Off the Top of Our Head

The current standard of care for locally advanced cutaneous squamous cell carcinoma consists of upfront resection followed by adjuvant radiation in the presence of high-risk features. In this case, several factors make surgery less desirable. We do not know whether there is tumor involvement of the sagittal sinus. Invasion of the sagittal sinus would preclude upfront surgery. Additionally, the extent of resection would require a large reconstruction with free tissue transfer. In the setting of active smoking, there is significant concern for failure of a free flap reconstruction.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research