. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Amardeep Grewal, Samuel Swisher-McClure Source Type: research

Dose-Response Model for Severe Late Laryngeal Toxicity after Stereotactic Body Radiation Therapy for Previously Irradiated Head and Neck Cancer
Prior studies have demonstrated elevated risk of late grade ≥3 toxicity following stereotactic body radiation therapy (SBRT) for re-irradiation of recurrent head and neck cancer (rHNC) affecting the larynx or hypopharynx. Laryngeal toxicity, which can manifest as dysphagia, aspiration, laryngeal edema, or laryngeal stenosis, is one of the most commonly rep orted toxicities after SBRT for rHNC. At this time, no validated dose-volume constraints for the larynx exist to guide SBRT treatment planning. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Diane Ling, John Vargo, Rachel Grimm, Brian Gebhardt, David Clump, Robert Ferris, James Ohr, Dwight Heron Source Type: research

Evidence-Based Methodology for Obtaining Commercial Insurance Coverage of Stereotactic Radiosurgery for Intractable Epilepsy
Despite the Level I evidence supporting stereotactic radiosurgery (SRS) as an efficacious treatment for medically intractable temporal lobe epilepsy (TLE) provided by the Radiosurgery versus Open Surgery for mesial temporal lobe Epilepsy (ROSE) multicenter randomized trial (Barbaro et al., Epilepsia 2018) and the inclusion of intractable epilepsy as an appropriate indication for SRS in the ASTRO published SRS model policies, recent work has indicated that the coverage policies of the largest publicly available commercial insurers in the United States do not include coverage of SRS for intractable epilepsy (Verma et al., Pr...
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Shearwood McClelland, Vivek Verma Source Type: research

Association between Facility Volume and Overall Survival for Patients with Grade II Meningioma after Gross Total Resection
For patients with grade II meningioma who undergo gross total resection (GTR), the role of adjuvant radiation is evolving and has prompted further evaluation in NRG BN003, a phase III national trial. Furthermore, the relationship between facility volume and outcomes in grade II meningioma patients who have undergone GTR has not been examined at a national level. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Chidinma Anakwenze, Susan McGovern, Nicolette Taku, Kaiping Liao, David Boyce-Fappiano, Carlos Kamiya-Matsuoka, Amol Ghia, Caroline Chung, Jing Li, Debra Nana Yeboa Source Type: research

A Phase I Dose Escalation Study of Neoadjuvant SBRT Plus Elective Nodal Radiation with Concurrent Capecitabine for Resectable Pancreatic Cancer
The role of neoadjuvant radiation therapy for resectable pancreatic cancer is controversial. Locoregional failure is a large component of patient morbidity, with a significant proportion of patients dying with progression of local disease (Iacobuzio-Donahue CA, et al. JCO 2009). With recent advances in systemic disease control (Conroy T, et al. NEJM 2018), the role of local therapy may become increasingly important. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Jacob Witt, Aleksandra Kuczmarska-Haas, Daniel Abbott, Sharon Weber, Rebecca Minter, Sean Ronnekleiv-Kelly, Noelle LoConte, Daniel Mulkerin, Sam Lubner, Nataliya Uboha, Dustin Deming, Adam Bayliss, Mark Ritter, Pranshu Mohindra, Michael Bassetti Source Type: research

Pancreatic Stereotactic Body Radiation Therapy (SBRT) in the Era of Multi-Agent Chemotherapy for Locally Advanced and Borderline Resectable Pancreatic Cancer: A Prospective Single Institution Study
Few studies have examined the role of stereotactic body radiation (SBRT) after multiagent chemotherapy (ChT) in pancreatic ductal adenocarcinoma (PDAC). This was a prospective study of SBRT after ChT for PDAC. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Susannah Ellsworth, Michael House, Bert O'Neil, Safi Shahda, Attila Nakeeb, Amy Miller, Sarah Brennan, Amikar Sehdev Source Type: research

Impact of Prior Y90 Dosimetry on Toxicity and Outcomes Following SBRT for Hepatocellular Carcinoma
Stereotactic body radiation therapy (SBRT) is the only non-invasive local therapy for the treatment of hepatocellular carcinoma (HCC) and is often utilized following transarterial embolization. There is a paucity of data reporting safety and outcomes of patients (pts) receiving SBRT after yttrium-90 (Y90). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Shauna Campbell, Aditya Juloori, Timothy Smile, Danielle LaHurd, Naichang Yu, Neil Woody, Kevin Stephans Source Type: research

Tumor Targeted Low Dose Radiation and Immunotherapy in Mouse Models of Melanoma
Immune checkpoint blockade has increased overall survival in patients with multiple late-stage malignancies, including melanoma. Not all patients with melanoma will respond to immunotherapy, and there has been general interest in developing methods capable of boosting clinical response rates. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Allen Rossetti-Chung, Siddheshvar Bhela, Lindsey Claps, Jessica Lawrence, Vaiva Vezys Source Type: research

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(Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Source Type: research

Biopsy Positivity in Prostate Cancer Patients Undergoing MpMRI-Targeted Radiation Dose Escalation
Radiation (RT) dose escalation improves prostate cancer outcomes, but when the whole gland is treated to high doses complications can arise. In prospective clinical trials, prostate multiparametric MRI (mpMRI) findings were used for targeted tumor dose escalation (MTDE). Since biopsy positivity is a known predictor of biochemical failure, prostate biopsy 2-3 years after completion of RT was planned for all patients treated with such dose escalation. Biopsy positivity of these MTDE patients are compared to those in another cohort in which standard whole gland RT doses were used. (Source: International Journal of Radiation O...
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Jessica Meshman, Benjamin Farnia, Radka Stoyanova, Isildinha Reis, Matthew Abramowitz, Alan Dal Pra, Eric Horwitz, Alan Pollack Source Type: research

Prediction of Gleason Grade Group of Prostate Cancer on Multiparametric MRI using Deep Machine Learning Models
The Gleason Grade (GG) Group system has been introduced recently for more accurate stratification of prostate cancer (PCa). The grading system is based on the histologic patterns which is accessed from needle core biopsy, therefore it could be negatively impacted by the intratumor heterogeneity. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Weiwei Zong, Joon Lee, Milan Pantelic, Ning Wen Source Type: research

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(Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Source Type: research

Prospective Randomized Trial of Email and/or Telephone Reminders to Enhance Vaginal Dilator Compliance in Patients Undergoing Brachytherapy for Gynecologic Malignancies
Vaginal stenosis (VS) is a known complication of pelvic radiotherapy resulting from high radiation doses delivered to significant portions of the vaginal canal. VS not only decreases patient quality of life as it can interfere with sexual function, but, importantly, it also precludes the ability to perform an adequate speculum exam to assess for tumor recurrence in the follow up period. The incidence of VS varies in the published literature and depends on patient and treatment-related factors, including cancer type, cancer stage, radiation type and total dose, and adherence to vaginal dilator use. (Source: International Jo...
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Margaret Kozak, Melissa Usoz, Dylann Fujimoto, Rie von Eyben, Elizabeth Kidd Source Type: research

Definitive Radiation Therapy for Medically Inoperable Endometrial Cancer
The standard of care for patients with endometrial cancer typically involves upfront surgery. External beam radiotherapy, brachytherapy, and/or chemotherapy are implemented in the adjuvant setting based on individual risk factors. In the subset of women who are unable to receive surgery due to medical comorbidities or tumor-related factors, external beam radiation and/or uterine brachytherapy can be employed in the definitive setting. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Aleksandra Kuczmarska-Haas, Adam Burr, David Francis, Jacob Witt, Bethany Anderson, Kristin Bradley Source Type: research

Adjuvant Vaginal Cuff Brachytherapy and Patterns of Failure for Early Stage Uterine Carcinosarcoma
Uterine carcinosarcoma (UCS) is a rare histologic type, for which the optimal adjuvant management has not been fully established. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Simeng Zhu, Remonda Khalil, Charlotte Burmeister, Mohamed Elshaikh Source Type: research

Federal Political Contribution Characteristics of Self-Identified Radiation Oncologists in the United States from 2003-2018
The health care industry has a diverse group of stakeholders who seek relationships within government to help ensure that certain interests are considered in the legislative process. One of these mechanisms of engagement is enabled through political action committees (PACs), which contribute to federal campaigns and influence candidates and legislation. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Arpan Prabhu, Eric Lehrer, David Clump, Thomas Kim Source Type: research

Moving to a Hypofractionated New World Order
The proposed CMS Radiation Oncology Model emphasizes bundling and hypofractionation. At one of our sites between fiscal years 2013 and 2016, the mean number of treatments per patient decreased from 19.3 to 17.7, while the number of patients increased by 19%. While this could be in part due to a higher frequency of palliation, the mean number of plans per patient has remained stable (1.14 to 1.17), so we consider it far more likely to be due to increasing hypofractionation where supporting clinical data exist. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Peter Johnstone, Stuart Wasserman, Evan Wuthrick Source Type: research

First Report of the Integration of Virtual Reality Relaxation in a Radiation Therapy Department
Virtual Reality (VR) has been successfully utilized to reduce stress and to promote relaxation. Within the healthcare environment it has been effectively used as distraction therapy to reduce procedural and chronic pain in various clinical contexts. It has been also used as distraction therapy in cancer-related settings, such as chemotherapy. To our knowledge, this is the first study to evaluate the use of VR as a relaxation technique for radiation oncology patients, family/friends and staff. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Isabella Amaniera, Fern Nibauer-Cohen, William Levin, James Metz Source Type: research

Gender-Based Analysis of the Academic Pediatric Radiation Oncology Workforce
Pediatric radiation oncology represents a small yet essential aspect of the field. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Shearwood McClelland, Christina Huang, Richard Zellars Source Type: research

Predicting Progression and Survival Outcomes for Early-Stage Non-Small Cell Lung Cancer Treated with Stereotactic Ablative Radiotherapy: Development and Validation of Robust Prognostic Nomograms
Stereotactic ablative radiotherapy (SABR) has been the standard treatment for medically inoperable patients with early-stage non-small cell lung cancer (ES-NSCLC); however, clinical outcomes after SABR vary significantly among studies. Yet as we transition into the era of personalized medicine, the ability to predict the prognoses of these patients is essential to guide clinical decision-making. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Jingjing Kang, Matthew Ning, Han Feng, Hongqi Li, Houda Bahig, Eric Brooks, James Welsh, Rui Ye, Hongyu Miao, Joe Chang Source Type: research

Utilization and Survival Impact of Definitive Hypofractionated Radiotherapy Compared to Conventionally Fractionated Radiotherapy in Stage I Non-Small Cell Lung Cancer
The real-world impact of definitive hypofractionated radiotherapy (HFRT) is unclear for patients with stage I non-small cell lung cancer (NSCLC) not suitable for surgery, stereotactic body radiation therapy (SBRT), or chemoradiotherapy. HFRT is more convenient, is less expensive, and is amenable to BED10 (biologically effective dose assuming α/β=10) escalation compared to conventionally fractionated radiotherapy (CFRT). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Henry Park, Nadia Saeed, Roy Decker Source Type: research

Long-term Outcomes of Proton Beam Re-irradiation for Locoregionally Recurrent Non-Small Cell Lung Cancer
The management of locoregionally recurrent NSCLC in the setting of prior radiation therapy is challenging. Proton radiotherapy (PRT) may be ideally suited to minimize toxicity to previously irradiated organs. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Abigail Berman, Hann-Hsiang Chao, Charles Simone, Timothy Kegelman, Charu Aggarwal, Joshua Bauml, Aditi Singh, William Levin, Keith Cengel, Steven Feigenberg, Ramesh Rengan, Corey Langer, Christine Ciunci, John Plastaras Source Type: research

Development and Validation of a Deep Learning Algorithm to Predict Radiation Pneumonitis and Esophagitis Following Lung Stereotactic Body Radiation Therapy
Radiation pneumonitis and esophagitis remain significant complications following stereotactic body radiation therapy (SBRT). Traditional prediction models for radiation pneumonitis and esophagitis rely primarily on static dosimetric values and often fail to objectively integrate patient-specific anatomy represented in diagnostic imaging data. We sought to evaluate the efficacy of deep learning methods for SBRT toxicity prediction. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Enoch Chang, Justin Du, Roy Decker, James Yu, Henry Park, Sanjay Aneja Source Type: research

Interim Analysis: Quality of Life and Cervical Cancer Chemoradiation Treatment Compliance at a Safety-Net Hospital
Local control and overall survival in locally advanced cervical cancer are highly dependent on patient compliance with radiation therapy. In other disease sites, compliance with treatment has been found to be associated with a patient ’s quality of life (QoL), but it remains unclear how QoL is associated with treatment compliance in patients with cervical cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Elizabeth Sult Case, Michelle Ludwig, Alison Yoder, Tracilyn Hall, Jane Montealegre Source Type: research

Prospective Patient-Reported Outcomes, Physician-Assessed Toxicities, and Treatment Outcomes in Sinonasal Malignancies Following Proton Beam Therapy
Historically, sinonasal cancer outcomes have had minimal improvement in the photon radiotherapy (XRT) treatment eras, with 3-year overall survival (OS) of 40-70% and grade 3+ (G3) physician-assessed toxicities (PATs) of 15-35%. Proton beam therapy (PBT) has the potential to improve outcomes but prospective data is scarce, particularly PATs and patient-reported outcomes (PROs). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Dario Pasalic, Ethan Ludmir, Nikhil Thaker, Brandon Gunn, Ehab Hanna, Shirley Su, Renata Ferrarotto, Bonnie Glisson, Jay Reddy, Clifton Fuller, Jack Phan, David Rosenthal, William Morrison, Adam Garden, Steven Frank Source Type: research

Enhancement of the Follicular Lymphoma International Prognostic Index (FLIPI) with Lymphopenia (FLIPI-L) to Predict Overall Survival and Histologic Transformation
Prognostic models for follicular lymphoma include FLIPI and FLIPI2 PRIMA-PI, and more recently have incorporated molecular and mutational components. FLIPI categorizes patients into low-, intermediate-, and high-risk groups with 5-year overall survival of 91%, 78% and 53%. Through a retrospective review, we compared the survival outcomes of follicular lymphoma patients with absolute lymphopenia (ALC (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Madeline Hooper, George Yang, Matthew Mills, Nicholas Figura, Catherine Doyle, Daniel Oliver, Timothy Robinson, Julio Chavez, Sungjune Kim Source Type: research

Management of Regional Nodes in the Treatment of Breast Cancer: An American Radium Society Appropriate Us Criteria Panel for Breast Cancer Systematic Review and Guideline
The management of regional nodes in breast cancer patients is a complex and evolving area of significant clinical impact. Numerous recent randomized trials and other studies have reported improved survival outcomes associated with the inclusion of regional nodal irradiation in patients with node positive breast cancer or even high risk node negative breast cancer. The selection of patients for extent of axillary surgery has also been the subject of numerous randomized trials with a resulting reduction in the use of axillary dissection in many populations. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Eleanor Harris, Eleanor Walker, Manjeet Chadha Source Type: research

Outcomes Among Hormone Receptor Positive Metastatic Inflammatory Breast Cancer (IBC)
Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer, accounting for only 1-5% of breast cancer diagnoses but up to 10% of breast cancer deaths annually in the United States. In contrast to findings in non-IBC patients, prior studies of stage III IBC patients suggest that compared to other receptor subtypes, hormone receptor (HR) positivity is not a favorable prognostic factor. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Wendy Woodward, Renae Van Wyhe, Rebecca Tidwell, Michael Stauder, Bora Lim, Mediget Teshome, Savitri Krishnamurthy, Huong Le-Petross, Naoto Ueno Source Type: research

Factors Associated with Fatigue in Breast Cancer Patients Undergoing External Beam Radiation Therapy
Cancer-related fatigue (CRF), a prevalent and potentially debilitating symptom among cancer patients, is a side effect of external beam radiotherapy (EBRT). Even when targeting organs unrelated to caloric intake or the CNS, radiotherapy can increase CRF, a complex and poorly understood toxicity resulting from patient-specific, systemic therapy-related, and radiation specific factors. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Michael LaRiviere, Hann-Hsiang Chao, Abigail Doucette, Timothy Kegelman, Neil Taunk, Gary Freedman, Neha Vapiwala Source Type: research

Long-term Risk of Fatal Heart Disease Among Breast Cancer Patients
In breast cancer patients, receipt of radiotherapy and chemotherapy may increase the risk of heart disease. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Nicholas Zaorsky, Aya Agha, Samantha Horn, Jennifer Rosenberg, Daniel Trifiletti, Roberto Diaz, Alexander Louie Source Type: research

Assessing Deformable Image Registration Accuracy in Cervical Brachytherapy Using A 3D Model Phantom
Cervical brachytherapy (BT) is a critical component in the definitive treatment for patients with cervical cancer. Current American Brachytherapy Society and GEC-ESTRO Working group guidelines recommend a 3D treatment planning approach for cervical brachytherapy1-3. Tumor delineation using magnetic resonance imaging (MRI) is superior to CT-guided contouring, resulting in improved local control, cancer specific survival, and overall survival4. Unfortunately, the logistics and cost of obtaining post implantation MRI is impractical for most Radiation Oncology Departments. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Vonetta Williams, Sarah Geneser, Christina Brunnquell, Landon Wootton, Lori Young, Juergen Meyer, Brandon Dyer Source Type: research