International Journal of Radiation Oncology * Biology * Physics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Assessing Feasibility and Acceptability of a Computerized Food Frequency Questionnaire (FFQ) Intervention to Determine Dietary Patterns in Head and Neck Cancer (HNC) Survivors
There is no systematic approach to diet assessment in HNC survivors. We piloted a novel computerized FFQ (VioScreen) that provides nutrition-specific feedback on diet quality with suggested dietary improvements in HNC survivors to assess feasibility and acceptability of the FFQ, explore associations between diet quality, QOL, and patient/treatment characteristics, and assess longitudinal changes in diet quality. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: M. Albert, K. Ahr, J. Senchak, B. Egleston, T.J. Galloway, J. Costa, K. Stromberg, J. Liu, C. Schmalbach, A. Giri, V. Vendra, C. Fang, R. Jain, J.R. Bauman Tags: 176 Source Type: research

Prospective Study of Plasma Biomarker-Guided Surveillance of HPV-positive Oropharynx Cancer Using TTMV-HPV DNA: The SPHERE Study
Previous observational studies suggest that circulating tumor HPV DNA may facilitate early detection of recurrent HPV-positive oropharynx cancer (OPC). This is the first prospective cohort study to investigate whether biomarker-guided surveillance detects recurrent disease sooner than standard of care. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: E.M. Rettig, J. Miller, B. Sargent, E. Carey, R.I. Haddad, D.N. Margalit, K. Sehgal, R. Sethi, R. Uppaluri, R.B. Tishler, L. Goguen, D.J. Annino, E. Sim, V. Jo, K. Wong, J.P. Guenette, J.D. Schoenfeld, G.J. Hanna Tags: 177 Source Type: research

Observations on Carotid Artery Stenosis Following Neck Irradiation
Carotid artery stenosis (CAS) is a known potential late effect of neck radiation. There are varying estimates of its incidence and mixed consensus on whether screening for this late effect standard practice should be. As treatment techniques have evolved and the presence of HPV has increased, the impact on the future trajectory of this problem is unclear. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: B.A. Harr, C.A. Reddy, R.M. Kahnert, M. Fox, S. Fryberger, D. Ives, A. Bishop, E. Cook, N. Karasik, J.A. Miller, S.R. Campbell, T. Sussman, E. Yilmaz, N.M. Woody, J.L. Geiger, S.A. Koyfman, J. Bodmann Tags: 178 Source Type: research

Health Care Utilization and Opioid Use in Patients Receiving an Integrated Palliative Care Intervention for Treatment of Head and Neck Cancer Compared to a Historical Control
Patients receiving chemoradiation therapy (CRT) for head and neck cancer (HNC) can develop significant symptomology (odynophagia, malnutrition) resulting in frequent hospitalizations and decreased quality of life (QOL) and continue to have chronic symptoms such as dysphagia and/or pain. The integration of a palliative care (PC) team during CRT has the potential to address the high symptom burden and improve QOL. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: F. Rizwan, C. D'Avella, M. Albert, T. King, B. Egleston, T.J. Galloway, M. Chwistek, C. Fang, A. El-jawahri, J.R. Bauman Tags: 179 Source Type: research

Oral Cavity Obliteration is a Novel Predictor of Functional Outcomes after Glossectomy Reconstruction
The primary goal for reconstruction of oral tongue defects is to improve speech and swallowing. We hypothesize that degree of oral cavity obliteration will correlate to a specific functional outcome. The purpose of this study is to present a new reconstructive metric that uses volume displacement to measure oral cavity obliteration and correlate this metric to outcomes of speech and swallowing. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: M.E. Heft-Neal, J.D. Smith, S.B. Chinn, E. Chanowski, R.J. Morrison, T. Lyden, D. Chepeha, M.E. Spector Tags: 180 Source Type: research

Patient-Reported and Dosimetric Determinants of Trismus after Chemoradiation for Nasopharyngeal Carcinoma: A Prospective Study
Trismus is a common side effect following radiation therapy for head and neck cancer and may be most severe for patients with nasopharyngeal carcinoma. To date, prospective efforts investigating patient reported outcomes combined with dosimetric predictors are lacking. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: M.S. Gentile, A.A. Aizer, T. Goldsmith, E.A. Weyman, A. Holman, J.A. Adams, A.W. Chan Tags: 181 Source Type: research

Testing and Validation of a Custom Trained Large Language Model for HN Patients with Guardrails
The goal is to custom-train an advanced large language model (LLM) chatbot utilizing data approved by qualified medical professionals (Physicians and Nurses), for a patient-focused platform for head and neck (HN) cancer patient survivorship and overall well-being. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: L. Zhu, A. Anand, G. Gevorkyan, L.A. McGee, J.C. Rwigema, Y. Rong, S.H. Patel Tags: 182 Source Type: research

Early Treatment With Mesenchymal Stromal Cells Prevents Development of Long-term Radiation Induced Salivary Dysfunction
There is a critical need for a treatment that will safely and effectively prevent the development of radiation-induced xerostomia (RIX) or salivary dysfunction. We preformed preclinical studies to test the ability of IFN- ɣ stimulated marrow-derived mesenchymal stromal cells (MSC(M)) to prevent the development of long-term salivary dysfunction in a mouse model. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: C. Paz, A.G. Frick, K.P. Nickel, I. Gurevic, G.C. Blitzer, S.S. McCoy, R.J. Kimple Tags: 183 Source Type: research

Incidence of Flap Failure Following Sinonasal Surgery, Flap Reconstruction and Postoperative Proton Radiation Therapy
Following sinonasal surgery, orofacial reconstruction often requires the use of tissue flaps (1). Currently, there is a paucity of data addressing the incidence of flap complications following postoperative radiation using proton therapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: F. Yang, I. Ganly, E. Matros, T. Hung, M. Cohen, R.J. Wong, Y. Wu, N.Y. Lee Tags: 184 Source Type: research

A Randomized, Double-blinded Pivotal Study of the Safety and Efficacy of a Novel Intraoral Photobiomodulation Device in Head and Neck Cancer Patients Undergoing Radiation Therapy With or Without Vhemotherapy
Oral mucositis (OM) is a significant adverse event (AE) that affects over 90% of head and neck cancer (HNC) patients undergoing radiation (RT) with chemotherapy (CT). OM is characterized by ulceration, erythema, and edema of the oral tissues and can result in interruptions in and/or early termination of cancer treatment, increased opioid usage, and decreased alimentation and quality of life. Pharmacological interventions for OM are limited; however supportive care treatment guidelines (MASCC, WALT) recommend photobiomodulation (PBM) therapy for the prevention/treatment of OM. (Source: International Journal of Radiation Onc...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: J.L. Frustino, K.S. Hu, N. Treister, C.D. Willey, J. Lazzara, M. Marotta, V. Kothari, N. Lipko Tags: 185 Source Type: research

Characteristics and Management of Post Treatment Pharyngeal Ulceration in Oropharyngeal Squamous Cell Carcinoma Patients Treated with Definitive Radiation/Chemoradiation
Treatment of oropharyngeal cancer with definitive radiation/chemoradiation (RT/CRT) is an effective treatment and rapid regression of tumor can occur. Following treatment some patients will develop a pharyngeal ulcer which may or may not be associated with disease persistence. Data for the management of ulcers could improve post radiation care. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: N.M. Woody, B. Prendes, K. Dennert, S.R. Campbell, R. Duggal, C.A. Fan, D.S. Buchberger, J. Ku, J. Scharpf, J.L. Geiger, E. Yilmaz, T. Sussman, N. Silver, J. Miller, N. Karasik, R.W. Davis, D. Bottalico, S.A. Koyfman, E. Lamarre Tags: 186 Source Type: research

Opioid and Adjunctive Medication Prescriptions in Curative-Intent Radiation Therapy for Head and Neck Cancer (HNC)
Managing pain during curative-intent radiation therapy for head and neck cancer (HNC) is crucial, yet little is known about opioid prescription trends and long-term use in these patients. For this patient population we sought to quantify opioid and adjunctive pain medications, as well as characterize HNC radiotherapy patients. Identifying individuals with higher opioid needs can inform targeted interventions to reduce overall opioid usage. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: S. Khan, R. Lu, B. Lasonde, S. Hawa Tags: 187 Source Type: research

Mitigating Oral Mucositis in Proton Therapy with Advanced Dose-, LET- and Organ Volume-based Constraints
Oral mucositis is one of the most frequent and impairing acute adverse effects of radiotherapy for head and neck malignancies, occurring in almost 100% of patients. Although proton therapy provides a superior sparing of the oral cavity compared to photon therapy, up to 70% of patients still experience oral mucositis. Currently, the only countermeasure for mitigating this sequela is to set dose limits in the oral cavity, whose values have been derived from photon therapy data using the Relative Biological Effectiveness (RBE) as a scaling factor. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: G. Cartechini, S. Liu, C. Washington, S. Samuels, C. La Tessa Tags: 188 Source Type: research

Twelve Month Follow Up on MARSH: A Pilot, First in Human Study of Autologous IFN-gamma Stimulated Mesenchymal Stromal Cells for Treatment of Radiation-induced Xerostomia
There are no existing effective treatments for radiation-induced xerostomia (RIX), a common side effect of head and neck radiation. Mesenchymal stromal cells (MSCs) exhibit regenerative effects in multiple tissues and may represent an effective cell therapy for the treatment of RIX. Here we present the updated primary safety and secondary efficacy endpoints of a first-in-human pilot study of IFN γ-stimulated autologous bone marrow- derived MSCs [MSC(M)] for the treatment of RIX. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: G.C. Blitzer, T. Glazer, S. Gustafson, A. Burr, R. Pena, R. Mattison, O. Ganz, R. Meyers, M. Weiss, K. McDowell, K.P. Nickel, R.J. Chappell, N. Pulia, J. Gallipeau, R.J. Kimple Tags: 189 Source Type: research

Phase II Trial of Quality-of-Life Outcomes after Proton Beam for Nasopharyngeal Carcinoma
Radiotherapy is a primary treatment modality for nasopharyngeal cancer (NPC). Advances in radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) have shown less detriment in quality of life (QOL). Proton beam therapy (PBT) has potential to further reduce detriment in QOL due to reduced exposure of normal tissues to low-dose radiation. The purpose of this study was to assess patient-reported QOL outcomes after PBT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: J. Slater, E.A. Weyman, A.W. Chan Tags: 190 Source Type: research