Longitudinal assessment of tumor-infiltrating lymphocytes in primary breast cancer following neoadjuvant radiotherapy
Tumor-infiltrating lymphocytes (TILs) have prognostic significance in several cancers, including breast. Despite interest in combining radiotherapy with immunotherapy, little is known about the effect of radiotherapy itself on the tumor-immune microenvironment, including TILs. Here, we interrogated longitudinal dynamics of tumor-infiltrating and systemic lymphocytes in patient samples taken before, during, and after neoadjuvant radiotherapy (NART), from XXX and XXX breast clinical trials.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Miki Yoneyama, Konstantinos Zormpas-Petridis, Ruth Robinson, Faranak Sobhani, Elena Provenzano, Harriet Steel, Sara Lightowlers, Catherine Towns, Simon P. Castillo, Selvakumar Anbalagan, Tom Lund, Erik Wennerberg, Alan Melcher, Charlotte E. Coles, Ioannis Tags: Biology Contribution Source Type: research
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